HUP0200088A2 - Piridazin-3-on-származékok és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Piridazin-3-on-származékok és a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0200088A2
HUP0200088A2 HU0200088A HUP0200088A HUP0200088A2 HU P0200088 A2 HUP0200088 A2 HU P0200088A2 HU 0200088 A HU0200088 A HU 0200088A HU P0200088 A HUP0200088 A HU P0200088A HU P0200088 A2 HUP0200088 A2 HU P0200088A2
Authority
HU
Hungary
Prior art keywords
group
optionally substituted
derivatives
pyridazin
same
Prior art date
Application number
HU0200088A
Other languages
English (en)
Inventor
Tomoko Furuyama
Takahiro Kitamura
Tomoyuki Koshi
Yoshinori Kyotani
Takayuki Matsuda
Masao Ohkuchi
Hiromichi Shigyo
Kyoko Yasuoka
Hideo Yoshizaki
Original Assignee
Kowa Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co., Ltd. filed Critical Kowa Co., Ltd.
Publication of HUP0200088A2 publication Critical patent/HUP0200088A2/hu
Publication of HUP0200088A3 publication Critical patent/HUP0200088A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány az interleukin-1b termelés ellen gátló hatással rendelkezőés immunrendszeri betegségek, gyulladásos betegségek, ischaemiásbetegségek stb. megelőzésére és kezelésére felhasználható újpiridazin-3-on-származékokra, valamint a vegyületeket hatóanyagkénttartalmazó gyógyszerkészítményekre vonatkozik. A találmány szerintivegyületek és sóik (1) általános képletében Ar1 adott esetbenszubsztituált aromás csoport, Ar2 legalább a 4-es helyzetbenszubsztituált fenilcsoport, R1 alkilcsoport, cikloalkilcsoport, adottesetben szubsztituált fenil- vagy fenil-alkil-csoport, és R2 ciano-,karboxi-, alkoxi-karbonil-csoport, adott esetben szubsztituált alkil-vagy karbamoilcsoport. Ó
HU0200088A 1999-02-26 2000-02-25 Pyridazin-3-one derivatives and pharmaceutical compositions containing the same HUP0200088A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11049758A JP2000247959A (ja) 1999-02-26 1999-02-26 ピリダジン−３−オン誘導体及びこれを含有する医薬

Publications (2)

Publication Number Publication Date
HUP0200088A2 true HUP0200088A2 (hu) 2002-11-28
HUP0200088A3 HUP0200088A3 (en) 2002-12-28

Family

ID=12840099

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0200088A HUP0200088A3 (en) 1999-02-26 2000-02-25 Pyridazin-3-one derivatives and pharmaceutical compositions containing the same

Country Status (18)

Country Link
US (1) US6680316B1 (hu)
EP (1) EP1156039B1 (hu)
JP (2) JP2000247959A (hu)
KR (1) KR100647726B1 (hu)
CN (1) CN1148355C (hu)
AT (1) ATE305926T1 (hu)
AU (1) AU764393B2 (hu)
CA (1) CA2364801C (hu)
DE (1) DE60022986T2 (hu)
DK (1) DK1156039T3 (hu)
ES (1) ES2250100T3 (hu)
HK (1) HK1044534B (hu)
HU (1) HUP0200088A3 (hu)
NO (1) NO319832B1 (hu)
NZ (1) NZ513578A (hu)
RU (1) RU2232755C2 (hu)
TW (1) TWI249533B (hu)
WO (1) WO2000050408A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2017266A1 (en) * 1997-11-19 2009-01-21 Kowa Co., Ltd. Pyridazine derivatives and medicines containing the same as effective ingredients
KR100770327B1 (ko) * 2000-09-18 2007-10-25 에자이 알앤드디 매니지먼트 가부시키가이샤 피리다지논 및 트리아지논 화합물류 및 그들의 의약 용도
AU761191B2 (en) * 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
CN1304379C (zh) * 2001-09-26 2007-03-14 兴和株式会社 水溶性苯基哒嗪衍生物及含有该衍生物的药物
WO2004078751A1 (ja) * 2003-03-07 2004-09-16 Kowa Co., Ltd. ベンゾフラン誘導体
MXPA05009972A (es) 2003-03-18 2005-11-04 Kowa Co Derivado de fenilpiridazina soluble en agua y medicina que contiene el mismo.
US20040254178A1 (en) * 2003-04-16 2004-12-16 Amgen Inc. Substituted heterocyclic compounds and methods of use
WO2007044796A2 (en) * 2005-10-11 2007-04-19 Nps Pharmaceuticals, Inc. Pyridazinone compounds as calcilytics
CN101296707A (zh) * 2005-10-28 2008-10-29 兴和株式会社 类风湿性关节炎的预防和/或治疗方法
WO2014121931A1 (en) * 2013-02-07 2014-08-14 Merck Patent Gmbh Pyridazinone-amides derivatives
BR112017014970B1 (pt) * 2015-02-06 2022-11-16 Merck Patent Gmbh Macrociclos de piridazinona como inibidores de irak, seus usos, e composição farmacêutica
FR3103701B1 (fr) * 2019-11-28 2021-11-26 Inst Nat Sante Rech Med Composés de typen2-arylméthyl-4-haloalkyl-pyridazin-3-one et leur utilisation
AU2021219788A1 (en) 2020-02-14 2022-09-08 Fmc Corporation Substituted 5,6-diphenyl-3(2H)-pyridazinones for use as fungicides

