HUE035506T2 - Eljárás vegyület elõállítására új sandmeyer-típusú reakcióval, felhasználva nitroxidgyök vegyületet mint reakciókatalizátort - Google Patents
Eljárás vegyület elõállítására új sandmeyer-típusú reakcióval, felhasználva nitroxidgyök vegyületet mint reakciókatalizátort Download PDFInfo
- Publication number
- HUE035506T2 HUE035506T2 HUE11814558A HUE11814558A HUE035506T2 HU E035506 T2 HUE035506 T2 HU E035506T2 HU E11814558 A HUE11814558 A HU E11814558A HU E11814558 A HUE11814558 A HU E11814558A HU E035506 T2 HUE035506 T2 HU E035506T2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Claims (2)
- SZAB AO A Í, Mi KSÊN V PONTOK1, Eljttt élet előtti l iiásáta, a?neiyet 3 kCAe Lezö képiéi: () ibj s-eprezes5t1s1:;·.< élissas îartsbtsazza.: {Lépést M; ä«’0\!«e.\ak wgxükt hs.'.S"ASAA,'î és téiokköaS hiötígx -s-tvoíPui W'OX i'kbtaiOö, LùV> ökOö't készítsöttk, ataelyet aztitstt Isbatkak I (bC-ra vagy kevesebbre és keverték, aboi s nttbaxsdgyPk egy vagy ke-tsi vegyöiet, steeiy la ose vaha.zsva a kévedo zOkéO; allô esepdöbók 4-bíd!'exi-2,2,ö>b-áeP'tppet:jpipééiétti t ·· >s : i. es 2,2.i\b oetraateti Ipipeski le Lase I I: [Lépést 2 j: egyidejűleg atliak a kővetkező (aj-t es (bid a (Lépés I j oidalúbtt itbC'Oö vagy kevesebben tiítrögéa vagy atgop gáz aiátiíszféra alatt: (a) vegyttlet vises öíd&ía, atüélyet a követkézé képiét ( I3a) reptezertlal, vagy a se hididija:és (b ) ajkai i lé ta ölték vagy alkati löidtéas tbírb vizes oldata: és az erediaeaytii kapót vegyület azt követé sePsiegeSitéséaek lépéséi: vizes alkali oldattak atttélyet kezelés követ patbtsoiszaifcasavvai, begy a vegyidetet kaplak, ateelyet a képiét ( i ib) reptazetstak 2. b ; iy. ayp''öt wiaw · iöUbi a: ep^oo, .««eb tosaöba ért dat.oza a iaattke.'o iejevesu pia képiét« vegyltiel sotaiegesöése sikállvaL ataeiyet atkii Iktenpaal és széediosiddai sala kezelés és további kezelés követ sósavval., hogy » (13a) képlet« vagy eletet kapjak:s, A 2. tgépyppttí szeéiíttl előállítási «(látás. ajtói az aikti IktóPt P--bt«il litité«.
- 4. Az t ·?·. isénypoalok bápöslyike szédítő előállítást eli&rás, ahol a ösPoxldgyök vegyidet zseispytsége SZäöehiöieetS'ikass« (köb a.S ötöiaíis ékvlvs-ietssek iáíáoasátsyábaö a vegyütétkez td2a) Viszottyitva vatt haszaálva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010175251 | 2010-08-04 | ||
| JP2010175250 | 2010-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE035506T2 true HUE035506T2 (hu) | 2018-05-02 |
Family
ID=45559433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE11814558A HUE035506T2 (hu) | 2010-08-04 | 2011-07-29 | Eljárás vegyület elõállítására új sandmeyer-típusú reakcióval, felhasználva nitroxidgyök vegyületet mint reakciókatalizátort |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9233980B2 (hu) |
| EP (1) | EP2602242B1 (hu) |
| JP (1) | JP5769714B2 (hu) |
| KR (1) | KR101848952B1 (hu) |
| CN (1) | CN103140466B (hu) |
| BR (1) | BR112013002744B1 (hu) |
| CA (1) | CA2807459C (hu) |
| ES (1) | ES2648146T3 (hu) |
| HU (1) | HUE035506T2 (hu) |
| IL (1) | IL224548B (hu) |
| TW (1) | TWI504438B (hu) |
| WO (1) | WO2012017932A1 (hu) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103204818B (zh) * | 2013-04-26 | 2015-04-15 | 清华大学 | 一种多取代喹唑啉衍生物的制备方法 |
| CA2940001C (en) * | 2014-02-18 | 2019-01-15 | Daiichi Sankyo Company, Limited | Method for producing inhibitor of activated blood coagulation factor x (fxa) |
| CN105777779B (zh) * | 2014-12-16 | 2019-03-26 | 四川海思科制药有限公司 | 一种对甲苯磺酸依度沙班化合物 |
| CN104761571B (zh) * | 2015-03-10 | 2017-03-08 | 山东科兴生物制品有限公司 | 一种依度沙班的合成方法 |
| CN106146393A (zh) * | 2015-04-14 | 2016-11-23 | 利尔化学股份有限公司 | 制备3,4,6-三氯吡啶-2-甲酸及其相应酯的方法 |
| CN107033163A (zh) * | 2015-07-16 | 2017-08-11 | 浙江海正药业股份有限公司 | 一种依度沙班对苯甲磺酸盐新晶型及其制备方法和应用 |
| CN105399667A (zh) * | 2015-12-15 | 2016-03-16 | 南京艾德凯腾生物医药有限责任公司 | 一种依度沙班中间体的制备方法 |
