HU227821B1 - Tablets containing beta-lactam antibiotic and process for producing the same - Google Patents
Tablets containing beta-lactam antibiotic and process for producing the same Download PDFInfo
- Publication number
- HU227821B1 HU227821B1 HU9901877A HUP9901877A HU227821B1 HU 227821 B1 HU227821 B1 HU 227821B1 HU 9901877 A HU9901877 A HU 9901877A HU P9901877 A HUP9901877 A HU P9901877A HU 227821 B1 HU227821 B1 HU 227821B1
- Authority
- HU
- Hungary
- Prior art keywords
- tablet
- tablets
- synthetic sweetener
- lactam antibiotic
- mixture
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 20
- 239000003782 beta lactam antibiotic agent Substances 0.000 title claims description 12
- 239000002132 β-lactam antibiotic Substances 0.000 title claims description 9
- 229940124586 β-lactam antibiotics Drugs 0.000 title claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 42
- 235000003599 food sweetener Nutrition 0.000 claims description 38
- 239000003765 sweetening agent Substances 0.000 claims description 38
- 239000000203 mixture Substances 0.000 claims description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 239000002245 particle Substances 0.000 claims description 26
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 25
- 239000011230 binding agent Substances 0.000 claims description 24
- 239000000377 silicon dioxide Substances 0.000 claims description 20
- OKBVVJOGVLARMR-QSWIMTSFSA-N cefixime Chemical compound S1C(N)=NC(C(=N\OCC(O)=O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 OKBVVJOGVLARMR-QSWIMTSFSA-N 0.000 claims description 14
- 229960002129 cefixime Drugs 0.000 claims description 14
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 14
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 14
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 14
- 239000006185 dispersion Substances 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 10
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims description 8
- 229960004029 silicic acid Drugs 0.000 claims description 8
- 239000007884 disintegrant Substances 0.000 claims description 7
- -1 hydroxyl propyl Chemical group 0.000 claims description 7
- 235000010980 cellulose Nutrition 0.000 claims description 6
- 229920002678 cellulose Polymers 0.000 claims description 6
- 239000001913 cellulose Substances 0.000 claims description 6
- RTXOFQZKPXMALH-GHXIOONMSA-N cefdinir Chemical compound S1C(N)=NC(C(=N\O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 RTXOFQZKPXMALH-GHXIOONMSA-N 0.000 claims description 4
- 229960003719 cefdinir Drugs 0.000 claims description 4
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- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 2
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
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- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 229960003415 propylparaben Drugs 0.000 claims 1
- 150000003952 β-lactams Chemical class 0.000 claims 1
- MQRKKLAGBPVXCD-UHFFFAOYSA-L calcium;1,1-dioxo-1,2-benzothiazol-2-id-3-one;hydrate Chemical compound O.[Ca+2].C1=CC=C2C([O-])=NS(=O)(=O)C2=C1.C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 MQRKKLAGBPVXCD-UHFFFAOYSA-L 0.000 description 23
- 229940043243 saccharin calcium Drugs 0.000 description 23
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 22
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 20
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 15
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- 238000002156 mixing Methods 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- 230000009747 swallowing Effects 0.000 description 3
- 229910002012 Aerosil® Inorganic materials 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 238000007605 air drying Methods 0.000 description 2
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 2
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- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- XUWHAWMETYGRKB-UHFFFAOYSA-N delta-valerolactam Natural products O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 2
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- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
