HU231414B1 - Tiadiazin származékok - Google Patents
Tiadiazin származékok Download PDFInfo
- Publication number
- HU231414B1 HU231414B1 HUP1800249A HUP1800249A HU231414B1 HU 231414 B1 HU231414 B1 HU 231414B1 HU P1800249 A HUP1800249 A HU P1800249A HU P1800249 A HUP1800249 A HU P1800249A HU 231414 B1 HU231414 B1 HU 231414B1
- Authority
- HU
- Hungary
- Prior art keywords
- disorders
- disorder
- dioxo
- trifluoromethyl
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP1800249A HU231414B1 (hu) | 2018-07-13 | 2018-07-13 | Tiadiazin származékok |
| TW108122604A TWI827628B (zh) | 2018-07-13 | 2019-06-27 | 噻二（ｔｈｉａｄｉａｚｉｎｅ）衍生物 |
| GEAP201915558A GEP20237459B (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
| IL279939A IL279939B2 (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
| SG11202012769QA SG11202012769QA (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
| ARP190101992A AR115783A1 (es) | 2018-07-13 | 2019-07-12 | DERIVADOS DE TIADIAZINAS, UN MÉTODO PARA SU PREPARACIÓN, COMPOSICIÓN Y COMBINACIÓN FARMACÉUTICA QUE LOS COMPRENDEN Y EL USO DE LOS MISMOS EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS AL RECEPTOR NICOTÍNICO DE ACETILCOLINA a7 |
| CA3104264A CA3104264A1 (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
| JP2021500540A JP7440486B2 (ja) | 2018-07-13 | 2019-07-12 | チアジアジン誘導体 |
| US17/259,975 US12194050B2 (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
| BR112020027016-4A BR112020027016A2 (pt) | 2018-07-13 | 2019-07-12 | Composto, uso de composto, método para tratamento ou prevenção de um transtorno associado à atividade de receptor nicotínico a7 de acetilcolina, composição farmacêutica, combinação, e, processo para a fabricação de compostos |
| CU2020000109A CU24622B1 (es) | 2018-07-13 | 2019-07-12 | Derivados de tiadiazina como moduladores del receptor nicotínico de acetilcolina alfa7 |
| MX2021000461A MX2021000461A (es) | 2018-07-13 | 2019-07-12 | Derivados de tiadiazina. |
| MYPI2020006712A MY207757A (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
| CN201980046660.4A CN112424198A (zh) | 2018-07-13 | 2019-07-12 | 噻二嗪衍生物 |
| PCT/IB2019/055949 WO2020012423A1 (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
| PE2021000052A PE20210465A1 (es) | 2018-07-13 | 2019-07-12 | Derivados de tiadiazina |
| EP19744869.9A EP3820865A1 (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
| KR1020217004286A KR20210033003A (ko) | 2018-07-13 | 2019-07-12 | 티아디아진 유도체 |
| EA202190246A EA202190246A1 (ru) | 2018-07-13 | 2019-07-12 | Производные тиадиазина |
| GEAP202215558A GEAP202215558A (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
| AU2019300515A AU2019300515B2 (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
| PH12021550007A PH12021550007A1 (en) | 2018-07-13 | 2021-01-04 | Thiadiazine derivatives |
| CL2021000081A CL2021000081A1 (es) | 2018-07-13 | 2021-01-12 | Derivados de tiadiazina |
| CONC2021/0001224A CO2021001224A2 (es) | 2018-07-13 | 2021-02-03 | Derivados de tiadiazina |
| JP2024020524A JP2024056879A (ja) | 2018-07-13 | 2024-02-14 | チアジアジン誘導体 |
