SG10201605048XA - Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains - Google Patents

Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains

Info

Publication number
SG10201605048XA
SG10201605048XA SG10201605048XA SG10201605048XA SG10201605048XA SG 10201605048X A SG10201605048X A SG 10201605048XA SG 10201605048X A SG10201605048X A SG 10201605048XA SG 10201605048X A SG10201605048X A SG 10201605048XA SG 10201605048X A SG10201605048X A SG 10201605048XA
Authority
SG
Singapore
Prior art keywords
predicting
techniques
detecting
variable domains
single variable
Prior art date
Application number
SG10201605048XA
Inventor
Judith Baumeister
Marie-Paule Lucienne Armanda Bouche
Carlo Boutton
Marie-Ange Buyse
Veerle Snoeck
Stephanie Staelens
Original Assignee
Ablynx Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47423024&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201605048X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2011/067132 external-priority patent/WO2012042026A1/en
Priority claimed from PCT/EP2012/061304 external-priority patent/WO2012175400A1/en
Application filed by Ablynx Nv filed Critical Ablynx Nv
Publication of SG10201605048XA publication Critical patent/SG10201605048XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
SG10201605048XA 2011-06-23 2012-06-25 Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains SG10201605048XA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161500360P 2011-06-23 2011-06-23
US201161500464P 2011-06-23 2011-06-23
US201161541368P 2011-09-30 2011-09-30
PCT/EP2011/067132 WO2012042026A1 (en) 2010-09-30 2011-09-30 Biological materials related to c-met
US13/435,567 US8703135B2 (en) 2010-09-30 2012-03-30 Biological materials related to c-Met
PCT/EP2012/061304 WO2012175400A1 (en) 2011-06-23 2012-06-14 Serum albumin binding proteins

Publications (1)

Publication Number Publication Date
SG10201605048XA true SG10201605048XA (en) 2016-07-28

Family

ID=47423024

Family Applications (4)

Application Number Title Priority Date Filing Date
SG10201805064SA SG10201805064SA (en) 2011-06-23 2012-06-25 Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
SG10201707604SA SG10201707604SA (en) 2011-06-23 2012-06-25 Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
SG2013084678A SG194982A1 (en) 2011-06-23 2012-06-25 Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
SG10201605048XA SG10201605048XA (en) 2011-06-23 2012-06-25 Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains

Family Applications Before (3)

Application Number Title Priority Date Filing Date
SG10201805064SA SG10201805064SA (en) 2011-06-23 2012-06-25 Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
SG10201707604SA SG10201707604SA (en) 2011-06-23 2012-06-25 Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
SG2013084678A SG194982A1 (en) 2011-06-23 2012-06-25 Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains

Country Status (22)

