HU231203B1 - Új eljárás travoprost előállítására - Google Patents

Új eljárás travoprost előállítására Download PDF

Info

Publication number
HU231203B1
HU231203B1 HU1100701A HUP1100701A HU231203B1 HU 231203 B1 HU231203 B1 HU 231203B1 HU 1100701 A HU1100701 A HU 1100701A HU P1100701 A HUP1100701 A HU P1100701A HU 231203 B1 HU231203 B1 HU 231203B1
Authority
HU
Hungary
Prior art keywords
formula
compound
process according
carried out
crystallization
Prior art date
Application number
HU1100701A
Other languages
English (en)
Hungarian (hu)
Inventor
Chinoin Zrt. dr. Kardos Zsuzsanna
Chinoin Zrt. Kiss Tibor
Chinoin Zrt. Lászlófi István
Chinoin Zrt. Hortobágyi Irén
Chinoin Zrt. Bischof Zoltán
Chinoin Zrt. Bódis Ádám
Chinoin Zrt. Havasi Gábor
Original Assignee
CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. filed Critical CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt.
Priority to HU1100701A priority Critical patent/HU231203B1/hu
Priority to US14/367,317 priority patent/US9212125B2/en
Priority to KR1020147020311A priority patent/KR102027889B1/ko
Priority to HK14112063.1A priority patent/HK1198584B/en
Priority to EP12816098.3A priority patent/EP2802562B1/en
Priority to TR2019/05687T priority patent/TR201905687T4/tr
Priority to ES12816098T priority patent/ES2721662T3/es
Priority to JP2014548213A priority patent/JP6174040B2/ja
Priority to CA2859923A priority patent/CA2859923C/en
Priority to BR112014014060A priority patent/BR112014014060A2/pt
Priority to PCT/HU2012/000132 priority patent/WO2013093528A1/en
Priority to CN201280063528.2A priority patent/CN103998423B/zh
Priority to RU2014129492A priority patent/RU2631316C2/ru
Priority to PL12816098T priority patent/PL2802562T3/pl
Priority to MX2014007684A priority patent/MX2014007684A/es
Priority to IN3482CHN2014 priority patent/IN2014CN03482A/en
Priority to TW101148584A priority patent/TWI640500B/zh
Publication of HUP1100701A2 publication Critical patent/HUP1100701A2/hu
Priority to IL232625A priority patent/IL232625B/en
Priority to ZA2014/04440A priority patent/ZA201404440B/en
Priority to US14/928,629 priority patent/US20160137621A1/en
Publication of HU231203B1 publication Critical patent/HU231203B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
HU1100701A 2011-12-21 2011-12-21 Új eljárás travoprost előállítására HU231203B1 (hu)

Priority Applications (20)

Application Number Priority Date Filing Date Title
HU1100701A HU231203B1 (hu) 2011-12-21 2011-12-21 Új eljárás travoprost előállítására
BR112014014060A BR112014014060A2 (pt) 2011-12-21 2012-12-10 processo para a preparação de travoprosta
RU2014129492A RU2631316C2 (ru) 2011-12-21 2012-12-10 Способ получения травопроста
HK14112063.1A HK1198584B (en) 2011-12-21 2012-12-10 Process for the preparation of travoprost
EP12816098.3A EP2802562B1 (en) 2011-12-21 2012-12-10 Process for the preparation of travoprost
TR2019/05687T TR201905687T4 (tr) 2011-12-21 2012-12-10 Travoprost hazırlanışına yönelik proses.
ES12816098T ES2721662T3 (es) 2011-12-21 2012-12-10 Proceso para la preparación de travoprost
JP2014548213A JP6174040B2 (ja) 2011-12-21 2012-12-10 トラボプロストの調製方法
CA2859923A CA2859923C (en) 2011-12-21 2012-12-10 Process for the preparation of travoprost
US14/367,317 US9212125B2 (en) 2011-12-21 2012-12-10 Process for the preparation of travoprost
PCT/HU2012/000132 WO2013093528A1 (en) 2011-12-21 2012-12-10 Process for the preparation of travoprost
CN201280063528.2A CN103998423B (zh) 2011-12-21 2012-12-10 曲伏前列素的制备方法
KR1020147020311A KR102027889B1 (ko) 2011-12-21 2012-12-10 트라보프로스트의 제조 방법
PL12816098T PL2802562T3 (pl) 2011-12-21 2012-12-10 Sposób otrzymywania trawoprostu
MX2014007684A MX2014007684A (es) 2011-12-21 2012-12-10 Proceso para la preparacion de travoprost.
IN3482CHN2014 IN2014CN03482A (enExample) 2011-12-21 2012-12-10
TW101148584A TWI640500B (zh) 2011-12-21 2012-12-20 製備曲伏前列腺素之新穎方法
IL232625A IL232625B (en) 2011-12-21 2014-05-14 Process for making trouver frost
ZA2014/04440A ZA201404440B (en) 2011-12-21 2014-06-17 Process for the preparation of travoprost
US14/928,629 US20160137621A1 (en) 2011-12-21 2015-10-30 Process for the preparation of travoprost

