HUP0100680A2 - Indolszármazékok és azokat tartalmazó gyógyszerkészítmények - Google Patents

Indolszármazékok és azokat tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0100680A2
HUP0100680A2 HU0100680A HUP0100680A HUP0100680A2 HU P0100680 A2 HUP0100680 A2 HU P0100680A2 HU 0100680 A HU0100680 A HU 0100680A HU P0100680 A HUP0100680 A HU P0100680A HU P0100680 A2 HUP0100680 A2 HU P0100680A2
Authority
HU
Hungary
Prior art keywords
group
indole derivatives
same
compositions containing
medicinal compositions
Prior art date
Application number
HU0100680A
Other languages
English (en)
Inventor
Yukiyoshi Ajisawa
Makio Kitazawa
Hiroshi Miyata
Toshiaki Yamaguchi
Original Assignee
Kissei Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co., Ltd. filed Critical Kissei Pharmaceutical Co., Ltd.
Publication of HUP0100680A2 publication Critical patent/HUP0100680A2/hu
Publication of HUP0100680A3 publication Critical patent/HUP0100680A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A találmány tárgyát az új (I) általános képletű indolszármazékok (ahol a képletben R jelentése etilcsoport vagy 2,2,2-trifluor-etilcsoport; Y jelentse hidroxicsoport vagypivaloiloxicsoport, azzal a kikötéssel, hogy Y jelentésepivaloiloxicsoport, amikor R jelentse 2,2,2-trifluor--etilcsoport;valamint az (R)-el jelölt szénatom (R) konfigurációjú szénatomotjelent) és azok gyógyszerészetileg elfogadható sói képezik, amelyek abelső szemnyomást hatékonyan és hosszú ideig csökkentik és belsőszemnyomás csökkentő szerekként alkalmazhatók. Ó
HU0100680A 1998-02-27 1999-02-19 Indole derivatives and medicinal compositions containing the same HUP0100680A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9057298 1998-02-27
PCT/JP1999/000732 WO1999043652A1 (fr) 1998-02-27 1999-02-19 Derives de l'indole et compositions medicales les renfermant

Publications (2)

Publication Number Publication Date
HUP0100680A2 true HUP0100680A2 (hu) 2001-08-28
HUP0100680A3 HUP0100680A3 (en) 2001-09-28

Family

ID=14002150

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100680A HUP0100680A3 (en) 1998-02-27 1999-02-19 Indole derivatives and medicinal compositions containing the same

Country Status (24)

Country Link
US (1) US6310086B1 (hu)
EP (1) EP1057813B1 (hu)
JP (1) JP4342101B2 (hu)
KR (1) KR100576207B1 (hu)
CN (1) CN1157375C (hu)
AR (1) AR014964A1 (hu)
AT (1) ATE264841T1 (hu)
AU (1) AU766088B2 (hu)
BR (1) BR9908301A (hu)
CA (1) CA2321547C (hu)
DE (1) DE69916586T2 (hu)
DK (1) DK1057813T3 (hu)
ES (1) ES2220043T3 (hu)
HK (1) HK1036974A1 (hu)
HU (1) HUP0100680A3 (hu)
NO (1) NO317257B1 (hu)
NZ (1) NZ506497A (hu)
PE (1) PE20000329A1 (hu)
PL (1) PL342477A1 (hu)
RU (1) RU2212404C2 (hu)
SK (1) SK12722000A3 (hu)
TW (2) TWI249525B (hu)
WO (1) WO1999043652A1 (hu)
ZA (1) ZA991590B (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL342477A1 (en) 1998-02-27 2001-06-04 Kissei Pharmaceutical Derivatives of indole and pharmacological compositions containing them
JP4634560B2 (ja) * 2000-01-14 2011-02-16 キッセイ薬品工業株式会社 光学活性なインドリン誘導体の製造方法およびその製造中間体
AU2001256714A1 (en) * 2000-05-15 2001-11-26 Kissei Pharmaceutical Co. Ltd. Water-based liquid preparation
AU2001256733A1 (en) * 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
JP4921646B2 (ja) * 2001-03-08 2012-04-25 キッセイ薬品工業株式会社 １−（３−ベンジルオキシプロピル）−５−（２−置換プロピル）インドリン誘導体およびその使用方法
CA2453476A1 (en) * 2001-07-13 2003-01-23 Kissei Pharmaceutical Co., Ltd. Medicinal compositions for opthalmic use
HU225505B1 (en) * 2002-09-09 2007-01-29 Richter Gedeon Vegyeszet Process for the preparation of r-(-)-tamsulosin hydrochloride and novel intermediates
AR050253A1 (es) 2004-06-24 2006-10-11 Smithkline Beecham Corp Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
BRPI0517515B8 (pt) * 2004-10-27 2021-05-25 Kissei Pharmaceutical composto de indolina, bem como métodos para produção de compostos de indolina
WO2006137368A1 (ja) * 2005-06-21 2006-12-28 Kowa Co., Ltd. 緑内障の予防又は治療剤
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
EP2125717B1 (en) * 2007-02-26 2013-07-03 Concert Pharmaceuticals Inc. Deuterated derivatives of silodosin as alpha ia-adrenoreceptor antagonists
US20100076010A1 (en) * 2007-02-26 2010-03-25 Concert Pharmaceuticals, Inc. Alpha 1a-adrenoceptor antagonists
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
US8354539B2 (en) 2009-03-10 2013-01-15 Glaxo Group Limited Indole derivatives as IKK2 inhibitors
CN104211631A (zh) * 2013-05-30 2014-12-17 中国科学院上海药物研究所 一类吲哚类化合物、其制备方法、药物组合物及应用
WO2016042441A1 (en) 2014-09-18 2016-03-24 Mankind Research Centre A novel process for the preparation of considerably pure silodosin
ES2607639B1 (es) 2015-09-30 2018-02-28 Urquima, S.A Sal de ácido maleico de un intermedio de silodosina

