CU24622B1 - Derivados de tiadiazina como moduladores del receptor nicotínico de acetilcolina alfa7 - Google Patents
Derivados de tiadiazina como moduladores del receptor nicotínico de acetilcolina alfa7Info
- Publication number
- CU24622B1 CU24622B1 CU2020000109A CU20200109A CU24622B1 CU 24622 B1 CU24622 B1 CU 24622B1 CU 2020000109 A CU2020000109 A CU 2020000109A CU 20200109 A CU20200109 A CU 20200109A CU 24622 B1 CU24622 B1 CU 24622B1
- Authority
- CU
- Cuba
- Prior art keywords
- modulators
- acetylcholine receptor
- nicotinic acetylcholine
- thiadiazine derivatives
- alpha7 nicotinic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP1800249A HU231414B1 (hu) | 2018-07-13 | 2018-07-13 | Tiadiazin származékok |
| PCT/IB2019/055949 WO2020012423A1 (en) | 2018-07-13 | 2019-07-12 | Thiadiazine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20200109A7 CU20200109A7 (es) | 2021-08-06 |
| CU24622B1 true CU24622B1 (es) | 2022-09-08 |
Family
ID=89992726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2020000109A CU24622B1 (es) | 2018-07-13 | 2019-07-12 | Derivados de tiadiazina como moduladores del receptor nicotínico de acetilcolina alfa7 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US12194050B2 (https=) |
| EP (1) | EP3820865A1 (https=) |
| JP (2) | JP7440486B2 (https=) |
| KR (1) | KR20210033003A (https=) |
| CN (1) | CN112424198A (https=) |
| AR (1) | AR115783A1 (https=) |
| AU (1) | AU2019300515B2 (https=) |
| BR (1) | BR112020027016A2 (https=) |
| CA (1) | CA3104264A1 (https=) |
| CL (1) | CL2021000081A1 (https=) |
| CO (1) | CO2021001224A2 (https=) |
| CU (1) | CU24622B1 (https=) |
| EA (1) | EA202190246A1 (https=) |
| GE (2) | GEAP202215558A (https=) |
| HU (1) | HU231414B1 (https=) |
| IL (1) | IL279939B2 (https=) |
| MX (1) | MX2021000461A (https=) |
| MY (1) | MY207757A (https=) |
| PE (1) | PE20210465A1 (https=) |
| PH (1) | PH12021550007A1 (https=) |
| SG (1) | SG11202012769QA (https=) |
| TW (1) | TWI827628B (https=) |
| WO (1) | WO2020012423A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4103191A4 (en) * | 2020-02-14 | 2024-03-06 | University of Pittsburgh - of the Commonwealth System of Higher Education | HEAT SHOCK PROTEIN MODULATORS AND THERAPEUTIC AGENTS FOR HUNTINGTON'S DISEASE |
| TWI901650B (zh) | 2020-03-26 | 2025-10-21 | 匈牙利商羅特格登公司 | 啶及吡啶并〔３，４－ｃ〕嗒衍生物 |
| CN111454232B (zh) * | 2020-05-30 | 2021-11-23 | 南方医科大学 | 一种1,3,4-噻二嗪类化合物及其应用 |
| HU231691B1 (hu) | 2021-09-29 | 2025-10-28 | Richter Gedeon Nyrt | GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006016548A1 (ja) | 2004-08-09 | 2006-02-16 | Eisai R & D Management Co., Ltd. | ヘテロ環化合物を含有する新規な抗マラリア剤 |
| NZ566036A (en) | 2005-09-13 | 2010-06-25 | Janssen Pharmaceutica Nv | 2-Aniline-4-aryl substituted thiazole derivatives that modulate the alpha7 nicotinic receptor |
| ES2274729B1 (es) | 2005-11-11 | 2008-06-01 | Consejo Superior Investig. Cientificas | Derivados de 5-carboxilato y 5-carboxamida 2-sustituidos de 1,1-dioxo-1,2,6-tiadiazina con propiedades cannabinoides. |
| US20100298314A1 (en) | 2006-12-20 | 2010-11-25 | Schering Corporation | Novel jnk inhibitors |
| MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
| MX2010003156A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de aril amida substituida con tetrazol y usos de los mismos. |
