DE69408598T2 - Pyridazine als Interleukin-1-beta Verwandlungsenzym Inhibitoren - Google Patents
Pyridazine als Interleukin-1-beta Verwandlungsenzym InhibitorenInfo
- Publication number
- DE69408598T2 DE69408598T2 DE69408598T DE69408598T DE69408598T2 DE 69408598 T2 DE69408598 T2 DE 69408598T2 DE 69408598 T DE69408598 T DE 69408598T DE 69408598 T DE69408598 T DE 69408598T DE 69408598 T2 DE69408598 T2 DE 69408598T2
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- aryl
- chr5
- compounds
- interleukin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7391493A | 1993-06-08 | 1993-06-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69408598D1 DE69408598D1 (de) | 1998-04-02 |
| DE69408598T2 true DE69408598T2 (de) | 1998-09-17 |
Family
ID=22116553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69408598T Expired - Lifetime DE69408598T2 (de) | 1993-06-08 | 1994-06-04 | Pyridazine als Interleukin-1-beta Verwandlungsenzym Inhibitoren |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6121266A (de) |
| EP (1) | EP0628550B1 (de) |
| JP (1) | JPH0769894A (de) |
| KR (1) | KR950000673A (de) |
| AT (1) | ATE163412T1 (de) |
| AU (1) | AU693786B2 (de) |
| CA (1) | CA2125359A1 (de) |
| CZ (1) | CZ140194A3 (de) |
| DE (1) | DE69408598T2 (de) |
| DK (1) | DK0628550T3 (de) |
| ES (1) | ES2114654T3 (de) |
| FI (1) | FI942693A (de) |
| HU (1) | HUT67413A (de) |
| IL (1) | IL109918A0 (de) |
| NO (1) | NO306061B1 (de) |
| NZ (1) | NZ260698A (de) |
| RU (1) | RU94019984A (de) |
| SK (1) | SK69794A3 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| ES2114654T3 (es) | 1993-06-08 | 1998-06-01 | Vertex Pharma | Piridazinas como inhibidores de la enzima de conversion de la interleuquina-1beta. |
| US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
| AU5122196A (en) * | 1995-03-31 | 1996-10-16 | Takeda Chemical Industries Ltd. | Cysteine protease inhibitor |
| US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
| GB9715640D0 (en) * | 1997-07-24 | 1997-10-01 | M J Highway Technology Limited | Road repair material |
| TWI241295B (en) * | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
| JP2000247959A (ja) | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−３−オン誘導体及びこれを含有する医薬 |
| EP1282435A2 (de) * | 2000-05-12 | 2003-02-12 | Immunex Corporation | Interleukin-1 inhibitoren zur behandlung von erkrankungen |
| US6664256B1 (en) | 2000-07-10 | 2003-12-16 | Kowa Co., Ltd. | Phenylpyridazine compounds and medicines containing the same |
| EP2264014A1 (de) | 2001-08-31 | 2010-12-22 | Université Louis Pasteur | Substituierte Pyridazine als Entzündungshemmer und Proteinkinasehemmer |
| TWI314455B (en) * | 2002-12-10 | 2009-09-11 | Nippon Kayaku Kk | 3-phenyl-cinnoline derivatives and anti-tumor agent containing the same |
| WO2004083188A1 (ja) | 2003-03-18 | 2004-09-30 | Kowa Co., Ltd. | 水溶性フェニルピリダジン誘導体及びこれを含有する医薬 |
| EP2284157A1 (de) | 2003-12-12 | 2011-02-16 | Wyeth | Quinolinen zur behandlung von cardiovascular krankheiten |
| JP4989456B2 (ja) | 2004-02-26 | 2012-08-01 | ベイラー リサーチ インスティテュート | 関節炎の全身処置のための組成物および方法 |
| NZ588448A (en) * | 2004-05-15 | 2012-01-12 | Vertex Pharma | Treating seizures using interleukin-1beta converting enzyme (ICE) inhibitors |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| EP2592075B1 (de) | 2004-11-02 | 2015-04-29 | Northwestern University | Pyridazinverbindungen zur behandlung von entzündlichen erkrankungen |
| WO2006050359A2 (en) | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds and methods |
| WO2007127475A2 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Pyridazines for demyelinating diseases and neuropathic pain |
| MX2008013843A (es) | 2006-04-28 | 2008-11-10 | Univ Northwestern | Formulaciones que contienen compuestos de piridazina para tratar enfermedades neuroinflamatorias. |
| US8158627B2 (en) | 2006-04-28 | 2012-04-17 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
| WO2012075393A2 (en) * | 2010-12-02 | 2012-06-07 | President And Fellows Of Harvard College | Activators of proteasomal degradation and uses thereof |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| KR102419136B1 (ko) | 2017-06-15 | 2022-07-08 | 삼성전자주식회사 | 다채널 특징맵을 이용하는 영상 처리 장치 및 방법 |
