HUE049941T2 - 4-amino-2-(1H-pirazolo[3,4-B]piridin-3-il)-6-oxo-6,7-dihidro-5H-pirrolo[2,3-D]pirimidin származékok és a megfelelõ (1H-indazol-3-il) származékok mint CGMP modulátorok cardiovaskuláris betegségek kezelésére - Google Patents
4-amino-2-(1H-pirazolo[3,4-B]piridin-3-il)-6-oxo-6,7-dihidro-5H-pirrolo[2,3-D]pirimidin származékok és a megfelelõ (1H-indazol-3-il) származékok mint CGMP modulátorok cardiovaskuláris betegségek kezeléséreInfo
- Publication number
- HUE049941T2 HUE049941T2 HUE16823455A HUE16823455A HUE049941T2 HU E049941 T2 HUE049941 T2 HU E049941T2 HU E16823455 A HUE16823455 A HU E16823455A HU E16823455 A HUE16823455 A HU E16823455A HU E049941 T2 HUE049941 T2 HU E049941T2
- Authority
- HU
- Hungary
- Prior art keywords
- derivatives
- indazol
- pyrazolo
- pyrrolo
- pyridin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2015/098251 WO2017107052A1 (en) | 2015-12-22 | 2015-12-22 | Soluble guanylate cyclase stimulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE049941T2 true HUE049941T2 (hu) | 2020-11-30 |
Family
ID=57758775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE16823455A HUE049941T2 (hu) | 2015-12-22 | 2016-12-20 | 4-amino-2-(1H-pirazolo[3,4-B]piridin-3-il)-6-oxo-6,7-dihidro-5H-pirrolo[2,3-D]pirimidin származékok és a megfelelõ (1H-indazol-3-il) származékok mint CGMP modulátorok cardiovaskuláris betegségek kezelésére |
Country Status (39)
| Country | Link |
|---|---|
| US (2) | US10030027B2 (hu) |
| EP (1) | EP3394067B1 (hu) |
| JP (1) | JP6454448B2 (hu) |
| KR (1) | KR102191312B1 (hu) |
| CN (1) | CN108738320B (hu) |
| AR (1) | AR107154A1 (hu) |
| AU (1) | AU2016377364B2 (hu) |
| BR (1) | BR112018012579B8 (hu) |
| CA (1) | CA3009193C (hu) |
| CL (1) | CL2018001671A1 (hu) |
| CO (1) | CO2018006300A2 (hu) |
| CR (1) | CR20180330A (hu) |
| CY (1) | CY1123173T1 (hu) |
| DK (1) | DK3394067T3 (hu) |
| DO (1) | DOP2018000153A (hu) |
| EA (1) | EA036445B1 (hu) |
| EC (1) | ECSP18054606A (hu) |
| ES (1) | ES2794654T3 (hu) |
| HK (1) | HK1255028A1 (hu) |
| HR (1) | HRP20200857T1 (hu) |
| HU (1) | HUE049941T2 (hu) |
| IL (1) | IL260020B (hu) |
| LT (1) | LT3394067T (hu) |
| ME (1) | ME03748B (hu) |
| MX (2) | MX2018007728A (hu) |
| MY (1) | MY194021A (hu) |
| NI (1) | NI201800069A (hu) |
| PE (1) | PE20181802A1 (hu) |
| PH (1) | PH12018501342A1 (hu) |
| PL (1) | PL3394067T3 (hu) |
| PT (1) | PT3394067T (hu) |
| RS (1) | RS60344B1 (hu) |
| SG (1) | SG11201805272XA (hu) |
| SI (1) | SI3394067T1 (hu) |
| SV (1) | SV2018005715A (hu) |
| TN (1) | TN2018000219A1 (hu) |
| TW (1) | TWI724079B (hu) |
| UA (1) | UA122264C2 (hu) |
| WO (2) | WO2017107052A1 (hu) |
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| US10245264B2 (en) | 2015-05-27 | 2019-04-02 | Merck Sharp & Dohme Corp. | Substituted imidazo[1,2-a]pyrazines as soluble guanylate cyclase activators |
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| EP3365340B1 (en) | 2015-10-19 | 2022-08-10 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| MD3377488T2 (ro) | 2015-11-19 | 2023-02-28 | Incyte Corp | Compuși heterociclici ca imunomodulatori |
| SG11201805300QA (en) | 2015-12-22 | 2018-07-30 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| WO2017107052A1 (en) | 2015-12-22 | 2017-06-29 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase stimulators |
| ES2906460T3 (es) | 2016-05-06 | 2022-04-18 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| WO2017197555A1 (en) | 2016-05-16 | 2017-11-23 | Merck Sharp & Dohme Corp. | Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators |
| EP3458063A4 (en) | 2016-05-18 | 2020-02-26 | Merck Sharp & Dohme Corp. | METHODS OF USING TRIAZOLO-PYRAZINYL-SOLUBLE GUANYLATE CYCLASE ACTIVATORS FOR FIBROTIC DISORDERS |
| US20170342060A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| CA3028685A1 (en) | 2016-06-20 | 2017-12-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20180016260A1 (en) | 2016-07-14 | 2018-01-18 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| ES2941716T3 (es) | 2016-08-29 | 2023-05-25 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| ES2934230T3 (es) | 2016-12-22 | 2023-02-20 | Incyte Corp | Derivados de benzooxazol como inmunomoduladores |
| HRP20221216T1 (hr) | 2016-12-22 | 2022-12-23 | Incyte Corporation | Derivati tetrahidro imidazo[4,5-c]piridina kao induktori internalizacije pd-l1 |
| US20180179179A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20180179201A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3609883B1 (en) * | 2017-04-11 | 2022-06-29 | Sunshine Lake Pharma Co., Ltd. | Fluorine-substituted indazole compounds and uses thereof |
| WO2019081456A1 (en) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
| EP3498298A1 (en) | 2017-12-15 | 2019-06-19 | Bayer AG | The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi) |
| FI3774791T3 (fi) | 2018-03-30 | 2023-03-21 | Incyte Corp | Heterosyklisiä yhdisteitä immunomodulaattoreina |
| EP3787610A1 (en) | 2018-04-30 | 2021-03-10 | Bayer Aktiengesellschaft | The use of sgc activators and sgc stimulators for the treatment of cognitive impairment |
| CN112752756A (zh) | 2018-05-11 | 2021-05-04 | 因赛特公司 | 作为PD-L1免疫调节剂的四氢-咪唑并[4,5-c]吡啶衍生物 |
| EP3574905A1 (en) | 2018-05-30 | 2019-12-04 | Adverio Pharma GmbH | Method of identifying a subgroup of patients suffering from dcssc which benefits from a treatment with sgc stimulators and sgc activators in a higher degree than a control group |
| US20220128561A1 (en) | 2019-01-17 | 2022-04-28 | Bayer Aktiengesellschaft | Methods to determine whether a subject is suitable of being treated with an agonist of soluble gyanylyl cyclase (sgc) |
| TW202115059A (zh) | 2019-08-09 | 2021-04-16 | 美商英塞特公司 | Ｐｄ—１／ｐｄ—ｌ１抑制劑之鹽 |
| AU2020357514A1 (en) | 2019-09-30 | 2022-04-07 | Incyte Corporation | Pyrido[3,2-d]pyrimidine compounds as immunomodulators |
| WO2021096849A1 (en) | 2019-11-11 | 2021-05-20 | Incyte Corporation | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
| IL302590A (en) | 2020-11-06 | 2023-07-01 | Incyte Corp | Process for preparing PD-1/PD-L1 inhibitor and salts and crystalline forms thereof |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
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-
2015
- 2015-12-22 WO PCT/CN2015/098251 patent/WO2017107052A1/en active Application Filing
-
2016
- 2016-12-20 PE PE2018001156A patent/PE20181802A1/es unknown
- 2016-12-20 SG SG11201805272XA patent/SG11201805272XA/en unknown
- 2016-12-20 CA CA3009193A patent/CA3009193C/en active Active
- 2016-12-20 MX MX2018007728A patent/MX2018007728A/es active IP Right Grant
- 2016-12-20 TW TW105142318A patent/TWI724079B/zh active
- 2016-12-20 EA EA201891303A patent/EA036445B1/ru not_active IP Right Cessation
- 2016-12-20 AR ARP160103930A patent/AR107154A1/es unknown
- 2016-12-20 UA UAA201808060A patent/UA122264C2/uk unknown
- 2016-12-20 ES ES16823455T patent/ES2794654T3/es active Active
- 2016-12-20 KR KR1020187020705A patent/KR102191312B1/ko active IP Right Grant
- 2016-12-20 CR CR20180330A patent/CR20180330A/es unknown
- 2016-12-20 EP EP16823455.7A patent/EP3394067B1/en active Active
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