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2839532A (en) * 1958-06-17 Pyridazone compounds and process of
GB788393A (en) * 1953-04-30 1958-01-02 Ciba Ltd Process for the manufacture of pyridazone compounds
US3840597A (en) 1971-02-24 1974-10-08 Riker Laboratories Inc Substituted 2-phenoxy alkane-sulfonanilides
AR206496A1 (es) 1972-07-03 1976-07-30 Riker Laboratories Inc Procedimiento para la preparacion de 2-fenoxi-4-nitro-alquil o haloalquilsulfonanilidas
US4238490A (en) * 1979-02-12 1980-12-09 Diamond Shamrock Corporation Antihypertensive pyridazin(2H)-3-ones
US4545810A (en) 1980-08-07 1985-10-08 Sds Biotech Corporation Herbicidal and plant growth regulant diphenylpyridazinones
WO1982000402A1 (en) * 1980-08-07 1982-02-18 Shamrock Corp Diamond Herbicidal and plant growth regulant diphenylpyridazinones
JPH0753725B2 (ja) 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
FI91062C (fi) 1988-12-28 1994-05-10 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisten naftaleenijohdannaisten valmistamiseksi
IL104369A0 (en) 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
DE69408598T2 (de) * 1993-06-08 1998-09-17 Vertex Pharmaceuticals Inc Cam Pyridazine als Interleukin-1-beta Verwandlungsenzym Inhibitoren
EP0871444A4 (en) 1995-08-10 1999-01-13 Merck & Co Inc 2.5 SUBSTITUTED ARYL PYRROL, THE COMPOSITIONS THAT CONTAIN AND THE USE THEREOF
BR9812127A (pt) 1997-08-22 2000-07-18 Abbott Lab Arilpiridazinonas como inibidores da biossìntese de prostagleina endoperóxido h sintase
PT1005460E (pt) 1997-08-22 2006-07-31 Abbott Lab Biossintese de inibidores de prostaglandina-endoperoxido h-sintase
EP2017266A1 (en) 1997-11-19 2009-01-21 Kowa Co., Ltd. Pyridazine derivatives and medicines containing the same as effective ingredients
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
KR100666838B1 (ko) 1998-10-27 2007-01-11 아보트 러보러터리즈 프로스타글란딘 엔도퍼옥사이드 ｈ 신타제 생합성 억제제 및 이를 포함하는 약제학적 조성물

Also Published As

Publication number Publication date
ATE305926T1 (de) 2005-10-15
EP1156039A1 (en) 2001-11-21
ES2250100T3 (es) 2006-04-16
NO20014099D0 (no) 2001-08-23
NO20014099L (no) 2001-10-23
NZ513578A (en) 2005-04-29
DE60022986D1 (de) 2006-02-16
KR20010101979A (ko) 2001-11-15
EP1156039B1 (en) 2005-10-05
WO2000050408A1 (fr) 2000-08-31
HK1044534A1 (en) 2002-10-25
AU2692800A (en) 2000-09-14
KR100647726B1 (ko) 2006-11-23
JP2000247959A (ja) 2000-09-12
CA2364801C (en) 2009-05-19
NO319832B1 (no) 2005-09-19
JP4456765B2 (ja) 2010-04-28
CN1148355C (zh) 2004-05-05
CN1341103A (zh) 2002-03-20
US6680316B1 (en) 2004-01-20
HK1044534B (zh) 2004-12-10
CA2364801A1 (en) 2000-08-31
EP1156039A4 (en) 2002-04-17
DE60022986T2 (de) 2006-05-11
AU764393B2 (en) 2003-08-14
RU2232755C2 (ru) 2004-07-20
DK1156039T3 (da) 2006-01-30
TWI249533B (en) 2006-02-21
HUP0200088A3 (en) 2002-12-28

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees