HUP0100019A2 - A cipamfillin új polimorf formái, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
A cipamfillin új polimorf formái, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0100019A2 HUP0100019A2 HU0100019A HUP0100019A HUP0100019A2 HU P0100019 A2 HUP0100019 A2 HU P0100019A2 HU 0100019 A HU0100019 A HU 0100019A HU P0100019 A HUP0100019 A HU P0100019A HU P0100019 A2 HUP0100019 A2 HU P0100019A2
- Authority
- HU
- Hungary
- Prior art keywords
- polymorphic forms
- cipamfylline
- preparation
- pharmaceutical compositions
- novel polymorphic
- Prior art date
Links
- KSPYMJJKQMWWNB-UHFFFAOYSA-N cipamfylline Chemical compound O=C1N(CC2CC2)C(=O)C=2NC(N)=NC=2N1CC1CC1 KSPYMJJKQMWWNB-UHFFFAOYSA-N 0.000 title 1
- 229950002405 cipamfylline Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 101100296720 Dictyostelium discoideum Pde4 gene Proteins 0.000 abstract 1
- 101100082610 Plasmodium falciparum (isolate 3D7) PDEdelta gene Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Abstract
A találmány (I) képletű 8-amino-1,3-bisz(ciklopropil-metil)-xantin,közismert nevén cipamfillin új, kristályos polimorf I., II. és IV.formájára, az új polimorf formák előállítási eljárásaira, valamint avegyületeknek PDE4 és TNF mediált betegségek kezelésére szolgálógyógyszerkészítmények előállítására történő felhasználására, továbbáaz új polimorf formákat tartalmazó gyógyszerkészítményekre vonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6323897P | 1997-10-23 | 1997-10-23 | |
| PCT/US1998/022451 WO1999020625A1 (en) | 1997-10-23 | 1998-10-23 | Novel polymorphic forms of cipamfylline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0100019A2 true HUP0100019A2 (hu) | 2002-01-28 |
| HUP0100019A3 HUP0100019A3 (en) | 2003-01-28 |
Family
ID=22047900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0100019A HUP0100019A3 (en) | 1997-10-23 | 1998-10-23 | Novel polymorphic forms of cipamfylline, process for their preparation and pharmaceutical compositions thereof |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6583283B1 (hu) |
| EP (1) | EP1025103A4 (hu) |
| JP (1) | JP2001520228A (hu) |
| KR (1) | KR20010031246A (hu) |
| CN (1) | CN1280579A (hu) |
| AP (1) | AP2000001793A0 (hu) |
| AR (1) | AR015190A1 (hu) |
| AU (1) | AU751561B2 (hu) |
| BG (1) | BG104368A (hu) |
| BR (1) | BR9814099A (hu) |
| CA (1) | CA2306980A1 (hu) |
| CO (1) | CO4990930A1 (hu) |
| DZ (1) | DZ2629A1 (hu) |
| EA (1) | EA003445B1 (hu) |
| HU (1) | HUP0100019A3 (hu) |
| ID (1) | ID23885A (hu) |
| IL (1) | IL135711A0 (hu) |
| MA (1) | MA24682A1 (hu) |
| NO (1) | NO20002012D0 (hu) |
| NZ (1) | NZ504051A (hu) |
| PE (1) | PE122599A1 (hu) |
| PL (1) | PL340257A1 (hu) |
| SA (1) | SA99191117A (hu) |
| SK (1) | SK5642000A3 (hu) |
| TR (1) | TR200001109T2 (hu) |
| UY (2) | UY25220A1 (hu) |
| WO (1) | WO1999020625A1 (hu) |
| ZA (1) | ZA989622B (hu) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL156412A0 (en) | 2001-01-31 | 2004-01-04 | Pfizer Prod Inc | Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes |
| IL156413A0 (en) | 2001-01-31 | 2004-01-04 | Pfizer Prod Inc | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
| OA12541A (en) | 2001-01-31 | 2006-06-05 | Pfizer Prod Inc | Ether derivatives useful as inhibitors of PDE4 isozymes. |
| US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| WO2003101991A1 (en) * | 2002-05-31 | 2003-12-11 | Schering Corporation | Xanthine phosphodiesterase v inhibitor polymorphs |
| CN101031293A (zh) | 2004-05-06 | 2007-09-05 | 普莱希科公司 | Pde4b抑制剂及其应用 |
| US7605168B2 (en) | 2004-09-03 | 2009-10-20 | Plexxikon, Inc. | PDE4B inhibitors |
