HK1044534B - 噠嗪-3-酮衍生物和含有該類化合物的藥物 - Google Patents

噠嗪-3-酮衍生物和含有該類化合物的藥物

Info

Publication number
HK1044534B
HK1044534B HK02106060.0A HK02106060A HK1044534B HK 1044534 B HK1044534 B HK 1044534B HK 02106060 A HK02106060 A HK 02106060A HK 1044534 B HK1044534 B HK 1044534B
Authority
HK
Hong Kong
Prior art keywords
group
substituted
unsubstituted
pyridazin
medicines
Prior art date
Application number
HK02106060.0A
Other languages
English (en)
Other versions
HK1044534A1 (en
Inventor
大口正夫
京谷善德
執行洋陸
吉崎榮男
古志朋之
北村崇博
松田隆行
安岡京子
古山智子
Original Assignee
興和株式會社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 興和株式會社 filed Critical 興和株式會社
Publication of HK1044534A1 publication Critical patent/HK1044534A1/xx
Publication of HK1044534B publication Critical patent/HK1044534B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK02106060.0A 1999-02-26 2002-08-20 噠嗪-3-酮衍生物和含有該類化合物的藥物 HK1044534B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP11049758A JP2000247959A (ja) 1999-02-26 1999-02-26 ピリダジン−３−オン誘導体及びこれを含有する医薬
PCT/JP2000/001098 WO2000050408A1 (fr) 1999-02-26 2000-02-25 Derives de pyridazin-3-one et medicaments contenant ces derives

Publications (2)

Publication Number Publication Date
HK1044534A1 HK1044534A1 (en) 2002-10-25
HK1044534B true HK1044534B (zh) 2004-12-10

Family

ID=12840099

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106060.0A HK1044534B (zh) 1999-02-26 2002-08-20 噠嗪-3-酮衍生物和含有該類化合物的藥物

Country Status (18)

Country Link
US (1) US6680316B1 (zh)
EP (1) EP1156039B1 (zh)
JP (2) JP2000247959A (zh)
KR (1) KR100647726B1 (zh)
CN (1) CN1148355C (zh)
AT (1) ATE305926T1 (zh)
AU (1) AU764393B2 (zh)
CA (1) CA2364801C (zh)
DE (1) DE60022986T2 (zh)
DK (1) DK1156039T3 (zh)
ES (1) ES2250100T3 (zh)
HK (1) HK1044534B (zh)
HU (1) HUP0200088A3 (zh)
NO (1) NO319832B1 (zh)
NZ (1) NZ513578A (zh)
RU (1) RU2232755C2 (zh)
TW (1) TWI249533B (zh)
WO (1) WO2000050408A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2209813C2 (ru) * 1997-11-19 2003-08-10 Кова Ко., Лтд. Производные пиридазина, лекарственные средства на их основе и способ лечения артрита
MXPA03002324A (es) * 2000-09-18 2003-06-06 Eisai Co Ltd Compuestos de piridazinona y triazinona y su uso como preparaciones farmaceuticas.
AU761191B2 (en) * 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
WO2003027077A1 (fr) * 2001-09-26 2003-04-03 Kowa Co., Ltd. Derives de phenylpyridazine solubles dans l'eau et medicaments contenant ceux-ci
WO2004078751A1 (ja) * 2003-03-07 2004-09-16 Kowa Co., Ltd. ベンゾフラン誘導体
WO2004083188A1 (ja) * 2003-03-18 2004-09-30 Kowa Co., Ltd. 水溶性フェニルピリダジン誘導体及びこれを含有する医薬
EP1628665A2 (en) * 2003-04-16 2006-03-01 Amgen Inc. 3-phenyl-4-(pyrimidin-2-yl)-6-(piperidin-4-yl) derivatives and related compounds as tnf-alpha and il-1 inhibitors for the treatment of inflammations
WO2007044796A2 (en) * 2005-10-11 2007-04-19 Nps Pharmaceuticals, Inc. Pyridazinone compounds as calcilytics
WO2007049732A1 (ja) * 2005-10-28 2007-05-03 Kowa Co., Ltd. 関節リウマチの予防及び／又は治療法
PL2953944T3 (pl) * 2013-02-07 2017-09-29 Merck Patent Gmbh Pochodne pirydazynonowe-amidowe
MX2017009624A (es) * 2015-02-06 2017-11-20 Merck Patent Gmbh Macrociclos de piridazinona como inhibidores de cinasas asociadas al receptor de interleucina 1(irak) y sus usos.
FR3103701B1 (fr) * 2019-11-28 2021-11-26 Inst Nat Sante Rech Med Composés de typen2-arylméthyl-4-haloalkyl-pyridazin-3-one et leur utilisation
JP2023513239A (ja) 2020-02-14 2023-03-30 エフ エム シー コーポレーション 殺真菌薬としての使用のための置換５，６－ジフェニル－３（２ｈ）－ピリダジノン

