BR9914034A - Processo para a preparação de monocloridrato de (-)-alfa-difluormetilornitina monohidrato - Google Patents
Processo para a preparação de monocloridrato de (-)-alfa-difluormetilornitina monohidratoInfo
- Publication number
- BR9914034A BR9914034A BR9914034-9A BR9914034A BR9914034A BR 9914034 A BR9914034 A BR 9914034A BR 9914034 A BR9914034 A BR 9914034A BR 9914034 A BR9914034 A BR 9914034A
- Authority
- BR
- Brazil
- Prior art keywords
- monohydrate
- preparation
- difluormethylornithine
- alpha
- monethydrate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Patente de Invenção: <B>"PROCESSO PARA A PREPARAçãO DE MONOCLORIDRATO DE (-)-ALFA-DIFLUORMETILORNITINA MONOHIDRATO"<D>. (N)-<244>-Difluormetilornitina é separada nos seus isómeros usando ácido (-)-O,O'-di-p-toluoil-L-tartárico. O monocloridrato de (N)-<244>-difluormetilormitina monohidrato e, em particular, o seu isómero (-), são inibidores de descarboxilase de ornitina e têm, desse modo, várias ações farmacológicas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98117982 | 1998-09-23 | ||
PCT/EP1999/007060 WO2000017153A1 (de) | 1998-09-23 | 1999-09-22 | VERFAHREN ZUR HERSTELLUNG VON (-)-α-(DIFLUORMETHYL)ORNITHIN-MONOHYDROCHLORID MONOHYDRAT |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9914034A true BR9914034A (pt) | 2001-08-14 |
Family
ID=8232678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9914034-9A BR9914034A (pt) | 1998-09-23 | 1999-09-22 | Processo para a preparação de monocloridrato de (-)-alfa-difluormetilornitina monohidrato |
Country Status (16)
Country | Link |
---|---|
US (1) | US6462229B1 (pt) |
EP (1) | EP1115696A1 (pt) |
JP (1) | JP2002526468A (pt) |
KR (1) | KR20010079913A (pt) |
CN (1) | CN1319085A (pt) |
AU (1) | AU764154B2 (pt) |
BR (1) | BR9914034A (pt) |
CA (1) | CA2345112A1 (pt) |
CZ (1) | CZ20011043A3 (pt) |
HU (1) | HUP0103658A3 (pt) |
IL (1) | IL142218A0 (pt) |
MX (1) | MXPA01003032A (pt) |
NO (1) | NO20011480L (pt) |
PL (1) | PL195164B1 (pt) |
SK (1) | SK4092001A3 (pt) |
WO (1) | WO2000017153A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1586551A4 (en) * | 2003-01-16 | 2006-07-26 | Toray Finechemicals Co Ltd | METHOD FOR OBTAINING OPTICALLY ACTIVE DIACYLTARTIC ACIDS |
WO2005021502A1 (ja) * | 2003-08-29 | 2005-03-10 | Takeda Pharmaceutical Company Limited | 光学活性トレオ−β−アルキルトリプトファン誘導体の製造法およびその中間体 |
TW201617326A (zh) * | 2014-03-06 | 2016-05-16 | Alphora研發股份有限公司 | (s)-1-((2r,3r,4s,5s)-5-烯丙-3-甲氧-4-(對甲苯磺醯甲基)四氫呋喃-2-基)-3-氨基丙-2-醇之結晶衍生物 |
WO2016130918A1 (en) * | 2015-02-12 | 2016-08-18 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for treating neuroblastoma |
CN105660637B (zh) * | 2016-01-07 | 2018-04-24 | 南京中医药大学 | 防治当归早薹的药物及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4309442A (en) * | 1977-07-11 | 1982-01-05 | Merrell Toraude Et Compagnie | Method for controlling fertility in mammals |
US4414141A (en) | 1980-11-21 | 1983-11-08 | The Lummus Company | Hydrotreating catalyst |
US4931557A (en) | 1988-10-17 | 1990-06-05 | Eli Lilly And Company | Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof |
DE69724095T2 (de) * | 1996-10-04 | 2004-05-27 | Ilex Oncology, Inc., San Antonio | DFMO und Taxol zur Behandlung bzw. Vorbeugung von Brustkrebs |
WO1998025603A1 (en) | 1996-12-13 | 1998-06-18 | Ilex Oncology, Inc. | Isomeric pharmaceutical formulation containing dfmo for the treatment of cancer |
-
1999
- 1999-09-22 PL PL99346900A patent/PL195164B1/pl not_active IP Right Cessation
- 1999-09-22 AU AU60865/99A patent/AU764154B2/en not_active Ceased
- 1999-09-22 EP EP99947408A patent/EP1115696A1/de not_active Withdrawn
- 1999-09-22 HU HU0103658A patent/HUP0103658A3/hu unknown
- 1999-09-22 CA CA002345112A patent/CA2345112A1/en not_active Abandoned
- 1999-09-22 JP JP2000574063A patent/JP2002526468A/ja active Pending
- 1999-09-22 KR KR1020017003766A patent/KR20010079913A/ko not_active Application Discontinuation
- 1999-09-22 MX MXPA01003032A patent/MXPA01003032A/es not_active Application Discontinuation
- 1999-09-22 BR BR9914034-9A patent/BR9914034A/pt not_active IP Right Cessation
- 1999-09-22 IL IL14221899A patent/IL142218A0/xx unknown
- 1999-09-22 US US09/787,420 patent/US6462229B1/en not_active Expired - Fee Related
- 1999-09-22 SK SK409-2001A patent/SK4092001A3/sk unknown
- 1999-09-22 CZ CZ20011043A patent/CZ20011043A3/cs unknown
- 1999-09-22 WO PCT/EP1999/007060 patent/WO2000017153A1/de not_active Application Discontinuation
- 1999-09-22 CN CN99811257A patent/CN1319085A/zh active Pending
-
2001
- 2001-03-22 NO NO20011480A patent/NO20011480L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1319085A (zh) | 2001-10-24 |
PL346900A1 (en) | 2002-03-11 |
NO20011480D0 (no) | 2001-03-22 |
CA2345112A1 (en) | 2000-03-30 |
CZ20011043A3 (cs) | 2001-09-12 |
HUP0103658A3 (en) | 2003-03-28 |
EP1115696A1 (de) | 2001-07-18 |
IL142218A0 (en) | 2002-03-10 |
NO20011480L (no) | 2001-03-23 |
JP2002526468A (ja) | 2002-08-20 |
MXPA01003032A (es) | 2002-07-02 |
PL195164B1 (pl) | 2007-08-31 |
KR20010079913A (ko) | 2001-08-22 |
AU764154B2 (en) | 2003-08-14 |
HUP0103658A2 (hu) | 2002-12-28 |
WO2000017153A1 (de) | 2000-03-30 |
US6462229B1 (en) | 2002-10-08 |
HU0103658D0 (en) | 2002-02-28 |
SK4092001A3 (en) | 2002-06-04 |
AU6086599A (en) | 2000-04-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |