MX2018007728A - Derivados de 4-amino-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-oxo-6,7- dihidro-5h-pirrolo[2,3-d]pirimidina y los respectivos derivados (1h-indazol-3-ilo) como moduladores de guanosin monofosfato ciclico (cgmp) para el tratamiento de enfermedades cardiovasculares. - Google Patents
Derivados de 4-amino-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-oxo-6,7- dihidro-5h-pirrolo[2,3-d]pirimidina y los respectivos derivados (1h-indazol-3-ilo) como moduladores de guanosin monofosfato ciclico (cgmp) para el tratamiento de enfermedades cardiovasculares.Info
- Publication number
- MX2018007728A MX2018007728A MX2018007728A MX2018007728A MX2018007728A MX 2018007728 A MX2018007728 A MX 2018007728A MX 2018007728 A MX2018007728 A MX 2018007728A MX 2018007728 A MX2018007728 A MX 2018007728A MX 2018007728 A MX2018007728 A MX 2018007728A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutically acceptable
- acceptable salts
- compounds
- derivatives
- pulmonary
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención proporciona compuestos de la fórmula (I) (ver Fórmula) o una sal farmacéuticamente aceptable de los mismos, en la que X, Y, Z, R1, R2, R4, Ra y los subíndices m, p y q son tal como se describen en el presente documento. Los compuestos o sus sales farmacéuticamente aceptables pueden modular la producción corporal de guanosín monofosfato cíclico ("GMPc") y son generalmente adecuados para el tratamiento y prevención de enfermedades que están asociadas con un equilibrio de GMPc perturbado, tales como enfermedad cardiovascular, disfunción endotelial, disfunción diastólica, aterosclerosis, hipertensión, insuficiencia cardiaca, hipertensión pulmonar (grupos I, II, III, IV de la OMS), angina de pecho, trombosis, restenosis, infarto de miocardio, apoplejía, insuficiencia cardiaca, fibrosis, hipertonía pulmonar, disfunción eréctil, asma, síndrome de dificultad respiratoria aguda (ARDS), enfermedad renal crónica, fibrosis quística, anemia de células falciformes, esclerodermia, síndrome de Raynaud, diabetes, retinopatía diabética, cirrosis hepática, enfermedad pulmonar obstructiva crónica (EPOC), lesión pulmonar aguda, fibrosis pulmonar o enfermedad pulmonar intersticial. La invención también proporciona composiciones farmacéuticas que comprenden compuestos de fórmula (I) o sales farmacéuticamente aceptables de los mismos. La invención también se refiere a los compuestos o sus sales farmacéuticamente aceptables para usarse en el tratamiento y prevención de las enfermedades mencionadas anteriormente y para la preparación de productos farmacéuticos para este fin.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2015/098251 WO2017107052A1 (en) | 2015-12-22 | 2015-12-22 | Soluble guanylate cyclase stimulators |
PCT/US2016/067654 WO2017112617A1 (en) | 2015-12-22 | 2016-12-20 | 4-amino-2-(1h-pyrazolo[3,4-b]pyridin-3-yl)-6-oxo-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidine derivatives and the respective (1h-indazol-3-yl) derivatives as cgmp modulators for treating cardiovascular diseases |
Publications (1)
Publication Number | Publication Date |
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MX2018007728A true MX2018007728A (es) | 2018-08-15 |
Family
ID=57758775
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018007728A MX2018007728A (es) | 2015-12-22 | 2016-12-20 | Derivados de 4-amino-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-oxo-6,7- dihidro-5h-pirrolo[2,3-d]pirimidina y los respectivos derivados (1h-indazol-3-ilo) como moduladores de guanosin monofosfato ciclico (cgmp) para el tratamiento de enfermedades cardiovasculares. |
MX2020011080A MX2020011080A (es) | 2015-12-22 | 2018-06-21 | Derivados de 4-amino-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-oxo-6,7- dihidro-5h-pirrolo[2,3-d]pirimidina y los respectivos derivados (1h-indazol-3-ilo) como moduladores de guanosin monofosfato ciclico (cgmp) para el tratamiento de enfermedades cardiovasculares. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020011080A MX2020011080A (es) | 2015-12-22 | 2018-06-21 | Derivados de 4-amino-2-(1h-pirazolo[3,4-b]piridin-3-il)-6-oxo-6,7- dihidro-5h-pirrolo[2,3-d]pirimidina y los respectivos derivados (1h-indazol-3-ilo) como moduladores de guanosin monofosfato ciclico (cgmp) para el tratamiento de enfermedades cardiovasculares. |
Country Status (39)
Country | Link |
---|---|
US (2) | US10030027B2 (es) |
EP (1) | EP3394067B1 (es) |
JP (1) | JP6454448B2 (es) |
KR (1) | KR102191312B1 (es) |
CN (1) | CN108738320B (es) |
AR (1) | AR107154A1 (es) |
AU (1) | AU2016377364B2 (es) |
BR (1) | BR112018012579B8 (es) |
CA (1) | CA3009193C (es) |
CL (1) | CL2018001671A1 (es) |
CO (1) | CO2018006300A2 (es) |
CR (1) | CR20180330A (es) |
CY (1) | CY1123173T1 (es) |
DK (1) | DK3394067T3 (es) |
DO (1) | DOP2018000153A (es) |
EA (1) | EA036445B1 (es) |
EC (1) | ECSP18054606A (es) |
ES (1) | ES2794654T3 (es) |
HK (1) | HK1255028A1 (es) |
HR (1) | HRP20200857T1 (es) |
HU (1) | HUE049941T2 (es) |
IL (1) | IL260020B (es) |
LT (1) | LT3394067T (es) |
ME (1) | ME03748B (es) |
MX (2) | MX2018007728A (es) |
MY (1) | MY194021A (es) |
NI (1) | NI201800069A (es) |
PE (1) | PE20181802A1 (es) |
PH (1) | PH12018501342A1 (es) |
PL (1) | PL3394067T3 (es) |
PT (1) | PT3394067T (es) |
RS (1) | RS60344B1 (es) |
SG (1) | SG11201805272XA (es) |
SI (1) | SI3394067T1 (es) |
SV (1) | SV2018005715A (es) |
TN (1) | TN2018000219A1 (es) |
TW (1) | TWI724079B (es) |
UA (1) | UA122264C2 (es) |
WO (2) | WO2017107052A1 (es) |
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