| AU2006292328B2 (en) * | 2005-09-20 | 2012-12-20 | Scinopharm Singapore Pte, Ltd. | Novel crystal forms of irinotecan hydrochloride |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8906792D0 (en) | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
| GB9020959D0 (en) * | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Novel compounds |
| GB9020921D0 (en) * | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Novel compounds |
-
1998
- 1998-10-21 MA MA25309A patent/MA24682A1/fr unknown
- 1998-10-21 AR ARP980105252A patent/AR015190A1/es not_active Application Discontinuation
- 1998-10-21 DZ DZ980239A patent/DZ2629A1/xx active
- 1998-10-22 ZA ZA989622A patent/ZA989622B/xx unknown
- 1998-10-23 HU HU0100019A patent/HUP0100019A3/hu unknown
- 1998-10-23 AU AU12744/99A patent/AU751561B2/en not_active Ceased
- 1998-10-23 EA EA200000448A patent/EA003445B1/ru not_active IP Right Cessation
- 1998-10-23 BR BR9814099-0A patent/BR9814099A/pt not_active IP Right Cessation
- 1998-10-23 CO CO98061838A patent/CO4990930A1/es unknown
- 1998-10-23 TR TR2000/01109T patent/TR200001109T2/xx unknown
- 1998-10-23 PE PE1998001002A patent/PE122599A1/es not_active Application Discontinuation
- 1998-10-23 US US09/529,865 patent/US6583283B1/en not_active Expired - Fee Related
- 1998-10-23 UY UY25220A patent/UY25220A1/es not_active Application Discontinuation
- 1998-10-23 JP JP2000516967A patent/JP2001520228A/ja not_active Withdrawn
- 1998-10-23 WO PCT/US1998/022451 patent/WO1999020625A1/en not_active Application Discontinuation
- 1998-10-23 EP EP98956156A patent/EP1025103A4/en not_active Withdrawn
- 1998-10-23 AP APAP/P/2000/001793A patent/AP2000001793A0/en unknown
- 1998-10-23 PL PL98340257A patent/PL340257A1/xx unknown
- 1998-10-23 CA CA002306980A patent/CA2306980A1/en not_active Abandoned
- 1998-10-23 NZ NZ504051A patent/NZ504051A/xx unknown
- 1998-10-23 SK SK564-2000A patent/SK5642000A3/sk unknown
- 1998-10-23 IL IL13571198A patent/IL135711A0/xx unknown
- 1998-10-23 CN CN98810380A patent/CN1280579A/zh active Pending
- 1998-10-23 KR KR1020007004228A patent/KR20010031246A/ko not_active Application Discontinuation
- 1998-10-23 ID IDW20000714A patent/ID23885A/id unknown
-
1999
- 1999-02-04 UY UY25380A patent/UY25380A1/es not_active IP Right Cessation
- 1999-02-27 SA SA99191117A patent/SA99191117A/ar unknown
-
2000
- 2000-04-17 NO NO20002012A patent/NO20002012D0/no not_active Application Discontinuation
- 2000-04-21 BG BG104368A patent/BG104368A/xx unknown
-
2002
- 2002-04-18 US US10/125,754 patent/US20020173648A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MA24682A1 (fr) | 1999-07-01 |
| NZ504051A (en) | 2003-02-28 |
| US6583283B1 (en) | 2003-06-24 |
| SA99191117A (ar) | 2005-12-03 |
| KR20010031246A (ko) | 2001-04-16 |
| EP1025103A1 (en) | 2000-08-09 |
| ID23885A (id) | 2000-05-25 |
| CO4990930A1 (es) | 2000-12-26 |
| EA003445B1 (ru) | 2003-06-26 |
| US20020173648A1 (en) | 2002-11-21 |
| NO20002012L (no) | 2000-04-17 |
| IL135711A0 (en) | 2001-05-20 |
| AU751561B2 (en) | 2002-08-22 |
| HUP0100019A3 (en) | 2003-01-28 |
| PE122599A1 (es) | 2000-02-12 |
| TR200001109T2 (tr) | 2000-09-21 |
| AP2000001793A0 (en) | 2000-06-30 |
| CA2306980A1 (en) | 1999-04-29 |
| AR015190A1 (es) | 2001-04-18 |
| EA200000448A1 (ru) | 2000-10-30 |
| UY25220A1 (es) | 2001-08-27 |
| EP1025103A4 (en) | 2001-11-14 |
| WO1999020625A1 (en) | 1999-04-29 |
| DZ2629A1 (fr) | 2003-03-08 |
| BG104368A (en) | 2001-02-28 |
| JP2001520228A (ja) | 2001-10-30 |
| UY25380A1 (es) | 1999-11-17 |
| BR9814099A (pt) | 2000-10-10 |
| NO20002012D0 (no) | 2000-04-17 |
| CN1280579A (zh) | 2001-01-17 |
| SK5642000A3 (en) | 2000-09-12 |
| AU1274499A (en) | 1999-05-10 |
| PL340257A1 (en) | 2001-01-29 |
| ZA989622B (en) | 1999-04-23 |
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