HU9403553D0 - One pot process for producing 3-quinolone-carboxylic acid derivatives - Google Patents
One pot process for producing 3-quinolone-carboxylic acid derivativesInfo
- Publication number
- HU9403553D0 HU9403553D0 HU9403553A HU9403553A HU9403553D0 HU 9403553 D0 HU9403553 D0 HU 9403553D0 HU 9403553 A HU9403553 A HU 9403553A HU 9403553 A HU9403553 A HU 9403553A HU 9403553 D0 HU9403553 D0 HU 9403553D0
- Authority
- HU
- Hungary
- Prior art keywords
- acid derivatives
- quinolone
- producing
- pot process
- carboxylic acid
- Prior art date
Links
- UBIKHJZIEKPIBU-UHFFFAOYSA-N 3-oxo-2h-quinoline-2-carboxylic acid Chemical class C1=CC=CC2=CC(=O)C(C(=O)O)N=C21 UBIKHJZIEKPIBU-UHFFFAOYSA-N 0.000 title abstract 2
- 238000005580 one pot reaction Methods 0.000 title abstract 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 abstract 1
- SPFYMRJSYKOXGV-UHFFFAOYSA-N Baytril Chemical compound C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 SPFYMRJSYKOXGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 229960003405 ciprofloxacin Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960000740 enrofloxacin Drugs 0.000 abstract 1
- 229960001699 ofloxacin Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4342186A DE4342186A1 (de) | 1993-12-10 | 1993-12-10 | Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9403553D0 true HU9403553D0 (en) | 1995-02-28 |
| HUT72058A HUT72058A (en) | 1996-03-28 |
| HU220597B1 HU220597B1 (hu) | 2002-03-28 |
Family
ID=6504693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9403553A HU220597B1 (hu) | 1993-12-10 | 1994-12-09 | Egyedényes eljárás 3-kinolon-karbonsav-származékok előállítására |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US5639886A (hu) |
| EP (1) | EP0657448B1 (hu) |
| JP (1) | JP3963490B2 (hu) |
| KR (1) | KR950018008A (hu) |
| CN (1) | CN1109877A (hu) |
| AT (1) | ATE163645T1 (hu) |
| AU (1) | AU693818B2 (hu) |
| BG (1) | BG61947B1 (hu) |
| CA (1) | CA2137523C (hu) |
| CO (1) | CO4180607A1 (hu) |
| CZ (1) | CZ288078B6 (hu) |
| DE (2) | DE4342186A1 (hu) |
| DK (1) | DK0657448T3 (hu) |
| EE (1) | EE03215B1 (hu) |
| ES (1) | ES2113040T3 (hu) |
| FI (1) | FI945776A (hu) |
| GR (1) | GR3026383T3 (hu) |
| HR (1) | HRP940950B1 (hu) |
| HU (1) | HU220597B1 (hu) |
| IL (1) | IL111921A (hu) |
| LV (1) | LV11470B (hu) |
| MY (1) | MY113302A (hu) |
| NO (1) | NO307180B1 (hu) |
| NZ (1) | NZ270086A (hu) |
| PE (1) | PE33795A1 (hu) |
| PL (1) | PL180022B1 (hu) |
| RO (1) | RO113345B1 (hu) |
| RU (1) | RU2138483C1 (hu) |
| SI (1) | SI0657448T1 (hu) |
| SK (1) | SK279950B6 (hu) |
| SV (1) | SV1994000071A (hu) |
| TW (1) | TW401412B (hu) |
| UA (1) | UA41323C2 (hu) |
| YU (1) | YU48865B (hu) |
| ZA (1) | ZA949830B (hu) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19826050A1 (de) * | 1998-06-12 | 1999-12-16 | Bayer Ag | Verfahren zur Herstellung von Chinolon- und Naphthyridoncarbonsäuren und deren Ester |
| CA2400819A1 (en) * | 2000-02-25 | 2001-08-30 | Daiichi Pharmaceutical Co., Ltd. | Method for producing quinolonecarboxylic acids and intermediates thereof |
| US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
| DE10026903A1 (de) * | 2000-06-03 | 2002-01-10 | Cpc Cellular Process Chemistry | Verfahren zur Herstellung von Chinolon-3-carbonsäuren |
| US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
| US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| US6664267B1 (en) | 2002-05-28 | 2003-12-16 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
| KR100519158B1 (ko) * | 2002-12-21 | 2005-10-06 | 주식회사유한양행 | 퀴놀론 카르복실레이트 유도체의 제조방법 |
| KR20120030558A (ko) * | 2003-09-04 | 2012-03-28 | 욱크하트 리미티드 | 벤조퀴놀리진-2-카복실산 아르기닌 염 사수화물 |
| WO2005026145A2 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| CN100412075C (zh) * | 2004-06-22 | 2008-08-20 | 浙江医药股份有限公司新昌制药厂 | 左旋氧氟沙星和氧氟沙星的制备方法 |