| KR20100124272A (ko) | 2008-02-07 | 2010-11-26 | 아보트 러보러터리즈 | 양성 알로스테릭 조절제로서의 아미드 유도체 및 이의 사용방법 |
| AR070936A1 (es) | 2008-03-19 | 2010-05-12 | Janssen Pharmaceutica Nv | 1,2,4 -triazoles trisustituidos |
| EP2110377A1 (en) | 2008-04-15 | 2009-10-21 | DAC S.r.l. | Spirocyclic derivatives as histone deacetylase inhibitors |
| WO2009127678A1 (en) | 2008-04-17 | 2009-10-22 | Glaxo Group Limited | Indoles as modulators of nicotinic acetylcholin receptor subtype alpha-71 |
| JP5486591B2 (ja) | 2008-05-09 | 2014-05-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | アセチルコリン受容体モジュレーターとしての三置換ピラゾール |
| CA2725940A1 (en) | 2008-05-30 | 2009-12-23 | Merck Sharp & Dohme Corp. | Novel substituted azabenzoxazoles |
| EP2488520B1 (en) * | 2009-10-13 | 2015-09-02 | Merck Sharp & Dohme B.V. | Condensed azine-derivatives for the treatment of diseases related to the acetylcholine receptor |
| EP3795573B1 (en) | 2009-12-31 | 2022-07-06 | Hutchison Medipharma Limited | Certain triazolopyrazines, compositions thereof and methods of use therefor |
| WO2012042915A1 (en) | 2010-10-01 | 2012-04-05 | Raqualia Pharma Inc. | Sulfamoyl benzoic acid heterobicyclic derivatives as trpm8 antagonists |
| SG192078A1 (en) * | 2011-02-03 | 2013-08-30 | Lupin Ltd | Pyrrole derivatives used as modulators of alpha7 nachr |
| US9617210B2 (en) * | 2013-03-13 | 2017-04-11 | Lupin Limited | Pyrrole derivatives as alpha 7 NACHR modulators |
| AR107928A1 (es) * | 2016-03-22 | 2018-06-28 | Merck Sharp & Dohme | Moduladores alostéricos de receptores de acetilcolina nicotínicos |
| US10870630B2 (en) | 2016-11-01 | 2020-12-22 | Merck Sharp & Dohme Corp. | Substituted bicyclic heteroaryl allosteric modulators of nicotinic acetylcholine receptors |
| WO2018112204A1 (en) | 2016-12-14 | 2018-06-21 | Cephalon, Inc. | Spiropiperidine derivatives |
| SG11201908012SA (en) | 2017-03-02 | 2019-09-27 | Assembly Biosciences Inc | Cyclic sulfamide compounds and methods of using same |
| HU231333B1 (hu) | 2018-07-13 | 2023-01-28 | Richter Gedeon Nyrt | Spirokromán származékok |
-
2018
- 2018-07-13 HU HUP1800249A patent/HU231414B1/hu unknown
-
2019
- 2019-06-27 TW TW108122604A patent/TWI827628B/zh active
- 2019-07-12 US US17/259,975 patent/US12194050B2/en active Active
- 2019-07-12 CA CA3104264A patent/CA3104264A1/en active Pending
- 2019-07-12 WO PCT/IB2019/055949 patent/WO2020012423A1/en not_active Ceased
- 2019-07-12 CN CN201980046660.4A patent/CN112424198A/zh active Pending
- 2019-07-12 BR BR112020027016-4A patent/BR112020027016A2/pt unknown
- 2019-07-12 IL IL279939A patent/IL279939B2/en unknown
- 2019-07-12 SG SG11202012769QA patent/SG11202012769QA/en unknown
- 2019-07-12 AR ARP190101992A patent/AR115783A1/es unknown
- 2019-07-12 EP EP19744869.9A patent/EP3820865A1/en active Pending
- 2019-07-12 PE PE2021000052A patent/PE20210465A1/es unknown
- 2019-07-12 KR KR1020217004286A patent/KR20210033003A/ko not_active Ceased
- 2019-07-12 GE GEAP202215558A patent/GEAP202215558A/en unknown
- 2019-07-12 AU AU2019300515A patent/AU2019300515B2/en not_active Expired - Fee Related
- 2019-07-12 MX MX2021000461A patent/MX2021000461A/es unknown
- 2019-07-12 JP JP2021500540A patent/JP7440486B2/ja active Active
