HUE031828T2 - Eljárások aspecifikus fehérje-interferencia elõrejelzésére, kimutatására és csökkentésére immunglobulin variábilis egydomént magában foglaló assay-kben - Google Patents

Eljárások aspecifikus fehérje-interferencia elõrejelzésére, kimutatására és csökkentésére immunglobulin variábilis egydomént magában foglaló assay-kben Download PDF

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HUE031828T2
HUE031828T2 HUE12729968A HUE12729968A HUE031828T2 HU E031828 T2 HUE031828 T2 HU E031828T2 HU E12729968 A HUE12729968 A HU E12729968A HU E12729968 A HUE12729968 A HU E12729968A HU E031828 T2 HUE031828 T2 HU E031828T2
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Judith Baumeister
Marie-Paule Lucienne Armanda Bouche
Carlo Boutton
Marie-Ange Buyse
Veerle Snoeck
Stephanie Staelens
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Ablynx Nv
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Priority claimed from PCT/EP2011/067132 external-priority patent/WO2012042026A1/en
Priority claimed from PCT/EP2012/061304 external-priority patent/WO2012175400A1/en
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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Claims (8)

  1. eljárások aseecifikus ferèiue-interferencîa előrejelzésére, kimutatására ÉS CSÖKKENTÉSÉRE IMMUNGLOBULIN VARIÁBILIS EGVBOMÉNT MAGÁBAN FOGLALÓ ASSAY-KBEN Szabadalmi igénypontok
    1. Fehérje vagy polipeptid terápiába való alkalmazásra, amely fehérje vagy poli pepik! C-tenninális végén imnnmoglobin variábilis; egydowént ÍISV) tartalmaz, almi az ISV VHH, szekvencia-optimalizált VH H, humanizált VHH vagy kaméliák (.jevéshetr} VH vagy VHH-íól, szekvenela^opiimaíizált VHH-íóí,. hums-nizáit VITH-tól vagy kamelizált VH-íóf különböző VH szekvenciái tartalmazó ISV, vagy VH szekvenciából származik, amelyik ISV C-ierminális vége tartalmazza a VTVSS(X)n szekveneiáL ahol: - r 1, 2 vagy 3, ahol mindegyik X “ Alá vagy Oly; vagy - n r:: 1,2 vagy 3, ahol mindegyik X " Alá; vagy - o ; : 1.2 vagy 3, ahol mindegyik X - Gíy; vagy - η 3 vagy 3, ahol legalább egy X "· Alá vagy Oly; vagy * í) 2 vagy 3; ahol egy kivételével mindegyik X! *« Alá vagy Oly. és amely fehérje vagy polipeptid magában foglal egy szérum albumim is (kő pepiidet vagy szérum aibuininf kötő dûment, és 1'A-bétakihHkifejezett féiéletideje emberben legalább háromtmp,
  2. 2. Az I. igény porti szerinti fehérje vagy polipeptid az ott meghatározott alkalmazásra, ahol a szérum albumim kötő pepiid vagy szérum albuméit kötö donién szérum albumint kötő ISV.
  3. 3. Az L igénypont szerinti fehérje vagy pohpeptkl az ott meghatározott alkalmazásra, ahol n~ 1 vagy tvXL 4 Az 1. igénypont szerinti fehérje vagy polipeptid az ott meghatározott alkalmazásra, ahol n--2 vagy 3 és legalább egy X jelentése Alá vagy Oly, vagy' n:;2 vagy 3 és egy kivételével mindegyik X jelentése Alá vagy Oly. ahol a maradék X arninosav bármely természetesen előforduló arninosav lehet. 5. A 4. igénypont szerinti fehérje vagy- polipeptid az ott meghatározott alkalmazásra, ahol a maradék X arninosav Val, Leu és/vsgy He közöl választott.
  4. 6. Az 1, igénypont szerinti fehérje vagy poiipeptid az ott meghatározott alkalmazásra, ahol -rt “ 1,2 vagy 3. ahol mindegyik X - Áfa vagy Gly; vagy - n 1,2 vagy 3 ahoi mindegyik X - .Alá; vagy * n - L 2 vagy 3 ahol mindegyik X ----- Oly,
  5. 7. Az i. igénypont szerinti fehérje vagy polipeptid ázott meghatározott alkalmazásra, ahol X jelentése cí&zteínföl különbözik