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- 150000003954 δ-lactams Chemical class 0.000 description 2
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- 244000215068 Acacia senegal Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
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- UQLLWWBDSUHNEB-CZUORRHYSA-N Cefaprin Chemical compound N([C@H]1[C@@H]2N(C1=O)C(=C(CS2)COC(=O)C)C(O)=O)C(=O)CSC1=CC=NC=C1 UQLLWWBDSUHNEB-CZUORRHYSA-N 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
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- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
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- 229930195725 Mannitol Natural products 0.000 description 1
- 229920003081 Povidone K 30 Polymers 0.000 description 1
- 229920003110 Primojel Polymers 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
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- 150000003863 ammonium salts Chemical class 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Physiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Seasonings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4274396 | 1996-02-29 | ||
| JP32026496 | 1996-11-29 | ||
| PCT/JP1997/000509 WO1997031639A1 (en) | 1996-02-29 | 1997-02-21 | TABLETS CONTAINING β-LACTAM ANTIBIOTIC AND PROCESS FOR PRODUCING THE SAME |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP9901877A1 HUP9901877A1 (hu) | 1999-12-28 |
| HUP9901877A3 HUP9901877A3 (en) | 2000-04-28 |
| HU227821B1 true HU227821B1 (en) | 2012-03-28 |
Family
ID=26382481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9901877A HU227821B1 (en) | 1996-02-29 | 1997-02-21 | Tablets containing beta-lactam antibiotic and process for producing the same |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US6423341B1 (enExample) |
| EP (2) | EP1166651B1 (enExample) |
| JP (1) | JP3180350B2 (enExample) |
| KR (1) | KR20040058360A (enExample) |
| CN (2) | CN1136853C (enExample) |
| AR (1) | AR006012A1 (enExample) |
| AT (2) | ATE287218T1 (enExample) |
| AU (1) | AU724946B2 (enExample) |
| BR (1) | BR9707780A (enExample) |
| CA (1) | CA2248179C (enExample) |
| DE (2) | DE69712332T2 (enExample) |
| DK (2) | DK1166651T3 (enExample) |
| EA (1) | EA001089B1 (enExample) |
| ES (2) | ES2173420T3 (enExample) |
| HU (1) | HU227821B1 (enExample) |
| IL (1) | IL125214A0 (enExample) |
| MX (1) | MX9806265A (enExample) |
| NZ (2) | NZ512609A (enExample) |
| PT (2) | PT1166651E (enExample) |
| TR (1) | TR199801680T2 (enExample) |
| TW (1) | TW473393B (enExample) |
| WO (1) | WO1997031639A1 (enExample) |
| ZA (1) | ZA971584B (enExample) |
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| EP2263660B1 (en) | 1998-05-18 | 2017-09-27 | Takeda Pharmaceutical Company Limited | Orally disintegrable tablets |
| DE69942777D1 (de) * | 1998-07-28 | 2010-10-28 | Takeda Pharmaceutical | Leicht zerfallende feste Zubereitung |
| US20080113025A1 (en) * | 1998-11-02 | 2008-05-15 | Elan Pharma International Limited | Compositions comprising nanoparticulate naproxen and controlled release hydrocodone |
| US20070160675A1 (en) * | 1998-11-02 | 2007-07-12 | Elan Corporation, Plc | Nanoparticulate and controlled release compositions comprising a cephalosporin |
| ECSP003699A (es) * | 1999-10-08 | 2002-04-23 | Smithkline Beecham Corp | Inhibidores de fab i |
| CA2311734C (en) * | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Flash-melt oral dosage formulation |
| FR2814679B1 (fr) * | 2000-09-29 | 2003-04-11 | Cll Pharma | Compositions pharmaceutiques dispersibles a base de cephalosporines, leur procede de preparation et leur utilisation |
| DE60230934D1 (de) * | 2001-04-06 | 2009-03-05 | Affinium Pharm Inc | Fab-i-inhibitoren |
| GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
| GB0209265D0 (en) | 2002-04-23 | 2002-06-05 | Novartis Ag | Organic compounds |
| JP4526247B2 (ja) * | 2002-07-08 | 2010-08-18 | 第一三共株式会社 | 経口用セファロスポリン製剤 |
| TW200404550A (en) * | 2002-07-08 | 2004-04-01 | Sankyo Co | Cepharospolin formulation for oral use |
| KR20110005727A (ko) * | 2002-08-13 | 2011-01-18 | 산도즈 아게 | 세프디니르 중간체 |
| EP1575951B1 (en) | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterocyclic compounds, methods of making them and their use in therapy |