Country Link
US (11) US20180009888A9 (en)
EP (1) EP2723769B2 (en)
JP (6) JP6258199B2 (en)
KR (7) KR102240318B1 (en)
CN (5) CN108659120A (en)
AU (7) AU2012273929B2 (en)
BR (3) BR112013032145B1 (en)
CA (3) CA3142288A1 (en)
DK (1) DK2723769T4 (en)
ES (1) ES2622006T5 (en)
HU (1) HUE031828T2 (en)
IL (4) IL293155A (en)
IN (1) IN2014CN00373A (en)
LT (1) LT2723769T (en)
MX (2) MX350074B (en)
PH (1) PH12017501178A1 (en)
PL (1) PL2723769T5 (en)
PT (1) PT2723769T (en)
RU (2) RU2019128430A (en)
SG (4) SG10201805064SA (en)
WO (1) WO2012175741A2 (en)
ZA (1) ZA201309295B (en)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9139825B2 (en) 2009-10-30 2015-09-22 Novartis Ag Universal fibronectin type III bottom-side binding domain libraries
ES2949159T3 (en) 2010-05-06 2023-09-26 Novartis Ag Compositions and methods of use for low-density lipoprotein-related protein 6 (LRP6) therapeutic antibodies
EP2621953B1 (en) 2010-09-30 2017-04-05 Ablynx N.V. Biological materials related to c-met
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
SG10201805064SA (en) * 2011-06-23 2018-07-30 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
AU2012271974B2 (en) 2011-06-23 2017-01-12 Ablynx Nv Serum albumin binding proteins
EP2974737A1 (en) 2011-06-23 2016-01-20 Ablynx N.V. Techniques for predicting, detecting and reducing a specific protein interference in assays involving immunoglobulin single variable domains
KR102143506B1 (en) * 2011-08-17 2020-08-12 글락소 그룹 리미티드 Modified proteins and peptides
WO2013073968A2 (en) * 2011-09-12 2013-05-23 Industrial Research Limited Agents for modulation of cell signalling
US9346884B2 (en) 2011-09-30 2016-05-24 Ablynx N.V. Biological materials related to c-Met
EP2773669B1 (en) 2011-11-04 2018-03-28 Novartis AG Low density lipoprotein-related protein 6 (lrp6) - half life extender constructs
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
CN104781277A (en) * 2012-09-13 2015-07-15 诺华股份有限公司 antigen binding molecule with terminal modification
CN105939767B (en) 2014-01-08 2018-04-06 弗洛设计声能学公司 Sound electrophoretic apparatus with alliteration electrophoresis chamber
NZ726448A (en) * 2014-05-16 2023-02-24 Ablynx Nv Improved immunoglobulin variable domains
PT3248986T (en) * 2014-05-16 2022-04-05 Ablynx Nv Immunoglobulin variable domains
DK3143403T3 (en) * 2014-05-16 2022-01-17 Ablynx Nv PROCEDURES FOR THE DETECTION AND / OR MEASUREMENT OF ANTI-DRUG ANTIBODIES, IN PARTICULAR, TREATMENT-INDUCTED ANTI-DRUG ANTIBODIES
NL2013661B1 (en) 2014-10-21 2016-10-05 Ablynx Nv KV1.3 Binding immunoglobulins.
WO2016118733A1 (en) 2015-01-21 2016-07-28 Inhibrx Biopharma LLC Non-immunogenic single domain antibodies
KR102622281B1 (en) 2015-03-31 2024-01-08 소리소 파마슈티컬스 인크. polypeptide
US10273305B2 (en) 2015-04-02 2019-04-30 Ablynx N.V. Bispecific CXCR4-CD4 polypeptides with potent anti-HIV activity
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
CA2985700C (en) 2015-05-13 2022-06-28 Ablynx N.V. T cell recruiting polypeptides based on cd3 reactivity
ES2754427T3 (en) 2015-05-13 2020-04-17 Ablynx Nv T cell recruitment polypeptides based on TCR alpha / beta reactivity
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
CN108350069B (en) 2015-10-30 2021-11-12 埃博灵克斯股份有限公司 Polypeptides directed against IL-23
TWI746473B (en) * 2015-11-02 2021-11-21 美商辛分子醫藥有限公司 Single domain antibodies directed against intracellular antigens
CN108431039B (en) * 2015-11-12 2022-06-28 埃博灵克斯股份有限公司 Improved P2X7 receptor binding agents and polypeptides comprising the same
NO2768984T3 (en) 2015-11-12 2018-06-09
CA3005061A1 (en) * 2015-11-13 2017-05-18 Ablynx Nv Improved serum albumin-binding immunoglobulin variable domains
CR20180279A (en) 2015-11-18 2018-08-24 Merck Sharp & Dohme CTLA4 BINDERS