| EP3820860A4 (de) * | 2018-07-09 | 2022-04-20 | Lieber Institute, Inc. | Pyridazinverbindungen zur hemmung von nav1.8 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1603244A (en) * | 1977-05-20 | 1981-11-18 | Max Planck Gesellschaft | Medicaments for the suppression of pathological processes |
| FR2511366A1 (fr) * | 1981-08-11 | 1983-02-18 | Sanofi Sa | Nouveaux derives de la pyridazine, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent |
| US4590194A (en) * | 1981-10-05 | 1986-05-20 | Sterling Drug Inc. | 3-[methyl or dimethyl)amino]-6-(pyridinyl)pyridazines and their cardiotonic use |
| ZA861446B (en) * | 1985-03-01 | 1986-10-29 | Duphar Int Res | Benzoyl urea derivatives having anti-tumor activity |
| US5055451A (en) * | 1986-12-22 | 1991-10-08 | Syntex Inc. | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors |
| DE4134467A1 (de) * | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5081145A (en) * | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
| WO1991015577A1 (en) * | 1990-04-04 | 1991-10-17 | Black, Roy, A. | INTERLEUKIN 1'beta' PROTEASE |
| EP0519748B1 (de) * | 1991-06-21 | 1998-09-02 | Merck & Co. Inc. | Peptidylderivate als Inhibitoren von Interleukin-1B-konvertierenden Enzymen |
| ES2114654T3 (es) | 1993-06-08 | 1998-06-01 | Vertex Pharma | Piridazinas como inhibidores de la enzima de conversion de la interleuquina-1beta. |
-
1994
- 1994-06-04 ES ES94201597T patent/ES2114654T3/es not_active Expired - Lifetime
- 1994-06-04 DK DK94201597T patent/DK0628550T3/da active
- 1994-06-04 AT AT94201597T patent/ATE163412T1/de not_active IP Right Cessation
- 1994-06-04 EP EP94201597A patent/EP0628550B1/de not_active Expired - Lifetime
- 1994-06-04 DE DE69408598T patent/DE69408598T2/de not_active Expired - Lifetime
- 1994-06-07 IL IL10991894A patent/IL109918A0/xx unknown
- 1994-06-07 JP JP6125091A patent/JPH0769894A/ja active Pending
- 1994-06-07 AU AU64556/94A patent/AU693786B2/en not_active Ceased
- 1994-06-07 CA CA002125359A patent/CA2125359A1/en not_active Abandoned
- 1994-06-07 KR KR1019940012681A patent/KR950000673A/ko not_active Application Discontinuation
- 1994-06-07 RU RU94019984/04A patent/RU94019984A/ru unknown
- 1994-06-07 NZ NZ260698A patent/NZ260698A/en unknown
- 1994-06-07 SK SK697-94A patent/SK69794A3/sk unknown
- 1994-06-08 CZ CZ941401A patent/CZ140194A3/cs unknown
- 1994-06-08 NO NO942133A patent/NO306061B1/no not_active IP Right Cessation
- 1994-06-08 HU HU9401714A patent/HUT67413A/hu unknown
- 1994-06-08 FI FI942693A patent/FI942693A/fi unknown
-
1995
- 1995-05-19 US US08/444,984 patent/US6121266A/en not_active Expired - Lifetime
-
1996
- 1996-04-03 US US08/625,680 patent/US6624166B1/en not_active Expired - Fee Related
-
2003
- 2003-09-22 US US10/668,475 patent/US6995261B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU693786B2 (en) | 1998-07-09 |
| KR950000673A (ko) | 1995-01-03 |
| NO306061B1 (no) | 1999-09-13 |
| NO942133D0 (no) | 1994-06-08 |
| AU6455694A (en) | 1994-12-15 |
| EP0628550A3 (en) | 1995-01-18 |
| JPH0769894A (ja) | 1995-03-14 |
| CZ140194A3 (en) | 1995-01-18 |
| FI942693A (fi) | 1994-12-09 |
| CA2125359A1 (en) | 1994-12-09 |
| HUT67413A (en) | 1995-04-28 |
| ATE163412T1 (de) | 1998-03-15 |
| NO942133L (no) | 1994-12-09 |
| IL109918A0 (en) | 1994-10-07 |
| NZ260698A (en) | 1996-09-25 |
| US20040110725A1 (en) | 2004-06-10 |
| FI942693A0 (fi) | 1994-06-08 |
| EP0628550A2 (de) | 1994-12-14 |
| US6624166B1 (en) | 2003-09-23 |
| US6121266A (en) | 2000-09-19 |
| HU9401714D0 (en) | 1994-09-28 |
| DK0628550T3 (da) | 1998-09-28 |
| US6995261B2 (en) | 2006-02-07 |
| EP0628550B1 (de) | 1998-02-25 |
| RU94019984A (ru) | 1997-04-10 |
| ES2114654T3 (es) | 1998-06-01 |
| DE69408598D1 (de) | 1998-04-02 |
| SK69794A3 (en) | 1995-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: VERTEX PHARMACEUTICALS INC., CAMBRIDGE, MASS. 0213 |
|
| 8328 | Change in the person/name/address of the agent |
Free format text: DERZEIT KEIN VERTRETER BESTELLT |
|
| 8364 | No opposition during term of opposition |