- 2019-07-12 CU CU2020000109A patent/CU24622B1/es unknown
- 2019-07-12 GE GEAP201915558A patent/GEP20237459B/en unknown
- 2019-07-12 EA EA202190246A patent/EA202190246A1/ru unknown
- 2019-07-12 MY MYPI2020006712A patent/MY207757A/en unknown
-
2021
- 2021-01-04 PH PH12021550007A patent/PH12021550007A1/en unknown
- 2021-01-12 CL CL2021000081A patent/CL2021000081A1/es unknown
- 2021-02-03 CO CONC2021/0001224A patent/CO2021001224A2/es unknown
-
2024
- 2024-02-14 JP JP2024020524A patent/JP2024056879A/ja not_active Withdrawn
- 2024-11-14 US US18/947,529 patent/US20250064823A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CU24622B1 (es) | Derivados de tiadiazina como moduladores del receptor nicotínico de acetilcolina alfa7 | |
| CO2018007738A2 (es) | Derivados de tiohidantoína sustituidos como antagonistas del receptor de andrógenos | |
| TR201904340T4 (tr) | Yeni bileşikler. | |
| UY36251A (es) | Procedimiento para la preparación de (4s)- 4-(4-ciano-2-metoxifenilo)-5-toxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificación para su uso como principio activo farmacéutico | |
| CU24517B1 (es) | Derivados de carbonucleósidos sustituidos útiles como agentes antineoplásicos | |
| BR112017010893A2 (pt) | análogos de ácidos biliares como agonistas de fxr/tgr5 e métodos de uso dos mesmos | |
| BR112016009630A8 (pt) | receptores de farnesoide x, seus usos, composição farmacêutica, e combinação | |
| BR112016025423A2 (pt) | compostos e composições como agonistas de receptores do tipo toll 7 | |
| CU24605B1 (es) | Pirimidin-2-il amino-1h-pirazoles útiles como inhibidores de lrrk2 | |
| MX2019010446A (es) | Compuestos de anillos fusionados biciclicos derivados de piridilo como inhibidores de fgfr4. | |
| BR112017009657A2 (pt) | análogos de ácidos biliares como agonistas de fxr/tgr5 e métodos de uso dos mesmos | |
| ECSP13012612A (es) | Derivados de quinazolin-4-(3h)-ona utilizados como inhibidores de p13 cinasa | |
| EA201492023A1 (ru) | Регуляторы пути комплемента и их применение | |
| CU20200108A7 (es) | Derivados de espirocromano como moduladores del receptor de acetilcolina nicotínica alfa7 | |
| UY34778A (es) | ?COMPUESTOS DE HEXAHIDROPIRANO[3,4-d][1,3]TIAZIN-2-AMINA HETEROCÍCLICOS SUSTITUÍDOS?. | |
| UY35381A (es) | Pirrolotriazinas como inhibidores del canal del ion potasio | |
| UY36348A (es) | Derivados de benzotiofenilo sustituidos como agonistas del gpr40 para el tratamiento de la diabetes tipo ii | |
| BR112016002459A8 (pt) | Derivados de benzimidazolil-metil ureia como agonistas receptores de alx | |
| EA201591815A1 (ru) | Бицикло [2.2.2] кислоты - модуляторы gpr120 | |
| GEP20166444B (en) | Epoxyeicosatrienoic acid analogs and methods of making and using the same | |
| BR112017016817A2 (pt) | derivados heterocíclicos formilados como inibidores de fgfr4 | |
| UY34612A (es) | ?procedimiento para la preparación de derivados de isoxazolina azetidina quirales como agentes antiparasitarios?. | |
| MX387775B (es) | Derivado de 2-acilaminotiazol o sal del mismo. | |
| CR20150144A (es) | Derivados de etinilo como moduladores del receptor de actividad mglur5 | |
| NI201200195A (es) | Procedimiento de preparación de la sal de l - arginina de perindoprilo |