EP3377525A2 (en) 2015-11-18 2018-09-26 Ablynx NV Improved serum albumin binders
EP3377526A1 (en) 2015-11-18 2018-09-26 Merck Sharp & Dohme Corp. PD1/CTLA4 Binders
IL300122A (en) 2015-11-18 2023-03-01 Merck Sharp ַ& Dohme Llc PD1 and/or LAG3 Binders
SG11201803976VA (en) 2015-11-27 2018-06-28 Ablynx Nv Polypeptides inhibiting cd40l
UA122079C2 (en) 2015-12-04 2020-09-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Biparatopic polypeptides antagonizing wnt signaling in tumor cells
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
KR102374912B1 (en) 2016-06-23 2022-03-16 아블린쓰 엔.브이. Improved Pharmacokinetic Assays for Immunoglobulin Single Variable Domains
WO2018050833A1 (en) 2016-09-15 2018-03-22 Ablynx Nv Immunoglobulin single variable domains directed against macrophage migration inhibitory factor
WO2018060453A1 (en) 2016-09-30 2018-04-05 Vhsquared Limited Compositions
EP3529347A1 (en) 2016-10-19 2019-08-28 Flodesign Sonics, Inc. Affinity cell extraction by acoustics
CA3043515A1 (en) 2016-11-16 2018-05-24 Ablynx Nv T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta
WO2018104444A1 (en) 2016-12-07 2018-06-14 Ablynx Nv Improved serum albumin binding immunoglobulin single variable domains
US11414481B2 (en) * 2017-01-17 2022-08-16 Ablynx N.V. Serum albumin binders
KR102653724B1 (en) * 2017-01-17 2024-04-02 아블린쓰 엔.브이. Improved serum albumin binder
US20220099682A9 (en) 2017-03-31 2022-03-31 Ablynx N.V. Improved immunogenicity assays
EA201992808A1 (en) 2017-05-31 2020-05-14 Бёрингер Ингельхайм Интернациональ Гмбх POLYPEPTIDES HINDERING THE TRANSMISSION OF Wnt SIGNALS IN TUMOR CELLS
US11261260B2 (en) 2017-06-02 2022-03-01 Merck Patent Gmbh ADAMTS binding immunoglobulins
WO2018220235A1 (en) 2017-06-02 2018-12-06 Merck Patent Gmbh Mmp13 binding immunoglobulins
JP7249961B2 (en) 2017-06-02 2023-03-31 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Polypeptides that bind ADAMTS5, MMP13 and aggrecan
AR112069A1 (en) 2017-06-02 2019-09-18 Ablynx Nv IMMUNOGLOBULINS THAT BIND AGGRECAN
WO2019016237A1 (en) 2017-07-19 2019-01-24 Vib Vzw Serum albumin binding agents
JP6708797B2 (en) 2017-08-23 2020-06-10 本田技研工業株式会社 Airbag device for saddle type vehicles
US11873347B2 (en) 2017-10-31 2024-01-16 Vib Vzw Antigen-binding chimeric proteins and methods and uses thereof
AU2018385759B2 (en) 2017-12-14 2021-10-21 Flodesign Sonics, Inc. Acoustic transducer driver and controller
EP3569618A1 (en) 2018-05-19 2019-11-20 Boehringer Ingelheim International GmbH Antagonizing cd73 antibody
TW202016151A (en) 2018-06-09 2020-05-01 德商百靈佳殷格翰國際股份有限公司 Multi-specific binding proteins for cancer treatment
MA53130A (en) * 2018-07-10 2021-05-19 Regeneron Pharma TARGET DRUG INTERFERENCE MITIGATION METHODS IN AN IMMUNOLOGICAL ASSAY OF ANTI-DRUG ANTIBODIES (ADA)
FR3088640A1 (en) 2018-10-14 2020-05-22 Smart Diagnostix Pharma NOVEL POLYPEPTIDE SPECIFICALLY BINDING TO PROTEIN P16
EP3962599A1 (en) 2019-04-30 2022-03-09 Vib Vzw Cystic fibrosis transmembrane conductance regulator stabilizing agents
EP3986571A1 (en) 2019-06-21 2022-04-27 Sorriso Pharmaceuticals, Inc. Polypeptides
CA3144566A1 (en) 2019-06-21 2020-12-24 Sorriso Pharmaceuticals, Inc. Polypeptides
TW202128756A (en) 2019-10-02 2021-08-01 德商百靈佳殷格翰國際股份有限公司 Multi-specific binding proteins for cancer treatment
GB201914468D0 (en) 2019-10-07 2019-11-20 Crescendo Biologics Ltd Binding Molecules
US20220411495A1 (en) 2019-11-27 2022-12-29 Vib Vzw Positive allosteric modulators of the calcium-sensing receptor
BR112022010231A2 (en) 2019-12-06 2022-09-06 Ablynx Nv POLYPEPTIDES COMPRISING SINGLE VARIABLE DOMAINS OF IMMUNOGLOBULIN TARGETED TNFALFA AND OX40L
CA3163877A1 (en) 2019-12-06 2021-06-10 Ablynx Nv Polypeptides comprising immunoglobulin single variable domains targeting tnf.alpha. and il-23
MX2022007035A (en) 2019-12-09 2022-06-23 Ablynx Nv Polypeptides comprising immunoglobulin single variable domains targeting il-13 and tslp.
AR120698A1 (en) 2019-12-09 2022-03-09 Ablynx Nv POLYPEPTIDES COMPRISING SINGLE VARIABLE DOMAINS OF IMMUNOGLOBULIN TARGETING IL-13 AND TSLP
WO2021123360A1 (en) 2019-12-20 2021-06-24 Vib Vzw Nanobody exchange chromatography
WO2021156490A2 (en) 2020-02-06 2021-08-12 Vib Vzw Corona virus binders
IL295892A (en) 2020-02-25 2022-10-01 Vib Vzw Leucine-rich repeat kinase 2 allosteric modulators
WO2022003156A1 (en) 2020-07-02 2022-01-06 Oncurious Nv Ccr8 non-blocking binders
IL301581A (en) 2020-09-25 2023-05-01 Ablynx Nv Polypeptides comprising immunoglobulin single variable domains targeting il-13 and ox40l
WO2022117569A1 (en) 2020-12-02 2022-06-09 Oncurious Nv A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer
WO2022117572A2 (en) 2020-12-02 2022-06-09 Oncurious Nv An ltbr agonist in combination therapy against cancer
CA3201219A1 (en) 2020-12-04 2022-06-09 Mir Ali Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof
BR112023011782A2 (en) 2020-12-14 2023-10-31 Takeda Pharmaceuticals Co CONDITIONALLY BIESPECIFIC BINDING PROTEINS
EP4262985A1 (en) 2020-12-18 2023-10-25 Ablynx N.V. Polypeptides comprising immunoglobulin single variable domains targeting glypican-3 and t cell receptor
WO2022129637A1 (en) 2020-12-18 2022-06-23 Ablynx Nv T cell recruiting polypeptides based on tcr alpha/beta reactivity
WO2022129572A1 (en) 2020-12-18 2022-06-23 Ablynx Nv Polypeptides comprising immunoglobulin single variable domains targeting il-6 and tnf-alpha
GB202020502D0 (en) 2020-12-23 2021-02-03 Vib Vzw Antibody composistion for treatment of corona virus infection
US20240101647A1 (en) 2021-02-05 2024-03-28 Vib Vzw Sarbecovirus binders
CN117794566A (en) 2021-02-05 2024-03-29 Vib研究所 Sha Bei viral binding agents
EP4294516A1 (en) 2021-02-19 2023-12-27 Vib Vzw Cation-independent mannose-6-phosphate receptor binders
CN113173978B (en) * 2021-04-22 2024-03-01 温州医科大学 Polypeptide with binding affinity to HPV16E6 protein and application thereof
WO2023016828A2 (en) 2021-07-30 2023-02-16 Vib Vzw Cation-independent mannose-6-phosphate receptor binders for targeted protein degradation
WO2023093899A1 (en) * 2021-11-29 2023-06-01 江苏恒瑞医药股份有限公司 Modified protein or polypeptide
WO2023110190A1 (en) 2021-12-13 2023-06-22 Heraeus Medical Gmbh Tests and methods for detecting bacterial infection
WO2023111266A1 (en) 2021-12-17 2023-06-22 Ablynx Nv POLYPEPTIDES COMPRISING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS TARGETING TCRαβ, CD33 AND CD123
WO2023135198A1 (en) 2022-01-12 2023-07-20 Vib Vzw Human ntcp binders for therapeutic use and liver-specific targeted delivery
TW202342521A (en) 2022-02-23 2023-11-01 日商武田藥品工業股份有限公司 Conditionally bispecific binding proteins
WO2023198848A1 (en) 2022-04-13 2023-10-19 Vib Vzw An ltbr agonist in combination therapy against cancer
WO2023222825A1 (en) 2022-05-18 2023-11-23 Vib Vzw Sarbecovirus spike s2 subunit binders
US20240002331A1 (en) 2022-06-08 2024-01-04 Tidal Therapeutics, Inc. Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof
US20240109965A1 (en) 2022-06-14 2024-04-04 Ablynx N.V. Immunoglobulin single variable domains targeting t cell receptor
WO2024023271A1 (en) 2022-07-27 2024-02-01 Ablynx Nv Polypeptides binding to a specific epitope of the neonatal fc receptor
WO2024068744A1 (en) 2022-09-27 2024-04-04 Vib Vzw Antivirals against human parainfluenza virus
EP4357778A1 (en) 2022-10-20 2024-04-24 Heraeus Medical GmbH Treatment of microbial infections diagnosed using the biomarker d-lactate