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1100701A HU231203B1 (hu) 2011-12-21 2011-12-21 Új eljárás travoprost előállítására

Publications (2)

Publication Number Publication Date
HUP1100701A2 HUP1100701A2 (en) 2013-07-29
HU231203B1 true HU231203B1 (hu) 2021-10-28

Family

ID=89990547

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1100701A HU231203B1 (hu) 2011-12-21 2011-12-21 Új eljárás travoprost előállítására

Country Status (18)

Country Link
US (2) US9212125B2 (enExample)
EP (1) EP2802562B1 (enExample)
JP (1) JP6174040B2 (enExample)
KR (1) KR102027889B1 (enExample)
CN (1) CN103998423B (enExample)
BR (1) BR112014014060A2 (enExample)
CA (1) CA2859923C (enExample)
ES (1) ES2721662T3 (enExample)
HU (1) HU231203B1 (enExample)
IL (1) IL232625B (enExample)
IN (1) IN2014CN03482A (enExample)
MX (1) MX2014007684A (enExample)
PL (1) PL2802562T3 (enExample)
RU (1) RU2631316C2 (enExample)
TR (1) TR201905687T4 (enExample)
TW (1) TWI640500B (enExample)
WO (1) WO2013093528A1 (enExample)
ZA (1) ZA201404440B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2723714T3 (pl) * 2011-06-02 2018-02-28 CHINOIN Zrt. Nowe sposoby otrzymywania amidów prostaglandyn
US9115109B2 (en) 2013-08-15 2015-08-25 Chirogate International Inc. Processes and intermediates for the preparations of isomer free prostaglandins
HU231214B1 (hu) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
EP3950672A4 (en) * 2019-03-27 2023-01-11 Kyowa Pharma Chemical Co., Ltd. PROCESS FOR PRODUCTION OF PROSTAGLANDIN
HU231350B1 (hu) * 2019-12-18 2023-01-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt Eljárás királis prosztaglandin-enol intermedier előállítására, és az eljárásban hasznos köztitermék vegyületek
CA3166738A1 (en) 2020-02-06 2021-08-12 Charles D. Blizzard Travoprost compositions and methods for treating ocular diseases
CA3177005A1 (en) 2020-04-27 2021-11-04 Michael Goldstein Methods of treating allergic conjunctivitis
WO2022138586A1 (ja) * 2020-12-23 2022-06-30 協和ファーマケミカル株式会社 幾何異性体の分離方法
CN114671906B (zh) * 2020-12-24 2024-03-15 武汉武药制药有限公司 制备曲伏前列素中间体的方法
CN116947725A (zh) * 2022-04-14 2023-10-27 广州楷石医药有限公司 曲伏前列素的合成方法
CN115806517A (zh) * 2022-12-21 2023-03-17 上海彩迩文生化科技有限公司 一种高纯度地诺前列腺素的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2328131C3 (de) * 1973-05-30 1986-11-13 Schering AG, 1000 Berlin und 4709 Bergkamen Neues Verfahren zur Herstellung von Prostaglandin-F↓2↓↓α↓ und seinen Analogen
HU184948B (en) * 1981-04-14 1984-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 5-substituted 4-oxo-pgi down 1 derivatives
HU190007B (en) 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
CS239696B1 (cs) * 1984-05-03 1986-01-16 Jiri Hajek Způsob dělení 15S-a 15R-isomerů 4-/4-/substituovaných X-fenoxy/-3-hydroxy-1butenyí/hexahydro-5-hydroxy- -2H-cyklopenta[b]furan-2-onů
HU212570B (en) * 1991-06-24 1996-08-29 Chinoin Gyogyszer Es Vegyeszet Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US7166730B2 (en) * 2000-01-27 2007-01-23 Fine Tech Laboratories, Ltd Process for the preparation of prostaglandin derivatives
GB0112699D0 (en) * 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
GB0329379D0 (en) * 2003-12-19 2004-01-21 Johnson Matthey Plc Prostaglandin synthesis
KR100850133B1 (ko) * 2004-01-05 2008-08-04 니콕스 에스. 에이. 프로스타글란딘 나이트로옥시 유도체
EP2143712A1 (en) 2008-07-10 2010-01-13 Sandoz AG Improved Process for the Production of Prostaglandins and Prostaglandin Analogs
IT1393112B1 (it) * 2009-02-27 2012-04-11 Sifavitor S R L Procedimento per la preparazione di derivati di prostaglandine
CA2777290C (en) * 2009-10-16 2016-06-28 Cayman Chemical Company, Incorporated Process for the preparation of f-series prostaglandins
WO2011055377A1 (en) 2009-11-05 2011-05-12 Biocon Limited A novel process for the preparation of prostaglandins and intermediates thereof
EP2495235B1 (en) 2011-03-04 2015-08-05 Newchem S.p.A. Process for the synthesis of prostaglandins and intermediates thereof
PL2723714T3 (pl) 2011-06-02 2018-02-28 CHINOIN Zrt. Nowe sposoby otrzymywania amidów prostaglandyn