  6. 8. Fehérje vagy polipeptid terápiában történő alkalmazásra, ahol a fehérje vagy polipeptid Ó-terminális végén 1SY-! tartalmaz., ahol az ISV a kővetkezők bármelyike: VHH, szekvencia-optimalizált VHH, humanizált VHH vagy kantél izéit VH, vagy VH szekvenciából származik, amelyik ISV C-terrm'nóKs vége tartalmazza a VTVSS(X)n szekvenciát, ahol π érteke 1-5, például 1.2, 3. 4 vagy 5, és ahol mindegyik X jelentése egymástól független arninosav, azzal a feltétellel, hogy X jelentése nem risztéin. és amely fehérje vagy poiipeptid magában foglal egy szérum album int köíö pepiidet vagy szérum albumin! köbé dóméiig és d-v-béraként kifejezett féiéletideje emberben legalább három nap. 9. A 8. igénypont szerinti fehérje vagy polípeptid az ott meghatározott alkalmazásra, ahol n értéke 1 vagy 2. 1:0. A & vagy 9. igénypont szerinti, fehérje vagy poiipeptid az ott meghatározott- alkalmazást»* aboi raindegyik Xjelentése természetesen előforduló .aminosav. í !. A 8- 10. igénypontok bármelyike szerinti fehérje vagy polípeptid az ott meghatározott alkalmazásra, ahol mindegyik X jelentése a kővetkezőkből álló csoportból választolt: ttíanin (A), gücin CG), vei in (V), leucine (1.) és ízoleucin (1).
  7. 12. Az i-í 1. igénypontok bármelyike szerinti fehérje vagy polípeptid az ott meghatározott alkalmazásra, ahol a <f-terminális: ÍSV VM1I, szekvencia-optimalizált VHH, humanizált Vi li i vagy kamelizáh VH. 13. A 8. igénypont szerinti fehérje vagy polípeptid az ott meghatározó« alkalmazásra, ahol ti szérum afoitmhn kötő pepiid vagy szérum aíbunünt kötő dómén szérűin aibumírtt kötö 1SV;
  8. 14. Gyógyászati készítmény terápiában való alkalmazásra, amely 1-1.5. igénypontok bármelyike szerinti fehérjét vagy polípeptidet és legalább egy alkalmas hordozót, hígítót vagy segédanyagot tartalmaz. 1-5, A- 14, igénypont szerinti gyógyászati készítmény terápiában való alkalmazási»*· ahol: - a készítmény, fehérje vagy poiipeptid emberben krónikus betegség kezelésére szánt, esívagy - a fehérje vagy» poiipeptid annak a személynek a keringésében, akinek beadják, legalább egy hétig jelen van, 'v'v'v'v''Wv^ - a fehérje vagy polipepítd tki-béraként kifejezett féléletideje emberben legalább három trap, ès-Xagy - a fehérje, polípeptid vagy gyógyászati készítmény embernek két vagy három krónikusan beadott dózisban adandó be. 16. Λ 15, igénypont szerinti gyógyászati készítmény terápiában való alkalmazásra, ahol a feltétje vagy poiipeptid annak a személynek a keringésében, akinek terápiástul aktív dózisban beadják, ííirmakoiógtaílag aktív-szinteken van jelen legalább egy hétét) át, 17. A 15. vagy ló. igénypont szersml gyógyászati készítmény terápiában való alkalmazásra, ahol a fehérje, poiipeptid vagy gyógyászati készítmény embernek két vagy' három krónikusan beadott dózisban adandó fff be,
HUE12729968A 2011-06-23 2012-06-25 Eljárások aspecifikus fehérje-interferencia elõrejelzésére, kimutatására és csökkentésére immunglobulin variábilis egydomént magában foglaló assay-kben HUE031828T2 (hu)

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US201161500464P 2011-06-23 2011-06-23
US201161500360P 2011-06-23 2011-06-23
US201161541368P 2011-09-30 2011-09-30
PCT/EP2011/067132 WO2012042026A1 (en) 2010-09-30 2011-09-30 Biological materials related to c-met
US13/435,567 US8703135B2 (en) 2010-09-30 2012-03-30 Biological materials related to c-Met
PCT/EP2012/061304 WO2012175400A1 (en) 2011-06-23 2012-06-14 Serum albumin binding proteins

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