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545106C3 (en) 1963-07-16 1979-05-31 Union Carbide Corp., New York, N.Y. (V.St.A.) Process for the production of linear polyarylene polyethers
KR0184860B1 (en) 1988-11-11 1999-04-01 메디칼 리써어치 카운실 Single domain ligands receptors comprising said ligands methods for their production and use of said ligands
CA2016842A1 (en) 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
GB9016299D0 (en) * 1990-07-25 1990-09-12 Brien Caroline J O Binding substances
CA2090126C (en) 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
US5608039A (en) * 1990-10-12 1997-03-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Single chain B3 antibody fusion proteins and their uses
DK0488470T3 (en) 1990-11-26 1997-12-22 Akzo Nobel Nv Method for producing antibodies
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
ES2358576T3 (en) 1999-07-05 2011-05-11 K.U. LEUVEN RESEARCH & DEVELOPMENT DETECTION OF THE ACTIVITY OF THE VON-WILLEBRAND FACTOR (VWF).
US6541225B1 (en) 2000-01-26 2003-04-01 Raven Biotechnologies, Inc. Methods and compositions for generating human monoclonal antibodies
AU2001289930A1 (en) 2000-09-25 2002-04-08 Rega Stichting Vzw Method for the production of human antibodies, antibodies thus obtained and their use in therapy and diagnosis
WO2004058821A2 (en) * 2002-12-27 2004-07-15 Domantis Limited Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
US20060002935A1 (en) 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
FR2846667B1 (en) 2002-11-06 2004-12-31 Pasteur Institut VARIABLE FRAGMENTS OF SINGLE-CHAIN CAMELIDE ANTIBODIES DIRECTED AGAINST BETA-AMYLOID PEPTIDE 1-42 AND THEIR APPLICATIONS FOR DIAGNOSIS AND TREATMENT OF NEUROAGREGATIVE DISEASES
JP2006524036A (en) 2002-11-08 2006-10-26 アブリンクス エン．ヴェー． Single domain antibodies targeting tumor necrosis factor alpha and uses thereof
JP4603894B2 (en) 2002-12-03 2010-12-22 ユセベ ファルマ ソシエテ アノニム Assays to identify antibody producing cells
EP2390270A1 (en) 2003-01-10 2011-11-30 Ablynx N.V. Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation
AU2004205631A1 (en) * 2003-01-16 2004-08-05 Genentech, Inc. Synthetic antibody phage libraries
WO2004102198A2 (en) 2003-05-15 2004-11-25 Cytos Biotechnology Ag Selection of b cells with specificity of interest: method of preparation and use
GB0312481D0 (en) 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
KR20070117002A (en) 2003-11-04 2007-12-11 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 Hyperlipemia/hyperalbuminemia model animal
SI1773885T1 (en) 2004-08-05 2010-08-31 Genentech Inc Humanized anti-cmet antagonists
BRPI0518622A2 (en) 2004-12-02 2008-12-02 Domantis Ltd uses of interleukin-1 (il-1r1) type 1 receptor antagonists for the manufacture of a medicament for the treatment of a respiratory disease; A pharmaceutical composition comprising an IL-1R1 antagonist and a physiologically acceptable carrier and drug delivery device.
EP1844073A1 (en) 2005-01-31 2007-10-17 Ablynx N.V. Method for generating variable domain sequences of heavy chain antibodies
AU2006249144B2 (en) † 2005-05-18 2011-11-17 Ablynx Nv Improved NanobodiesTM against Tumor Necrosis Factor-alpha
NZ563392A (en) * 2005-05-20 2009-12-24 Ablynx Nv Improved Nanobodies(TM) for the treatment of aggregation-mediated disorders
DE102005023617A1 (en) * 2005-05-21 2006-11-23 Aspre Ag Method for mixing colors in a display
WO2006129843A2 (en) † 2005-05-31 2006-12-07 Canon Kabushiki Kaisha Bispecific capturing molecule
JP2007008925A (en) * 2005-05-31 2007-01-18 Canon Inc Target substance-catching molecule
WO2006129828A2 (en) 2005-05-31 2006-12-07 Canon Kabushiki Kaisha Target substance capturing molecule
TW200730539A (en) 2005-12-01 2007-08-16 Domantis Ltd Noncompetitive domain antibody formats that bind interleukin 1 receptor type 1
WO2007063311A2 (en) 2005-12-01 2007-06-07 Domantis Limited Competitive domain antibody formats that bind interleukin 1 receptor type 1
FR2894741B1 (en) 2005-12-08 2009-12-04 Centre Nat Etd Spatiales SATELLITE RECEPTION CHAIN
AU2007209201A1 (en) 2006-01-24 2007-08-02 Domantis Limited Fusion proteins that contain natural junctions
CA2646048A1 (en) 2006-03-30 2007-11-08 Novartis Ag Compositions and methods of use for antibodies of c-met