| JP2010509305A (ja) | 2006-11-13 | 2010-03-25 | シプラ・リミテッド | モキシフロキサシン塩酸塩の合成方法 |
| EP1992626A1 (en) * | 2007-05-10 | 2008-11-19 | Sandoz AG | Process for the preparation of moxifloxacin hydrochloride |
| FR2916446B1 (fr) * | 2007-05-24 | 2009-08-21 | Biocodex Sa | Nouveau procede de synthese de fluoroquinolones |
| EP2083010A1 (en) | 2008-01-08 | 2009-07-29 | Chemo Ibérica, S.A. | Polymorphic Forms of Moxifloxacin hydrochloride and processes for preparation thereof |
| CN101781299B (zh) * | 2010-01-13 | 2012-06-27 | 杭州师范大学 | 一种喹诺酮类药物关键中间体的一锅法合成方法 |
| IT1398952B1 (it) * | 2010-03-19 | 2013-03-28 | F S I Fabbrica Italiana Sint | Processo di preparazione della moxifloxacina e suoi sali |
| CN102675306A (zh) * | 2011-03-17 | 2012-09-19 | 苏州中科天马肽工程中心有限公司 | 一种莫西沙星或其盐的制备方法 |
| CN102267994B (zh) * | 2011-06-17 | 2013-01-30 | 江苏正大丰海制药有限公司 | 一种盐酸莫西沙星已知杂质的制备方法 |
| WO2013157018A1 (en) | 2012-04-18 | 2013-10-24 | Indian Institute Of Technology Madras | A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics |
| US9388178B2 (en) | 2012-12-04 | 2016-07-12 | Mankind Research Centre | Process for the preparation of moxifloxacin hydrochloride |
| UA106556C2 (uk) * | 2013-05-13 | 2014-09-10 | Наталья Николаевна Деркач | СПОСІБ ОДЕРЖАННЯ (1-ЦИКЛОПРОПІЛ-6-ФТОР-1,4-ДИГІДРО-8-МЕТОКСІ-7-[(4aS,7aS)-ОКТАГІДРО-6Н-ПІРОЛО[3,4-b]-4-ОКСО-3-ХІНОЛІНКАРБОНОВОЇ КИСЛОТИ |
| EP3638648A4 (en) * | 2017-06-12 | 2021-02-17 | Virginia Commonwealth University | STREAMLINED SYNTHESES OF FLUORCHINOLONES |
| CN115385856A (zh) * | 2022-09-05 | 2022-11-25 | 常州大学 | 一锅法合成诺氟沙星中间体的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3420743A1 (de) | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| US5468861A (en) * | 1984-06-04 | 1995-11-21 | Bayer Aktiengesellschaft | 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof |
| JPS62215572A (ja) * | 1986-03-17 | 1987-09-22 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
| JPS63179856A (ja) | 1987-01-21 | 1988-07-23 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体の製造方法並びにその中間体 |
| DE3724466A1 (de) | 1987-07-24 | 1989-02-02 | Bayer Ag | Verfahren zur herstellung von chinoloncarbonsaeuren |
| US4780468A (en) * | 1987-08-07 | 1988-10-25 | Warner-Lambert Company | 8-trifluoromethyl quinolones as antibacterial agents |
| WO1989005643A1 (en) * | 1987-12-18 | 1989-06-29 | Pfizer Inc. | Heterocyclic-substituted quinoline-carboxylic acids |
| DE3906365A1 (de) | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| DE4208792A1 (de) | 1992-03-19 | 1993-09-23 | Bayer Ag | Enantiomerenreine chinolincarbonsaeure-derivate |
| DE4208789A1 (de) | 1992-03-19 | 1993-09-23 | Bayer Ag | Enantiomerenreine chinolincarbonsaeure-derivate |
| TW209865B (hu) * | 1992-01-10 | 1993-07-21 | Bayer Ag | |
| AU4272793A (en) * | 1993-04-24 | 1994-11-21 | Korea Research Institute Of Chemical Technology | Novel quinolone carboxylic acid derivatives and process for preparing the same |
| EP0713487B1 (en) * | 1993-08-13 | 2000-04-19 | Dong Wha Pharmaceutical Industrial Co. Ltd. | Novel quinolone carboxylic acid derivatives |
-
1993
- 1993-12-10 DE DE4342186A patent/DE4342186A1/de not_active Withdrawn
-
1994
- 1994-11-18 EE EE9400332A patent/EE03215B1/xx not_active IP Right Cessation
- 1994-11-21 TW TW083110792A patent/TW401412B/zh not_active IP Right Cessation
- 1994-11-23 HR HRP4342186.5A patent/HRP940950B1/xx not_active IP Right Cessation
- 1994-11-28 SI SI9430120T patent/SI0657448T1/xx unknown
- 1994-11-28 CO CO94054149A patent/CO4180607A1/es unknown
- 1994-11-28 AT AT94118676T patent/ATE163645T1/de not_active IP Right Cessation
- 1994-11-28 ES ES94118676T patent/ES2113040T3/es not_active Expired - Lifetime
- 1994-11-28 DE DE59405376T patent/DE59405376D1/de not_active Expired - Lifetime
- 1994-11-28 DK DK94118676T patent/DK0657448T3/da active
- 1994-11-28 EP EP94118676A patent/EP0657448B1/de not_active Expired - Lifetime
- 1994-12-02 US US08/348,400 patent/US5639886A/en not_active Expired - Lifetime
- 1994-12-05 JP JP32920694A patent/JP3963490B2/ja not_active Expired - Lifetime
- 1994-12-06 RO RO94-01949A patent/RO113345B1/ro unknown
- 1994-12-06 AU AU80244/94A patent/AU693818B2/en not_active Ceased
- 1994-12-07 CA CA002137523A patent/CA2137523C/en not_active Expired - Lifetime
- 1994-12-07 NZ NZ270086A patent/NZ270086A/en unknown
- 1994-12-07 PE PE1994256625A patent/PE33795A1/es not_active Application Discontinuation
- 1994-12-07 SK SK1514-94A patent/SK279950B6/sk unknown
- 1994-12-07 IL IL11192194A patent/IL111921A/xx not_active IP Right Cessation
- 1994-12-08 FI FI945776A patent/FI945776A/fi unknown
- 1994-12-08 YU YU71694A patent/YU48865B/sh unknown
- 1994-12-08 SV SV1994000071A patent/SV1994000071A/es not_active Application Discontinuation
- 1994-12-08 BG BG99248A patent/BG61947B1/bg unknown
- 1994-12-09 PL PL94306198A patent/PL180022B1/pl unknown
- 1994-12-09 KR KR1019940033433A patent/KR950018008A/ko not_active Application Discontinuation
- 1994-12-09 UA UA94129157A patent/UA41323C2/uk unknown
- 1994-12-09 HU HU9403553A patent/HU220597B1/hu not_active IP Right Cessation
- 1994-12-09 RU RU94043645A patent/RU2138483C1/ru active
- 1994-12-09 ZA ZA949830A patent/ZA949830B/xx unknown
- 1994-12-09 LV LVP-94-241A patent/LV11470B/lv unknown
- 1994-12-09 NO NO944786A patent/NO307180B1/no not_active IP Right Cessation
- 1994-12-09 MY MYPI94003290A patent/MY113302A/en unknown
- 1994-12-09 CN CN94112890A patent/CN1109877A/zh active Pending
- 1994-12-09 CZ CZ19943105A patent/CZ288078B6/cs not_active IP Right Cessation
-
1998
- 1998-03-17 GR GR980400579T patent/GR3026383T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HU9403553D0 (en) | One pot process for producing 3-quinolone-carboxylic acid derivatives | |
| AU637086B2 (en) | Use of 5-methyltetrahydrofolic acid, 5-formyltetrahydrofolic acid and their pharmaceutically acceptable salts in the preparation of pharmaceutical compositions in controlled- release form active in the therapy of organic mental disturbances, and the relative pharmaceutical compositions | |
| HUT64310A (en) | Compositions containing substituted aryl-halogenalkyl-pyrazol derivatives having herbicidal activity and process for producing said compounds | |
| AU7651191A (en) | Pyridazinone derivative | |
| HUT62893A (en) | Process for producing substituted pyrimidine derivatives and pharmaceutical compositions comprising such compounds as active ingredient | |
| ES8603870A1 (es) | Un procedimiento para la preparacion de derivados de 2,2'-iminobisetanol. | |
| EP0807633A3 (en) | Novel 2,3-disubstituted-(5,6)- heteroarylfused-pyrimidine-4-ones | |
| HU910930D0 (en) | Process for the production of 2,8-dioxa-bicyclo/3.2.1/octane derivatives and medical preparations containing them | |
| PL301576A1 (en) | Novel hiv protease inhibitors, method of obtaining such inhibitors, pharmaceutical preparation and novel initial compounds | |
| HU908413D0 (en) | Process for the production of pyridazine-amine derivatives and medical preparations containing such compounds | |
| GR3022604T3 (en) | Inhibitors of hiv protease useful for the treatment of aids. | |
| NZ232207A (en) | Dihydrobenz(c)acridine derivatives and pharmaceutical compositions | |
| EP0381114A3 (en) | Exo-3',4'-0-benzylidene-3"-demethylchartreusin and its salts | |
| AU6791690A (en) | Isomers of 1-azabicyclo(2.2.2)oct-3-yl 1,4-dihydro-2,6- dimethyl-4-(3-nitrophenyl)-5-nitropyridine-3-carboyxylate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HMM4 | Cancellation of final prot. due to non-payment of fee |