NO306061B1 - Pyridaziner som inhibitorer av interleukin-1<beta>-omdannende enzym, farmasöytisk preparat inneholdende slike forbindelser og deres anvendelse - Google Patents
Pyridaziner som inhibitorer av interleukin-1<beta>-omdannende enzym, farmasöytisk preparat inneholdende slike forbindelser og deres anvendelseInfo
- Publication number
- NO306061B1 NO306061B1 NO942133A NO942133A NO306061B1 NO 306061 B1 NO306061 B1 NO 306061B1 NO 942133 A NO942133 A NO 942133A NO 942133 A NO942133 A NO 942133A NO 306061 B1 NO306061 B1 NO 306061B1
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- compounds
- aryl
- chr5
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7391493A | 1993-06-08 | 1993-06-08 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO942133D0 NO942133D0 (no) | 1994-06-08 |
| NO942133L NO942133L (no) | 1994-12-09 |
| NO306061B1 true NO306061B1 (no) | 1999-09-13 |
Family
ID=22116553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO942133A NO306061B1 (no) | 1993-06-08 | 1994-06-08 | Pyridaziner som inhibitorer av interleukin-1<beta>-omdannende enzym, farmasöytisk preparat inneholdende slike forbindelser og deres anvendelse |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6121266A (no) |
| EP (1) | EP0628550B1 (no) |
| JP (1) | JPH0769894A (no) |
| KR (1) | KR950000673A (no) |
| AT (1) | ATE163412T1 (no) |
| AU (1) | AU693786B2 (no) |
| CA (1) | CA2125359A1 (no) |
| CZ (1) | CZ140194A3 (no) |
| DE (1) | DE69408598T2 (no) |
| DK (1) | DK0628550T3 (no) |
| ES (1) | ES2114654T3 (no) |
| FI (1) | FI942693A (no) |
| HU (1) | HUT67413A (no) |
| IL (1) | IL109918A0 (no) |
| NO (1) | NO306061B1 (no) |
| NZ (1) | NZ260698A (no) |
| RU (1) | RU94019984A (no) |
| SK (1) | SK69794A3 (no) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| EP0628550B1 (en) | 1993-06-08 | 1998-02-25 | Sanofi | Pyridazines as interleukin-1beta converting enzyme inhibitors |
| US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US6162828A (en) * | 1995-03-31 | 2000-12-19 | Takeda Chemical Industries, Ltd. | Cysteine protease inhibitor |
| US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
| GB9715640D0 (en) * | 1997-07-24 | 1997-10-01 | M J Highway Technology Limited | Road repair material |
| TWI241295B (en) * | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
| JP2000247959A (ja) * | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−３−オン誘導体及びこれを含有する医薬 |
| EP2241328A1 (en) | 2000-05-12 | 2010-10-20 | Immunex Corporation | Interleukin-1 inhibitors in the treatment of diseases |
| US6664256B1 (en) | 2000-07-10 | 2003-12-16 | Kowa Co., Ltd. | Phenylpyridazine compounds and medicines containing the same |
| EP1430033A4 (en) | 2001-08-31 | 2004-12-15 | Univ Northwestern | PROTEIN KINASE ANTI-INFLAMMATORY AND INHIBITOR COMPOSITION AND METHOD OF USE |
| TWI314455B (en) * | 2002-12-10 | 2009-09-11 | Nippon Kayaku Kk | 3-phenyl-cinnoline derivatives and anti-tumor agent containing the same |
| CA2518227A1 (en) | 2003-03-18 | 2004-09-30 | Kowa Co., Ltd | Water-soluble phenylpyridazine derivative and medicine containing the same |
| EP2284157A1 (en) * | 2003-12-12 | 2011-02-16 | Wyeth | Quinolines useful in treating cardiovascular disease |
| ES2523147T3 (es) * | 2004-02-26 | 2014-11-21 | Baylor Research Institute | Composiciones y métodos para el tratamiento sistémico de la artritis |
| NZ588448A (en) * | 2004-05-15 | 2012-01-12 | Vertex Pharma | Treating seizures using interleukin-1beta converting enzyme (ICE) inhibitors |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| CN101087766B (zh) | 2004-11-02 | 2011-09-07 | 西北大学 | 哒嗪化合物、组合物和方法 |
| EP1812007B1 (en) | 2004-11-02 | 2011-09-07 | Northwestern University | Pyridazine compounds and methods |
| US20090325973A1 (en) | 2006-04-28 | 2009-12-31 | Watterson D Martin | Formulations containing pyridazine compounds |
| EP2015750A2 (en) | 2006-04-28 | 2009-01-21 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
| WO2007127475A2 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Pyridazines for demyelinating diseases and neuropathic pain |
| WO2012075393A2 (en) * | 2010-12-02 | 2012-06-07 | President And Fellows Of Harvard College | Activators of proteasomal degradation and uses thereof |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| KR102419136B1 (ko) | 2017-06-15 | 2022-07-08 | 삼성전자주식회사 | 다채널 특징맵을 이용하는 영상 처리 장치 및 방법 |
| SG11202100137TA (en) | 2018-07-09 | 2021-02-25 | Lieber Institute Inc | PYRIDAZINE COMPOUNDS FOR INHIBITING Nav1.8 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1603244A (en) * | 1977-05-20 | 1981-11-18 | Max Planck Gesellschaft | Medicaments for the suppression of pathological processes |
| FR2511366A1 (fr) * | 1981-08-11 | 1983-02-18 | Sanofi Sa | Nouveaux derives de la pyridazine, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent |
| US4590194A (en) * | 1981-10-05 | 1986-05-20 | Sterling Drug Inc. | 3-[methyl or dimethyl)amino]-6-(pyridinyl)pyridazines and their cardiotonic use |
| AU601145B2 (en) * | 1985-03-01 | 1990-09-06 | Duphar International Research B.V. | Benzoyl urea derivatives having anti-tumor activity |
| US5055451A (en) * | 1986-12-22 | 1991-10-08 | Syntex Inc. | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors |
| DE4134467A1 (de) * | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5081145A (en) * | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
| AU7775991A (en) * | 1990-04-04 | 1991-10-30 | Immunex Corporation | Interleukin 1beta protease |
| CA2071674C (en) * | 1991-06-21 | 2003-08-19 | Kevin T. Chapman | Peptidyl derivatives as inhibitors of interleukin-1.beta. converting enzyme |
| EP0628550B1 (en) | 1993-06-08 | 1998-02-25 | Sanofi | Pyridazines as interleukin-1beta converting enzyme inhibitors |
-
1994
- 1994-06-04 EP EP94201597A patent/EP0628550B1/en not_active Expired - Lifetime
- 1994-06-04 DE DE69408598T patent/DE69408598T2/de not_active Expired - Lifetime
- 1994-06-04 AT AT94201597T patent/ATE163412T1/de not_active IP Right Cessation
- 1994-06-04 ES ES94201597T patent/ES2114654T3/es not_active Expired - Lifetime
- 1994-06-04 DK DK94201597T patent/DK0628550T3/da active
- 1994-06-07 JP JP6125091A patent/JPH0769894A/ja active Pending
- 1994-06-07 IL IL10991894A patent/IL109918A0/xx unknown
- 1994-06-07 RU RU94019984/04A patent/RU94019984A/ru unknown
- 1994-06-07 CA CA002125359A patent/CA2125359A1/en not_active Abandoned
- 1994-06-07 AU AU64556/94A patent/AU693786B2/en not_active Ceased
- 1994-06-07 NZ NZ260698A patent/NZ260698A/en unknown
- 1994-06-07 SK SK697-94A patent/SK69794A3/sk unknown
- 1994-06-07 KR KR1019940012681A patent/KR950000673A/ko not_active Application Discontinuation
- 1994-06-08 FI FI942693A patent/FI942693A/fi unknown
- 1994-06-08 NO NO942133A patent/NO306061B1/no not_active IP Right Cessation
- 1994-06-08 CZ CZ941401A patent/CZ140194A3/cs unknown
- 1994-06-08 HU HU9401714A patent/HUT67413A/hu unknown
-
1995
- 1995-05-19 US US08/444,984 patent/US6121266A/en not_active Expired - Lifetime
-
1996
- 1996-04-03 US US08/625,680 patent/US6624166B1/en not_active Expired - Fee Related
-
2003
- 2003-09-22 US US10/668,475 patent/US6995261B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0769894A (ja) | 1995-03-14 |
| US6995261B2 (en) | 2006-02-07 |
| DE69408598D1 (de) | 1998-04-02 |
| DK0628550T3 (da) | 1998-09-28 |
| SK69794A3 (en) | 1995-02-08 |
| KR950000673A (ko) | 1995-01-03 |
| US20040110725A1 (en) | 2004-06-10 |
| NO942133L (no) | 1994-12-09 |
| DE69408598T2 (de) | 1998-09-17 |
| NZ260698A (en) | 1996-09-25 |
| FI942693A0 (fi) | 1994-06-08 |
| AU693786B2 (en) | 1998-07-09 |
| ES2114654T3 (es) | 1998-06-01 |
| ATE163412T1 (de) | 1998-03-15 |
| AU6455694A (en) | 1994-12-15 |
| EP0628550A2 (en) | 1994-12-14 |
| IL109918A0 (en) | 1994-10-07 |
| CA2125359A1 (en) | 1994-12-09 |
| NO942133D0 (no) | 1994-06-08 |
| HU9401714D0 (en) | 1994-09-28 |
| HUT67413A (en) | 1995-04-28 |
| FI942693A (fi) | 1994-12-09 |
| CZ140194A3 (en) | 1995-01-18 |
| EP0628550B1 (en) | 1998-02-25 |
| US6121266A (en) | 2000-09-19 |
| US6624166B1 (en) | 2003-09-23 |
| EP0628550A3 (en) | 1995-01-18 |
| RU94019984A (ru) | 1997-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |