US6024090A
(en)
*
|
1993-01-29 |
2000-02-15 |
Aradigm Corporation |
Method of treating a diabetic patient by aerosolized administration of insulin lispro
|
EP1607086A1
(en)
*
|
1993-01-29 |
2005-12-21 |
Aradigm Corporation |
Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
|
US5888477A
(en)
*
|
1993-01-29 |
1999-03-30 |
Aradigm Corporation |
Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin
|
US6131567A
(en)
*
|
1993-01-29 |
2000-10-17 |
Aradigm Corporation |
Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin
|
DK72793D0
(da)
*
|
1993-06-21 |
1993-06-21 |
Novo Nordisk As |
Nyt produkt
|
US5461031A
(en)
*
|
1994-06-16 |
1995-10-24 |
Eli Lilly And Company |
Monomeric insulin analog formulations
|
US5547929A
(en)
*
|
1994-09-12 |
1996-08-20 |
Eli Lilly And Company |
Insulin analog formulations
|
YU18596A
(sh)
*
|
1995-03-31 |
1998-07-10 |
Eli Lilly And Company |
Analogne formulacije monomernog insulina
|
US6274549B1
(en)
*
|
1995-06-30 |
2001-08-14 |
Novo Nordisk A/S |
Treatment of type 1 diabetes
|
ATE208208T1
(de)
*
|
1996-06-20 |
2001-11-15 |
Novo Nordisk As |
Halogenid-enthaltende insulinzubereitungen
|
US5898067A
(en)
*
|
1997-02-07 |
1999-04-27 |
Novo Nordisk A/S |
Crystallization of proteins
|
AU5749198A
(en)
*
|
1997-02-07 |
1998-08-26 |
Novo Nordisk A/S |
Crystallisation of proteins
|
ZA984697B
(en)
*
|
1997-06-13 |
1999-12-01 |
Lilly Co Eli |
Stable insulin formulations.
|
EP1283051B1
(en)
*
|
1997-06-13 |
2006-06-14 |
Eli Lilly And Company |
Stable insulin formulations
|
EP1039920A4
(en)
*
|
1997-10-24 |
2003-05-28 |
Lilly Co Eli |
INSULIN ANALOGS ACYLATED BY FATTY ACID
|
US6531448B1
(en)
|
1997-12-23 |
2003-03-11 |
Eli Lilly And Company |
Insoluble compositions for controlling blood glucose
|
US20010053761A1
(en)
*
|
1998-01-08 |
2001-12-20 |
Dimarchi Richard Dennis |
Method for administering aspb28-human insulin
|
US20040214747A1
(en)
*
|
1999-01-06 |
2004-10-28 |
Dimarchi Richard Dennis |
Method for administering monomeric insulin
|
US6624141B1
(en)
|
1999-03-17 |
2003-09-23 |
The Regents Of The University Of Michigan |
Protamine fragment compositions and methods of use
|
US7169889B1
(en)
|
1999-06-19 |
2007-01-30 |
Biocon Limited |
Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
|
US7678364B2
(en)
|
1999-08-25 |
2010-03-16 |
Alkermes, Inc. |
Particles for inhalation having sustained release properties
|
KR20030005204A
(ko)
*
|
2000-12-25 |
2003-01-17 |
가부시키가이샤 시세이도 |
교감신경 활성화 향료 조성물
|
HUP0500733A3
(en)
*
|
2001-02-09 |
2010-01-28 |
Genentech Inc |
Crystallization of igf-1
|
US7060675B2
(en)
|
2001-02-15 |
2006-06-13 |
Nobex Corporation |
Methods of treating diabetes mellitus
|
US6867183B2
(en)
|
2001-02-15 |
2005-03-15 |
Nobex Corporation |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
US7713932B2
(en)
|
2001-06-04 |
2010-05-11 |
Biocon Limited |
Calcitonin drug-oligomer conjugates, and uses thereof
|
US6835802B2
(en)
*
|
2001-06-04 |
2004-12-28 |
Nobex Corporation |
Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
|
US6828305B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
US6858580B2
(en)
*
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
US6828297B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
US6713452B2
(en)
*
|
2001-06-04 |
2004-03-30 |
Nobex Corporation |
Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
MXPA04001560A
(es)
*
|
2001-08-28 |
2004-05-17 |
Lilly Co Eli |
Premezclas de glp-1 e insulina basal.
