PL334337A1 - Derivatives of sulphonamides, method of obtaining them and their application as drugs - Google Patents
Derivatives of sulphonamides, method of obtaining them and their application as drugsInfo
- Publication number
- PL334337A1 PL334337A1 PL97334337A PL33433797A PL334337A1 PL 334337 A1 PL334337 A1 PL 334337A1 PL 97334337 A PL97334337 A PL 97334337A PL 33433797 A PL33433797 A PL 33433797A PL 334337 A1 PL334337 A1 PL 334337A1
- Authority
- PL
- Poland
- Prior art keywords
- sulphonamides
- drugs
- derivatives
- obtaining
- application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9626377.7A GB9626377D0 (en) | 1996-12-19 | 1996-12-19 | Novel compounds |
| GBGB9700901.3A GB9700901D0 (en) | 1997-01-17 | 1997-01-17 | Novel compounds |
| GBGB9722757.3A GB9722757D0 (en) | 1997-10-27 | 1997-10-27 | Novel compounds |
| PCT/EP1997/007159 WO1998027081A1 (en) | 1996-12-19 | 1997-12-15 | Sulphonamide derivatives, process for their preparation, and their use as medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL334337A1 true PL334337A1 (en) | 2000-02-28 |
Family
ID=27268644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL97334337A PL334337A1 (en) | 1996-12-19 | 1997-12-15 | Derivatives of sulphonamides, method of obtaining them and their application as drugs |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US6423717B1 (en) |
| EP (1) | EP0946539B1 (en) |
| JP (1) | JP2001506646A (en) |
| KR (1) | KR20000069554A (en) |
| CN (1) | CN1246116A (en) |
| AP (1) | AP1277A (en) |
| AR (1) | AR010795A1 (en) |
| AT (1) | ATE247099T1 (en) |
| AU (1) | AU729056B2 (en) |
| BG (1) | BG103530A (en) |
| BR (1) | BR9713734A (en) |
| CA (1) | CA2275492A1 (en) |
| CZ (1) | CZ220399A3 (en) |
| DE (1) | DE69724142T2 (en) |
| DZ (1) | DZ2376A1 (en) |
| EA (1) | EA002351B1 (en) |
| ES (1) | ES2203831T3 (en) |
| HU (1) | HUP0000658A3 (en) |
| ID (1) | ID22821A (en) |
| IL (1) | IL130297A0 (en) |
| MA (1) | MA24426A1 (en) |
| NO (1) | NO993003D0 (en) |
| NZ (1) | NZ335970A (en) |
| OA (1) | OA11066A (en) |
| PE (1) | PE46899A1 (en) |
| PL (1) | PL334337A1 (en) |
| SK (1) | SK80899A3 (en) |
| TR (1) | TR199901361T2 (en) |
| TW (1) | TW418205B (en) |
| UY (1) | UY24819A1 (en) |
| WO (1) | WO1998027081A1 (en) |
Families Citing this family (130)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ2376A1 (en) * | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | New sulfonamide derivatives process for their preparation and pharmaceutical compositions containing them. |
| IL133870A0 (en) * | 1997-07-11 | 2001-04-30 | Smithkline Beecham Plc | Sulphonamide derivatives being 5-ht6 receptor antagonists and process for their preparation |
| AU759255B2 (en) | 1998-01-29 | 2003-04-10 | Amgen, Inc. | PPAR-gamma modulators |
| GB9803411D0 (en) * | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
| US6194410B1 (en) | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| GB9810671D0 (en) * | 1998-05-18 | 1998-07-15 | Pfizer Ltd | Anti-pruritic agents |
| GB9818916D0 (en) * | 1998-08-28 | 1998-10-21 | Smithkline Beecham Plc | Use |
| GB9818914D0 (en) * | 1998-08-28 | 1998-10-21 | Smithkline Beecham Plc | Use |
