HUP0003355A2 - Tieno[2,3-d]pirimidindion-származékok és ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra és alkalmazásuk - Google Patents

Tieno[2,3-d]pirimidindion-származékok és ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra és alkalmazásuk

Info

Publication number
HUP0003355A2
HUP0003355A2 HU0003355A HUP0003355A HUP0003355A2 HU P0003355 A2 HUP0003355 A2 HU P0003355A2 HU 0003355 A HU0003355 A HU 0003355A HU P0003355 A HUP0003355 A HU P0003355A HU P0003355 A2 HUP0003355 A2 HU P0003355A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
hydrogen atom
thieno
preparation
Prior art date
Application number
HU0003355A
Other languages
English (en)
Inventor
David Cheshire
Andrew Cooke
Martin Cooper
David Donald
Mark Furber
Matthew Perry
Philip Thorne
Original Assignee
Astrazeneca Ab.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab. filed Critical Astrazeneca Ab.
Publication of HUP0003355A2 publication Critical patent/HUP0003355A2/hu
Publication of HUP0003355A3 publication Critical patent/HUP0003355A3/hu
Publication of HU226627B1 publication Critical patent/HU226627B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A találmány tárgyát az (I) általános képletű vegyületek - ahol R -C(O)Ar1, -C(R4R5)Ar1 vagy Ar2 általános képletű csoport; R1 és R2 hidrogénatom, alkil-, alkenil- vagy cikloalkilcsoport; R3 hidrogénatom, -X-R9 vagy -X-Ar3 általános képletű csoport; R4 hidrogénatom vagy alkilcsoport; R5 hidrogénatom vagy hidroxicsoport; R9 különböző csoportokkal szubsztituált alkil- vagy alkenilcsoport; R10 hidrogénatom vagy alkilcsoport, vagy az R9 csoporttal és ahozzájuk kapcsolódó nitrogénatommal heterociklust képezhet; X -S(O)n, -C(O)O, -C(O)NR10, -NH(CO)NR10, -NHC(O)O vagy -SO2NR10(általános) képletű csoport; n = 0, 1 vagy 2; Ar1 naftil- vagy különböző heterociklusos csoport; Ar2 heterociklusos csoport; Ar3 fenil-, piridil- vagy piridin-N-oxid-csoport - és ezekettartalmazó gyógyszerkészítmények és előállításuk, valamintalkalmazásuk képezik. A találmány szerinti vegyületekimmunszuppresszív hatásúak. Ó
HU0003355A 1997-05-28 1998-05-18 Thieno[2,3-d]pyrimidinedione derivatives and pharmaceutical compositions containing them, process for their preparation and use thereof HU226627B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9702001A SE9702001D0 (sv) 1997-05-28 1997-05-28 Novel compounds
PCT/SE1998/000935 WO1998054190A1 (en) 1997-05-28 1998-05-18 Novel compounds

Publications (3)

Publication Number Publication Date
HUP0003355A2 true HUP0003355A2 (hu) 2001-02-28
HUP0003355A3 HUP0003355A3 (en) 2003-03-28
HU226627B1 HU226627B1 (en) 2009-05-28

Family

ID=20407123

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003355A HU226627B1 (en) 1997-05-28 1998-05-18 Thieno[2,3-d]pyrimidinedione derivatives and pharmaceutical compositions containing them, process for their preparation and use thereof

Country Status (28)

Country Link
US (2) US6180635B1 (hu)
EP (1) EP0991653B1 (hu)
JP (1) JP2002500666A (hu)
KR (1) KR100561988B1 (hu)
CN (1) CN1122037C (hu)
AT (1) ATE226205T1 (hu)
AU (1) AU723708B2 (hu)
BR (1) BR9809481A (hu)
CA (1) CA2289509C (hu)
CZ (1) CZ297536B6 (hu)
DE (1) DE69808765T2 (hu)
DK (1) DK0991653T3 (hu)
EE (1) EE04018B1 (hu)
ES (1) ES2184270T3 (hu)
HU (1) HU226627B1 (hu)
ID (1) ID28432A (hu)
IL (2) IL132763A0 (hu)
IS (1) IS1983B (hu)
NO (1) NO323752B1 (hu)
NZ (1) NZ500853A (hu)
PL (1) PL199567B1 (hu)
PT (1) PT991653E (hu)
RU (1) RU2225410C2 (hu)
SE (1) SE9702001D0 (hu)
SK (1) SK283589B6 (hu)
TR (1) TR199902904T2 (hu)
UA (1) UA61111C2 (hu)
WO (1) WO1998054190A1 (hu)

