HUP0202713A2 - Kináz inhibitorokként alkalmazható pteridinonok - Google Patents

Kináz inhibitorokként alkalmazható pteridinonok

Info

Publication number
HUP0202713A2
HUP0202713A2 HU0202713A HUP0202713A HUP0202713A2 HU P0202713 A2 HUP0202713 A2 HU P0202713A2 HU 0202713 A HU0202713 A HU 0202713A HU P0202713 A HUP0202713 A HU P0202713A HU P0202713 A2 HUP0202713 A2 HU P0202713A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
optionally substituted
aryl
amino
Prior art date
Application number
HU0202713A
Other languages
English (en)
Inventor
Williams Alexander Denny
Ellen Myra Dobrusin
James Bernard Kramer
Dennis Joseph Mcnamara
Gordon William Rewcastle
Howard Daniel Hollis Showalter
Peter Laurence Toogood
Original Assignee
Warner-Lambert Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Co. filed Critical Warner-Lambert Co.
Publication of HUP0202713A2 publication Critical patent/HUP0202713A2/hu
Publication of HUP0202713A3 publication Critical patent/HUP0202713A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)

Abstract

A találmány (Ia), (Ib , (Ic), (Id) és (Ie) általános képletűvegyületekre és gyógyászatilag elfogadható sóikra, észtereikre,amidjaikra és prodrogjaikra vonatkozik, ahol az általános képletekben W NH, O, S, SO vagy S02 csoport; R2 alkil-, alkenil-, alkinil-, cikloalkil-, aril-(CH2)n-, -COR4, heteroaril- (CH2)n- vagy heterociklil-(CH2)n- képletű csoport, ahol az előbbi alkil-, alkenil-, alkinil-, cikloalkil-, aril-, heteroaril- és heterociklilcsoportok mindegyike adott esetben szubsztituált; R4, R6, R6' és R9 jelentése (a) hidrogén-, halogénatom, alkil-, alkoxicsoport, szubsztituált alkilcsoport, alkenil-(CH2)n-, alkinil(CH2)n-, ciano-(CH2)n-, amino-, amino-alkoxi-, fenoxi-, hidroxi-, trifluor-metil-, mono- vagy dialkil-amino-, (mono- vagy dialkil-amino)- alkoxi-, merkapto-, alkil-tio-, ciano-, nitro-, karboxilcsoport, észteresített karboxilcsoport, szubsztituált karbamoilcsoport, -S03Z, -P03Z, amino-alkanoil-, karbamoil-,[amino-(3-7 szénatomos cikloalkil)]-karbonil-, valamint (alkil-amino)-karbonil- és (dialkil-amino)-karbonil-csoport: (b) aril-(CH2)n-, heteroaril-(CH2)n-, aril-alkil- vagy heteroaril-alkil-csoport, ahol valamennyi aril- és heteroarilcsoport adott esetben szubsztituált; R8 jelentése (a) hidrogénatom, alkil-, szubsztituált alkil-, alkenil- (CH2)n-, alkinil-(CH2)n- csoport vagy egy olyan karbocikil- (CH2)n- csoport, amelyben a karbociklusos csoport 3-7 tagú, ahol a gyűrűtagok közül legfeljebb kettő oxigén- és/vagy nitrogénatom, és ahol a karbociklusos csoport adott esetben szubsztituált; (b) aril- (CH2)n-, heteroaril-(CH2)n-, aril- alkil- vagy heteroaril-alkil-csoport, ahol az aril- vagy heteroarilcsoportok mindegyike adott esetben szubsztituált; Z jelentése hidrogénatom, alkilcsoport, szubsztituált alkilcsoport, hidroxi-, alkoxi-, amino-, alkil-amino-, dialkil-amino-csoport, adott esetben szubsztituált piperidilcsoport, adott esetben szubsztituált morfolinilcsoport vagy adott esetben szubsztituált piperazinilcsoport; és n értéke 0, 1, 2, 3, 4, 5 vagy 6; azzal a megkötéssel, hogy R8 jelentése hidrogénatomtól vagy 1-3 szénatomos alkilcsoporttól eltérő, ha R2 jelentése metil-, etil- vagy acetilcsoport. A találmány olyan 8H- pteridin-8-on-, tetrahidropteridin-7-on-, 5H,8H-pteridin-6,7- dion- és pteridin-7-karbamid-származékokra vonatkozik, amelyek gátolják a ciklinfüggő szerin/treonin-kinázt, a Wee 1 tirozin-kinázt, valamint a növekedési faktor által mediált tirozin-kináz enzimet, és amelyek így fel
HU0202713A 1999-09-15 2000-06-21 Pteridinones as kinase inhibitors HUP0202713A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15409599P 1999-09-15 1999-09-15
PCT/US2000/017037 WO2001019825A1 (en) 1999-09-15 2000-06-21 Pteridinones as kinase inhibitors

Publications (2)

Publication Number Publication Date
HUP0202713A2 true HUP0202713A2 (hu) 2002-12-28
HUP0202713A3 HUP0202713A3 (en) 2005-02-28

Family

ID=22549985

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202713A HUP0202713A3 (en) 1999-09-15 2000-06-21 Pteridinones as kinase inhibitors

Country Status (29)

Country Link
US (2) US7169778B2 (hu)
EP (1) EP1409487A1 (hu)
JP (1) JP2003509425A (hu)
KR (1) KR20020027649A (hu)
CN (1) CN1373763A (hu)
AP (1) AP2002002479A0 (hu)
AU (1) AU777468B2 (hu)
BG (1) BG106594A (hu)
BR (1) BR0013952A (hu)
CA (1) CA2393896A1 (hu)
CR (1) CR6586A (hu)
CZ (1) CZ2002846A3 (hu)
DZ (1) DZ3186A1 (hu)
EA (1) EA005287B1 (hu)
EE (1) EE200200140A (hu)
HK (1) HK1048992A1 (hu)
HU (1) HUP0202713A3 (hu)
IL (1) IL148614A0 (hu)
IS (1) IS6298A (hu)
MA (1) MA26819A1 (hu)
MX (1) MXPA02001108A (hu)
NO (1) NO20021239L (hu)
NZ (1) NZ516872A (hu)
OA (1) OA12010A (hu)
PL (1) PL353269A1 (hu)
SK (1) SK3542002A3 (hu)
WO (1) WO2001019825A1 (hu)
YU (1) YU18502A (hu)
ZA (1) ZA200200896B (hu)

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