US7741273B2 (en) * 2006-04-13 2010-06-22 Warsaw Orthopedic, Inc. Drug depot implant designs
CN101553505B (en) * 2006-08-03 2013-07-17 阿斯利康(瑞典)有限公司 Antibodies directed to alphaVbeta6 and uses thereof
US8629244B2 (en) 2006-08-18 2014-01-14 Ablynx N.V. Interleukin-6 receptor binding polypeptides
CN101646689A (en) * 2006-09-08 2010-02-10 埃博灵克斯股份有限公司 Serum albumin binding proteins with long half-lives
AU2007306340A1 (en) * 2006-10-11 2008-04-17 Ablynx N.V. Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the pH, compounds comprising the same, and use thereof
JP2010511397A (en) * 2006-12-05 2010-04-15 アブリンクス エン．ヴェー． Peptides that can bind to serum proteins
PT2121751T (en) 2006-12-08 2017-04-18 Lexicon Pharmaceuticals Inc Monoclonal antibodies against angptl3
AU2007331672A1 (en) * 2006-12-15 2008-06-19 Ablynx N.V. Amino acid sequences that modulate the interaction between cells of the immune system
US8906680B2 (en) * 2006-12-22 2014-12-09 Ablynx N.V. Amino acid sequences directed against chemokines and polypeptides comprising the same for the treatment of chemokine-related diseases and disorders
CN101663319A (en) 2007-02-21 2010-03-03 埃博灵克斯股份有限公司 Be used for the treatment of at the aminoacid sequence of vascular endothelial growth factor and the polypeptide that comprises it and be characterised in that excessive and/or pathologic vessels takes place or the illness and the disease of neovascularization
GB0706793D0 (en) 2007-04-05 2007-05-16 Evotec Ag Compounds
CN104231082B (en) * 2007-05-24 2018-12-21 埃博灵克斯股份有限公司 The amino acid sequence for RANK-L for treating bone disease and illness and the polypeptide including it
EP2014681A1 (en) 2007-07-12 2009-01-14 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
AR062123A1 (en) * 2007-07-27 2008-10-15 Inst Nac De Tecnologia Agropec VHH MONOMERIC DOMAIN DERIVED FROM ANTI-VP6 CAMELID ANTIBODIES, DIMERIC DOMAIN, ROTAVIRUS IMMUNODETECTION METHOD, COMPOSITIONS, ROTAVIRUS INFECTION PREVENTION AND TREATMENT METHODS
JP6126773B2 (en) * 2007-09-04 2017-05-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア High affinity anti-prostatic stem cell antigen (PSCA) antibody for cancer targeting and detection
WO2009042589A1 (en) * 2007-09-24 2009-04-02 Vanderbilt University Monoclonal antibodies to respiratory syncytial virus and uses thereof
EP2650311A3 (en) 2007-11-27 2014-06-04 Ablynx N.V. Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
CA2709399C (en) * 2007-12-28 2021-01-19 Genentech, Inc. Anti-hedgehog antibodies
BRPI0907648B1 (en) 2008-01-29 2022-01-11 Institute Of Molecular Biology And Genetics National Academy Of Science Of Ukraine ISOLATED HUMANIZED ANTIBODY, USES OF AN ANTIBODY, METHODS FOR PREPARING AN ANTIBODY, FOR GENERATING IMMUNOREATIVE ANTIBODIES WITH SLC34A2, AND FOR SCREENING OR IDENTIFYING AGENTS OR COMPOUNDS THAT MODULATE SLC34A2, COMPOSITIONS, ISOLATED NUCLEIC ACID, AND, HOST MICROORGANISM
WO2009127691A1 (en) * 2008-04-17 2009-10-22 Ablynx N.V. Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
DE102008023620A1 (en) 2008-05-15 2009-11-19 Mettler-Toledo (Albstadt) Gmbh Function unit with an invocable function and method for calling it
JP6034023B2 (en) * 2008-05-16 2016-11-30 アブリンクス エン．ヴェー． Amino acid sequences directed to CXCR4 and other GPCRs and compounds containing the same
US7858729B2 (en) 2008-05-29 2010-12-28 Novomer, Inc. Methods of controlling molecular weight distribution of polymers and compositions thereof
DK2285408T3 (en) * 2008-06-05 2019-02-04 Ablynx Nv AMINO ACID SEQUENCES AGAINST COATING PROTEINS IN A VIRUS AND POLYPEPTIDES INCLUDING THESE FOR TREATMENT OF VIRUSAL DISEASES
EP2143735A1 (en) * 2008-07-10 2010-01-13 Institut Pasteur Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins
WO2010042815A2 (en) † 2008-10-09 2010-04-15 Duke University Vhh antibody fragments for use in the detection and treatment of cancer
US8372808B2 (en) 2008-10-31 2013-02-12 Wisconsin Alumni Research Foundation Suppression of glial fibrillary acidic protein
US10005830B2 (en) † 2009-03-05 2018-06-26 Ablynx N.V. Antigen binding dimer-complexes, methods of making/avoiding and uses thereof
MX2011010151A (en) 2009-03-27 2011-12-14 Glaxo Group Ltd Drug fusions and conjugates.