| WO2004082586A2 (en) * | 2003-03-17 | 2004-09-30 | Affinium Pharmaceuticals, Inc. | Phamaceutical compositions comprising inhibitors of fab i and further antibiotics |
| CN100357294C (zh) * | 2003-03-24 | 2007-12-26 | 桑多斯股份公司 | 7－[2－(2－氨基噻唑－4－基)－2－羟基亚氨基乙酰胺－3－乙烯基－3－头孢烯－4－羧酸(顺式异构体)的新型晶体和其制备方法 |
| WO2005013964A1 (ja) * | 2003-08-08 | 2005-02-17 | Ajinomoto Co., Inc. | ナテグリニド含有製剤 |
| US20050059819A1 (en) * | 2003-09-12 | 2005-03-17 | Duerst Richard W. | Cefdinir pyridine salt |
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| US20050059818A1 (en) * | 2003-09-12 | 2005-03-17 | Duerst Richard W. | Polymorph of a pharmaceutical |
| JP2005162696A (ja) * | 2003-12-04 | 2005-06-23 | Nichiko Pharmaceutical Co Ltd | 溶出性に優れたセフジトレンピボキシル製剤 |
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| US20060211676A1 (en) * | 2004-03-16 | 2006-09-21 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
| US20060142261A1 (en) * | 2004-03-16 | 2006-06-29 | Devalina Law | Crystalline anhydrous cefdinir and crystalline cefdinir hydrates |
| US20060069079A1 (en) * | 2004-09-27 | 2006-03-30 | Sever Nancy E | Stable amorphous cefdinir |
| BRPI0418769A (pt) * | 2004-05-10 | 2007-10-09 | Lupin Ltd | composição farmacêutica compreendendo cefixima, processo para a preparação de uma forma de dosagem oral sólida compreendendo de partìculas de cefixima, método para conseguir bio-equivalência entre a forma de dosagem oral e uma suspensão e comprimido mastigável compreendendo cefixima |
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| US20060099253A1 (en) * | 2004-10-20 | 2006-05-11 | Wyeth | Antibiotic product formulation |
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| CA2632476A1 (en) * | 2005-12-05 | 2007-06-14 | Affinium Pharmaceuticals, Inc. | Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
| US20070128268A1 (en) * | 2005-12-07 | 2007-06-07 | Herwig Jennewein | Pharmaceutical compositions comprising an antibiotic |
| US20090197855A1 (en) * | 2006-05-01 | 2009-08-06 | Makarand Krishnakumar Avachat | Pharmaceutical compositions of cefdinir |
| EP2687533B1 (en) | 2006-07-20 | 2017-07-19 | Debiopharm International SA | Acrylamide derivatives as FAB I inhibitors |
| US20100004279A1 (en) * | 2006-12-07 | 2010-01-07 | Tomoyuki Watanabe | Solid medicinal preparation containing mannitol or lactose |
| WO2008072533A1 (ja) * | 2006-12-07 | 2008-06-19 | Daiichi Sankyo Company, Limited | 固形製剤の製造方法 |
| WO2008072535A1 (ja) * | 2006-12-07 | 2008-06-19 | Daiichi Sankyo Company, Limited | 低置換度ヒドロキシプロピルセルロースを含有する医薬組成物 |
| WO2008098374A1 (en) * | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| US8614315B2 (en) | 2009-12-25 | 2013-12-24 | Mahmut Bilgic | Cefdinir and cefixime formulations and uses thereof |
| TR200909785A1 (tr) * | 2009-12-25 | 2011-07-21 | Bi̇lgi̇ç Mahmut | Aktif ajan olarak sefdinir içeren farmasötik kompozisyonlar. |
| WO2011078830A1 (en) * | 2009-12-25 | 2011-06-30 | Bilgic Mahmut | Rapidly dispersing effervescent formulation |
| TR200909786A1 (tr) * | 2009-12-25 | 2011-07-21 | Bi̇lgi̇ç Mahmut | Sefiksim içeren efervesan tablet ve granül formülasyonu. |
| TR201000686A1 (tr) * | 2010-01-29 | 2011-08-22 | B�Lg�� Mahmut | Bakteriyel enfeksiyonların tedavisinde suda çözünebilir sefdinir ve klavulanik asit formülasyonları.@ |
| TR201000687A1 (tr) * | 2010-01-29 | 2011-08-22 | Bi̇lgi̇ç Mahmut | Aktif madde olarak sefiksim ve klavulanik asit içeren efervesan formülasyonlar |
| TR201001417A1 (tr) * | 2010-02-25 | 2011-09-21 | Sanovel İlaç San. Ve Ti̇c. A. Ş. | Geliştirilmiş çözünme hızına sahip sefdinir formülasyonu |
| EP2566448B1 (en) * | 2010-05-04 | 2015-06-17 | Mahmut Bilgic | Efervescent formulations comprising cefdinir |
| WO2011142731A2 (en) * | 2010-05-14 | 2011-11-17 | Mahmut Bilgic | Formulations comprising a third generation cephalosporin and clavulanic acid |
| EA021874B1 (ru) * | 2010-09-13 | 2015-09-30 | ЛИМОНОВ, Виктор Львович | Фармацевтическая композиция антимикробного действия для парентерального введения и способ ее получения |
| TR201009166A2 (tr) * | 2010-11-05 | 2012-05-21 | Bi̇lgi̇ç Mahmut | Sefdinir içeren farmasötik bileşim için üretim yöntemi |
| TR201010212A2 (tr) * | 2010-12-08 | 2012-06-21 | Bi̇lgi̇ç Mahmut | Sefdinir içeren katı oral dozaj formu. |