| GB9820113D0 (en) | 1998-09-15 | 1998-11-11 | Merck Sharp & Dohme | Therapeutic agents |
| US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| GB9926302D0 (en) * | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| WO2001045694A1 (en) * | 1999-12-21 | 2001-06-28 | Smithkline Beecham Corporation | Urotensin-ii receptor antagonists |
| SE9904723D0 (en) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
| SE0001899D0 (en) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| US6818639B2 (en) | 2000-07-21 | 2004-11-16 | Biovitrum Ab | Pharmaceutical combination formulation and method of treatment with the combination |
| US6399617B1 (en) | 2000-07-21 | 2002-06-04 | Biovitrum Ab | Use |
| SE0002754D0 (en) * | 2000-07-21 | 2000-07-21 | Pharmacia & Upjohn Ab | New pharmaceutical combination formulation and method of treatment with the combination |
| SE0002739D0 (en) * | 2000-07-21 | 2000-07-21 | Pharmacia & Upjohn Ab | New use |
| US7071220B2 (en) | 2000-09-18 | 2006-07-04 | Toa Eiyo Ltd. | N-substituted benzothiophenesulfonamide derivatives |
| CA2422807C (en) * | 2000-09-18 | 2009-12-08 | Toa Eiyo Ltd. | N-substituted benzothiophenesulfonamide derivatives |
| US7034029B2 (en) | 2000-11-02 | 2006-04-25 | Wyeth | 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands |
| EP1341783A1 (en) | 2000-11-21 | 2003-09-10 | Smithkline Beecham Plc | Isoquinoline derivatives useful in the treatment of cns disorders |
| CA2432713C (en) | 2000-12-22 | 2009-10-27 | Ishihara Sangyo Kaisha, Ltd. | Aniline derivatives or salts thereof and cytokine production inhibitors containing the same |
| JP2004534017A (en) * | 2001-04-27 | 2004-11-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | BACE inhibitors |
| WO2002089740A2 (en) * | 2001-05-07 | 2002-11-14 | Smithkline Beecham Corporation | Sulfonamides |
| JP2004535390A (en) * | 2001-05-07 | 2004-11-25 | スミスクライン・ビーチャム・コーポレイション | Sulfonamide |
| JP2004529168A (en) * | 2001-05-07 | 2004-09-24 | スミスクライン・ビーチャム・コーポレイション | Sulfonamide |
| US6743796B2 (en) | 2001-05-07 | 2004-06-01 | Wyeth | Piperazinyl-isatins |
| AR033879A1 (en) | 2001-05-07 | 2004-01-07 | Smithkline Beecham Corp | SULFONAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT, ITS USE TO PREPARE SUCH COMPOSITION AND PROCEDURE FOR OBTAINING SUCH COMPOUND |
| US20040198979A1 (en) * | 2001-05-07 | 2004-10-07 | Dashyant Dhanak | Sulfonamides |
| GB0111186D0 (en) * | 2001-05-08 | 2001-06-27 | Smithkline Beecham Plc | Novel compounds |
| NZ528450A (en) | 2001-05-11 | 2006-02-24 | Biovitrum Ab | Novel, arylsulfonamide compounds for the treatment of obesity, type II diabetes and CNS-disorders |
| US7718650B2 (en) | 2001-05-11 | 2010-05-18 | Biovitrum Ab | Aryl sulfonamide compounds for treating obesity |
| RS88803A (en) * | 2001-05-11 | 2007-02-05 | Biovitrum Ab., | Novel-arylsulfonamide compounds for the treatment of obesity type ii diabetes and cns-disorders |
| JP4187642B2 (en) | 2001-06-07 | 2008-11-26 | エフ．ホフマン−ラ ロシュ アーゲー | Novel indole derivatives having 5-HT6 receptor affinity |