NZ595461A (en) * 2009-04-10 2013-01-25 Ablynx Nv Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
WO2010130832A2 (en) 2009-05-15 2010-11-18 Ablynx N.V. Amino acid sequences directed against dickkopf-1 and polypeptides comprising the same for the treatment of diseases and disorders associated with bone loss and/or osteolytic lesions
HUE051430T2 (en) * 2009-07-10 2021-03-01 Ablynx Nv Method for the production of variable domains
US8306355B2 (en) 2009-07-13 2012-11-06 Sharp Laboratories Of America, Inc. Methods and systems for reducing compression artifacts
US9644022B2 (en) * 2009-11-30 2017-05-09 Ablynx N.V. Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
US8962807B2 (en) 2009-12-14 2015-02-24 Ablynx N.V. Single variable domain antibodies against OX40L, constructs and therapeutic use
SG181707A1 (en) * 2009-12-18 2012-07-30 Sanofi Sa Novel antagonist antibodies and their fab fragments against gpvi and uses thereof
KR20170084357A (en) * 2009-12-23 2017-07-19 에스바테크 - 어 노바티스 컴파니 엘엘씨 Method for decreasing immunogenicity
AR080446A1 (en) * 2010-03-03 2012-04-11 Boehringer Ingelheim Int UNION TO A-BETA POLYPEPTIDES (AMYLOID BETA)
CN103003307B (en) 2010-03-10 2017-08-11 根马布股份公司 Anti- c MEt monoclonal antibody
US8937164B2 (en) * 2010-03-26 2015-01-20 Ablynx N.V. Biological materials related to CXCR7
CN102971341A (en) 2010-04-30 2013-03-13 埃博灵克斯股份有限公司 Amino acid sequences of nanobodies directed against p19 subunit of the heterodimeric cytokine IL-23
RU2012149227A (en) * 2010-05-20 2014-06-27 Аблинкс Нв BIOLOGICAL MATERIALS RELATING TO HER3
EP2621953B1 (en) 2010-09-30 2017-04-05 Ablynx N.V. Biological materials related to c-met
US11644471B2 (en) 2010-09-30 2023-05-09 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
ES2627299T3 (en) * 2011-01-06 2017-07-27 Glaxo Group Limited Ligands that bind to TGF-beta receptor II
CN103547592A (en) 2011-03-30 2014-01-29 埃博灵克斯股份有限公司 Methods of treating immune disorders with single domain antibodies against TNF-alpha
WO2012130314A1 (en) † 2011-03-31 2012-10-04 Elara Pharmaceuticals Gmbh Composition comprising docetaxel
AU2012271974B2 (en) 2011-06-23 2017-01-12 Ablynx Nv Serum albumin binding proteins
SG10201805064SA (en) 2011-06-23 2018-07-30 Ablynx Nv Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
US20150344568A1 (en) 2011-06-23 2015-12-03 Ablynx N.V. Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
CA2842099A1 (en) 2011-07-27 2013-01-31 Glaxo Group Limited Antigen binding constructs
KR102143506B1 (en) * 2011-08-17 2020-08-12 글락소 그룹 리미티드 Modified proteins and peptides
US9346884B2 (en) 2011-09-30 2016-05-24 Ablynx N.V. Biological materials related to c-Met
US8614548B2 (en) 2012-01-19 2013-12-24 Sonoco Development Incorporated Electroluminescent display and method for production
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
WO2013177271A2 (en) 2012-05-22 2013-11-28 Owens Corning Intellectual Capital, Llc Laminated foam product and methods for making laminated foam products
WO2014111550A1 (en) † 2013-01-17 2014-07-24 Glaxosmithkline Intellectual Property Development Limited Modified anti-serum albumin binding proteins
NZ726448A (en) * 2014-05-16 2023-02-24 Ablynx Nv Improved immunoglobulin variable domains
CA2963712A1 (en) 2014-10-21 2016-04-28 Ablynx Nv Treatment of il-6r related diseases
NO2768984T3 (en) * 2015-11-12 2018-06-09
CR20180279A (en) 2015-11-18 2018-08-24 Merck Sharp & Dohme CTLA4 BINDERS
EP3377526A1 (en) 2015-11-18 2018-09-26 Merck Sharp & Dohme Corp. PD1/CTLA4 Binders
EP3377525A2 (en) * 2015-11-18 2018-09-26 Ablynx NV Improved serum albumin binders
IL300122A (en) 2015-11-18 2023-03-01 Merck Sharp ַ& Dohme Llc PD1 and/or LAG3 Binders
JP7096458B2 (en) 2016-01-26 2022-07-06 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル Anti-VWF D'D3 single domain antibody and polypeptide containing it
WO2018104444A1 (en) * 2016-12-07 2018-06-14 Ablynx Nv Improved serum albumin binding immunoglobulin single variable domains
US11414481B2 (en) * 2017-01-17 2022-08-16 Ablynx N.V. Serum albumin binders
US11261260B2 (en) * 2017-06-02 2022-03-01 Merck Patent Gmbh ADAMTS binding immunoglobulins
AR120698A1 (en) * 2019-12-09 2022-03-09 Ablynx Nv POLYPEPTIDES COMPRISING SINGLE VARIABLE DOMAINS OF IMMUNOGLOBULIN TARGETING IL-13 AND TSLP

