HU230223B1 - Substituted pyridines and pyridazines with angiogenesis inhibiting activity and pharmaceutical compositions containing them - Google Patents

Info

Publication number

HU230223B1

HU230223B1 HU0202704A HUP0202704A HU230223B1 HU 230223 B1 HU230223 B1 HU 230223B1 HU 0202704 A HU0202704 A HU 0202704A HU P0202704 A HUP0202704 A HU P0202704A HU 230223 B1 HU230223 B1 HU 230223B1

Authority

HU

Hungary

Prior art keywords

group

alkyl

short

substituted

optionally

Prior art date

1999-09-28

Links

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• 239000008194 pharmaceutical composition Substances 0.000 title claims description 8
• 230000033115 angiogenesis Effects 0.000 title description 9
• 150000003222 pyridines Chemical class 0.000 title description 3
• 150000004892 pyridazines Chemical class 0.000 title description 2
• 230000002401 inhibitory effect Effects 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 185
• 125000000217 alkyl group Chemical group 0.000 claims description 147
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• 238000000034 method Methods 0.000 claims description 63
• 125000004429 atom Chemical group 0.000 claims description 52
• 229910052717 sulfur Inorganic materials 0.000 claims description 52
• 229910052760 oxygen Inorganic materials 0.000 claims description 51
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• 125000001424 substituent group Chemical group 0.000 claims description 43
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• 229910052757 nitrogen Inorganic materials 0.000 claims description 37
• 125000001072 heteroaryl group Chemical group 0.000 claims description 34
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 33
• 125000003118 aryl group Chemical group 0.000 claims description 33
• 229910052799 carbon Inorganic materials 0.000 claims description 33
• 125000004432 carbon atom Chemical group C* 0.000 claims description 33
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• 150000003839 salts Chemical class 0.000 claims description 28
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• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 15
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• ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical group C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims description 2
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