HUE025530T2 - Szklerosztin kötõ szerek - Google Patents

Szklerosztin kötõ szerek Download PDF

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Publication number
HUE025530T2
HUE025530T2 HUE10014362A HUE10014362A HUE025530T2 HU E025530 T2 HUE025530 T2 HU E025530T2 HU E10014362 A HUE10014362 A HU E10014362A HU E10014362 A HUE10014362 A HU E10014362A HU E025530 T2 HUE025530 T2 HU E025530T2
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Hungary
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seq
antibody
bone
acid sequence
cdr
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HUE10014362A
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English (en)
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Christopher Paszty
Martyn Kim Robinson
Kevin Graham
Alistair James Henry
Kelly Sue Hoffmann
John Latham
Alastair Lawson
Hsieng Sen Lu
Aaron George Winters
David Winkler
Wenyan Shen
Andy Popplewell
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Amgen Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36992590&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE025530(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of HUE025530T2 publication Critical patent/HUE025530T2/hu

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Claims (9)

  1. (Szklerosztin kötő .szerek) Szabadé lm i IgÉnyppptQk 1. yonoklonálls antitest egy emlősben e csontképzödés, csont ásványt anyag sűrűség, csont ásványi anyag tartalom, csonttömeg, csontminéség és csontsak lárdság legalább egyikének növelésére szolgáié eljárásban és ezáltal egy olyan állapot: kezelésében való alkalmazásra, amelynek során a csontképzödés, csont ásványi anyag sűrűség, osont ásványi anyag tartalom, csonttömeg, esontmlnosèg és csont-szilárdság legalább egyikének nevelése kívánatos, ahol a moooklonáfls antitest (a) humán szklerosztlnhoz 1 x 1CT° y mái kisebb vagy azzal egyenlő kötési aktivitással kötődik, és (h) kereszi-blokkolfa Ab-13 vagy Ab-14 antitest szklemsztinhoz való kötődését és/vagy szklerosztlnhoz való kötődése Ab-13 vagy Ab-14 antitest által kereszt--blokkoiodik, ahol az Ab-13 antitest SEQ 10 NO; 20S szekvenciáid könnyű láncokkal és SEQ 10 MO: 209 szekvenciáid nehéz láncokkal rendelkezik, és az Ab-14 antitest SEQ ID NO: 213 szekvenciáid könnyű láncokkal és SEQ ID NO; 217 vagy 393 szekvenciáid nehéz láncokkal rendelkezik.
  2. 2. NfonoklonátíS antitest az: 1. Igénypont szerinti alkalmazásra, amely magában foglal egy könnyű lánc és/vagy egy nehéz lánc konstans régiói. 3. yonoklonálls antitest a 2. igénypont, szerinti alkalmazásra, amely magában foglal egy IgG konstans régiéi
  3. 4. Monoklonalis antitest a 3. igénypont szerinti alkalmazásra, amely magában foglal egy lgG4 vagy ígG2 konstans régiót, 5. yonoklonálls antitest az 1, Igénypont szerinti alkalmazásra, amely egy egyetlen doménes (slngle-domalni antitest, egy egyiáoed (slngfe-ehaln) antitest vagy egy FfabV. Fab-, Fab!~ vagy Fv-fragmentum, 8. yonoklonálls antitest az 1 - 3. igénypontok bármelyike szerinti alkalmazásra, amely egy humanizált antitest vagy egy humán antitest, 7, yonoklonálls antitest az 1 - b. Igénypontok bármelyike szerinti alkalmazásra, amely 1 x 1íT! M-ná! kisebb vagy azzal egyenlő vagy 1 x 10'M-nál kisebb vagy azzal egyenlő kötési aktivitással kötődik szklerosztinhoz. 8.. yonoklonálls antitest az 1 - 7. Igénypontok bármelyike szerinti .alkalmazásra, amely legalább őö-szer, íŰO-szor, 250-szer, őOO-szor, löűO-szer vagy 10 ÖŰO-szer nagyobb affinitással kötődik humán szkierosztlnhoz, mint a tsfásMiétfe lizozlmhoz való affinitás,
  4. 9, MonoklonálíS' .antitest: az 1 - 8. igénypontok bármelyike szerinti alkalmazásra,. abet a kereszt-blokkolási feleleti plazmen rezonanciával vagy EllSA-val határozzuk meg.
  5. 10, .Monokionáiis antitest a 9, igénypont szerinti alkalmazásra, ahol az antitest egy kereszt-blokkoló antitest, amely szkierosztlnhoz egy Blaeore kereszt-blokkolás meghatározásban úgy kötődik, hogy a meghatározás alatt és egy második antitest jelenlétében az észlelt kötődés kombinációban a két antitest maximális elméleti kötődése 75%-töl 4%-ig terjedő erősségét éri el 11, yonoklonálls antitest a 9, Igénypont szerinti alkalmazásra, amely oldat fázisban ELISA esetében az ELISAdapra antitest bevonat altat kötött szklerosztln mennyiségében 60% és 109% közötti: csökkenést okoz a bevonat antitest által kötött szkierotirr mennyiségéhez viszonyítva az oldat fázisú: antitest hiányában.
  6. 12, Az 1 - 11. igénypontok, bármelyike szerinti mönöklonális antitest osteoporosis vagy osteopenia kezelésében való alkalmazásra.