|
US7196059B2
(en)
|
2001-09-07 |
2007-03-27 |
Biocon Limited |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
US6913903B2
(en)
|
2001-09-07 |
2005-07-05 |
Nobex Corporation |
Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
US7166571B2
(en)
|
2001-09-07 |
2007-01-23 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
US7312192B2
(en)
|
2001-09-07 |
2007-12-25 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
US6770625B2
(en)
|
2001-09-07 |
2004-08-03 |
Nobex Corporation |
Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
|
US7030082B2
(en)
*
|
2001-09-07 |
2006-04-18 |
Nobex Corporation |
Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
|
US20030068361A1
(en)
*
|
2001-10-09 |
2003-04-10 |
Rimona Margalit |
Liposome-encapsulated insulin formulations
|
US7179788B2
(en)
*
|
2001-10-19 |
2007-02-20 |
Eli Lilly And Company |
Biphasic mixtures of GLP-1 and insulin
|
AU2002346491A1
(en)
*
|
2001-12-19 |
2003-07-09 |
Eli Lilly And Company |
Crystalline compositions for controlling blood glucose
|
AU2003236521A1
(en)
*
|
2002-06-13 |
2003-12-31 |
Nobex Corporation |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
|
US20060258561A1
(en)
*
|
2003-03-13 |
2006-11-16 |
Novo Nordisk A/S |
Novel NPH insulin preparations
|
AU2004247762B2
(en)
|
2003-06-17 |
2010-05-27 |
Sembiosys Genetics Inc. |
Methods for the production of insulin in plants
|
US20050054818A1
(en)
*
|
2003-07-02 |
2005-03-10 |
Brader Mark Laurence |
Crystalline compositions for controlling blood glucose
|
ES2328579T3
(es)
*
|
2003-07-25 |
2009-11-16 |
Conjuchem Biotechnologies Inc. |
Derivados de insulina de larga duracion y procedimientos asociados.
|
AU2005209199B2
(en)
*
|
2004-01-16 |
2008-09-11 |
Biodel Inc. |
Sublingual drug delivery device
|
US20080096800A1
(en)
*
|
2004-03-12 |
2008-04-24 |
Biodel, Inc. |
Rapid mucosal gel or film insulin compositions
|
US20080090753A1
(en)
|
2004-03-12 |
2008-04-17 |
Biodel, Inc. |
Rapid Acting Injectable Insulin Compositions
|
PL1740154T3
(pl)
*
|
2004-03-12 |
2009-11-30 |
Biodel Inc |
Kompozycje insuliny o ulepszonym wchłanianiu
|
US20080248999A1
(en)
*
|
2007-04-04 |
2008-10-09 |
Biodel Inc. |
Amylin formulations
|
US20080085298A1
(en)
*
|
2004-03-12 |
2008-04-10 |
Biodel, Inc. |
Rapid Mucosal Gel or Film Insulin Compositions
|
CA2580313C
(en)
|
2004-07-19 |
2016-03-15 |
Biocon Limited |
Insulin-oligomer conjugates, formulations and uses thereof
|
EP1789074A4
(en)
*
|
2004-08-09 |
2009-08-12 |
Alios Biopharma Inc |
PROTEASE-RESISTANT HYPERGLYCOSYL SYNTHETIC POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME
|
US7597884B2
(en)
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
EP2926828B1
(en)
*
|
2004-10-05 |
2019-12-11 |
Novo Nordisk A/S |
A pharmaceutical formulation
|
JP4874989B2
(ja)
|
2004-11-22 |
2012-02-15 |
ノヴォ ノルディスク アー/エス |
可溶性で安定なインスリン含有調合物
|
US7833513B2
(en)
|
2004-12-03 |
2010-11-16 |
Rhode Island Hospital |
Treatment of Alzheimer's Disease
|
US8084420B2
(en)
*
|
2005-09-29 |
2011-12-27 |
Biodel Inc. |
Rapid acting and long acting insulin combination formulations
|
US7713929B2
(en)
*
|
2006-04-12 |
2010-05-11 |
Biodel Inc. |
Rapid acting and long acting insulin combination formulations
|
CN100371346C
(zh)
*
|
2005-12-14 |
2008-02-27 |
浙江大学 |
人工合成胰岛素模拟肽及其应用
|
ATE482977T1
(de)
*
|
2006-02-27 |
2010-10-15 |
Novo Nordisk As |
Insulinderivate
|
WO2007121318A2
(en)
|
2006-04-12 |
2007-10-25 |
Emisphere Technologies, Inc. |
Formulations for delivering insulin
|
MX2008013165A
(es)
*
|
2006-04-12 |
2009-01-29 |
Biodel Inc |
Formulaciones de combinacion de insulina de accion rapida y accion larga.
|
CN101062948B
(zh)
*
|
2006-04-29 |
2010-05-12 |
上海生物泰生命科学研究有限公司 |
单体速效胰岛素及其制法和用途
|
US20080260820A1
(en)
*
|
2007-04-19 |
2008-10-23 |
Gilles Borrelly |
Oral dosage formulations of protease-resistant polypeptides
|
BRPI0818004B8
(pt)
|
2007-10-16 |
2021-05-25 |
Biocon Ltd |
composição farmacêutica sólida administrável por via oral e o processo da mesma.
|
AU2009204309B2
(en)
*
|
2008-01-04 |
2012-11-22 |
Biodel, Inc. |
Insulin formulations for insulin release as a function of tissue glucose levels
|
ES2477552T3
(es)
|
2008-09-08 |
2014-07-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos
|
EP2349279A4
(en)
|
2008-10-28 |
2013-12-25 |
Univ Leland Stanford Junior |
ALDEHYDE DEHYDROGENASE MODULATORS AND METHOD OF USE THEREOF
|
SG173112A1
(en)
|
2009-01-28 |
2011-08-29 |
Smartcells Inc |
Conjugate based systems for controlled drug delivery
|
CA2750252A1
(en)
|
2009-01-28 |
2010-08-05 |
Smartcells, Inc. |
Synthetic conjugates and uses thereof
|
US20110293562A1
(en)
|
2009-02-12 |
2011-12-01 |
Proyecto De Biomedicina Cima, S.L. |
Use of cardiotrophin-1 for the treatment of metabolic diseases
|
US9060927B2
(en)
*
|
2009-03-03 |
2015-06-23 |
Biodel Inc. |
Insulin formulations for rapid uptake
|
AU2010226243A1
(en)
|
2009-03-20 |
2011-09-22 |
Smartcells, Inc. |
Terminally-functionalized conjugates and uses thereof
|
HUP0900482A2
(en)
*
|
2009-08-03 |
2011-03-28 |
Cera Med Kft |
Pharmaceutical formulation for oral administration
|
AU2011282988A1
(en)
|
2010-07-28 |
2013-01-31 |
Smartcells, Inc. |
Recombinantly expressed insulin polypeptides and uses thereof
|
KR20140015266A
(ko)
*
|
2010-11-24 |
2014-02-06 |
듀렉트 코퍼레이션 |
생분해성 약물 전달 조성물
|
UY33872A
(es)
|
2011-01-20 |
2012-08-31 |
Zealand Pharma As |
Uso de análogos de glucagón acilados
|
US10457659B2
(en)
|
2011-04-29 |
2019-10-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for increasing proliferation of adult salivary stem cells
|
CA2890048C
(en)
|
2012-12-03 |
2022-05-03 |
Merck Sharp & Dohme Corp. |
O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues
|
CN105358531B
(zh)
|
2013-03-14 |
2017-11-14 |
利兰-斯坦福大学初级学院的董事会 |
线粒体醛脱氢酶‑2调节剂和其使用方法
|
BR112016007176A2
(pt)
|
2013-10-04 |
2018-01-23 |
Merck Sharp & Dohme |
conjugado, composição, usos de um conjugado e de uma composição, e, método para tratar um indivíduo que tem diabete
|
JP6564369B2
(ja)
|
2013-12-09 |
2019-08-21 |
デュレクト コーポレイション |
薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
|
WO2015104311A1
(en)
*
|
2014-01-09 |
2015-07-16 |
Sanofi |
Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
|
CN106102763A
(zh)
|
2014-01-13 |
2016-11-09 |
塞尔玛琳糖尿病有限责任公司 |
速效胰岛素制剂和药物递送系统
|
AR099569A1
(es)
|
2014-02-28 |
2016-08-03 |
Novo Nordisk As |
Derivados de insulina y los usos médicos de estos
|
EP3006045B3
(en)
|
2014-10-07 |
2021-03-17 |
Cyprumed GmbH |
Pharmaceutical formulations for the oral delivery of peptide or protein drugs
|
WO2017163159A1
(en)
|
2016-03-21 |
2017-09-28 |
Wockhardt Limited |
Biphasic pharmaceutical composition of insulin human
|
TWI762706B
(zh)
|
2017-08-24 |
2022-05-01 |
丹麥商諾佛 儂迪克股份有限公司 |
Glp-1組成物及其用途
|
US11110063B2
(en)
|
2017-08-25 |
2021-09-07 |
MAIA Pharmaceuticals, Inc. |
Storage stable sincalide formulations
|
EP3740212A4
(en)
|
2017-12-18 |
2021-10-27 |
Merck Sharp & Dohme Corp. |
CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY
|
EP3727424A4
(en)
|
2017-12-18 |
2021-10-27 |
Merck Sharp & Dohme Corp. |
CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN RELEASE
|
CN110063932A
(zh)
*
|
2019-04-12 |
2019-07-30 |
浙江大学 |
一种多肽蛋白类药物的缓释组合物制剂及其制备方法
|
WO2021144476A1
(en)
|
2020-02-18 |
2021-07-22 |
Novo Nordisk A/S |
Pharmaceutical formulations
|
PE20230457A1
(es)
|
2020-03-31 |
2023-03-10 |
Protomer Tech Inc |
Conjugados para reactividad selectiva a dioles vecinales
|
EP4247429A1
(en)
|
2020-11-19 |
2023-09-27 |
Protomer Technologies Inc. |
Aromatic boron-containing compounds and insulin analogs
|
WO2023225534A1
(en)
|
2022-05-18 |
2023-11-23 |
Protomer Technologies Inc. |
Aromatic boron-containing compounds and related insulin analogs
|