HUP0200088A2 - Piridazin-3-on-származékok és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Piridazin-3-on-származékok és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0200088A2 HUP0200088A2 HU0200088A HUP0200088A HUP0200088A2 HU P0200088 A2 HUP0200088 A2 HU P0200088A2 HU 0200088 A HU0200088 A HU 0200088A HU P0200088 A HUP0200088 A HU P0200088A HU P0200088 A2 HUP0200088 A2 HU P0200088A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- optionally substituted
- derivatives
- pyridazin
- same
- Prior art date
Links
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyano- Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000023589 ischemic disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány az interleukin-1b termelés ellen gátló hatással rendelkezőés immunrendszeri betegségek, gyulladásos betegségek, ischaemiásbetegségek stb. megelőzésére és kezelésére felhasználható újpiridazin-3-on-származékokra, valamint a vegyületeket hatóanyagkénttartalmazó gyógyszerkészítményekre vonatkozik. A találmány szerintivegyületek és sóik (1) általános képletében Ar1 adott esetbenszubsztituált aromás csoport, Ar2 legalább a 4-es helyzetbenszubsztituált fenilcsoport, R1 alkilcsoport, cikloalkilcsoport, adottesetben szubsztituált fenil- vagy fenil-alkil-csoport, és R2 ciano-,karboxi-, alkoxi-karbonil-csoport, adott esetben szubsztituált alkil-vagy karbamoilcsoport. Ó
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11049758A JP2000247959A (ja) | 1999-02-26 | 1999-02-26 | ピリダジン−3−オン誘導体及びこれを含有する医薬 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0200088A2 true HUP0200088A2 (hu) | 2002-11-28 |
HUP0200088A3 HUP0200088A3 (en) | 2002-12-28 |
Family
ID=12840099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0200088A HUP0200088A3 (en) | 1999-02-26 | 2000-02-25 | Pyridazin-3-one derivatives and pharmaceutical compositions containing the same |
Country Status (18)
Country | Link |
---|---|
US (1) | US6680316B1 (hu) |
EP (1) | EP1156039B1 (hu) |
JP (2) | JP2000247959A (hu) |
KR (1) | KR100647726B1 (hu) |
CN (1) | CN1148355C (hu) |
AT (1) | ATE305926T1 (hu) |
AU (1) | AU764393B2 (hu) |
CA (1) | CA2364801C (hu) |
DE (1) | DE60022986T2 (hu) |
DK (1) | DK1156039T3 (hu) |
ES (1) | ES2250100T3 (hu) |
HK (1) | HK1044534B (hu) |
HU (1) | HUP0200088A3 (hu) |
NO (1) | NO319832B1 (hu) |
NZ (1) | NZ513578A (hu) |
RU (1) | RU2232755C2 (hu) |
TW (1) | TWI249533B (hu) |
WO (1) | WO2000050408A1 (hu) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2017266A1 (en) * | 1997-11-19 | 2009-01-21 | Kowa Co., Ltd. | Pyridazine derivatives and medicines containing the same as effective ingredients |
KR100770327B1 (ko) * | 2000-09-18 | 2007-10-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 피리다지논 및 트리아지논 화합물류 및 그들의 의약 용도 |
AU761191B2 (en) * | 2001-05-24 | 2003-05-29 | Pfizer Products Inc. | Therapies for tissue damage resulting from ischemia |
CN1304379C (zh) * | 2001-09-26 | 2007-03-14 | 兴和株式会社 | 水溶性苯基哒嗪衍生物及含有该衍生物的药物 |
WO2004078751A1 (ja) * | 2003-03-07 | 2004-09-16 | Kowa Co., Ltd. | ベンゾフラン誘導体 |
MXPA05009972A (es) | 2003-03-18 | 2005-11-04 | Kowa Co | Derivado de fenilpiridazina soluble en agua y medicina que contiene el mismo. |
US20040254178A1 (en) * | 2003-04-16 | 2004-12-16 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
WO2007044796A2 (en) * | 2005-10-11 | 2007-04-19 | Nps Pharmaceuticals, Inc. | Pyridazinone compounds as calcilytics |
CN101296707A (zh) * | 2005-10-28 | 2008-10-29 | 兴和株式会社 | 类风湿性关节炎的预防和/或治疗方法 |
WO2014121931A1 (en) * | 2013-02-07 | 2014-08-14 | Merck Patent Gmbh | Pyridazinone-amides derivatives |
BR112017014970B1 (pt) * | 2015-02-06 | 2022-11-16 | Merck Patent Gmbh | Macrociclos de piridazinona como inibidores de irak, seus usos, e composição farmacêutica |
FR3103701B1 (fr) * | 2019-11-28 | 2021-11-26 | Inst Nat Sante Rech Med | Composés de typen2-arylméthyl-4-haloalkyl-pyridazin-3-one et leur utilisation |
AU2021219788A1 (en) | 2020-02-14 | 2022-09-08 | Fmc Corporation | Substituted 5,6-diphenyl-3(2H)-pyridazinones for use as fungicides |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2839532A (en) * | 1958-06-17 | Pyridazone compounds and process of | ||
GB788393A (en) * | 1953-04-30 | 1958-01-02 | Ciba Ltd | Process for the manufacture of pyridazone compounds |