  7. 13, Az 1-11. igénypontok bármelyike szerinti monoklonális antitest osteopenia, osteoporosis vagy achondroplasia által okozott csontveszieség, deldocranialls dysostosis, enchondromatosis, fibroses dysplasia, Sauoher-kon hypophosphatemias moh ills, yarfan-szindróma, öröklődő többszörös csontkinövések, neurofibromatosis, osteogenesis imperfecta, osteopoikilosis, sdemilous leslek, pseudoarthrosis, pyogen Osteomyelitis, periodontalls betegség:, anteepiieptieus hatóanyagok által kiváltott csont-veszteség, primer és seconder hyperparathyroidlsmos, familiáris hyperparathyroidismus szindrómák, súlytalanság áltel kiválói osontveszteség, férfiaknál fellépő osteoporosis, posfmenopausalis osontveszteség, osteoarthritis, renells osteodystrophia, osont Infiltrativ rendellenességei, orális osontveszteség, az állkapocs osteoneemslsa, ifjúkori Faget-kör, meiorheostosls, metaCollkus eaonfbetegségek, mastocytosis, sarlósejtes vérszegény-ségfpetegség:, szervátültetéssel kapcsolatos ösontveszteség, veseátültetéssel kapcsolatos oso:n:lveszteség:, systemkus lupus erythematosus, Iznlstmerevedéaes: spondylitis, epilepszia:, juvenile artbhtldek, thalassemia. mucopolysacohaddosisok, fabry-betegség, ïomer-azindrôma, Down-szlndróma, Kknefelter-szindréma, lepra, Perthes-kór, serdülö-keri idiopathfas scoliosis, csecsemőkorban föllépő multi-system gyulladásos betegség, Wfnöhestet-szindréma, yenkes-szlndrorna, \yï\mn~kùî, ischemieus esöotbetegség (így Legg-Calve-Pednes-szlndrôma, regionális osgratobus osteoporosis), anémiés állapotok, szferoldok állat okozott állapotok, glükokorhkoid által kiváltott csontveszfeség, heparin áltat kiváltott csontvesztesig, csontvelő rendellenességek, skorátrt hiányos tápláltság, kaloiumhlány, Miopathiás osteopenia vagy osteoporosis, eoogenitaiis osteopenia vagy osteoporosis, alkoholizmus, krónikus májbetegség, posztmenopauzálls áh lapot, krónikus gyulladásos átlapolok, rheumatoid: arthritis, gyulladásos bélbetegség, uiceratlv colitis, gyulladásos coliás, Crohn-betegség, oligomenorrhea, amenorrhea, terhesség., diabetes mellitus, hyperthyroïdismes, pajzarnirlgy rendellenességek, mellékpajzsmirigy rendellenességek, Cmshing-kér, skromegâfe, hypogonsdismus., immobilizáció vagy mozgáshiány, rsflex-sympstheticns dystrophia szindróma, regionális osteoporosis, osteomalacia, izűieípotlással kapcsolatos esontveszteség, HlV-vel kap-csolâtos cscnivesateség:, növekedési hormon veszteséggel kapcsolatos osontvesztés, oisztás ílbíöztssal társult csontvesztés, JatM-liehtensteln-szindrdma, kemoterápiával kapcsolatos osohtvosztés, tumor indukált csonlvesztés, rákkal kapcsolatos esontvesz-tőség, hormon abiatlv csontveszteség, multiple myeloma, drug által kiváltott csontveszte» ség, anorexia nervosa, facialis csontvesztéssel társult betegség, koponyacsoot vesztéssel társult betegség, az állkapocs osontvesztésével társult betegség, a koponya cső elvesztésével társult betegség vagy űrutazással kapcsolatos csontvesztés kezeié» seben való alkalmazásra.
  8. 14, Az 1 » 11 Igénypontok bármelyike szerinti monoklonáiis antitest ortopéd beavatkozásokban, fogászati beavatkozásokban, sebészeti impiantálásban, ízület pótlásnál, csonibeultetésnél, osont kozmetikai sebészetben vagy csonlheiyreállltásnál, például térés gyógyításánál, ósszeforrás hiánya miatti kezelésnél, késlekedő összefér-rás miatti kezelésnél vagy arcrekonstrukciónál az eredmények javításában való alkalmazásra.
  9. 16. Gyógyszerészeti kompozíció, amely magában foglal egy antitestet és egy gyogyszerészeflieg elfogadható hordozót segédanyagot vagy hígítót, ahol az anth test égy monoklonáls antitest, amely (a) humán szkierosztinhoz 1 x 10 ,v M-nál kisebb vagy azzal egyenlő kötési aktivitással kötődik, és (b) kereszi-blokkolja az Ab-13 vagy Ab-14 antitest szkieroszinhoz való kötődését, és/vagy szkierosztinhoz való kötődése Ab-13 vagy AM4 antitest által kereszt-blokkolédik, ahol az Ab -13 antitest SEG ID NO: 20S 7;; jSí -í/;íAS szekvenciája könnyű láncokkal és SEQ ID NO: 209 szekvenciáié neééz láncokkal rendelkezik, és az Ab-14 antitest SEQ ID NO: 213 szekvenctájy könnyű láncokkal és SEQ ID NO: 217 vagy 303 szekvenciáié nehéz láncokkal rendelkezik, és ahol a gyógyszerészeti kompozíció egy emlősben a csontkápzckiés, csent ásványi anyag sűrűség, csont ásványi anyag tartalom, csonttömeg. osontnNnöség és csontsziláröség legalább egyikének növelésére szolgáló eljárásban és ezáltal egy olyan állapot kezelésében való alkalmazásra szolgál, amelyben a csontképzodés, csont ásványi anyag sűrűség, csont ásványi anyag tartalom, csonttömeg, csontmlnöség és csóotszilárd-sag legalább egyikének növelése kívánatos.
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