HUP0103658A2 - Eljárás (-)-alfa-difluormetilornitin-monohidroklorid-monohidrát előállítására - Google Patents

Eljárás (-)-alfa-difluormetilornitin-monohidroklorid-monohidrát előállítására

Info

Publication number
HUP0103658A2
HUP0103658A2 HU0103658A HUP0103658A HUP0103658A2 HU P0103658 A2 HUP0103658 A2 HU P0103658A2 HU 0103658 A HU0103658 A HU 0103658A HU P0103658 A HUP0103658 A HU P0103658A HU P0103658 A2 HUP0103658 A2 HU P0103658A2
Authority
HU
Hungary
Prior art keywords
ornithine
difluoromethyl
alpha
producing
monohydrochloride monohydrate
Prior art date
Application number
HU0103658A
Other languages
English (en)
Inventor
Thomas Meul
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of HU0103658D0 publication Critical patent/HU0103658D0/hu
Publication of HUP0103658A2 publication Critical patent/HUP0103658A2/hu
Publication of HUP0103658A3 publication Critical patent/HUP0103658A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A találmány (I) képletű (+)- vagy (-)-a-difluormetilornitin (-)-O,O'-di-p-toluoil-L-borkősavval alkotott diasztereomer sóira, valamint (<)-a-difluormetilornitin (-)-O,O'-di-p-toluoil-L-borkősav alkalmazásávalvégzett rezolválási eljárására vonatkozik. A (<)-a-difluormetilornitin-monohidroklorid-monohidrát, különösen a (-)-izomer, az ornitin dekarboxiláz egyik inhibitora és számosfarmakológiai hatással rendelkezik. Ó
HU0103658A 1998-09-23 1999-09-22 Method for producing (-)-alpha-(difluoromethyl)ornithine-monohydrochloride monohydrate HUP0103658A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98117982 1998-09-23
PCT/EP1999/007060 WO2000017153A1 (de) 1998-09-23 1999-09-22 VERFAHREN ZUR HERSTELLUNG VON (-)-α-(DIFLUORMETHYL)ORNITHIN-MONOHYDROCHLORID MONOHYDRAT

Publications (3)

Publication Number Publication Date
HU0103658D0 HU0103658D0 (en) 2002-02-28
HUP0103658A2 true HUP0103658A2 (hu) 2002-12-28
HUP0103658A3 HUP0103658A3 (en) 2003-03-28

Family

ID=8232678

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103658A HUP0103658A3 (en) 1998-09-23 1999-09-22 Method for producing (-)-alpha-(difluoromethyl)ornithine-monohydrochloride monohydrate

Country Status (16)

Country Link
US (1) US6462229B1 (hu)
EP (1) EP1115696A1 (hu)
JP (1) JP2002526468A (hu)
KR (1) KR20010079913A (hu)
CN (1) CN1319085A (hu)
AU (1) AU764154B2 (hu)
BR (1) BR9914034A (hu)
CA (1) CA2345112A1 (hu)
CZ (1) CZ20011043A3 (hu)
HU (1) HUP0103658A3 (hu)
IL (1) IL142218A0 (hu)
MX (1) MXPA01003032A (hu)
NO (1) NO20011480L (hu)
PL (1) PL195164B1 (hu)
SK (1) SK4092001A3 (hu)
WO (1) WO2000017153A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1586551A4 (en) * 2003-01-16 2006-07-26 Toray Finechemicals Co Ltd METHOD FOR OBTAINING OPTICALLY ACTIVE DIACYLTARTIC ACIDS
WO2005021502A1 (ja) * 2003-08-29 2005-03-10 Takeda Pharmaceutical Company Limited 光学活性トレオ−β−アルキルトリプトファン誘導体の製造法およびその中間体
TW201617326A (zh) * 2014-03-06 2016-05-16 Ａｌｐｈｏｒａ研發股份有限公司 （ｓ）－１－（（２ｒ，３ｒ，４ｓ，５ｓ）－５－烯丙－３－甲氧－４－（對甲苯磺醯甲基）四氫呋喃－２－基）－３－氨基丙－２－醇之結晶衍生物
JP2018507910A (ja) * 2015-02-12 2018-03-22 ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ジ・ユニバーシティ・オブ・アリゾナ 神経芽細胞腫を治療する方法
CN105660637B (zh) * 2016-01-07 2018-04-24 南京中医药大学 防治当归早薹的药物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309442A (en) * 1977-07-11 1982-01-05 Merrell Toraude Et Compagnie Method for controlling fertility in mammals
US4414141A (en) 1980-11-21 1983-11-08 The Lummus Company Hydrotreating catalyst
US4931557A (en) * 1988-10-17 1990-06-05 Eli Lilly And Company Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof
WO1998014188A1 (en) * 1996-10-04 1998-04-09 Ilex Oncology, Inc. Dfmo and taxol for the treatment or prevention of breast cancer
WO1998025603A1 (en) * 1996-12-13 1998-06-18 Ilex Oncology, Inc. Isomeric pharmaceutical formulation containing dfmo for the treatment of cancer

Also Published As

Publication number Publication date
CA2345112A1 (en) 2000-03-30
CZ20011043A3 (cs) 2001-09-12
NO20011480D0 (no) 2001-03-22
BR9914034A (pt) 2001-08-14
NO20011480L (no) 2001-03-23
AU6086599A (en) 2000-04-10
EP1115696A1 (de) 2001-07-18
HU0103658D0 (en) 2002-02-28
MXPA01003032A (es) 2002-07-02
SK4092001A3 (en) 2002-06-04
HUP0103658A3 (en) 2003-03-28
PL346900A1 (en) 2002-03-11
CN1319085A (zh) 2001-10-24
KR20010079913A (ko) 2001-08-22
US6462229B1 (en) 2002-10-08
WO2000017153A1 (de) 2000-03-30
AU764154B2 (en) 2003-08-14
JP2002526468A (ja) 2002-08-20
PL195164B1 (pl) 2007-08-31
IL142218A0 (en) 2002-03-10

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