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021410A (en) * 1989-05-22 1991-06-04 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
DE69319551T2 (de) * 1992-12-02 1998-10-29 Kissei Pharmaceutical Indolin Verbindungen zur Behandlung von Dysurien
JP3331047B2 (ja) * 1994-06-01 2002-10-07 キッセイ薬品工業株式会社 インドリン誘導体
JP3331048B2 (ja) * 1994-06-01 2002-10-07 キッセイ薬品工業株式会社 インドール誘導体
JPH08143557A (ja) * 1994-11-24 1996-06-04 Toyobo Co Ltd 新規なフェニルピペラジン誘導体、その塩及びその溶媒和物
JPH0912563A (ja) * 1995-06-30 1997-01-14 Toyobo Co Ltd 新規ベンジルアルコ−ル誘導体、その製造方法およびその用途
WO1999015202A1 (fr) * 1997-09-22 1999-04-01 Kissei Pharmaceutical Co., Ltd. Medicaments contre la dysurie resultant d'une hypertrophie de la prostate
PL342477A1 (en) 1998-02-27 2001-06-04 Kissei Pharmaceutical Derivatives of indole and pharmacological compositions containing them

Also Published As

Publication number Publication date
WO1999043652A1 (fr) 1999-09-02
ATE264841T1 (de) 2004-05-15
KR20010041403A (ko) 2001-05-15
NO20004277D0 (no) 2000-08-25
TWI241293B (en) 2005-10-11
CA2321547A1 (en) 1999-09-02
JP4342101B2 (ja) 2009-10-14
CA2321547C (en) 2010-01-19
NZ506497A (en) 2004-12-24
CN1157375C (zh) 2004-07-14
AR014964A1 (es) 2001-04-11
US6310086B1 (en) 2001-10-30
DE69916586D1 (de) 2004-05-27
HK1036974A1 (en) 2002-01-25
DK1057813T3 (da) 2004-08-16
NO317257B1 (no) 2004-09-27
RU2212404C2 (ru) 2003-09-20
EP1057813A1 (en) 2000-12-06
KR100576207B1 (ko) 2006-05-03
SK12722000A3 (sk) 2001-03-12
EP1057813A4 (en) 2001-11-21
ZA991590B (en) 1999-08-27
ES2220043T3 (es) 2004-12-01
EP1057813B1 (en) 2004-04-21
AU766088B2 (en) 2003-10-09
PE20000329A1 (es) 2000-04-13
AU2547899A (en) 1999-09-15
BR9908301A (pt) 2000-10-31
NO20004277L (no) 2000-09-11
PL342477A1 (en) 2001-06-04
TWI249525B (en) 2006-02-21
CN1291976A (zh) 2001-04-18
HUP0100680A3 (en) 2001-09-28
DE69916586T2 (de) 2004-09-16

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