HU226812B1 - Enzymatically divisible dye compounds for diagnosis with near infrared light - Google Patents

Enzymatically divisible dye compounds for diagnosis with near infrared light Download PDF

Info

Publication number
HU226812B1
HU226812B1 HU0003132A HUP0003132A HU226812B1 HU 226812 B1 HU226812 B1 HU 226812B1 HU 0003132 A HU0003132 A HU 0003132A HU P0003132 A HUP0003132 A HU P0003132A HU 226812 B1 HU226812 B1 HU 226812B1
Authority
HU
Hungary
Prior art keywords
formula
dye
defined above
compound
compounds according
Prior art date
Application number
HU0003132A
Other languages
English (en)
Hungarian (hu)
Inventor
Kai Licha
Bjoern Riefke
Wolfhard Semmler
Wolfgang Wrasidlo
Original Assignee
Diagnostikforschung Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagnostikforschung Inst filed Critical Diagnostikforschung Inst
Publication of HUP0003132A2 publication Critical patent/HUP0003132A2/hu
Publication of HUP0003132A3 publication Critical patent/HUP0003132A3/hu
Publication of HU226812B1 publication Critical patent/HU226812B1/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052Small organic molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058Antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/252Naphthacene radicals, e.g. daunomycins, adriamycins
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00Dyes not provided for by a single group of this subclass
    • C09B69/10Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/583Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with non-fluorescent dye label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HU0003132A 1997-04-23 1998-04-02 Enzymatically divisible dye compounds for diagnosis with near infrared light HU226812B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19717904A DE19717904A1 (de) 1997-04-23 1997-04-23 Sรคurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
PCT/DE1998/001001 WO1998047538A2 (de) 1997-04-23 1998-04-02 Sรคurelabile und enzymatisch spaltbare farbstoffkonstrukte zur diagnostik mit nahinfrarotlicht und zur therapie

Publications (3)

Publication Number Publication Date
HUP0003132A2 HUP0003132A2 (hu) 2001-01-29
HUP0003132A3 HUP0003132A3 (en) 2003-03-28
HU226812B1 true HU226812B1 (en) 2009-11-30

Family

ID=7827982

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003132A HU226812B1 (en) 1997-04-23 1998-04-02 Enzymatically divisible dye compounds for diagnosis with near infrared light

Country Status (16)

Country Link
US (1) US6534041B1 (enExample)
EP (1) EP0988060B1 (enExample)
JP (2) JP5118790B2 (enExample)
KR (1) KR100613306B1 (enExample)
CN (1) CN1253507A (enExample)
AT (1) ATE364404T1 (enExample)
AU (1) AU733757B2 (enExample)
CA (1) CA2287262C (enExample)
CY (1) CY1106860T1 (enExample)
DE (2) DE19717904A1 (enExample)
DK (1) DK0988060T3 (enExample)
ES (1) ES2289786T3 (enExample)
HU (1) HU226812B1 (enExample)
NO (1) NO327495B1 (enExample)
PT (1) PT988060E (enExample)
WO (1) WO1998047538A2 (enExample)

Families Citing this family (146)

* Cited by examiner, โ€  Cited by third party
Publication number Priority date Publication date Assignee Title
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Sรคurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US6083486A (en) * 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag ่ฟ‘่ตคๅค–่›ๅ…‰้€ ๅฝฑๅ‰คใŠใ‚ˆใณ่›ๅ…‰้€ ๅฝฑๆ–นๆณ•
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel fรผr die optische Diagnostik
US6114350A (en) * 1999-04-19 2000-09-05 Nen Life Science Products, Inc. Cyanine dyes and synthesis methods thereof
FR2793414B1 (fr) * 1999-05-10 2003-05-23 Centre Nat Rech Scient Conjugue acide nucleique-anticorps pour delivrer un acide nucleique etranger dans les cellules
WO2001089584A2 (en) * 2000-05-23 2001-11-29 Amersham Health As Contrast agents
US7597878B2 (en) * 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
DE10046215B4 (de) 2000-09-19 2004-04-15 Institut fรผr Chemo- und Biosensorik Mรผnster e.V. i.Ins. Fluorochrome und deren Verwendung
US20040180809A1 (en) * 2000-10-16 2004-09-16 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US20070092450A1 (en) * 2000-10-16 2007-04-26 Mallinckrodt Inc. Tissue-specific exogenous optical agents
US6716413B1 (en) * 2000-10-16 2004-04-06 Mallinckrodt, Inc. Indole compounds as tissue-specific exogenous optical agents
US7383076B2 (en) 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
US20030044353A1 (en) * 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
US20030031627A1 (en) * 2001-07-31 2003-02-13 Mallinckrodt Inc. Internal image antibodies for optical imaging and therapy
EP2014310B8 (en) 2002-03-01 2012-12-26 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
EP1485716A1 (en) * 2002-03-11 2004-12-15 Visen Medical, Inc. Optical imaging probes
GB0208989D0 (en) 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
WO2004065491A1 (en) * 2003-01-24 2004-08-05 Schering Ag Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis
ES2396368T3 (es) 2003-03-03 2013-02-21 Dyax Corporation Pรฉptidos que se unen especรญficamente al receptor del HGF (CMET) y usos de los mismos
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
JP2005170812A (ja) * 2003-12-09 2005-06-30 Konica Minolta Medical & Graphic Inc ่›ๅ…‰้€ ๅฝฑๅ‰คๅŠใณ่›ๅ…‰้€ ๅฝฑๆ–นๆณ•
US7018775B2 (en) * 2003-12-15 2006-03-28 Eastman Kodak Company Infrared absorbing N-alkylsulfate cyanine compounds
EP1901781A2 (en) * 2005-06-21 2008-03-26 Mallinckrodt, Inc. Optical imaging contrast agents
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
EP1896086A1 (en) * 2005-06-30 2008-03-12 Bristol-Myers Squibb Pharma Company Hydrazide conjugates as imaging agents
EP1745739A3 (en) * 2005-07-14 2009-04-22 Bundesrepublik Deutschland, vertr. d.d. Bundes- ministerium f. Wirtschaft- und Technologie, dieses vertr. d.d. Prรคs. d. Phys.-Techn. Bundesanstalt Optical imaging of rheumatoid arthritis
JP5106397B2 (ja) 2005-09-02 2012-12-26 ใƒ“ใ‚ปใƒณ ใƒกใƒ‡ใ‚ฃใ‚ซใƒซ๏ผŒ ใ‚คใƒณใ‚ณใƒผใƒใƒฌใ‚คใƒ†ใƒƒใƒ‰ ็”Ÿไฝ“้ฉๅˆๆ€ง๏ฝŽ๏ผŒ๏ฝŽโˆ’ไบŒ็ฝฎๆ›ใ‚นใƒซใƒ›ใƒณใ‚ขใƒŸใƒ‰ๅซๆœ‰่›ๅ…‰่‰ฒ็ด ๆจ™่ญ˜
US7947256B2 (en) * 2005-09-02 2011-05-24 Visen Medical, Inc. Biocompatible fluorescent imaging agents
US8173819B2 (en) * 2005-09-02 2012-05-08 Visen Medical, Inc. Nicotinic and picolinic acid derived near-infrared fluorophores
DE102006029454A1 (de) 2005-12-05 2007-06-06 Dyomics Gmbh Hydrophile Marker auf Basis von diasteromeren
US20070148094A1 (en) * 2005-12-22 2007-06-28 Uzgiris Egidijus E Polymeric imaging agents and medical imaging methods
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
US9201063B2 (en) * 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
US7741045B2 (en) * 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US7629125B2 (en) 2006-11-16 2009-12-08 General Electric Company Sequential analysis of biological samples
US9333272B2 (en) 2006-12-11 2016-05-10 Bracco Imaging Spa Fibrin binding peptide conjugates for diagnostic and therapeutic applications
ES2670852T3 (es) 2007-02-09 2018-06-01 Visen Medical, Inc. Colorantes con policiclo y uso de los mismos