| US18/947,529 US20250064823A1 (en) | 2018-07-13 | 2024-11-14 | Thiadiazine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP1800249A HU231414B1 (hu) | 2018-07-13 | 2018-07-13 | Tiadiazin származékok |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP1800249A2 HUP1800249A2 (en) | 2020-01-28 |
| HU231414B1 true HU231414B1 (hu) | 2023-08-28 |
Family
ID=89992726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUP1800249A HU231414B1 (hu) | 2018-07-13 | 2018-07-13 | Tiadiazin származékok |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US12194050B2 (https=) |
| EP (1) | EP3820865A1 (https=) |
| JP (2) | JP7440486B2 (https=) |
| KR (1) | KR20210033003A (https=) |
| CN (1) | CN112424198A (https=) |
| AR (1) | AR115783A1 (https=) |
| AU (1) | AU2019300515B2 (https=) |
| BR (1) | BR112020027016A2 (https=) |
| CA (1) | CA3104264A1 (https=) |
| CL (1) | CL2021000081A1 (https=) |
| CO (1) | CO2021001224A2 (https=) |
| CU (1) | CU24622B1 (https=) |
| EA (1) | EA202190246A1 (https=) |
| GE (2) | GEAP202215558A (https=) |
| HU (1) | HU231414B1 (https=) |
| IL (1) | IL279939B2 (https=) |
| MX (1) | MX2021000461A (https=) |
| MY (1) | MY207757A (https=) |
| PE (1) | PE20210465A1 (https=) |
| PH (1) | PH12021550007A1 (https=) |
| SG (1) | SG11202012769QA (https=) |
| TW (1) | TWI827628B (https=) |
| WO (1) | WO2020012423A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4103191A4 (en) * | 2020-02-14 | 2024-03-06 | University of Pittsburgh - of the Commonwealth System of Higher Education | HEAT SHOCK PROTEIN MODULATORS AND THERAPEUTIC AGENTS FOR HUNTINGTON'S DISEASE |
| TWI901650B (zh) | 2020-03-26 | 2025-10-21 | 匈牙利商羅特格登公司 | 啶及吡啶并〔３，４－ｃ〕嗒衍生物 |
| CN111454232B (zh) * | 2020-05-30 | 2021-11-23 | 南方医科大学 | 一种1,3,4-噻二嗪类化合物及其应用 |
| HU231691B1 (hu) | 2021-09-29 | 2025-10-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006016548A1 (ja) | 2004-08-09 | 2006-02-16 | Eisai R & D Management Co., Ltd. | ヘテロ環化合物を含有する新規な抗マラリア剤 |
| NZ566036A (en) | 2005-09-13 | 2010-06-25 | Janssen Pharmaceutica Nv | 2-Aniline-4-aryl substituted thiazole derivatives that modulate the alpha7 nicotinic receptor |
| ES2274729B1 (es) | 2005-11-11 | 2008-06-01 | Consejo Superior Investig. Cientificas | Derivados de 5-carboxilato y 5-carboxamida 2-sustituidos de 1,1-dioxo-1,2,6-tiadiazina con propiedades cannabinoides. |
| US20100298314A1 (en) | 2006-12-20 | 2010-11-25 | Schering Corporation | Novel jnk inhibitors |
| MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
| MX2010003156A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de aril amida substituida con tetrazol y usos de los mismos. |
| KR20100124272A (ko) | 2008-02-07 | 2010-11-26 | 아보트 러보러터리즈 | 양성 알로스테릭 조절제로서의 아미드 유도체 및 이의 사용방법 |
| AR070936A1 (es) | 2008-03-19 | 2010-05-12 | Janssen Pharmaceutica Nv | 1,2,4 -triazoles trisustituidos |
| EP2110377A1 (en) | 2008-04-15 | 2009-10-21 | DAC S.r.l. | Spirocyclic derivatives as histone deacetylase inhibitors |
| WO2009127678A1 (en) | 2008-04-17 | 2009-10-22 | Glaxo Group Limited | Indoles as modulators of nicotinic acetylcholin receptor subtype alpha-71 |
| JP5486591B2 (ja) | 2008-05-09 | 2014-05-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | アセチルコリン受容体モジュレーターとしての三置換ピラゾール |
| CA2725940A1 (en) | 2008-05-30 | 2009-12-23 | Merck Sharp & Dohme Corp. | Novel substituted azabenzoxazoles |
