CL2018001671A1 - Derivados de pirimidina 4-amino-2-(1h-pirazolo[3,4-b]piridina-3-yl)-6-oxo-6,7-dihidro-5h-pirrolo[2,3-d] y los derivados respectivos (1h-indazol-3-yl) como moduladores cgmp para el tratamiento de enfermedades cardiovasculares. - Google Patents

Derivados de pirimidina 4-amino-2-(1h-pirazolo[3,4-b]piridina-3-yl)-6-oxo-6,7-dihidro-5h-pirrolo[2,3-d] y los derivados respectivos (1h-indazol-3-yl) como moduladores cgmp para el tratamiento de enfermedades cardiovasculares.

Info

Publication number
CL2018001671A1
CL2018001671A1 CL2018001671A CL2018001671A CL2018001671A1 CL 2018001671 A1 CL2018001671 A1 CL 2018001671A1 CL 2018001671 A CL2018001671 A CL 2018001671A CL 2018001671 A CL2018001671 A CL 2018001671A CL 2018001671 A1 CL2018001671 A1 CL 2018001671A1
Authority
CL
Chile
Prior art keywords
derivatives
treatment
pharmaceutically acceptable
compounds
indazol
Prior art date
Application number
CL2018001671A
Other languages
English (en)
Inventor
Jianmin Fu
Raphaelle Berger
Yi-Heng Chen
Guoqing Li
Joie Garfunkle
Hong Li
Shouwu Miao
Subharekha Raghavan
Cameron J Smith
Alan Whitehead
Rui Zhang
Yong Zhang
Gang Ji
Falong Jiang
John Stelmach
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of CL2018001671A1 publication Critical patent/CL2018001671A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCIÓN PROPORCIONA COMPUESTOS DE LA FÓRMULA (I), O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DE LOS MISMOS, EN LA QUE X, Y, Z, R1, R2, R4, RA Y LOS SUBÍNDICES M, P Y Q SON TAL COMO SE DESCRIBEN EN EL PRESENTE DOCUMENTO. LOS COMPUESTOS O SUS SALES FARMACÉUTICAMENTE ACEPTABLES PUEDEN MODULAR LA PRODUCCIÓN CORPORAL DE GUANOSÍN MONOFOSFATO CÍCLICO ("GMPC") Y SON GENERALMENTE ADECUADOS PARA EL TRATAMIENTO Y LA PREVENCIÓN DE ENFERMEDADES QUE ESTÁN ASOCIADAS CON UN EQUILIBRIO DE GMPC PERTURBADO. LA INVENCIÓN TAMBIÉN PROPORCIONA COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN COMPUESTOS DE FÓRMULA (I) O SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS. LA INVENCIÓN TAMBIÉN SE REFIERE A PROCEDIMIENTOS PARA EL USO DE LOS COMPUESTOS O SUS SALES FARMACÉUTICAMENTE ACEPTABLES EN EL TRATAMIENTO Y LA PREVENCIÓN DE LAS ENFERMEDADES MENCIONADAS ANTERIORMENTE Y PARA LA PREPARACIÓN DE PRODUCTOS FARMACÉUTICOS PARA ESTE FIN.
CL2018001671A 2015-12-22 2018-06-19 Derivados de pirimidina 4-amino-2-(1h-pirazolo[3,4-b]piridina-3-yl)-6-oxo-6,7-dihidro-5h-pirrolo[2,3-d] y los derivados respectivos (1h-indazol-3-yl) como moduladores cgmp para el tratamiento de enfermedades cardiovasculares. CL2018001671A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2015/098251 WO2017107052A1 (en) 2015-12-22 2015-12-22 Soluble guanylate cyclase stimulators

Publications (1)

Publication Number Publication Date
CL2018001671A1 true CL2018001671A1 (es) 2018-08-03

Family

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Family Applications (1)

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CL2018001671A CL2018001671A1 (es) 2015-12-22 2018-06-19 Derivados de pirimidina 4-amino-2-(1h-pirazolo[3,4-b]piridina-3-yl)-6-oxo-6,7-dihidro-5h-pirrolo[2,3-d] y los derivados respectivos (1h-indazol-3-yl) como moduladores cgmp para el tratamiento de enfermedades cardiovasculares.

