HUP9901022A2 - Hidroxámsav-alapú kollagenáz inhibitorok - Google Patents
Hidroxámsav-alapú kollagenáz inhibitorokInfo
- Publication number
- HUP9901022A2 HUP9901022A2 HU9901022A HUP9901022A HUP9901022A2 HU P9901022 A2 HUP9901022 A2 HU P9901022A2 HU 9901022 A HU9901022 A HU 9901022A HU P9901022 A HUP9901022 A HU P9901022A HU P9901022 A2 HUP9901022 A2 HU P9901022A2
- Authority
- HU
- Hungary
- Prior art keywords
- hydroxamic acid
- acid based
- collagenase inhibitors
- alkenyl
- alkyl
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 239000002442 collagenase inhibitor Substances 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000005002 aryl methyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány az s-CD23 túlzőtt termelésével összefüggésben állórendellenességek kezelésére és megelőzésére felhasználható (I)általánős képletű vegyületekre - amelyek képletében R és R3mindegyikének jelentése egymástól függetlenül hidrőgénatőm, alkil-,alkenil-, alkinil- vagy arilcsőpőrt; R1 jelentése aril-metil-csőpőrt;és R2 jelentése alkil-, alkenil-, aril-, ciklőalkil- vagyciklőalkenilcsőpőrt - és gyógyászatilag elfőgadható származékaikravőnatkőzik. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9601041.8A GB9601041D0 (en) | 1996-01-17 | 1996-01-17 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9901022A2 true HUP9901022A2 (hu) | 1999-07-28 |
| HUP9901022A3 HUP9901022A3 (en) | 2001-11-28 |
Family
ID=10787226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901022A HUP9901022A3 (en) | 1996-01-17 | 1997-01-14 | Hydroxamic acid based collagenase inhibitors |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0912545A1 (hu) |
| JP (1) | JP2000503312A (hu) |
| KR (1) | KR19990077325A (hu) |
| CN (1) | CN1213368A (hu) |
| AR (1) | AR005472A1 (hu) |
| AU (1) | AU725056B2 (hu) |
| BR (1) | BR9707024A (hu) |
| CA (1) | CA2242913A1 (hu) |
| CZ (1) | CZ222498A3 (hu) |
| GB (1) | GB9601041D0 (hu) |
| HU (1) | HUP9901022A3 (hu) |
| IL (1) | IL125381A0 (hu) |
| NO (1) | NO983283L (hu) |
| NZ (1) | NZ326352A (hu) |
| PL (1) | PL327820A1 (hu) |
| TR (1) | TR199801380T2 (hu) |
| TW (1) | TW462967B (hu) |
| WO (1) | WO1997026257A1 (hu) |
| ZA (1) | ZA97345B (hu) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548084B2 (en) | 1995-07-20 | 2003-04-15 | Smithkline Beecham Plc | Controlled release compositions |
| GB9609795D0 (en) * | 1996-05-10 | 1996-07-17 | Smithkline Beecham Plc | Novel compounds |
| AU1960100A (en) * | 1999-01-06 | 2000-07-24 | Mcmaster University | Method of preventing immune and hypersensitivity reactions |
| GB9922825D0 (en) * | 1999-09-25 | 1999-11-24 | Smithkline Beecham Biolog | Medical use |
| AU2001271068A1 (en) * | 2000-07-18 | 2002-01-30 | Chugai Seiyaku Kabushiki Kaisha | Matrix metalloprotease inhibitors |
| JP2005532261A (ja) * | 2002-01-28 | 2005-10-27 | エイムスコ・リミテッド | 治療 |
| US7521563B2 (en) | 2004-08-10 | 2009-04-21 | Shizuoka Coffein Co., Ltd. | Hydroxamic acid derivative and medicine containing the same as active ingredient |
| KR100844277B1 (ko) * | 2005-04-29 | 2008-07-07 | (주)아모레퍼시픽 | 히드록삼산 유도체 및 이의 제조방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4743587A (en) * | 1985-09-10 | 1988-05-10 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
| GB8827305D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| GB9504084D0 (en) * | 1995-03-01 | 1995-04-19 | British Biotech Pharm | Synthesis of carboxylic and hydroxamic acid derivatives |
-
1996
- 1996-01-17 GB GBGB9601041.8A patent/GB9601041D0/en active Pending
-
1997
- 1997-01-14 EP EP97901055A patent/EP0912545A1/en not_active Withdrawn
- 1997-01-14 TR TR1998/01380T patent/TR199801380T2/xx unknown
- 1997-01-14 AU AU14436/97A patent/AU725056B2/en not_active Ceased
- 1997-01-14 PL PL97327820A patent/PL327820A1/xx unknown
- 1997-01-14 IL IL12538197A patent/IL125381A0/xx unknown
- 1997-01-14 CA CA002242913A patent/CA2242913A1/en not_active Abandoned
- 1997-01-14 NZ NZ326352A patent/NZ326352A/xx unknown
- 1997-01-14 CN CN97192982A patent/CN1213368A/zh active Pending
- 1997-01-14 HU HU9901022A patent/HUP9901022A3/hu unknown
- 1997-01-14 WO PCT/EP1997/000196 patent/WO1997026257A1/en not_active Application Discontinuation
- 1997-01-14 BR BR9707024A patent/BR9707024A/pt unknown
- 1997-01-14 CZ CZ982224A patent/CZ222498A3/cs unknown
- 1997-01-14 KR KR1019980705472A patent/KR19990077325A/ko not_active Application Discontinuation
- 1997-01-14 JP JP9525693A patent/JP2000503312A/ja active Pending
- 1997-01-15 AR ARP970100153A patent/AR005472A1/es unknown
- 1997-01-16 ZA ZA97345A patent/ZA97345B/xx unknown
- 1997-01-30 TW TW086101017A patent/TW462967B/zh active
-
1998
- 1998-07-16 NO NO983283A patent/NO983283L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL125381A0 (en) | 1999-03-12 |
| AU725056B2 (en) | 2000-10-05 |
| ZA97345B (en) | 1998-07-16 |
| NO983283D0 (no) | 1998-07-16 |
| CZ222498A3 (cs) | 1999-03-17 |
| NZ326352A (en) | 2000-03-27 |
| TW462967B (en) | 2001-11-11 |
| KR19990077325A (ko) | 1999-10-25 |
| TR199801380T2 (xx) | 1998-10-21 |
| AR005472A1 (es) | 1999-06-23 |
| CA2242913A1 (en) | 1997-07-24 |
| CN1213368A (zh) | 1999-04-07 |
| NO983283L (no) | 1998-09-16 |
| AU1443697A (en) | 1997-08-11 |
| PL327820A1 (en) | 1999-01-04 |
| GB9601041D0 (en) | 1996-03-20 |
| JP2000503312A (ja) | 2000-03-21 |
| EP0912545A1 (en) | 1999-05-06 |
| BR9707024A (pt) | 1999-07-20 |
| WO1997026257A1 (en) | 1997-07-24 |
| HUP9901022A3 (en) | 2001-11-28 |
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