| EP2488520B1 (en) * | 2009-10-13 | 2015-09-02 | Merck Sharp & Dohme B.V. | Condensed azine-derivatives for the treatment of diseases related to the acetylcholine receptor |
| EP3795573B1 (en) | 2009-12-31 | 2022-07-06 | Hutchison Medipharma Limited | Certain triazolopyrazines, compositions thereof and methods of use therefor |
| WO2012042915A1 (en) | 2010-10-01 | 2012-04-05 | Raqualia Pharma Inc. | Sulfamoyl benzoic acid heterobicyclic derivatives as trpm8 antagonists |
| SG192078A1 (en) * | 2011-02-03 | 2013-08-30 | Lupin Ltd | Pyrrole derivatives used as modulators of alpha7 nachr |
| US9617210B2 (en) * | 2013-03-13 | 2017-04-11 | Lupin Limited | Pyrrole derivatives as alpha 7 NACHR modulators |
| AR107928A1 (es) * | 2016-03-22 | 2018-06-28 | Merck Sharp & Dohme | Moduladores alostéricos de receptores de acetilcolina nicotínicos |
| US10870630B2 (en) | 2016-11-01 | 2020-12-22 | Merck Sharp & Dohme Corp. | Substituted bicyclic heteroaryl allosteric modulators of nicotinic acetylcholine receptors |
| WO2018112204A1 (en) | 2016-12-14 | 2018-06-21 | Cephalon, Inc. | Spiropiperidine derivatives |
| SG11201908012SA (en) | 2017-03-02 | 2019-09-27 | Assembly Biosciences Inc | Cyclic sulfamide compounds and methods of using same |
| HU231333B1 (hu) | 2018-07-13 | 2023-01-28 | Richter Gedeon Nyrt | Spirokromán származékok |
-
2018
- 2018-07-13 HU HUP1800249A patent/HU231414B1/hu unknown
-
2019
- 2019-06-27 TW TW108122604A patent/TWI827628B/zh active
- 2019-07-12 US US17/259,975 patent/US12194050B2/en active Active
- 2019-07-12 CA CA3104264A patent/CA3104264A1/en active Pending
- 2019-07-12 WO PCT/IB2019/055949 patent/WO2020012423A1/en not_active Ceased
- 2019-07-12 CN CN201980046660.4A patent/CN112424198A/zh active Pending
- 2019-07-12 BR BR112020027016-4A patent/BR112020027016A2/pt unknown
- 2019-07-12 IL IL279939A patent/IL279939B2/en unknown
- 2019-07-12 SG SG11202012769QA patent/SG11202012769QA/en unknown
- 2019-07-12 AR ARP190101992A patent/AR115783A1/es unknown
- 2019-07-12 EP EP19744869.9A patent/EP3820865A1/en active Pending
- 2019-07-12 PE PE2021000052A patent/PE20210465A1/es unknown
- 2019-07-12 KR KR1020217004286A patent/KR20210033003A/ko not_active Ceased
- 2019-07-12 GE GEAP202215558A patent/GEAP202215558A/en unknown
- 2019-07-12 AU AU2019300515A patent/AU2019300515B2/en not_active Expired - Fee Related
- 2019-07-12 MX MX2021000461A patent/MX2021000461A/es unknown
- 2019-07-12 JP JP2021500540A patent/JP7440486B2/ja active Active
- 2019-07-12 CU CU2020000109A patent/CU24622B1/es unknown
- 2019-07-12 GE GEAP201915558A patent/GEP20237459B/en unknown
- 2019-07-12 EA EA202190246A patent/EA202190246A1/ru unknown
- 2019-07-12 MY MYPI2020006712A patent/MY207757A/en unknown
-
2021
- 2021-01-04 PH PH12021550007A patent/PH12021550007A1/en unknown
- 2021-01-12 CL CL2021000081A patent/CL2021000081A1/es unknown
- 2021-02-03 CO CONC2021/0001224A patent/CO2021001224A2/es unknown
-
2024
- 2024-02-14 JP JP2024020524A patent/JP2024056879A/ja not_active Withdrawn
- 2024-11-14 US US18/947,529 patent/US20250064823A1/en active Pending
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