Country Status (39)

Country Link
US (2) US10030027B2 (es)
EP (1) EP3394067B1 (es)
JP (1) JP6454448B2 (es)
KR (1) KR102191312B1 (es)
CN (1) CN108738320B (es)
AR (1) AR107154A1 (es)
AU (1) AU2016377364B2 (es)
BR (1) BR112018012579B8 (es)
CA (1) CA3009193C (es)
CL (1) CL2018001671A1 (es)
CO (1) CO2018006300A2 (es)
CR (1) CR20180330A (es)
CY (1) CY1123173T1 (es)
DK (1) DK3394067T3 (es)
DO (1) DOP2018000153A (es)
EA (1) EA036445B1 (es)
EC (1) ECSP18054606A (es)
ES (1) ES2794654T3 (es)
HK (1) HK1255028A1 (es)
HR (1) HRP20200857T1 (es)
HU (1) HUE049941T2 (es)
IL (1) IL260020B (es)
LT (1) LT3394067T (es)
ME (1) ME03748B (es)
MX (2) MX2018007728A (es)
MY (1) MY194021A (es)
NI (1) NI201800069A (es)
PE (1) PE20181802A1 (es)
PH (1) PH12018501342A1 (es)
PL (1) PL3394067T3 (es)
PT (1) PT3394067T (es)
RS (1) RS60344B1 (es)
SG (1) SG11201805272XA (es)
SI (1) SI3394067T1 (es)
SV (1) SV2018005715A (es)
TN (1) TN2018000219A1 (es)
TW (1) TWI724079B (es)
UA (1) UA122264C2 (es)
WO (2) WO2017107052A1 (es)

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AU2016377364B2 (en) 2019-02-14
ECSP18054606A (es) 2018-12-31
MY194021A (en) 2022-11-08
ES2794654T3 (es) 2020-11-18
SV2018005715A (es) 2018-10-19
SG11201805272XA (en) 2018-07-30
TN2018000219A1 (en) 2019-10-04
BR112018012579A2 (pt) 2018-12-04
JP6454448B2 (ja) 2019-01-16
EA201891303A1 (ru) 2018-11-30
US10428076B2 (en) 2019-10-01
BR112018012579B8 (pt) 2023-11-21
US20180305366A1 (en) 2018-10-25
AR107154A1 (es) 2018-03-28
DK3394067T3 (da) 2020-06-15
EP3394067B1 (en) 2020-04-01
HRP20200857T1 (hr) 2020-11-13
EP3394067A1 (en) 2018-10-31
EA036445B1 (ru) 2020-11-11
CO2018006300A2 (es) 2018-07-10
HUE049941T2 (hu) 2020-11-30
SI3394067T1 (sl) 2020-07-31
CY1123173T1 (el) 2021-10-29
WO2017112617A1 (en) 2017-06-29
KR102191312B1 (ko) 2020-12-15
PT3394067T (pt) 2020-06-02
NI201800069A (es) 2018-10-05
AU2016377364A1 (en) 2018-06-14
US20170174693A1 (en) 2017-06-22
BR112018012579B1 (pt) 2023-10-24
LT3394067T (lt) 2020-06-10
KR20180095904A (ko) 2018-08-28
PE20181802A1 (es) 2018-11-19
IL260020B (en) 2021-05-31
MX2018007728A (es) 2018-08-15
TWI724079B (zh) 2021-04-11
UA122264C2 (uk) 2020-10-12
CN108738320A (zh) 2018-11-02
DOP2018000153A (es) 2018-11-30
CA3009193A1 (en) 2017-06-29
US10030027B2 (en) 2018-07-24
CN108738320B (zh) 2021-11-19
PH12018501342A1 (en) 2019-02-18
CA3009193C (en) 2020-09-15
MX2020011080A (es) 2020-11-06
CR20180330A (es) 2018-08-21
RS60344B1 (sr) 2020-07-31
ME03748B (me) 2021-04-20
HK1255028A1 (zh) 2019-08-02
WO2017107052A1 (en) 2017-06-29
JP2018538333A (ja) 2018-12-27
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