US3840597A (en) | 1971-02-24 | 1974-10-08 | Riker Laboratories Inc | Substituted 2-phenoxy alkane-sulfonanilides |
AR206496A1 (es) | 1972-07-03 | 1976-07-30 | Riker Laboratories Inc | Procedimiento para la preparacion de 2-fenoxi-4-nitro-alquil o haloalquilsulfonanilidas |
US4238490A (en) * | 1979-02-12 | 1980-12-09 | Diamond Shamrock Corporation | Antihypertensive pyridazin(2H)-3-ones |
US4545810A (en) | 1980-08-07 | 1985-10-08 | Sds Biotech Corporation | Herbicidal and plant growth regulant diphenylpyridazinones |
WO1982000402A1 (en) * | 1980-08-07 | 1982-02-18 | Shamrock Corp Diamond | Herbicidal and plant growth regulant diphenylpyridazinones |
JPH0753725B2 (ja) | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
FI91062C (fi) | 1988-12-28 | 1994-05-10 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisten naftaleenijohdannaisten valmistamiseksi |
IL104369A0 (en) | 1992-01-13 | 1993-05-13 | Smithkline Beecham Corp | Novel compounds and compositions |
DE69408598T2 (de) * | 1993-06-08 | 1998-09-17 | Vertex Pharmaceuticals Inc Cam | Pyridazine als Interleukin-1-beta Verwandlungsenzym Inhibitoren |
EP0871444A4 (en) | 1995-08-10 | 1999-01-13 | Merck & Co Inc | 2.5 SUBSTITUTED ARYL PYRROL, THE COMPOSITIONS THAT CONTAIN AND THE USE THEREOF |
BR9812127A (pt) | 1997-08-22 | 2000-07-18 | Abbott Lab | Arilpiridazinonas como inibidores da biossìntese de prostagleina endoperóxido h sintase |
PT1005460E (pt) | 1997-08-22 | 2006-07-31 | Abbott Lab | Biossintese de inibidores de prostaglandina-endoperoxido h-sintase |
EP2017266A1 (en) | 1997-11-19 | 2009-01-21 | Kowa Co., Ltd. | Pyridazine derivatives and medicines containing the same as effective ingredients |
TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
KR100666838B1 (ko) | 1998-10-27 | 2007-01-11 | 아보트 러보러터리즈 | 프로스타글란딘 엔도퍼옥사이드 h 신타제 생합성 억제제 및 이를 포함하는 약제학적 조성물 |
-
1999
- 1999-02-26 JP JP11049758A patent/JP2000247959A/ja active Pending
-
2000
- 2000-02-25 KR KR1020017009829A patent/KR100647726B1/ko not_active IP Right Cessation
- 2000-02-25 RU RU2001126063/04A patent/RU2232755C2/ru active
- 2000-02-25 JP JP2000600991A patent/JP4456765B2/ja not_active Expired - Fee Related
- 2000-02-25 AT AT00905344T patent/ATE305926T1/de not_active IP Right Cessation
- 2000-02-25 CN CNB00804242XA patent/CN1148355C/zh not_active Expired - Fee Related
- 2000-02-25 ES ES00905344T patent/ES2250100T3/es not_active Expired - Lifetime
- 2000-02-25 NZ NZ513578A patent/NZ513578A/en not_active Application Discontinuation
- 2000-02-25 US US09/926,040 patent/US6680316B1/en not_active Expired - Fee Related
- 2000-02-25 TW TW089103388A patent/TWI249533B/zh not_active IP Right Cessation
- 2000-02-25 DE DE60022986T patent/DE60022986T2/de not_active Expired - Lifetime
- 2000-02-25 EP EP00905344A patent/EP1156039B1/en not_active Expired - Lifetime
- 2000-02-25 DK DK00905344T patent/DK1156039T3/da active
- 2000-02-25 CA CA002364801A patent/CA2364801C/en not_active Expired - Fee Related
- 2000-02-25 AU AU26928/00A patent/AU764393B2/en not_active Ceased
- 2000-02-25 HU HU0200088A patent/HUP0200088A3/hu unknown
- 2000-02-25 WO PCT/JP2000/001098 patent/WO2000050408A1/ja active IP Right Grant
-
2001
- 2001-08-23 NO NO20014099A patent/NO319832B1/no not_active IP Right Cessation
-
2002
- 2002-08-20 HK HK02106060.0A patent/HK1044534B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE305926T1 (de) | 2005-10-15 |
EP1156039A1 (en) | 2001-11-21 |
ES2250100T3 (es) | 2006-04-16 |
NO20014099D0 (no) | 2001-08-23 |
NO20014099L (no) | 2001-10-23 |
NZ513578A (en) | 2005-04-29 |
DE60022986D1 (de) | 2006-02-16 |
KR20010101979A (ko) | 2001-11-15 |
EP1156039B1 (en) | 2005-10-05 |
WO2000050408A1 (fr) | 2000-08-31 |
HK1044534A1 (en) | 2002-10-25 |
AU2692800A (en) | 2000-09-14 |
KR100647726B1 (ko) | 2006-11-23 |
JP2000247959A (ja) | 2000-09-12 |
CA2364801C (en) | 2009-05-19 |
NO319832B1 (no) | 2005-09-19 |
JP4456765B2 (ja) | 2010-04-28 |
CN1148355C (zh) | 2004-05-05 |
CN1341103A (zh) | 2002-03-20 |
US6680316B1 (en) | 2004-01-20 |
HK1044534B (zh) | 2004-12-10 |
CA2364801A1 (en) | 2000-08-31 |
EP1156039A4 (en) | 2002-04-17 |
DE60022986T2 (de) | 2006-05-11 |
AU764393B2 (en) | 2003-08-14 |
RU2232755C2 (ru) | 2004-07-20 |
DK1156039T3 (da) | 2006-01-30 |
TWI249533B (en) | 2006-02-21 |
HUP0200088A3 (en) | 2002-12-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |