IL109918A0 - Pyridazines and pharmaceutical compositions containing them - Google Patents
Pyridazines and pharmaceutical compositions containing themInfo
- Publication number
- IL109918A0 IL109918A0 IL10991894A IL10991894A IL109918A0 IL 109918 A0 IL109918 A0 IL 109918A0 IL 10991894 A IL10991894 A IL 10991894A IL 10991894 A IL10991894 A IL 10991894A IL 109918 A0 IL109918 A0 IL 109918A0
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- aryl
- chr5
- compounds
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7391493A | 1993-06-08 | 1993-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL109918A0 true IL109918A0 (en) | 1994-10-07 |
Family
ID=22116553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10991894A IL109918A0 (en) | 1993-06-08 | 1994-06-07 | Pyridazines and pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
US (3) | US6121266A (xx) |
EP (1) | EP0628550B1 (xx) |
JP (1) | JPH0769894A (xx) |
KR (1) | KR950000673A (xx) |
AT (1) | ATE163412T1 (xx) |
AU (1) | AU693786B2 (xx) |
CA (1) | CA2125359A1 (xx) |
CZ (1) | CZ140194A3 (xx) |
DE (1) | DE69408598T2 (xx) |
DK (1) | DK0628550T3 (xx) |
ES (1) | ES2114654T3 (xx) |
FI (1) | FI942693A (xx) |
HU (1) | HUT67413A (xx) |
IL (1) | IL109918A0 (xx) |
NO (1) | NO306061B1 (xx) |
NZ (1) | NZ260698A (xx) |
RU (1) | RU94019984A (xx) |
SK (1) | SK69794A3 (xx) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US6204261B1 (en) | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
DK0628550T3 (da) | 1993-06-08 | 1998-09-28 | Vertex Pharma | Pyridazin som interleukin-1 beta-omdannede enzyminhibitorer |
US6420522B1 (en) | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5756466A (en) * | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
CA2215211A1 (en) * | 1995-03-31 | 1996-10-03 | Takeda Chemical Industries, Ltd. | Cysteine protease inhibitor |
US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
GB9715640D0 (en) * | 1997-07-24 | 1997-10-01 | M J Highway Technology Limited | Road repair material |
TWI241295B (en) * | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
JP2000247959A (ja) | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−3−オン誘導体及びこれを含有する医薬 |
EP2329842A3 (en) | 2000-05-12 | 2011-07-27 | Immunex Corporation | Interleukin-1 inhibitors in the treatment of diseases |
US6664256B1 (en) | 2000-07-10 | 2003-12-16 | Kowa Co., Ltd. | Phenylpyridazine compounds and medicines containing the same |
US20030176437A1 (en) | 2001-08-31 | 2003-09-18 | D.M. Watterson | Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death |
TWI314455B (en) * | 2002-12-10 | 2009-09-11 | Nippon Kayaku Kk | 3-phenyl-cinnoline derivatives and anti-tumor agent containing the same |
WO2004083188A1 (ja) | 2003-03-18 | 2004-09-30 | Kowa Co., Ltd. | 水溶性フェニルピリダジン誘導体及びこれを含有する医薬 |
TW200529845A (en) * | 2003-12-12 | 2005-09-16 | Wyeth Corp | Quinolines useful in treating cardiovascular disease |
EP2784090A1 (en) * | 2004-02-26 | 2014-10-01 | Baylor Research Institute | Compositions for the treatment of systemic onset juvenile idiopathic arthritis |
US20060128696A1 (en) * | 2004-05-15 | 2006-06-15 | Annamaria Vezzani | Treating seizures using ice inhibitors |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
BRPI0517947A (pt) | 2004-11-02 | 2008-10-21 | Univ Northwestern | composto de piridazina, composições e métodos |
WO2006050359A2 (en) | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds and methods |
