DE3683342D1 - Verfahren zur herstellung von tabletten von isosorbid-5-mononitrat mit verzoegerter abgabe und so erhaltene zusammensetzungen. - Google Patents

Verfahren zur herstellung von tabletten von isosorbid-5-mononitrat mit verzoegerter abgabe und so erhaltene zusammensetzungen.

Info

Publication number
DE3683342D1
DE3683342D1 DE8686201705T DE3683342T DE3683342D1 DE 3683342 D1 DE3683342 D1 DE 3683342D1 DE 8686201705 T DE8686201705 T DE 8686201705T DE 3683342 T DE3683342 T DE 3683342T DE 3683342 D1 DE3683342 D1 DE 3683342D1
Authority
DE
Germany
Prior art keywords
mononitrate
isosorbide
compositions obtained
delayed delivery
producing tablets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686201705T
Other languages
English (en)
Inventor
Massimo Calanchi
Piergiorgio Rossi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adare Pharmaceuticals SRL
Original Assignee
Eurand International SpA
Eurand Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand International SpA, Eurand Italia SpA filed Critical Eurand International SpA
Application granted granted Critical
Publication of DE3683342D1 publication Critical patent/DE3683342D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8686201705T 1985-10-15 1986-10-02 Verfahren zur herstellung von tabletten von isosorbid-5-mononitrat mit verzoegerter abgabe und so erhaltene zusammensetzungen. Expired - Lifetime DE3683342D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22493/85A IT1187750B (it) 1985-10-15 1985-10-15 Procedimento per la preparazione di compresse,anche a rilascio prolungato,di iscsorbide-5-mononitrato stabilizzato e formulazioni cosi' ottenute

Publications (1)

Publication Number Publication Date
DE3683342D1 true DE3683342D1 (de) 1992-02-20

Family

ID=11197007

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686201705T Expired - Lifetime DE3683342D1 (de) 1985-10-15 1986-10-02 Verfahren zur herstellung von tabletten von isosorbid-5-mononitrat mit verzoegerter abgabe und so erhaltene zusammensetzungen.

Country Status (12)

Country Link
US (1) US4812316A (de)
EP (1) EP0219161B1 (de)
JP (1) JPS62123114A (de)
AT (1) ATE71290T1 (de)
AU (1) AU591185B2 (de)
CA (1) CA1285489C (de)
DE (1) DE3683342D1 (de)
ES (1) ES2035819T3 (de)
GR (1) GR3004285T3 (de)
HK (1) HK12295A (de)
IT (1) IT1187750B (de)
ZA (1) ZA867768B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE64726B1 (en) * 1987-11-20 1995-08-23 Elan Corp Plc Pharmaceutical formulations for preventing drug tolerance
IT1237638B (it) * 1989-10-25 1993-06-12 Ghirardi Paolo E. Impiego dell'isosorbide 2-mononitrato per la preparazione di composi- zioni farmaceutiche atte al trattamento dell'angina pectoris
FR2666506A1 (fr) * 1990-09-07 1992-03-13 Pf Medicament Comprime a liberation prolongee a base de 5-mononitrate d'isosorbide et son procede de preparation.
FR2677886B1 (fr) * 1991-06-18 1995-03-31 Adir Comprime matriciel permettant la liberation prolongee d'indapamide apres administration par voie orale.
IT1251114B (it) * 1991-07-26 1995-05-04 Farcon Ag Forme farmaceutiche antivirali per applicazione vaginale
DE4313726A1 (de) * 1993-04-27 1994-11-03 Byk Nederland Bv Feste Darreichungsform
US6080428A (en) 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6676967B1 (en) * 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6129930A (en) 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US20060263428A1 (en) * 1993-09-20 2006-11-23 Eugenio Cefali Methods for treating hyperlipidemia with intermediate release nicotinic acid compositions having unique biopharmaceutical characteristics
DE19515972A1 (de) * 1995-05-02 1996-11-07 Bayer Ag Arzneizubereitungen mit kontrollierter Freisetzung und Verfahren zu ihrer Herstellung
US5900425A (en) * 1995-05-02 1999-05-04 Bayer Aktiengesellschaft Pharmaceutical preparations having controlled release of active compound and processes for their preparation
WO1998005306A1 (en) * 1996-08-02 1998-02-12 Cal International Limited Controlled release tablet formulation of isosorbide-5-mononitrate
US5851555A (en) * 1997-08-15 1998-12-22 Fuisz Technologies Ltd. Controlled release dosage forms containing water soluble drugs
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
JP4696210B2 (ja) * 2000-06-07 2011-06-08 トーアエイヨー株式会社 イソソルビド‐５‐モノニトレートを有効成分とする徐放性錠剤及びその製造方法
JP4840549B2 (ja) * 2000-11-20 2011-12-21 トーアエイヨー株式会社 安定な血管拡張剤及びその製造方法
US7008979B2 (en) * 2002-04-30 2006-03-07 Hydromer, Inc. Coating composition for multiple hydrophilic applications
US20040109889A1 (en) * 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
CN101442982B (zh) * 2006-03-16 2012-07-18 格莱克劳吉克有限公司 用于诱导饱满感的包含优选处理过的淀粉的胃漂浮物组合物
CN111068644B (zh) * 2019-12-20 2023-01-03 中海油天津化工研究设计院有限公司 一种均四甲苯氧化制均酐催化剂及其制备方法
CN115487162B (zh) * 2022-10-13 2023-10-13 山东力诺制药有限公司 一种单硝酸异山梨酯缓释片的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2301664C3 (de) * 1973-01-13 1979-07-12 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Oral verabreichbares, Nitroglycerin enthaltendes Arzneimittel
US3972995A (en) * 1975-04-14 1976-08-03 American Home Products Corporation Dosage form
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
IL61721A (en) * 1980-12-16 1984-03-30 Blank Izhak Nitroglycerin preparations
US4369172A (en) * 1981-12-18 1983-01-18 Forest Laboratories Inc. Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
DE3325652A1 (de) * 1983-07-15 1985-01-24 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Feste, stabile isosorbid-5-mononitrat enthaltende arzneimittelzubereitungen und verfahren zu ihrer herstellung
JPS60181052A (ja) * 1984-02-29 1985-09-14 Tooa Eiyoo Kk 安定なイソソルビド硝酸エステル組成物及びその製造法

Also Published As

Publication number Publication date
AU6383186A (en) 1987-04-16
ZA867768B (en) 1987-06-24
EP0219161A3 (en) 1988-01-13
US4812316A (en) 1989-03-14
JPS62123114A (ja) 1987-06-04
GR3004285T3 (de) 1993-03-31
IT1187750B (it) 1987-12-23
EP0219161A2 (de) 1987-04-22
EP0219161B1 (de) 1992-01-08
IT8522493A0 (it) 1985-10-15
CA1285489C (en) 1991-07-02
HK12295A (en) 1995-02-03
ES2035819T3 (es) 1993-05-01
JPH0524888B2 (de) 1993-04-09
AU591185B2 (en) 1989-11-30
ATE71290T1 (de) 1992-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: EURAND INTERNATIONAL S.P.A., MAILAND/MILANO, IT

8328 Change in the person/name/address of the agent

Free format text: TERGAU, E., DIPL.-ING., PAT.-ANW., 90482 NUERNBERG

8339 Ceased/non-payment of the annual fee