| EA008476B1 (en) * | 2001-06-11 | 2007-06-29 | Биовитрум Аб | Substituted sulfonamide compounds, process for their use as medicaments for the treatment of cns disorders, obesity and type ii diabetes |
| ES2268113T3 (en) | 2001-06-15 | 2007-03-16 | F. Hoffmann-La Roche Ag | DERIVATIVES OF 4-PIPERAZINYLINDOL WITH AFFECTION TO THE RECEIVER 5-HT6. |
| US6727264B1 (en) | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
| JP2005527463A (en) * | 2001-08-07 | 2005-09-15 | スミスクライン ビーチャム パブリック リミテッド カンパニー | 3-Arylsulfonyl-7-piperazinyl-indole, -benzofuran and -benzothiophene with 5-HT6 receptor affinity for treating CNS diseases |
| ES2316619T3 (en) | 2001-08-10 | 2009-04-16 | F. Hoffmann-La Roche Ag | ARILSULFONYL DERIVATIVES WITH 5-HT RECEPTING AFFINITY 6. |
| DE60223936D1 (en) * | 2001-09-05 | 2008-01-17 | Eisai R&D Man Co Ltd | MEANS FOR EXCITING APPETITE AND AGENT FOR TREATING ANOREXIA |
| SE0103644D0 (en) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic isoquinoline compounds |
| JP2005511594A (en) * | 2001-11-09 | 2005-04-28 | ビオヴィトルム・アクチボラゲット | Use of sulfonamide derivatives in the treatment of obesity or for reducing food intake |
| US7094792B2 (en) | 2001-11-22 | 2006-08-22 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| EA200400708A1 (en) | 2001-11-22 | 2004-10-28 | Биовитрум Аб | INHIBITORS 11-BETA-HYDROXYSTEROID DEGYDROGENASE TYPE 1 |
| EP1453514B1 (en) * | 2001-11-30 | 2007-07-18 | F. Hoffmann-La Roche Ag | Piperazine derivatives for use as ccr-3 receptor antagonists in the treatment of asthma |
| BR0307429A (en) * | 2002-02-05 | 2004-12-28 | Novo Nordisk As | Compound, use thereof, pharmaceutical composition, and method for treating h3 histamine receptor related disorders or diseases |
| EP1471912A1 (en) * | 2002-02-05 | 2004-11-03 | Glaxo Group Limited | Method of promoting neuronal growth |
| JP2005526724A (en) * | 2002-02-13 | 2005-09-08 | グラクソ グループ リミテッド | Benzenesulfonamide derivatives as antipsychotic agents |
| DE60304695T2 (en) * | 2002-02-13 | 2006-09-21 | Glaxo Group Ltd., Greenford | 7-ARYLSULFONAMIDO-2,3,4,5-TETRAHYDRO-1H-BENZO [D] AZEPINE DERIVATIVES WITH 5-HAT-6-RECEPTOR AFFINITY FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM |
| EP1495004A2 (en) * | 2002-02-13 | 2005-01-12 | Glaxo Group Limited | Benzenesulfonamide derivatives and their use as dopamine d3 and d2 receptor ligands |
| JP4455064B2 (en) * | 2002-03-27 | 2010-04-21 | グラクソ グループ リミテッド | Quinoline derivatives and their use as 5-HT6 ligands |
| US20040142948A1 (en) * | 2002-05-07 | 2004-07-22 | Dashyant Dhanak | Sulfonamides |
| UA76877C2 (en) * | 2002-05-13 | 2006-09-15 | Ф.Хоффманн-Ля Рош Аг | Benzoxazine derivatives as 5-НТ6 modulators anD use thereof |
| MXPA04012914A (en) * | 2002-06-20 | 2005-03-31 | Biovitrum Ab | New compounds useful for the treatment of obesity, type ii diabetes and cns disorders. |
| JP4754821B2 (en) * | 2002-06-20 | 2011-08-24 | プロキシマゲン・リミテッド | Novel compounds useful for the treatment of obesity, type II diabetes and CNS disorders |
| EP1897881A3 (en) | 2002-06-20 | 2009-03-18 | Biovitrum AB (publ) | Compounds useful for the treatment of obesity, type II diabetes and CNS disorders |