WO2007127474A2 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
WO2007127475A2 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Pyridazines for demyelinating diseases and neuropathic pain |
CN101754762A (zh) | 2006-04-28 | 2010-06-23 | 西北大学 | 用于治疗神经炎症性疾病的包含哒嗪化合物的制剂 |
WO2012075393A2 (en) * | 2010-12-02 | 2012-06-07 | President And Fellows Of Harvard College | Activators of proteasomal degradation and uses thereof |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
KR102419136B1 (ko) | 2017-06-15 | 2022-07-08 | 삼성전자주식회사 | 다채널 특징맵을 이용하는 영상 처리 장치 및 방법 |
US20210139456A1 (en) * | 2018-07-09 | 2021-05-13 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting nav1.8 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1603244A (en) * | 1977-05-20 | 1981-11-18 | Max Planck Gesellschaft | Medicaments for the suppression of pathological processes |
FR2511366A1 (fr) * | 1981-08-11 | 1983-02-18 | Sanofi Sa | Nouveaux derives de la pyridazine, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent |
US4590194A (en) * | 1981-10-05 | 1986-05-20 | Sterling Drug Inc. | 3-[methyl or dimethyl)amino]-6-(pyridinyl)pyridazines and their cardiotonic use |
AU601145B2 (en) * | 1985-03-01 | 1990-09-06 | Duphar International Research B.V. | Benzoyl urea derivatives having anti-tumor activity |
US5055451A (en) * | 1986-12-22 | 1991-10-08 | Syntex Inc. | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors |
DE4134467A1 (de) * | 1991-10-18 | 1993-04-22 | Thomae Gmbh Dr K | Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
US5081145A (en) * | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
WO1991015577A1 (en) * | 1990-04-04 | 1991-10-17 | Black, Roy, A. | INTERLEUKIN 1'beta' PROTEASE |
CA2071674C (en) * | 1991-06-21 | 2003-08-19 | Kevin T. Chapman | Peptidyl derivatives as inhibitors of interleukin-1.beta. converting enzyme |
DK0628550T3 (da) | 1993-06-08 | 1998-09-28 | Vertex Pharma | Pyridazin som interleukin-1 beta-omdannede enzyminhibitorer |
-
1994
- 1994-06-04 DK DK94201597T patent/DK0628550T3/da active
- 1994-06-04 ES ES94201597T patent/ES2114654T3/es not_active Expired - Lifetime
- 1994-06-04 AT AT94201597T patent/ATE163412T1/de not_active IP Right Cessation
- 1994-06-04 EP EP94201597A patent/EP0628550B1/en not_active Expired - Lifetime
- 1994-06-04 DE DE69408598T patent/DE69408598T2/de not_active Expired - Lifetime
- 1994-06-07 SK SK697-94A patent/SK69794A3/sk unknown
- 1994-06-07 AU AU64556/94A patent/AU693786B2/en not_active Ceased
- 1994-06-07 NZ NZ260698A patent/NZ260698A/en unknown
- 1994-06-07 KR KR1019940012681A patent/KR950000673A/ko not_active Application Discontinuation
- 1994-06-07 CA CA002125359A patent/CA2125359A1/en not_active Abandoned
- 1994-06-07 IL IL10991894A patent/IL109918A0/xx unknown
- 1994-06-07 RU RU94019984/04A patent/RU94019984A/ru unknown
- 1994-06-07 JP JP6125091A patent/JPH0769894A/ja active Pending
- 1994-06-08 FI FI942693A patent/FI942693A/fi unknown
- 1994-06-08 CZ CZ941401A patent/CZ140194A3/cs unknown
- 1994-06-08 NO NO942133A patent/NO306061B1/no not_active IP Right Cessation
- 1994-06-08 HU HU9401714A patent/HUT67413A/hu unknown
-
1995
- 1995-05-19 US US08/444,984 patent/US6121266A/en not_active Expired - Lifetime
-
1996
- 1996-04-03 US US08/625,680 patent/US6624166B1/en not_active Expired - Fee Related
-
2003
- 2003-09-22 US US10/668,475 patent/US6995261B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO942133D0 (no) | 1994-06-08 |
