HU228976B1 - Antisense modulation of insulin-like growth factor binding protein 5 expression - Google Patents

Antisense modulation of insulin-like growth factor binding protein 5 expression Download PDF

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Publication number
HU228976B1
HU228976B1 HU0402327A HUP0402327A HU228976B1 HU 228976 B1 HU228976 B1 HU 228976B1 HU 0402327 A HU0402327 A HU 0402327A HU P0402327 A HUP0402327 A HU P0402327A HU 228976 B1 HU228976 B1 HU 228976B1
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Prior art keywords
acid
pat
antisense
compounds
sequence
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HU0402327A
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English (en)
Hungarian (hu)
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Susan M Freier
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Isis Pharmaceuticals Inc
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Publication of HUP0402327A2 publication Critical patent/HUP0402327A2/hu
Publication of HUP0402327A3 publication Critical patent/HUP0402327A3/hu
Publication of HU228976B1 publication Critical patent/HU228976B1/hu

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Wood Science & Technology (AREA)
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  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU0402327A 2001-10-09 2002-10-07 Antisense modulation of insulin-like growth factor binding protein 5 expression HU228976B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/975,123 US6750019B2 (en) 2001-10-09 2001-10-09 Antisense modulation of insulin-like growth factor binding protein 5 expression
US10/491,712 US20050049211A1 (en) 2001-10-09 2002-10-07 Antisense modulation of insulin-like growth factor binding protein 5 expression
PCT/US2002/032060 WO2003030826A2 (en) 2001-10-09 2002-10-07 Antisense modulation of insulin-like growth factor binding protein 5 expression

Publications (3)

Publication Number Publication Date
HUP0402327A2 HUP0402327A2 (hu) 2005-02-28
HUP0402327A3 HUP0402327A3 (en) 2010-01-28
HU228976B1 true HU228976B1 (en) 2013-07-29

Family

ID=37772670

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402327A HU228976B1 (en) 2001-10-09 2002-10-07 Antisense modulation of insulin-like growth factor binding protein 5 expression

Country Status (8)

Country Link
US (2) US6750019B2 (enExample)
EP (2) EP2270230B1 (enExample)
JP (1) JP2005506066A (enExample)
KR (1) KR100622275B1 (enExample)
CA (1) CA2463521C (enExample)
HU (1) HU228976B1 (enExample)
IL (1) IL161277A0 (enExample)
WO (1) WO2003030826A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491816B2 (en) * 1999-07-19 2009-02-17 The University Of British Columbia Antisense therapy for hormone-regulated tumors
ATE393220T1 (de) 1999-07-19 2008-05-15 Univ British Columbia Antisense-therapie für hormonregulierte tumoren
WO2003062421A1 (en) * 2002-01-17 2003-07-31 The University Of British Columbia Bispecific antisense olignucleotides that inhibit igfbp-2 and igfbp-5 and methods of using same
US7825235B2 (en) * 2003-08-18 2010-11-02 Isis Pharmaceuticals, Inc. Modulation of diacylglycerol acyltransferase 2 expression
WO2005030260A1 (en) * 2003-10-01 2005-04-07 The University Of British Columbia Bispecific oligonucleotide for the treatment of cns malignancies
WO2005071080A2 (en) * 2004-01-20 2005-08-04 Isis Pharmaceuticals, Inc. Modulation of glucocorticoid receptor expression
US20090062914A1 (en) * 2007-08-29 2009-03-05 Marino James F Devices and methods for intervertebral therapy
WO2009067243A2 (en) * 2007-11-20 2009-05-28 Isis Pharmaceuticals Inc. Modulation of cd40 expression
JP5390179B2 (ja) * 2008-12-24 2014-01-15 花王株式会社 Ｉｇｆｂｐ−５発現抑制剤
CA2862628C (en) 2012-01-27 2021-08-24 Prosensa Technologies B.V. Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy
EP3868396A1 (en) * 2020-02-20 2021-08-25 Enthera S.R.L. Inhibitors and uses thereof

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WO2003030826A2 (en) 2003-04-17
IL161277A0 (en) 2004-09-27
KR20050035150A (ko) 2005-04-15
US20030087857A1 (en) 2003-05-08
US20050049211A1 (en) 2005-03-03
HUP0402327A3 (en) 2010-01-28
EP1442140B1 (en) 2011-07-13
HUP0402327A2 (hu) 2005-02-28
EP2270230A3 (en) 2011-04-20
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WO2003030826A3 (en) 2003-08-07
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