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2839532A (en) * 1958-06-17 Pyridazone compounds and process of
GB788393A (en) * 1953-04-30 1958-01-02 Ciba Ltd Process for the manufacture of pyridazone compounds
US3840597A (en) 1971-02-24 1974-10-08 Riker Laboratories Inc Substituted 2-phenoxy alkane-sulfonanilides
AR206496A1 (es) 1972-07-03 1976-07-30 Riker Laboratories Inc Procedimiento para la preparacion de 2-fenoxi-4-nitro-alquil o haloalquilsulfonanilidas
US4238490A (en) * 1979-02-12 1980-12-09 Diamond Shamrock Corporation Antihypertensive pyridazin(2H)-3-ones
US4545810A (en) 1980-08-07 1985-10-08 Sds Biotech Corporation Herbicidal and plant growth regulant diphenylpyridazinones
JPS57501328A (zh) * 1980-08-07 1982-07-29
JPH0753725B2 (ja) 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
FI91062C (fi) 1988-12-28 1994-05-10 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisten naftaleenijohdannaisten valmistamiseksi
MX9300141A (es) 1992-01-13 1994-07-29 Smithkline Beecham Corp Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
DE69408598T2 (de) 1993-06-08 1998-09-17 Vertex Pharmaceuticals Inc Cam Pyridazine als Interleukin-1-beta Verwandlungsenzym Inhibitoren
CA2228050A1 (en) 1995-08-10 1997-02-20 Harold G. Selnick 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
PT1005460E (pt) 1997-08-22 2006-07-31 Abbott Lab Biossintese de inibidores de prostaglandina-endoperoxido h-sintase
WO1999010331A1 (en) 1997-08-22 1999-03-04 Abbott Laboratories Arylpyridazinones as prostaglandin endoperoxide h synthase biosynthesis inhibitors
RU2209813C2 (ru) 1997-11-19 2003-08-10 Кова Ко., Лтд. Производные пиридазина, лекарственные средства на их основе и способ лечения артрита
TWI241295B (en) 1998-03-02 2005-10-11 Kowa Co Pyridazine derivative and medicine containing the same as effect component
ES2249919T3 (es) 1998-10-27 2006-04-01 Abbott Laboratories Inhibidores de la biosintesis de prostaglandina endoperoxido h sintasa.

Also Published As

Publication number Publication date
CA2364801A1 (en) 2000-08-31
DE60022986T2 (de) 2006-05-11
RU2232755C2 (ru) 2004-07-20
EP1156039A4 (en) 2002-04-17
WO2000050408A1 (fr) 2000-08-31
JP2000247959A (ja) 2000-09-12
DE60022986D1 (de) 2006-02-16
TWI249533B (en) 2006-02-21
KR100647726B1 (ko) 2006-11-23
CN1148355C (zh) 2004-05-05
NO319832B1 (no) 2005-09-19
DK1156039T3 (da) 2006-01-30
NZ513578A (en) 2005-04-29
ATE305926T1 (de) 2005-10-15
CA2364801C (en) 2009-05-19
EP1156039B1 (en) 2005-10-05
HK1044534A1 (en) 2002-10-25
NO20014099D0 (no) 2001-08-23
AU764393B2 (en) 2003-08-14
US6680316B1 (en) 2004-01-20
EP1156039A1 (en) 2001-11-21
KR20010101979A (ko) 2001-11-15
CN1341103A (zh) 2002-03-20
NO20014099L (no) 2001-10-23
AU2692800A (en) 2000-09-14
HUP0200088A2 (hu) 2002-11-28
JP4456765B2 (ja) 2010-04-28
HUP0200088A3 (en) 2002-12-28
ES2250100T3 (es) 2006-04-16

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100225