JPH0769894A (ja) | 1995-03-14 |
SK69794A3 (en) | 1995-02-08 |
EP0628550A3 (en) | 1995-01-18 |
AU693786B2 (en) | 1998-07-09 |
ES2114654T3 (es) | 1998-06-01 |
DE69408598D1 (de) | 1998-04-02 |
US6624166B1 (en) | 2003-09-23 |
HU9401714D0 (en) | 1994-09-28 |
EP0628550A2 (en) | 1994-12-14 |
NO942133L (no) | 1994-12-09 |
US6995261B2 (en) | 2006-02-07 |
NZ260698A (en) | 1996-09-25 |
FI942693A0 (fi) | 1994-06-08 |
RU94019984A (ru) | 1997-04-10 |
DE69408598T2 (de) | 1998-09-17 |
ATE163412T1 (de) | 1998-03-15 |
FI942693A (fi) | 1994-12-09 |
HUT67413A (en) | 1995-04-28 |
KR950000673A (ko) | 1995-01-03 |
CA2125359A1 (en) | 1994-12-09 |
AU6455694A (en) | 1994-12-15 |
DK0628550T3 (da) | 1998-09-28 |
EP0628550B1 (en) | 1998-02-25 |
US6121266A (en) | 2000-09-19 |
US20040110725A1 (en) | 2004-06-10 |
NO306061B1 (no) | 1999-09-13 |
CZ140194A3 (en) | 1995-01-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL109918A0 (en) | Pyridazines and pharmaceutical compositions containing them | |
GB8711802D0 (en) | Dithioacetal compounds | |
NZ222922A (en) | Morpholinoethylester of mycophenolic acid and derivatives and pharmaceutical compositions | |
SG63579A1 (en) | Bicyclic fibrinogen antagonists | |
EP0218999A3 (en) | New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them | |
FI892787A0 (fi) | Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-indolyylialkyyli-4-(substituoitu pyridinyyli)piperatsiinien valmistamiseksi | |
MY100574A (en) | 5-substituted-2-cyclopropyl-6, 8-difluoroquinoline derivatives and processes for preparation thereof | |
HUT52059A (en) | Process for producing pharmaceutical compositions and new quinoline derivatives as a group of active components | |
EP0322738A3 (en) | Benzylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells | |
IL105478A0 (en) | Androsta-3,5-diene-3-carboxylic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same | |
HUT63598A (en) | Process for producing phenyl cycloalkyl derivatives and pharmaceutical compositions comprising such compounds as active ingredient | |
HUT40101A (en) | Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents | |
MY131193A (en) | 7-(2-aminoethyl)-benzothiazolones | |
EP0228845A3 (en) | N-containing heterocyclic compounds, processes for the preparation thereof and composition comprising the same | |
BG51251A3 (en) | Method for the preparetion of tetrahydroimidazo /1,4/-benzodiazepine (?)-2-ketons | |
PL276046A1 (en) | Method for manufacturing new derivatives of purine | |
DE3267188D1 (en) | Hydroxybenzylamino-aryl compounds, process for preparing and pharmaceutical compositions containing the same | |
WO1986007059A3 (en) | Oxodiazine compounds | |
DE3572808D1 (en) | 4-(nitrophenyl)-tetrahydropyridines, process for their preparation and their application as pharmaceutical compounds | |
HUT47535A (en) | Process for producing ethanonoxime derivatives and pharmaceuticals comprising such active ingredient | |
DE3664048D1 (en) | Phosphoric acid derivatives, process for their preparation and their use for combatting pests | |
IE831445L (en) | Process for the production of 1-ethoxycarbonyloxyethyl ester¹of 6-(d-(-)-ó-amino-ó-phenylacetamido) penicillanic acid | |
MX9706187A (es) | Derivados de 3-pirrolidiliden-2-ona-cefalosporinas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC | Change of name of proprietor(s) |