HUP0000658A2 - Szulfonamidszármazékok, eljárás előállításukra és gyógyszerként való alkalmazásuk - Google Patents

Szulfonamidszármazékok, eljárás előállításukra és gyógyszerként való alkalmazásuk

Info

Publication number
HUP0000658A2
HUP0000658A2 HU0000658A HUP0000658A HUP0000658A2 HU P0000658 A2 HUP0000658 A2 HU P0000658A2 HU 0000658 A HU0000658 A HU 0000658A HU P0000658 A HUP0000658 A HU P0000658A HU P0000658 A2 HUP0000658 A2 HU P0000658A2
Authority
HU
Hungary
Prior art keywords
group
alkoxy
alkyl
hydroxy
heterocyclic group
Prior art date
Application number
HU0000658A
Other languages
English (en)
Inventor
Steven Mark Bromidge
Francis David King
Paul Adrian Wyman
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9626377.7A external-priority patent/GB9626377D0/en
Priority claimed from GBGB9700901.3A external-priority patent/GB9700901D0/en
Priority claimed from GBGB9722757.3A external-priority patent/GB9722757D0/en
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of HUP0000658A2 publication Critical patent/HUP0000658A2/hu
Publication of HUP0000658A3 publication Critical patent/HUP0000658A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

A találmány központi idegrendszeri aktivitással rendelkező (I)általános képletű vegyületekre - amelyek képletében P fenil-, naftilcsoport, biciklusos heterociklusos csoport vagy 5-7tagú heterociklusos csoport; A egyes kötés, alkilén- vagy alkeniléncsoport; R1 halogénatom, adott esetben egy vagy több halogénatommalszubsztituált alkilcsoport, cikloalkil-, alkil-karbonil-, alkoxi-,trifluor-metoxi-, hidroxi-, hidroxi-alkil-, hidroxi-alkoxi-, alkoxi-alkoxi-, alkanoil-, nitro-, amino-, alkil-amino-, dialkil-amino-,ciano-, fenil-, naftilcsoport, biciklusos heterociklusos csoport vagy5-7 tagú heterociklusos csoport; n 0, 1, 2, 3, 4, 5 vagy 6; R2 hidrogénatom, alkil- vagy aril-alkil-csoport; R3 jelentése azonos R5 jelentésével, vagy R3 és R5 együtt -(CH2)2O- vagy -(CH2)3O- csoportot képez, vagy R3 és R2 együtt -(CH2)2- vagy -(CH2)3- csoportot képez; R4 -X(CH2)p-R6 csoport, ahol X egyes kötés, metiléncsoport, oxigénatom, imino- vagy alkil-Ncsoport, p 0, 1, 2, 3, 4, 5 vagy 6, és R6 adott esetben szubsztituált 5-7 tagú heterociklusos csoport, vagy -NR7R8 általános képletű csoport; R5 hidrogén-, halogénatom, alkil-, cikloalkil-, alkil-karbonil-,alkoxi-, hidroxi-, hidroxi-alkil-, hidroxi-alkoxi-, alkoxi-alkoxi-,alkanoil-, nitro-, trifluor-metil-, ciano- vagy arilcsoport - ésgyógyászatilag elfogadható sóikra, előállítási eljárásaikra, avegyületeket tartalmazó gyógyszerkészítményekre és a vegyületekközponti idegrendszeri rendellenességek kezelésére történőalkalmazására vonatkozik. Ó
HU0000658A 1996-12-19 1997-12-15 Sulphonamide derivatives, process for their preparation, and their use as medicaments HUP0000658A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9626377.7A GB9626377D0 (en) 1996-12-19 1996-12-19 Novel compounds
GBGB9700901.3A GB9700901D0 (en) 1997-01-17 1997-01-17 Novel compounds
GBGB9722757.3A GB9722757D0 (en) 1997-10-27 1997-10-27 Novel compounds

Publications (2)

Publication Number Publication Date
HUP0000658A2 true HUP0000658A2 (hu) 2001-02-28
HUP0000658A3 HUP0000658A3 (en) 2001-03-28

Family

ID=27268644

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000658A HUP0000658A3 (en) 1996-12-19 1997-12-15 Sulphonamide derivatives, process for their preparation, and their use as medicaments

Country Status (31)

Country Link
US (2) US6423717B1 (hu)
EP (1) EP0946539B1 (hu)
JP (1) JP2001506646A (hu)
KR (1) KR20000069554A (hu)
CN (1) CN1246116A (hu)
AP (1) AP1277A (hu)
AR (1) AR010795A1 (hu)
AT (1) ATE247099T1 (hu)
AU (1) AU729056B2 (hu)
BG (1) BG103530A (hu)
BR (1) BR9713734A (hu)
CA (1) CA2275492A1 (hu)
CZ (1) CZ220399A3 (hu)
DE (1) DE69724142T2 (hu)
DZ (1) DZ2376A1 (hu)
EA (1) EA002351B1 (hu)
ES (1) ES2203831T3 (hu)
HU (1) HUP0000658A3 (hu)
ID (1) ID22821A (hu)
IL (1) IL130297A0 (hu)
MA (1) MA24426A1 (hu)
NO (1) NO993003D0 (hu)
NZ (1) NZ335970A (hu)
OA (1) OA11066A (hu)
PE (1) PE46899A1 (hu)
PL (1) PL334337A1 (hu)
SK (1) SK80899A3 (hu)
TR (1) TR199901361T2 (hu)
TW (1) TW418205B (hu)
UY (1) UY24819A1 (hu)
WO (1) WO1998027081A1 (hu)

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