Also Published As

Publication number Publication date
PH12017501178A1 (en) 2018-07-23
ES2622006T3 (en) 2017-07-05
RU2014102007A (en) 2015-11-27
KR102240318B1 (en) 2021-04-15
KR102246924B1 (en) 2021-04-30
AU2021201506A1 (en) 2021-03-25
JP6258199B2 (en) 2018-01-10
US10858418B2 (en) 2020-12-08
KR102025035B1 (en) 2019-11-04
AU2018202782B2 (en) 2020-07-16
SG10201707604SA (en) 2017-11-29
AU2018202782A1 (en) 2018-05-10
US20170275360A1 (en) 2017-09-28
NZ716279A (en) 2017-07-28
MX2013014614A (en) 2014-08-01
BR122018012485B1 (en) 2022-09-20
CN104203975A (en) 2014-12-10
US20200325221A1 (en) 2020-10-15
KR101965462B1 (en) 2019-04-04
WO2012175741A3 (en) 2013-02-14
AU2019201606A1 (en) 2019-04-04
CA2837998C (en) 2022-03-01
US20200216532A1 (en) 2020-07-09
KR20190041513A (en) 2019-04-22
IL229503B (en) 2022-06-01
IL293163A (en) 2022-07-01
US20220119497A1 (en) 2022-04-21
BR122017005075B1 (en) 2022-09-20
NZ617995A (en) 2016-06-24
ZA201309295B (en) 2015-01-28
AU2012273929B2 (en) 2017-04-27
CN108659121A (en) 2018-10-16
CN108653728B (en) 2022-11-18
US20180009888A9 (en) 2018-01-11
KR20210047369A (en) 2021-04-29
US20220298227A9 (en) 2022-09-22
KR20190107200A (en) 2019-09-18
JP2021107426A (en) 2021-07-29
SG194982A1 (en) 2013-12-30
KR20220114104A (en) 2022-08-17
CA2837998A1 (en) 2012-12-27
DK2723769T4 (en) 2022-09-05
US11192938B2 (en) 2021-12-07
MX350074B (en) 2017-08-25
IN2014CN00373A (en) 2015-04-03
US20140199295A1 (en) 2014-07-17
CA3141978A1 (en) 2012-12-27
RU2700630C2 (en) 2019-09-18
PT2723769T (en) 2017-04-04
AU2019201606B2 (en) 2021-04-01
KR20140040779A (en) 2014-04-03
PL2723769T5 (en) 2022-10-17
CN108663504A (en) 2018-10-16
CN108653728A (en) 2018-10-16
JP6869923B2 (en) 2021-05-12
IL229503A0 (en) 2014-01-30
KR20180086280A (en) 2018-07-30
JP2022031790A (en) 2022-02-22
SG10201805064SA (en) 2018-07-30
CN108663504B (en) 2021-06-22
US20170275361A1 (en) 2017-09-28
HUE031828T2 (en) 2017-08-28
ES2622006T5 (en) 2022-10-13
IL250396B (en) 2022-06-01
BR112013032145B1 (en) 2022-09-20
BR122017005075A2 (en) 2019-09-03
EP2723769B2 (en) 2022-06-15
CA3142288A1 (en) 2012-12-27
US20210388061A1 (en) 2021-12-16
AU2017204339A1 (en) 2017-07-13
EP2723769B1 (en) 2017-01-11
JP6982400B2 (en) 2021-12-17
DK2723769T3 (en) 2017-04-03
KR102430693B1 (en) 2022-08-08
JP2018162305A (en) 2018-10-18
IL250396A0 (en) 2017-03-30
BR112013032145A8 (en) 2018-07-03
US20210403536A1 (en) 2021-12-30
KR20240033183A (en) 2024-03-12
EP2723769A2 (en) 2014-04-30
IL293155A (en) 2022-07-01
WO2012175741A2 (en) 2012-12-27
JP2014520134A (en) 2014-08-21
RU2019128430A (en) 2019-10-25
AU2020230299B2 (en) 2022-10-06
JP2017160230A (en) 2017-09-14
AU2024200309A1 (en) 2024-02-08
AU2017204339B2 (en) 2019-03-28
AU2021201506B2 (en) 2023-10-19
US20230242620A1 (en) 2023-08-03
US20180355031A1 (en) 2018-12-13
US20210388062A1 (en) 2021-12-16
CN104203975B (en) 2018-05-11
LT2723769T (en) 2017-04-10
CN108659120A (en) 2018-10-16
PL2723769T3 (en) 2017-07-31
JP2024050769A (en) 2024-04-10
AU2020230299A1 (en) 2020-10-01
US11192937B2 (en) 2021-12-07
MX2018007826A (en) 2021-12-08
BR112013032145A2 (en) 2017-12-05

Similar Documents

Publication Publication Date Title
IL250396A0 (en) Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
HK1256304A1 (en) Methods and reagents for creating monoclonal antibodies
SI2723769T1 (en) Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains
IL232778A0 (en) Anti-pd-l1 antibodies and uses thereof
HK1200493A1 (en) Anti-b7-h4 antibodies and their uses b7-h4
ZA201400768B (en) Interleukin-31 monoclonal antibody
EP2733982A4 (en) Cell measurement method, cell resource sharing method, and related device
HK1190341A1 (en) Deimmunized serum-binding domains and their use for extending serum half- life
GB201115529D0 (en) Antibodies, uses and methods
GB201115280D0 (en) Antibodies, uses and methods
PL2673641T3 (en) Reduced step dual path immunoassay device and method
EP2742067A4 (en) Anti-fzd10 monoclonal antibodies and methods for their use
EP2593475A4 (en) Anti-addl monoclonal antibody and uses thereof
SI2564202T1 (en) Methods for detecting anti-drug antibodies
IL231404A0 (en) Antibody against affinity complex
EP2322562A4 (en) Monoclonal antibody, and immunoassay using same
EP2746394A4 (en) Antibody and antibody-containing composition
SG11201402709WA (en) Method and device for assaying an antigen present on erythrocytes or an antibody binding to an antigen present on erythrocytes
EP2536817A4 (en) Immunoassay device for detecting antibodies and antigens
EP2599865A4 (en) Anti-fdp monoclonal antibody, fdp measurement reagent and reagent kit using same, and fdp measurement method
HK1215174A1 (en) Humanized monoclonal antibodies against activated protein and uses thereof
EP2669296A4 (en) Anti-il28b antibody and method for assaying il28b using same
EP2751556A4 (en) Device and method for detection and quantification of immunological proteins, pathogenic and microbial agents and cells