Also Published As

Publication number Publication date
WO2013093528A1 (en) 2013-06-27
RU2014129492A (ru) 2016-02-10
RU2631316C2 (ru) 2017-09-21
US20140343299A1 (en) 2014-11-20
US9212125B2 (en) 2015-12-15
IL232625B (en) 2019-03-31
MX2014007684A (es) 2014-07-28
EP2802562B1 (en) 2019-01-23
EP2802562A1 (en) 2014-11-19
CN103998423B (zh) 2018-04-27
JP2015506343A (ja) 2015-03-02
CA2859923A1 (en) 2013-06-27
CN103998423A (zh) 2014-08-20
HK1198584A1 (en) 2015-04-30
BR112014014060A2 (pt) 2017-06-13
KR20140107541A (ko) 2014-09-04
IN2014CN03482A (enExample) 2015-07-03
JP6174040B2 (ja) 2017-08-02
ZA201404440B (en) 2015-12-23
US20160137621A1 (en) 2016-05-19
TWI640500B (zh) 2018-11-11
HUP1100701A2 (en) 2013-07-29
TR201905687T4 (tr) 2019-05-21
CA2859923C (en) 2020-11-24
ES2721662T3 (es) 2019-08-02
IL232625A0 (en) 2014-06-30
TW201336816A (zh) 2013-09-16
KR102027889B1 (ko) 2019-10-04
PL2802562T3 (pl) 2019-08-30

Similar Documents

Publication Publication Date Title
HU231203B1 (hu) Új eljárás travoprost előállítására
US20020099034A1 (en) Process for stereoselective synthesis of prostacyclin derivatives
TWI738687B (zh) 製備卡前列素氨丁三醇之新穎方法
CN101307048B (zh) 立体选择性制备拉米夫定的方法
EP1886992A1 (en) Method for preparing prostaglandin derivative
JP4433156B2 (ja) 光学活性オキソヘプテン酸エステルの製造方法
EP1700851B1 (en) Crystalline citalopram diol intermediate alkali
JP5729512B2 (ja) テトラヒドロピラン化合物の製造中間体
CN104016954B (zh) 奈必洛尔中间体的制备及纯化方法
US7642370B2 (en) Method for preparing prostaglandin derivative
TWI792440B (zh) 製備拉坦前列烯布諾德（ｌａｔａｎｏｐｒｏｓｔｅｎｅ ｂｕｎｏｄ）之方法及其中間物與包含其之組合物
CN102050771A (zh) 一个一种前列腺素衍生物的制造方法
CN107746396B (zh) 一种新型化合物6,6-二甲基四氢吡喃-2-甲醇及其制备方法
HK1198584B (en) Process for the preparation of travoprost
CN114685554A (zh) 一种4aa非对映异构体的制备方法
WO2004037815A1 (ja) 光学活性ｎ−（２，３−エポキシプロパンー１−イル）フタルイミドの製造法
CN113880724A (zh) 一种3-(2-氨基苯基)-2-丙烯酸酯的制备方法
CN114539125A (zh) 一种帕西洛韦中间体的合成方法
CN104926806A (zh) 一种合成拉米夫定中间体的方法
CN105503686A (zh) 一种依替米贝的合成方法
CN103694196A (zh) 细胞色素p450单加氧酶抑制剂中间体及其制法和用途

Legal Events

Date Code Title Description
FH91 Appointment of a representative

Representative=s name: DANUBIA SZABADALMI ES JOGI IRODA KFT., HU

GB9A Succession in title

Owner name: EUROAPI HUNGARY LIMITED LIABILITY COMPANY, HU

Free format text: FORMER OWNER(S): CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA ZRT., HU