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SE9801399D0 (sv) 1998-04-21 1998-04-21 Astra Pharma Prod Method and apparatus for filling containers
GB9819382D0 (en) * 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
GB9819384D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds II
ATE272642T1 (de) * 2000-05-04 2004-08-15 Astrazeneca Ab Thieno(2,3-d)pyrimidindione und ihre verwendung als pharmazeutische mittel
GB2361917A (en) * 2000-05-04 2001-11-07 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones
GB2363377B (en) * 2000-06-14 2004-06-09 Astrazeneca Ab Novel thieno[2,3-d]pyrimidinediones and therapeutic uses thereof
MXPA03004926A (es) * 2001-02-14 2005-02-14 Warner Lambert Co Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas.
GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
BR0215212A (pt) * 2001-12-21 2004-12-07 Novo Nordisk As Ativador de carboxamida ou sulfonamida de glicoquinase, composto, composição farmacêutica, e, uso de um composto
KR101116627B1 (ko) * 2002-06-27 2012-10-09 노보 노르디스크 에이/에스 치료제로서 아릴 카르보닐 유도체
US6890923B2 (en) * 2002-12-16 2005-05-10 Astrazeneca Ab Compounds
SE0300120D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
WO2004065395A1 (en) * 2003-01-17 2004-08-05 Astrazeneca Ab Thienopyridazinones and their use in modulation of autoimmune disease
SE0300117D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel Compounds
SE0300119D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
DK1723128T3 (da) 2004-01-06 2013-02-18 Novo Nordisk As Heteroarylurinstoffer og deres anvendelse som glucokinaseaktivatorer
JP2009500378A (ja) * 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス グルコキナーゼ活性化剤としてのジシクロアルキルカルバモイル尿素
CA2614518A1 (en) * 2005-07-08 2007-01-18 Novo-Nordisk A/S Dicycloalkyl urea glucokinase activators
JP4960355B2 (ja) * 2005-07-14 2012-06-27 ノボ・ノルデイスク・エー／エス ウレア型グルコキナーゼ活性化剤
JP2009528389A (ja) * 2006-03-02 2009-08-06 シーブイ・セラピューティクス・インコーポレイテッド Ａ２ａアデノシン受容体拮抗剤
CN101186612B (zh) * 2006-11-15 2012-10-03 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用
JP2010511628A (ja) * 2006-12-01 2010-04-15 ギリアード・パロ・アルト・インコーポレイテッド Ａ２ａアデノシン受容体アンタゴニスト
US8138185B2 (en) * 2007-01-09 2012-03-20 Novo Nordisk A/S Urea glucokinase activators
AU2008204530B2 (en) * 2007-01-11 2013-08-01 Vtv Therapeutics Llc Urea glucokinase activators
EP2008656A1 (en) 2007-06-28 2008-12-31 Bergen Teknologioverforing AS Compositions for the treatment of hyperphenylalaninemia
AU2010227225A1 (en) * 2009-03-23 2011-09-15 Glenmark Pharmaceuticals, S.A. Furopyrimidinedione derivatives as TRPA1 modulators
PL2776038T3 (pl) 2011-11-11 2018-06-29 Gilead Apollo, Llc Inhibitory acc i ich zastosowania
WO2014042176A1 (ja) * 2012-09-14 2014-03-20 キッセイ薬品工業株式会社 縮合複素環誘導体の製造方法およびその製造中間体
AU2014334040A1 (en) 2013-10-07 2016-04-28 Bayer Pharma Aktiengesellschaft Cyclic thienouracil-carboxamides and use thereof
UY36586A (es) 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
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Also Published As

Publication number Publication date
IL132763A0 (en) 2001-03-19
RU2225410C2 (ru) 2004-03-10
EP0991653B1 (en) 2002-10-16
CN1122037C (zh) 2003-09-24
CZ297536B6 (cs) 2007-01-03
CN1264382A (zh) 2000-08-23
WO1998054190A1 (en) 1998-12-03
CZ420199A3 (cs) 2000-07-12
IL132763A (en) 2007-03-08
HUP0003355A3 (en) 2003-03-28
SK151399A3 (en) 2000-05-16
ATE226205T1 (de) 2002-11-15
EE04018B1 (et) 2003-04-15
ID28432A (id) 2001-05-24
DE69808765T2 (de) 2003-07-24
DK0991653T3 (da) 2003-01-06
PL337126A1 (en) 2000-07-31
SK283589B6 (sk) 2003-10-07
ES2184270T3 (es) 2003-04-01
UA61111C2 (uk) 2003-11-17
NO995810L (no) 2000-01-27
NZ500853A (en) 2001-05-25
DE69808765D1 (de) 2002-11-21
PL199567B1 (pl) 2008-10-31
IS1983B (is) 2005-01-14
JP2002500666A (ja) 2002-01-08
CA2289509C (en) 2007-10-02
IS5264A (is) 1999-11-23
EP0991653A1 (en) 2000-04-12
NO995810D0 (no) 1999-11-26
US6342502B1 (en) 2002-01-29
NO323752B1 (no) 2007-07-02
BR9809481A (pt) 2000-06-20
TR199902904T2 (xx) 2000-06-21
CA2289509A1 (en) 1998-12-03
KR100561988B1 (ko) 2006-03-17
SE9702001D0 (sv) 1997-05-28
AU7680898A (en) 1998-12-30
AU723708B2 (en) 2000-09-07
US6180635B1 (en) 2001-01-30
PT991653E (pt) 2003-02-28
KR20010013107A (ko) 2001-02-26
EE9900539A (et) 2000-06-15
HU226627B1 (en) 2009-05-28

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