UY25380A1 - Procedimientos para la preparación de formas polimórficas de la cipamfilina - Google Patents
Procedimientos para la preparación de formas polimórficas de la cipamfilinaInfo
- Publication number
- UY25380A1 UY25380A1 UY25380A UY25380A UY25380A1 UY 25380 A1 UY25380 A1 UY 25380A1 UY 25380 A UY25380 A UY 25380A UY 25380 A UY25380 A UY 25380A UY 25380 A1 UY25380 A1 UY 25380A1
- Authority
- UY
- Uruguay
- Prior art keywords
- preparation
- cypamfilin
- procedures
- dicicyclopropylmethyl
- aminoxanthine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
Procedimiento para la preparación de un polimorfo cristalino de 1,3-diciciclopropilmetil-8-aminoxantina, que exhibe un modelo de difracción de rayos X a través de polvo que tiene picos característicos expresados en distancias interplanares d (A), en intensidad decreciente, a aproximadamente 12,302, 7,702, 8,532, 4,289 y 2,854, que comprende: disolver 1,3-diciciclopropilmetil-8-aminoxantina en 1-propanol (el cual puede mezclarse con agua), en acetona, o en tetrahidrofurano y enfriar la disolución (a una temperatura entre 0 y 25ºC) para que cristalice la forma I polimórfica deseada en la disolución. La figura 1 es un dibujo estéreo de la molécula de forma I. La cipamfilina es un inhibidor de PDE4 y es útil en el tratamiento de la profilaxis y de estados de enfermedad medidos por ella.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6323897P | 1997-10-23 | 1997-10-23 | |
| UY25220A UY25220A1 (es) | 1997-10-23 | 1998-10-23 | Nuevas formas polimórficas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY25380A1 true UY25380A1 (es) | 1999-11-17 |
Family
ID=22047900
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25220A UY25220A1 (es) | 1997-10-23 | 1998-10-23 | Nuevas formas polimórficas |
| UY25380A UY25380A1 (es) | 1997-10-23 | 1999-02-04 | Procedimientos para la preparación de formas polimórficas de la cipamfilina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25220A UY25220A1 (es) | 1997-10-23 | 1998-10-23 | Nuevas formas polimórficas |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US6583283B1 (es) |
| EP (1) | EP1025103A4 (es) |
| JP (1) | JP2001520228A (es) |
| KR (1) | KR20010031246A (es) |
| CN (1) | CN1280579A (es) |
| AP (1) | AP2000001793A0 (es) |
| AR (1) | AR015190A1 (es) |
| AU (1) | AU751561B2 (es) |
| BG (1) | BG104368A (es) |
| BR (1) | BR9814099A (es) |
| CA (1) | CA2306980A1 (es) |
| CO (1) | CO4990930A1 (es) |
| DZ (1) | DZ2629A1 (es) |
| EA (1) | EA003445B1 (es) |
| HU (1) | HUP0100019A3 (es) |
| ID (1) | ID23885A (es) |
| IL (1) | IL135711A0 (es) |
| MA (1) | MA24682A1 (es) |
| NO (1) | NO20002012D0 (es) |
| NZ (1) | NZ504051A (es) |
| PE (1) | PE122599A1 (es) |
| PL (1) | PL340257A1 (es) |
| SA (1) | SA99191117A (es) |
| SK (1) | SK5642000A3 (es) |
| TR (1) | TR200001109T2 (es) |
| UY (2) | UY25220A1 (es) |
| WO (1) | WO1999020625A1 (es) |
| ZA (1) | ZA989622B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK8942003A3 (en) | 2001-01-31 | 2004-10-05 | Pfizer Prod Inc | Ether derivatives useful as inhibitors |
| US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| OA12542A (en) | 2001-01-31 | 2006-06-05 | Pfizer Prod Inc | Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4isozymes. |
| EE200300360A (et) | 2001-01-31 | 2003-12-15 | Pfizer Products Inc. | PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid |
| TW200404802A (en) * | 2002-05-31 | 2004-04-01 | Schering Corp | Xanthine phosphodiesterase V inhibitor polymorphs |
| EP1742627A4 (en) | 2004-05-06 | 2009-08-26 | Plexxikon Inc | PDE4B HEMMER AND ITS USE |
| US7605168B2 (en) | 2004-09-03 | 2009-10-20 | Plexxikon, Inc. | PDE4B inhibitors |
