DK1003750T3 - Fremgangsmåde til at fremstille og oprense 9-nitro-20-camptothecin - Google Patents

Fremgangsmåde til at fremstille og oprense 9-nitro-20-camptothecin

Info

Publication number
DK1003750T3
DK1003750T3 DK98933340T DK98933340T DK1003750T3 DK 1003750 T3 DK1003750 T3 DK 1003750T3 DK 98933340 T DK98933340 T DK 98933340T DK 98933340 T DK98933340 T DK 98933340T DK 1003750 T3 DK1003750 T3 DK 1003750T3
Authority
DK
Denmark
Prior art keywords
camptothecin
nitrocamptothecin
purifying
nitro
preparing
Prior art date
Application number
DK98933340T
Other languages
English (en)
Inventor
Zhisong Cao
Original Assignee
Stehlin Foundation For Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stehlin Foundation For Cancer filed Critical Stehlin Foundation For Cancer
Application granted granted Critical
Publication of DK1003750T3 publication Critical patent/DK1003750T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK98933340T 1997-08-05 1998-07-10 Fremgangsmåde til at fremstille og oprense 9-nitro-20-camptothecin DK1003750T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/906,434 US5922877A (en) 1997-08-05 1997-08-05 Methods of preparing and purifying 9-nitro-20-camptothecin
PCT/US1998/014532 WO1999007709A1 (en) 1997-08-05 1998-07-10 Methods of preparing and purifying 9-nitro-20-camptothecin

Publications (1)

Publication Number Publication Date
DK1003750T3 true DK1003750T3 (da) 2008-07-21

Family

ID=25422444

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98933340T DK1003750T3 (da) 1997-08-05 1998-07-10 Fremgangsmåde til at fremstille og oprense 9-nitro-20-camptothecin

Country Status (14)

Country Link
US (1) US5922877A (da)
EP (1) EP1003750B1 (da)
JP (2) JP3651778B2 (da)
CN (2) CN101186609A (da)
AT (1) ATE390429T1 (da)
AU (1) AU736323B2 (da)
CA (1) CA2296731C (da)
DE (1) DE69839306T2 (da)
DK (1) DK1003750T3 (da)
ES (1) ES2303355T3 (da)
HU (1) HUP0003206A3 (da)
IL (2) IL134224A0 (da)
PT (1) PT1003750E (da)
WO (1) WO1999007709A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527913A (en) * 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
DE10063766B4 (de) * 2000-12-21 2005-01-27 Daimlerchrysler Ag Airbagvorrichtung für einen Personenkraftwagen
US6482830B1 (en) 2002-02-21 2002-11-19 Supergen, Inc. Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US6703399B2 (en) 2002-05-06 2004-03-09 The Stehlin Foundation For Cancer Research Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
US6699875B2 (en) 2002-05-06 2004-03-02 The Stehlin Foundation For Cancer Research Cascade esters of camptothecins and methods of treating cancer using these compounds
US20040204435A1 (en) * 2003-04-09 2004-10-14 Joachim Liehr Alternating treatment with topoisomerase I and topoisomerase II inhibitors
CN1324032C (zh) * 2004-01-07 2007-07-04 重庆医药工业研究院有限责任公司 一种新的9－硝基喜树碱晶型和药物组合物
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
CN1312155C (zh) * 2005-01-21 2007-04-25 华东理工大学 一种分离纯化9－硝基喜树碱的方法
US7928235B2 (en) * 2006-08-11 2011-04-19 The Christus Stehlin Foundation For Cancer Research Methods of making esters of camptothecins
US7572803B2 (en) * 2007-10-25 2009-08-11 The Christus Stehlin Foundation For Cancer Research Hydrated crystalline esters of camptothecin
JP2012155651A (ja) * 2011-01-28 2012-08-16 Sony Corp 信号処理装置および方法、並びに、プログラム
CN104628737B (zh) * 2015-01-28 2017-06-06 华南理工大学 两种新晶型的9‑硝基喜树碱及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5527913A (en) * 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
US5731316A (en) * 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives

Also Published As

Publication number Publication date
HUP0003206A2 (hu) 2001-10-28
JP2005145981A (ja) 2005-06-09
DE69839306D1 (de) 2008-05-08
EP1003750A1 (en) 2000-05-31
HUP0003206A3 (en) 2001-12-28
JP3651778B2 (ja) 2005-05-25
AU736323B2 (en) 2001-07-26
CA2296731A1 (en) 1999-02-18
EP1003750B1 (en) 2008-03-26
IL134224A (en) 2006-10-31
ATE390429T1 (de) 2008-04-15
ES2303355T3 (es) 2008-08-01
CN101186609A (zh) 2008-05-28
IL134224A0 (en) 2001-04-30
DE69839306T2 (de) 2009-04-09
PT1003750E (pt) 2008-04-29
AU8300398A (en) 1999-03-01
US5922877A (en) 1999-07-13
JP2001512732A (ja) 2001-08-28
CN1266435A (zh) 2000-09-13
WO1999007709A1 (en) 1999-02-18
JP3842278B2 (ja) 2006-11-08
CA2296731C (en) 2007-01-09

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