| KR102333564B1 (ko) | 2019-11-28 | 2021-12-01 | 동방에프티엘(주) | 광학 활성 다이아민 유도체 및 티아졸 유도체의 생산을 위한 새로운 합성경로 |
| CN111217655B (zh) * | 2020-01-23 | 2022-09-27 | 上海中化科技有限公司 | 一种芳香族化合物羟基化的方法 |
| CN112940012B (zh) * | 2021-05-17 | 2021-09-03 | 上海翰森生物医药科技有限公司 | 一种依度沙班及其中间体的制备方法 |
| CN113582847B (zh) * | 2021-07-16 | 2023-09-12 | 湖北工业大学 | 一种改进桑德迈尔反应制备碘代苯甲酸（酯）的方法 |
| CN114456194B (zh) * | 2021-12-14 | 2023-07-07 | 浙江九洲药业股份有限公司 | 甲苯磺酸艾多沙班的中间体及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0713041B2 (ja) * | 1985-05-31 | 1995-02-15 | 杏林製薬株式会社 | ハロゲノニトロベンゼン誘導体とその製造方法 |
| JP2502999B2 (ja) * | 1987-01-31 | 1996-05-29 | 三菱化学株式会社 | 芳香族フツ素化物の製造法 |
| US5424431A (en) | 1990-10-24 | 1995-06-13 | Yamanouchi Pharmaceutical Co., Ltd. | Thiazole derivatives |
| JP4376387B2 (ja) * | 1998-11-26 | 2009-12-02 | 昭和電工株式会社 | シアノベンジル化合物の製造方法 |
| JP2001294572A (ja) | 2000-02-09 | 2001-10-23 | Dai Ichi Seiyaku Co Ltd | 新規スルホニル誘導体 |
| US6579328B2 (en) * | 2000-05-01 | 2003-06-17 | Ciba Specialty Chemicals Corporation | Transition-metal-catalyzed process for the preparation of sterically hindered N-substituted aryloxyamines |
| JP2002003410A (ja) * | 2000-06-27 | 2002-01-09 | Fuji Photo Film Co Ltd | 芳香族ハロゲン化物の製造方法。 |
| CA2451605C (en) | 2001-06-20 | 2010-08-10 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| AU2002328596B2 (en) | 2001-08-09 | 2007-09-20 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| AU2003292828B9 (en) | 2002-12-25 | 2009-10-01 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| CN1878778B (zh) * | 2003-11-12 | 2010-12-29 | 第一三共株式会社 | 噻唑衍生物的制备方法 |
| KR101215153B1 (ko) * | 2003-11-12 | 2012-12-24 | 다이이찌 산쿄 가부시키가이샤 | 티아졸 유도체의 제조법 |
| JP2007106759A (ja) * | 2005-09-16 | 2007-04-26 | Dai Ichi Seiyaku Co Ltd | 光学活性なジアミン誘導体およびその製造方法 |
| TWI410420B (zh) * | 2008-02-05 | 2013-10-01 | Dainippon Sumitomo Pharma Co | 苄基哌啶化合物 |
| TW200946504A (en) * | 2008-03-13 | 2009-11-16 | Du Pont | Improved process for the manufacture of 2,3-dichloropyridine |
| EP2407450B1 (en) * | 2009-03-13 | 2015-04-22 | Daiichi Sankyo Company, Limited | Method for producing optically active diamine derivative |
-
2011
- 2011-07-29 CN CN201180048276.1A patent/CN103140466B/zh active Active
- 2011-07-29 WO PCT/JP2011/067408 patent/WO2012017932A1/ja active Application Filing
- 2011-07-29 HU HUE11814558A patent/HUE035506T2/hu unknown
- 2011-07-29 ES ES11814558.0T patent/ES2648146T3/es active Active
- 2011-07-29 BR BR112013002744-4A patent/BR112013002744B1/pt active IP Right Grant
- 2011-07-29 CA CA2807459A patent/CA2807459C/en active Active
- 2011-07-29 EP EP11814558.0A patent/EP2602242B1/en active Active
- 2011-07-29 JP JP2012527706A patent/JP5769714B2/ja active Active
- 2011-07-29 KR KR1020137002628A patent/KR101848952B1/ko active IP Right Grant
- 2011-08-03 TW TW100127491A patent/TWI504438B/zh active
-
2013
- 2013-02-01 US US13/756,939 patent/US9233980B2/en active Active
- 2013-02-03 IL IL224548A patent/IL224548B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US9233980B2 (en) | 2016-01-12 |
| CA2807459C (en) | 2015-09-08 |
| WO2012017932A1 (ja) | 2012-02-09 |
| EP2602242B1 (en) | 2017-08-23 |
| CN103140466B (zh) | 2016-02-17 |
| JPWO2012017932A1 (ja) | 2013-10-03 |
| CN103140466A (zh) | 2013-06-05 |
| CA2807459A1 (en) | 2012-02-09 |
| KR101848952B1 (ko) | 2018-04-13 |
| KR20130095728A (ko) | 2013-08-28 |
| EP2602242A4 (en) | 2014-01-01 |
| TWI504438B (zh) | 2015-10-21 |
| ES2648146T3 (es) | 2017-12-28 |
| BR112013002744A2 (pt) | 2018-01-30 |
| TW201221216A (en) | 2012-06-01 |
| IL224548B (en) | 2018-08-30 |
| JP5769714B2 (ja) | 2015-08-26 |
| BR112013002744B1 (pt) | 2022-01-18 |
| US20130144061A1 (en) | 2013-06-06 |
| EP2602242A1 (en) | 2013-06-12 |
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