SG11202012769QA - Thiadiazine derivatives - Google Patents

Thiadiazine derivatives

Info

Publication number
SG11202012769QA
SG11202012769QA SG11202012769QA SG11202012769QA SG11202012769QA SG 11202012769Q A SG11202012769Q A SG 11202012769QA SG 11202012769Q A SG11202012769Q A SG 11202012769QA SG 11202012769Q A SG11202012769Q A SG 11202012769QA SG 11202012769Q A SG11202012769Q A SG 11202012769QA
Authority
SG
Singapore
Prior art keywords
thiadiazine derivatives
thiadiazine
derivatives
Prior art date
Application number
SG11202012769QA
Inventor
István Ledneczki
János Éles
Pál Tapolcsányi
Erszébet Jablonkai
Eszter Gábor
András Visegrádi
Zsolt Némethy
György István Lévay
József Levente Petro
György Selényi
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of SG11202012769QA publication Critical patent/SG11202012769QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15Six-membered rings
    • C07D285/16Thiadiazines; Hydrogenated thiadiazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11202012769QA 2018-07-13 2019-07-12 Thiadiazine derivatives SG11202012769QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP1800249A HU231414B1 (en) 2018-07-13 2018-07-13 Thiadiazine derivatives
PCT/IB2019/055949 WO2020012423A1 (en) 2018-07-13 2019-07-12 Thiadiazine derivatives

Publications (1)

Publication Number Publication Date
SG11202012769QA true SG11202012769QA (en) 2021-02-25

Family

ID=89992726

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202012769QA SG11202012769QA (en) 2018-07-13 2019-07-12 Thiadiazine derivatives

Country Status (22)

Country Link
US (1) US20210267993A1 (en)
EP (1) EP3820865A1 (en)
JP (2) JP7440486B2 (en)
KR (1) KR20210033003A (en)
CN (1) CN112424198A (en)
AR (1) AR115783A1 (en)
AU (1) AU2019300515A1 (en)
BR (1) BR112020027016A2 (en)
CA (1) CA3104264A1 (en)
CL (1) CL2021000081A1 (en)
CO (1) CO2021001224A2 (en)
CU (1) CU24622B1 (en)
EA (1) EA202190246A1 (en)
GE (1) GEP20237459B (en)
HU (1) HU231414B1 (en)
IL (1) IL279939A (en)
MX (1) MX2021000461A (en)
PE (1) PE20210465A1 (en)
PH (1) PH12021550007A1 (en)
SG (1) SG11202012769QA (en)
TW (1) TWI827628B (en)
WO (1) WO2020012423A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4103191A4 (en) * 2020-02-14 2024-03-06 Univ Pittsburgh Commonwealth Sys Higher Education Heat shock protein modulators and anti-huntington disease therapeutic agents
TW202202495A (en) 2020-03-26 2022-01-16 匈牙利商羅特格登公司 Naphthyridine and pyrido〔3,4-c〕pyridazine derivatives as gamma-aminobutyric acid a receptor subunit alpha 5 receptor modulators
CN111454232B (en) * 2020-05-30 2021-11-23 南方医科大学 1,3, 4-thiadiazine compound and application thereof
HUP2100338A1 (en) 2021-09-29 2023-04-28 Richter Gedeon Nyrt Bicyclic amine derivatives as gabaa alfa5 receptor modulators

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ566036A (en) 2005-09-13 2010-06-25 Janssen Pharmaceutica Nv 2-Aniline-4-aryl substituted thiazole derivatives that modulate the alpha7 nicotinic receptor
MX2010003156A (en) 2007-10-04 2010-04-01 Hoffmann La Roche Tetrazole-substituted aryl amide derivatives and uses thereof.
CN101815512B (en) 2007-10-04 2013-04-24 弗·哈夫曼-拉罗切有限公司 Cyclopropyl aryl amide derivatives and uses thereof
RU2010137114A (en) 2008-02-07 2012-03-20 Эбботт Лэборетриз (Us) AMIDIC DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS AND WAYS OF THEIR APPLICATION
CA2714662C (en) 2008-03-19 2016-05-10 Janssen Pharmaceutica Nv Trisubstituted 1,2,4-triazoles as nicotinic acetylcholine receptor modulators
AU2009237650B2 (en) 2008-04-17 2012-05-31 Proximagen Limited Indoles as modulators of nicoticic acetylcholine receptor subtype alpha-7
CL2009001125A1 (en) 2008-05-09 2011-02-11 Janssen Pharmaceutica Nv Compounds derived from trisubstituted pyrazole, positive allosteric modulators of ach nicotinic receptors; pharmaceutical composition that includes them; composition preparation process; and its use in the treatment of CNS or inflammatory diseases.
JP2013507417A (en) * 2009-10-13 2013-03-04 エム・エス・ディー・オス・ベー・フェー Condensed azine derivatives for the treatment of diseases associated with acetylcholine receptors
US20130310419A1 (en) * 2011-02-03 2013-11-21 Lupin Limited Pyrrole derivatives used as modulators of alpha7 nachr
CA2892682A1 (en) * 2013-03-13 2014-09-18 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
HRP20211960T1 (en) * 2016-03-22 2022-03-18 Merck Sharp & Dohme Corp. Allosteric modulators of nicotinic acetylcholine receptors
JP7041141B2 (en) 2016-11-01 2022-03-23 メルク・シャープ・アンド・ドーム・コーポレーション Substituted bicyclic heteroaryl nicotinic acetylcholine receptor allosteric regulator
SG11201908012SA (en) * 2017-03-02 2019-09-27 Assembly Biosciences Inc Cyclic sulfamide compounds and methods of using same

Also Published As

Publication number Publication date
JP7440486B2 (en) 2024-02-28
KR20210033003A (en) 2021-03-25
GEP20237459B (en) 2023-01-25
IL279939A (en) 2021-03-01
CA3104264A1 (en) 2020-01-16
CU20200109A7 (en) 2021-08-06
EP3820865A1 (en) 2021-05-19
AR115783A1 (en) 2021-02-24
MX2021000461A (en) 2021-06-23
TWI827628B (en) 2024-01-01
HU231414B1 (en) 2023-08-28
CU24622B1 (en) 2022-09-08
CL2021000081A1 (en) 2021-10-29
CN112424198A (en) 2021-02-26
WO2020012423A1 (en) 2020-01-16
CO2021001224A2 (en) 2021-02-17
PH12021550007A1 (en) 2021-09-20
TW202019431A (en) 2020-06-01
AU2019300515A1 (en) 2021-02-11
BR112020027016A2 (en) 2021-04-06
US20210267993A1 (en) 2021-09-02
HUP1800249A2 (en) 2020-01-28
JP2024056879A (en) 2024-04-23
EA202190246A1 (en) 2021-04-20
JP2021529813A (en) 2021-11-04
PE20210465A1 (en) 2021-03-08

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