HUP0003206A2 - Eljárás 9-nitro-20-kamptotecin előállítására és tisztítására - Google Patents
Eljárás 9-nitro-20-kamptotecin előállítására és tisztításáraInfo
- Publication number
- HUP0003206A2 HUP0003206A2 HU0003206A HUP0003206A HUP0003206A2 HU P0003206 A2 HUP0003206 A2 HU P0003206A2 HU 0003206 A HU0003206 A HU 0003206A HU P0003206 A HUP0003206 A HU P0003206A HU P0003206 A2 HUP0003206 A2 HU P0003206A2
- Authority
- HU
- Hungary
- Prior art keywords
- camptothecin
- nitro
- purifying
- preparing
- methods
- Prior art date
Links
- 229940127093 camptothecin Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 abstract 3
- 229950009213 rubitecan Drugs 0.000 abstract 3
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- OMBRFUXPXNIUCZ-UHFFFAOYSA-N dioxidonitrogen(1+) Chemical compound O=[N+]=O OMBRFUXPXNIUCZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000002823 nitrates Chemical class 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
A találmány 9-nitro-kamptotecin előállítási eljárására vonatkozik,amelynek során egy 20-kamptotecint a 9-nitro-kamptotecinkialakulásához megfelelő hőmérsékleten és ideig legalább egyszervetlen nitrátsóval és legalább egy olyan savval reagáltatnak,amely sav hatásosan katalizálja egy nitróniumion képződését. Atalálmány kiterjed a 9-nitro-kamptotecin kromatográfiás éskristályosítással végzett tisztítási eljárásaira is. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/906,434 US5922877A (en) | 1997-08-05 | 1997-08-05 | Methods of preparing and purifying 9-nitro-20-camptothecin |
PCT/US1998/014532 WO1999007709A1 (en) | 1997-08-05 | 1998-07-10 | Methods of preparing and purifying 9-nitro-20-camptothecin |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0003206A2 true HUP0003206A2 (hu) | 2001-10-28 |
HUP0003206A3 HUP0003206A3 (en) | 2001-12-28 |
Family
ID=25422444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0003206A HUP0003206A3 (en) | 1997-08-05 | 1998-07-10 | Methods of preparing and purifying 9-nitro-20-camptothecin |
Country Status (14)
Country | Link |
---|---|
US (1) | US5922877A (hu) |
EP (1) | EP1003750B1 (hu) |
JP (2) | JP3651778B2 (hu) |
CN (2) | CN1266435A (hu) |
AT (1) | ATE390429T1 (hu) |
AU (1) | AU736323B2 (hu) |
CA (1) | CA2296731C (hu) |
DE (1) | DE69839306T2 (hu) |
DK (1) | DK1003750T3 (hu) |
ES (1) | ES2303355T3 (hu) |
HU (1) | HUP0003206A3 (hu) |
IL (2) | IL134224A0 (hu) |
PT (1) | PT1003750E (hu) |
WO (1) | WO1999007709A1 (hu) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5527913A (en) * | 1993-02-25 | 1996-06-18 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
US6407118B1 (en) | 1996-01-30 | 2002-06-18 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
US5731316A (en) | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
US6352996B1 (en) | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
EP2266607A3 (en) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Immunoconjugates for treating cancer |
DE10063766B4 (de) * | 2000-12-21 | 2005-01-27 | Daimlerchrysler Ag | Airbagvorrichtung für einen Personenkraftwagen |
US7071202B2 (en) * | 2002-02-21 | 2006-07-04 | Supergen, Inc. | Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor |
EP2266590A3 (en) | 2002-02-22 | 2011-04-20 | Shire LLC | Active agent delivery sytems and methods for protecting and administering active agents |
US6703399B2 (en) | 2002-05-06 | 2004-03-09 | The Stehlin Foundation For Cancer Research | Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds |
US6699875B2 (en) | 2002-05-06 | 2004-03-02 | The Stehlin Foundation For Cancer Research | Cascade esters of camptothecins and methods of treating cancer using these compounds |
US20040204435A1 (en) * | 2003-04-09 | 2004-10-14 | Joachim Liehr | Alternating treatment with topoisomerase I and topoisomerase II inhibitors |
CN1324032C (zh) * | 2004-01-07 | 2007-07-04 | 重庆医药工业研究院有限责任公司 | 一种新的9-硝基喜树碱晶型和药物组合物 |
CN100334089C (zh) * | 2004-07-21 | 2007-08-29 | 王洋 | 一种9-硝基喜树碱的生产方法 |
CN1312155C (zh) * | 2005-01-21 | 2007-04-25 | 华东理工大学 | 一种分离纯化9-硝基喜树碱的方法 |
RU2441008C2 (ru) * | 2006-08-11 | 2012-01-27 | Дзе Кристус Стелин Фаундейшн Фор Кэнсер Рисерч | Способы получения сложных эфиров камптотецинов |
US7572803B2 (en) * | 2007-10-25 | 2009-08-11 | The Christus Stehlin Foundation For Cancer Research | Hydrated crystalline esters of camptothecin |
JP2012155651A (ja) * | 2011-01-28 | 2012-08-16 | Sony Corp | 信号処理装置および方法、並びに、プログラム |
CN104628737B (zh) * | 2015-01-28 | 2017-06-06 | 华南理工大学 | 两种新晶型的9‑硝基喜树碱及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US5527913A (en) * | 1993-02-25 | 1996-06-18 | The Stehlin Foundation For Cancer Research | Methods for purifying camptothecin compounds |
GB9319944D0 (en) * | 1993-09-28 | 1993-11-17 | Erba Carlo Spa | Process for the preparation of 9-amino camptothecin |
US5731316A (en) * | 1996-01-30 | 1998-03-24 | The Stehlin Foundation For Cancer Research | Derivatives of camptothecin and methods of treating cancer using these derivatives |
-
1997
- 1997-08-05 US US08/906,434 patent/US5922877A/en not_active Ceased
-
1998
- 1998-07-10 DK DK98933340T patent/DK1003750T3/da active
- 1998-07-10 WO PCT/US1998/014532 patent/WO1999007709A1/en active IP Right Grant
- 1998-07-10 CN CN98807978A patent/CN1266435A/zh active Pending
- 1998-07-10 CA CA002296731A patent/CA2296731C/en not_active Expired - Fee Related
- 1998-07-10 DE DE69839306T patent/DE69839306T2/de not_active Expired - Fee Related
- 1998-07-10 AU AU83003/98A patent/AU736323B2/en not_active Ceased
- 1998-07-10 IL IL13422498A patent/IL134224A0/xx active IP Right Grant
- 1998-07-10 PT PT98933340T patent/PT1003750E/pt unknown
- 1998-07-10 HU HU0003206A patent/HUP0003206A3/hu unknown
- 1998-07-10 ES ES98933340T patent/ES2303355T3/es not_active Expired - Lifetime
- 1998-07-10 CN CNA2007101625950A patent/CN101186609A/zh active Pending
- 1998-07-10 EP EP98933340A patent/EP1003750B1/en not_active Expired - Lifetime
- 1998-07-10 JP JP2000506212A patent/JP3651778B2/ja not_active Expired - Fee Related
- 1998-07-10 AT AT98933340T patent/ATE390429T1/de not_active IP Right Cessation
-
2000
- 2000-01-26 IL IL134224A patent/IL134224A/en not_active IP Right Cessation
-
2004
- 2004-12-22 JP JP2004372250A patent/JP3842278B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE390429T1 (de) | 2008-04-15 |
IL134224A (en) | 2006-10-31 |
DK1003750T3 (da) | 2008-07-21 |
JP2001512732A (ja) | 2001-08-28 |
PT1003750E (pt) | 2008-04-29 |
WO1999007709A1 (en) | 1999-02-18 |
JP2005145981A (ja) | 2005-06-09 |
JP3651778B2 (ja) | 2005-05-25 |
DE69839306D1 (de) | 2008-05-08 |
AU736323B2 (en) | 2001-07-26 |
IL134224A0 (en) | 2001-04-30 |
ES2303355T3 (es) | 2008-08-01 |
HUP0003206A3 (en) | 2001-12-28 |
EP1003750B1 (en) | 2008-03-26 |
CA2296731A1 (en) | 1999-02-18 |
US5922877A (en) | 1999-07-13 |
CA2296731C (en) | 2007-01-09 |
DE69839306T2 (de) | 2009-04-09 |
CN101186609A (zh) | 2008-05-28 |
EP1003750A1 (en) | 2000-05-31 |
CN1266435A (zh) | 2000-09-13 |
AU8300398A (en) | 1999-03-01 |
JP3842278B2 (ja) | 2006-11-08 |
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