| JP5119153B2 (ja) * | 2005-09-20 | 2013-01-16 | シノファーム シンガポール ピーティーイー，リミテッド | イリノテカン塩酸塩の新規結晶形 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8906792D0 (en) | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
| GB9020921D0 (en) * | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Novel compounds |
| GB9020959D0 (en) * | 1990-09-26 | 1990-11-07 | Beecham Group Plc | Novel compounds |
-
1998
- 1998-10-21 MA MA25309A patent/MA24682A1/fr unknown
- 1998-10-21 DZ DZ980239A patent/DZ2629A1/xx active
- 1998-10-21 AR ARP980105252A patent/AR015190A1/es not_active Application Discontinuation
- 1998-10-22 ZA ZA989622A patent/ZA989622B/xx unknown
- 1998-10-23 JP JP2000516967A patent/JP2001520228A/ja not_active Withdrawn
- 1998-10-23 TR TR2000/01109T patent/TR200001109T2/xx unknown
- 1998-10-23 HU HU0100019A patent/HUP0100019A3/hu unknown
- 1998-10-23 NZ NZ504051A patent/NZ504051A/xx unknown
- 1998-10-23 IL IL13571198A patent/IL135711A0/xx unknown
- 1998-10-23 KR KR1020007004228A patent/KR20010031246A/ko not_active Application Discontinuation
- 1998-10-23 CO CO98061838A patent/CO4990930A1/es unknown
- 1998-10-23 PE PE1998001002A patent/PE122599A1/es not_active Application Discontinuation
- 1998-10-23 BR BR9814099-0A patent/BR9814099A/pt not_active IP Right Cessation
- 1998-10-23 CN CN98810380A patent/CN1280579A/zh active Pending
- 1998-10-23 AU AU12744/99A patent/AU751561B2/en not_active Ceased
- 1998-10-23 CA CA002306980A patent/CA2306980A1/en not_active Abandoned
- 1998-10-23 WO PCT/US1998/022451 patent/WO1999020625A1/en not_active Application Discontinuation
- 1998-10-23 US US09/529,865 patent/US6583283B1/en not_active Expired - Fee Related
- 1998-10-23 ID IDW20000714A patent/ID23885A/id unknown
- 1998-10-23 UY UY25220A patent/UY25220A1/es not_active Application Discontinuation
- 1998-10-23 AP APAP/P/2000/001793A patent/AP2000001793A0/en unknown
- 1998-10-23 SK SK564-2000A patent/SK5642000A3/sk unknown
- 1998-10-23 EA EA200000448A patent/EA003445B1/ru not_active IP Right Cessation
- 1998-10-23 PL PL98340257A patent/PL340257A1/xx unknown
- 1998-10-23 EP EP98956156A patent/EP1025103A4/en not_active Withdrawn
-
1999
- 1999-02-04 UY UY25380A patent/UY25380A1/es not_active IP Right Cessation
- 1999-02-27 SA SA99191117A patent/SA99191117A/ar unknown
-
2000
- 2000-04-17 NO NO20002012A patent/NO20002012D0/no not_active Application Discontinuation
- 2000-04-21 BG BG104368A patent/BG104368A/xx unknown
-
2002
- 2002-04-18 US US10/125,754 patent/US20020173648A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| SK5642000A3 (en) | 2000-09-12 |
| CO4990930A1 (es) | 2000-12-26 |
| US6583283B1 (en) | 2003-06-24 |
| DZ2629A1 (fr) | 2003-03-08 |
| PL340257A1 (en) | 2001-01-29 |
| AU751561B2 (en) | 2002-08-22 |
| EA200000448A1 (ru) | 2000-10-30 |
| AR015190A1 (es) | 2001-04-18 |
| PE122599A1 (es) | 2000-02-12 |
| TR200001109T2 (tr) | 2000-09-21 |
| BR9814099A (pt) | 2000-10-10 |
| SA99191117A (ar) | 2005-12-03 |
| US20020173648A1 (en) | 2002-11-21 |
| CA2306980A1 (en) | 1999-04-29 |
| NO20002012L (no) | 2000-04-17 |
| CN1280579A (zh) | 2001-01-17 |
| EP1025103A1 (en) | 2000-08-09 |
| EP1025103A4 (en) | 2001-11-14 |
| AP2000001793A0 (en) | 2000-06-30 |
| MA24682A1 (fr) | 1999-07-01 |
| AU1274499A (en) | 1999-05-10 |
| EA003445B1 (ru) | 2003-06-26 |
| ID23885A (id) | 2000-05-25 |
| IL135711A0 (en) | 2001-05-20 |
| JP2001520228A (ja) | 2001-10-30 |
| HUP0100019A2 (hu) | 2002-01-28 |
| NO20002012D0 (no) | 2000-04-17 |
| BG104368A (en) | 2001-02-28 |
| UY25220A1 (es) | 2001-08-27 |
| NZ504051A (en) | 2003-02-28 |
| HUP0100019A3 (en) | 2003-01-28 |
| WO1999020625A1 (en) | 1999-04-29 |
| ZA989622B (en) | 1999-04-23 |
| KR20010031246A (ko) | 2001-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| VENC | Patent expired |
Effective date: 20160515 |