KR102027889B1 - 트라보프로스트의 제조 방법 - Google Patents

트라보프로스트의 제조 방법 Download PDF

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KR102027889B1
KR102027889B1 KR1020147020311A KR20147020311A KR102027889B1 KR 102027889 B1 KR102027889 B1 KR 102027889B1 KR 1020147020311 A KR1020147020311 A KR 1020147020311A KR 20147020311 A KR20147020311 A KR 20147020311A KR 102027889 B1 KR102027889 B1 KR 102027889B1
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formula
compound
crystallization
reduction
mixture
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KR20140107541A (ko
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주전너 커르도시
티보르 키시
이슈트반 라슬로피
이렌 호르토바지이
졸탄 비슈츠호프
아담 보디시
가보르 허버시
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키노인 기요기스제르 에스 베기에스제티 테르메크에크 기야라 제트알티.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
KR1020147020311A 2011-12-21 2012-12-10 트라보프로스트의 제조 방법 Active KR102027889B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HUP1100701 2011-12-21
HU1100701A HU231203B1 (hu) 2011-12-21 2011-12-21 Új eljárás travoprost előállítására
PCT/HU2012/000132 WO2013093528A1 (en) 2011-12-21 2012-12-10 Process for the preparation of travoprost

Publications (2)

Publication Number Publication Date
KR20140107541A KR20140107541A (ko) 2014-09-04
KR102027889B1 true KR102027889B1 (ko) 2019-10-04

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KR1020147020311A Active KR102027889B1 (ko) 2011-12-21 2012-12-10 트라보프로스트의 제조 방법

Country Status (18)

Country Link
US (2) US9212125B2 (enExample)
EP (1) EP2802562B1 (enExample)
JP (1) JP6174040B2 (enExample)
KR (1) KR102027889B1 (enExample)
CN (1) CN103998423B (enExample)
BR (1) BR112014014060A2 (enExample)
CA (1) CA2859923C (enExample)
ES (1) ES2721662T3 (enExample)
HU (1) HU231203B1 (enExample)
IL (1) IL232625B (enExample)
IN (1) IN2014CN03482A (enExample)
MX (1) MX2014007684A (enExample)
PL (1) PL2802562T3 (enExample)
RU (1) RU2631316C2 (enExample)
TR (1) TR201905687T4 (enExample)
TW (1) TWI640500B (enExample)
WO (1) WO2013093528A1 (enExample)
ZA (1) ZA201404440B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2723714T3 (pl) * 2011-06-02 2018-02-28 CHINOIN Zrt. Nowe sposoby otrzymywania amidów prostaglandyn
US9115109B2 (en) 2013-08-15 2015-08-25 Chirogate International Inc. Processes and intermediates for the preparations of isomer free prostaglandins
HU231214B1 (hu) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
EP3950672A4 (en) * 2019-03-27 2023-01-11 Kyowa Pharma Chemical Co., Ltd. PROCESS FOR PRODUCTION OF PROSTAGLANDIN
HU231350B1 (hu) * 2019-12-18 2023-01-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt Eljárás királis prosztaglandin-enol intermedier előállítására, és az eljárásban hasznos köztitermék vegyületek
CA3166738A1 (en) 2020-02-06 2021-08-12 Charles D. Blizzard Travoprost compositions and methods for treating ocular diseases
CA3177005A1 (en) 2020-04-27 2021-11-04 Michael Goldstein Methods of treating allergic conjunctivitis
WO2022138586A1 (ja) * 2020-12-23 2022-06-30 協和ファーマケミカル株式会社 幾何異性体の分離方法
CN114671906B (zh) * 2020-12-24 2024-03-15 武汉武药制药有限公司 制备曲伏前列素中间体的方法
CN116947725A (zh) * 2022-04-14 2023-10-27 广州楷石医药有限公司 曲伏前列素的合成方法
CN115806517A (zh) * 2022-12-21 2023-03-17 上海彩迩文生化科技有限公司 一种高纯度地诺前列腺素的制备方法

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DE2328131C3 (de) * 1973-05-30 1986-11-13 Schering AG, 1000 Berlin und 4709 Bergkamen Neues Verfahren zur Herstellung von Prostaglandin-F↓2↓↓α↓ und seinen Analogen
HU184948B (en) * 1981-04-14 1984-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 5-substituted 4-oxo-pgi down 1 derivatives
HU190007B (en) 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
CS239696B1 (cs) * 1984-05-03 1986-01-16 Jiri Hajek Způsob dělení 15S-a 15R-isomerů 4-/4-/substituovaných X-fenoxy/-3-hydroxy-1butenyí/hexahydro-5-hydroxy- -2H-cyklopenta[b]furan-2-onů
HU212570B (en) * 1991-06-24 1996-08-29 Chinoin Gyogyszer Es Vegyeszet Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US7166730B2 (en) * 2000-01-27 2007-01-23 Fine Tech Laboratories, Ltd Process for the preparation of prostaglandin derivatives
GB0112699D0 (en) * 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
GB0329379D0 (en) * 2003-12-19 2004-01-21 Johnson Matthey Plc Prostaglandin synthesis
KR100850133B1 (ko) * 2004-01-05 2008-08-04 니콕스 에스. 에이. 프로스타글란딘 나이트로옥시 유도체
EP2143712A1 (en) 2008-07-10 2010-01-13 Sandoz AG Improved Process for the Production of Prostaglandins and Prostaglandin Analogs
IT1393112B1 (it) * 2009-02-27 2012-04-11 Sifavitor S R L Procedimento per la preparazione di derivati di prostaglandine
CA2777290C (en) * 2009-10-16 2016-06-28 Cayman Chemical Company, Incorporated Process for the preparation of f-series prostaglandins
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Also Published As

Publication number Publication date
WO2013093528A1 (en) 2013-06-27
RU2014129492A (ru) 2016-02-10
RU2631316C2 (ru) 2017-09-21
US20140343299A1 (en) 2014-11-20
US9212125B2 (en) 2015-12-15
IL232625B (en) 2019-03-31
MX2014007684A (es) 2014-07-28
EP2802562B1 (en) 2019-01-23
EP2802562A1 (en) 2014-11-19
CN103998423B (zh) 2018-04-27
JP2015506343A (ja) 2015-03-02
CA2859923A1 (en) 2013-06-27
CN103998423A (zh) 2014-08-20
HU231203B1 (hu) 2021-10-28
HK1198584A1 (en) 2015-04-30
BR112014014060A2 (pt) 2017-06-13
KR20140107541A (ko) 2014-09-04
IN2014CN03482A (enExample) 2015-07-03
JP6174040B2 (ja) 2017-08-02
ZA201404440B (en) 2015-12-23
US20160137621A1 (en) 2016-05-19
TWI640500B (zh) 2018-11-11
HUP1100701A2 (en) 2013-07-29
TR201905687T4 (tr) 2019-05-21
CA2859923C (en) 2020-11-24
ES2721662T3 (es) 2019-08-02
IL232625A0 (en) 2014-06-30
TW201336816A (zh) 2013-09-16
PL2802562T3 (pl) 2019-08-30

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