| KR101720885B1 (ko) | 2012-06-19 | 2017-03-28 | 데비오팜 인터네셔날 에스 에이 | (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체 |
| WO2014051532A1 (en) * | 2012-09-28 | 2014-04-03 | Bilgic Mahmut | Pharmaceutical tablet formulations comprising cefdinir |
| PL2903457T3 (pl) * | 2012-10-02 | 2018-07-31 | Montero Gida Sanayi Ve Ticaret A.S. | Preparat mogrozydu i sposób jego wytwarzania |
| EP2906203B1 (en) | 2012-10-11 | 2018-01-03 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Effervescent cefdinir formulation |
| EP2815743A1 (en) | 2013-06-21 | 2014-12-24 | Sanovel Ilac Sanayi ve Ticaret A.S. | Ceftibuten formulations |
| US10207004B2 (en) | 2014-04-04 | 2019-02-19 | Douxmatok Ltd | Method for producing sweetener compositions and sweetener compositions |
| US10231476B2 (en) | 2014-04-04 | 2019-03-19 | Douxmatok Ltd | Sweetener compositions and foods, beverages, and consumable products made thereof |
| US20160242439A1 (en) | 2014-04-04 | 2016-08-25 | Douxmatok Ltd | Method for producing sweetener compositions and sweetener compositions |
| RS61312B1 (sr) | 2016-02-26 | 2021-02-26 | Debiopharm Int Sa | Lek za lečenje infekcija dijabetskog stopala |
| MY203711A (en) | 2019-02-14 | 2024-07-15 | Debiopharm Int Sa | Afabicin formulation, method for making the same and uses thereof |
| JP7418475B2 (ja) | 2019-06-14 | 2024-01-19 | デバイオファーム インターナショナル エス．エー． | バイオフィルムが関与する細菌感染症を治療するための医薬及びその使用 |
| CN115607514B (zh) * | 2021-07-16 | 2023-12-12 | 广州白云山天心制药股份有限公司 | 一种含有头孢地尼颗粒的制备方法 |
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-
1997
- 1997-02-21 JP JP53078297A patent/JP3180350B2/ja not_active Expired - Fee Related
- 1997-02-21 EP EP01123407A patent/EP1166651B1/en not_active Expired - Lifetime
- 1997-02-21 KR KR10-2004-7008345A patent/KR20040058360A/ko not_active Ceased
- 1997-02-21 ES ES97904616T patent/ES2173420T3/es not_active Expired - Lifetime
- 1997-02-21 TR TR1998/01680T patent/TR199801680T2/xx unknown
- 1997-02-21 AT AT01123407T patent/ATE287218T1/de not_active IP Right Cessation
- 1997-02-21 IL IL12521497A patent/IL125214A0/xx not_active IP Right Cessation
- 1997-02-21 BR BR9707780A patent/BR9707780A/pt not_active Application Discontinuation
- 1997-02-21 WO PCT/JP1997/000509 patent/WO1997031639A1/ja not_active Ceased
- 1997-02-21 DE DE69712332T patent/DE69712332T2/de not_active Expired - Lifetime
- 1997-02-21 AT AT97904616T patent/ATE216887T1/de active
- 1997-02-21 DK DK01123407T patent/DK1166651T3/da active
- 1997-02-21 NZ NZ512609A patent/NZ512609A/xx unknown
- 1997-02-21 AU AU17347/97A patent/AU724946B2/en not_active Ceased
- 1997-02-21 PT PT01123407T patent/PT1166651E/pt unknown
- 1997-02-21 US US09/117,295 patent/US6423341B1/en not_active Expired - Fee Related
- 1997-02-21 HU HU9901877A patent/HU227821B1/hu unknown
- 1997-02-21 TW TW086102101A patent/TW473393B/zh not_active IP Right Cessation
- 1997-02-21 EP EP97904616A patent/EP0890359B1/en not_active Expired - Lifetime
- 1997-02-21 DE DE69732312T patent/DE69732312T8/de active Active
- 1997-02-21 DK DK97904616T patent/DK0890359T3/da active
- 1997-02-21 ES ES01123407T patent/ES2231369T3/es not_active Expired - Lifetime
- 1997-02-21 CA CA002248179A patent/CA2248179C/en not_active Expired - Fee Related
- 1997-02-21 CN CNB971926492A patent/CN1136853C/zh not_active Expired - Fee Related
- 1997-02-21 NZ NZ330864A patent/NZ330864A/en not_active IP Right Cessation
- 1997-02-21 EA EA199900359A patent/EA001089B1/ru not_active IP Right Cessation
- 1997-02-21 PT PT97904616T patent/PT890359E/pt unknown
- 1997-02-24 ZA ZA9701584A patent/ZA971584B/xx unknown
- 1997-02-27 AR ARP970100776A patent/AR006012A1/es active IP Right Grant
-
1998
- 1998-08-04 MX MX9806265A patent/MX9806265A/es unknown
-
2002
- 2002-05-28 US US10/154,904 patent/US20020192281A1/en not_active Abandoned
- 2002-06-26 CN CN02141260A patent/CN1409995A/zh active Pending
-
2003
- 2003-01-17 US US10/346,120 patent/US20030129227A1/en not_active Abandoned
-
2007
- 2007-02-26 US US11/678,945 patent/US20070134325A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
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| GB9A | Succession in title |
Owner name: ASTELLAS PHARMA INC., JP Free format text: FORMER OWNER(S): FUJISAWA PHARMACEUTICAL CO., LTD., JP |