| ES2274285T3 (en) | 2002-10-18 | 2007-05-16 | F. Hoffmann-La Roche Ag | 4-PIPERANZINILBENCENOSULFONILINDOLES WITH AFFINITY TO THE RECEIVER 5-HT6. |
| AU2003295408A1 (en) * | 2002-11-06 | 2004-06-03 | Smithkline Beecham Corporation | Sulfonamides |
| WO2004043369A2 (en) * | 2002-11-06 | 2004-05-27 | Smithkline Beecham Corporation | Sulfonamides |
| US8293751B2 (en) | 2003-01-14 | 2012-10-23 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
| US7153858B2 (en) | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
| US20060257613A1 (en) * | 2003-02-13 | 2006-11-16 | Horst Berneth | Metal complexes as light-absorbing compounds in the information layer of optical data carriers |
| EP2415760A3 (en) * | 2003-02-20 | 2012-02-22 | Encysive Pharmaceuticals, Inc. | CCR-9 antagonists |
| TWI289141B (en) * | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
| US7262197B2 (en) * | 2003-03-31 | 2007-08-28 | Janssen Pharmaceutica, N.V | Phospholipase C inhibitors for use in treating inflammatory disorders |
| US6946466B2 (en) * | 2003-04-10 | 2005-09-20 | Schering Ag | Aromatic sulfonamides as peroxynitrite-rearrangement catalysts |
| US20040204422A1 (en) * | 2003-04-14 | 2004-10-14 | Abbott Gmbh & Co. Kg. | N-[(Piperazinyl)hetaryl]arylsulfonamide compounds |
| ATE313532T1 (en) | 2003-07-22 | 2006-01-15 | Arena Pharm Inc | DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONINE RECEPTOR, SUITABLE FOR THE PROPHYLAXIS AND TREATMENT OF RELATED DISEASES |
| GB0320320D0 (en) * | 2003-08-29 | 2003-10-01 | Glaxo Group Ltd | Novel compounds |
| US7223761B2 (en) | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| SE0303480D0 (en) | 2003-12-19 | 2003-12-19 | Biovitrum Ab | Benzofuranes |
| KR20060127886A (en) * | 2003-12-19 | 2006-12-13 | 바이오비트럼 에이비 | Novel benzofuran derivatives, which can be used in prophylaxis or treatment of 5-ht6 receptor-related disorder |
| AR053407A1 (en) | 2004-07-28 | 2007-05-09 | Glaxo Group Ltd | PIPERAZINE DERIVATIVES, PROCESS FOR THE PREPARATION OF SUCH COMPOUND AND PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT. |
| RU2420318C2 (en) * | 2004-09-30 | 2011-06-10 | Ф.Хоффманн-Ля Рош Аг | Compositions and methods for treating cognitive disorders |
| EP1812389B1 (en) | 2004-10-14 | 2011-08-17 | Abbott GmbH & Co. KG | Azabicycloheptyl compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
| CA2583983C (en) | 2004-10-14 | 2013-07-16 | Abbott Gmbh & Co. Kg | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
| WO2006062481A1 (en) * | 2004-12-09 | 2006-06-15 | Biovitrum Ab | New benzofuran derivatives and their use in the treatment of obesity, type ii diabetes and cns disorders . |
| EP1676841A1 (en) * | 2004-12-30 | 2006-07-05 | Esteve Laboratorios Dr. Esteve S.A. | Substitited indazolyl sulfonamide and 2,3-dihydro-indolyl sulfonamide compounds, their prepartion and use in medicaments |
| KR100931928B1 (en) * | 2005-01-12 | 2009-12-15 | 인제대학교 산학협력단 | Pharmaceutical composition comprising a p25/cdk5 inhibitor for preventing or treating a neurodegenerative disease |
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