WO2008109832A2 (en) * 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
US7906106B2 (en) * 2007-06-27 2011-03-15 General Electric Company In vivo cell trafficking
US8021647B2 (en) * 2007-06-29 2011-09-20 General Electric Company In vivo optical imaging
AU2009205950C1 (en) 2008-01-18 2015-08-06 Visen Medical, Inc. Fluorescent imaging agents
WO2009129220A2 (en) 2008-04-14 2009-10-22 The Gereral Hospital Corporation Plectin-1 targeted agents for detection and treatment of pancreatic ductal adenocarcinoma
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
US7951959B2 (en) 2008-09-17 2011-05-31 Thermo Fisher Scientific (Milwaukee) LLC Hydrophilic labels for biomolecules
US20110280806A1 (en) * 2008-11-20 2011-11-17 Robert James Domett Nairne Dye conjugate imaging agents
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
CA2758952C (en) * 2009-04-17 2016-01-12 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
US20110021908A1 (en) 2009-05-27 2011-01-27 Lumicell Diagnostics, Inc. Methods and systems for spatially identifying abnormal cells
US20120226119A1 (en) 2009-07-09 2012-09-06 Hoffmann-La Roche Inc. Vivo tumor vasculature imaging
CA2768330A1 (en) 2009-07-28 2011-02-03 F. Hoffmann-La Roche Ag Non-invasive in vivo optical imaging method
EP2470887B1 (en) 2009-08-28 2020-03-11 VisEn Medical, Inc. Systems for tomographic imaging in diffuse media using a hybrid inversion technique
CA2810822C (en) 2009-09-22 2018-03-06 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
US9677125B2 (en) * 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
EP2567234B1 (en) 2010-05-07 2018-09-19 F.Hoffmann-La Roche Ag Diagnostic method for the detection of cells ex vivo
WO2012003334A2 (en) * 2010-06-30 2012-01-05 Case Western Reserve University Molecular probes for imaging of myelin
US8524239B2 (en) 2010-07-09 2013-09-03 The United States of America as represented by the Secrectary, Department of Health and Human Services Photosensitizing antibody-fluorophore conjugates
EP2618849B1 (en) 2010-09-20 2020-10-21 Caliper Life Sciences, Inc. Multivalent fluorescent probes
WO2012054749A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Cyanine dyes and their conjugates
WO2012058638A2 (en) 2010-10-29 2012-05-03 President And Fellows Of Harvard College Nucleic acid nanostructure barcode probes
WO2012061403A1 (en) * 2010-11-02 2012-05-10 Life Technologies Corporation Modified hydrocyanine dyes for the detection of reactive oxygen species
US9314304B2 (en) 2010-12-08 2016-04-19 Lumicell, Inc. Methods and system for image guided cell ablation with microscopic resolution
EP2655327B1 (en) 2010-12-21 2016-02-24 Pierce Biotechnology, Inc. Fluorescent compounds
US20140099264A1 (en) 2011-03-07 2014-04-10 F. Hoffman-La Roche Ag Means and methods for in vivo testing of therapeutic antibodies
JP6385060B2 (ja) 2011-03-07 2018-09-05 ใ‚จใƒ•ใƒปใƒ›ใƒ•ใƒžใƒณโˆ’ใƒฉใƒปใƒญใ‚ทใƒฅใƒปใ‚ขใ‚ฏใƒใ‚งใƒณใ‚ฒใ‚ผใƒซใ‚ทใƒฃใƒ•ใƒˆ ๆฒป็™‚็š„ใซๆดปๆ€งใชๆŠ—ไฝ“ใฎใ‚คใƒณใƒ“ใƒœใซใŠใ‘ใ‚‹้ธๆŠž
US20140080162A1 (en) 2011-03-25 2014-03-20 Almac Sciences (Scotland) Limited Fluorescence lifetime epigenetics assays
AU2012253502C1 (en) 2011-05-09 2017-12-14 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
EP2731626B1 (en) * 2011-07-11 2018-12-19 THE UNITED STATES OF AMERICA, represented by the S Photosensitizing antibody-fluorophore conjugates
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
EP2764406B1 (en) * 2011-10-07 2018-03-14 Cedars-Sinai Medical Center Compositions and methods for tumor imaging and targeting by a class of organic heptamethine cyanine dyes that possess dual nuclear and near-infrared properties
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
WO2013130761A1 (en) 2012-03-02 2013-09-06 Pierce Biotechnology, Inc. Indole derivatives as labeling dye for biomolecule
WO2013148319A1 (en) 2012-03-30 2013-10-03 Visen Medical, Inc. Bacterial imaging agents and methods of using same
WO2013148038A1 (en) * 2012-03-30 2013-10-03 Life Technologies Corporation Modified nucleic acid binding cyanine dyes for the detection of reactive oxygen species
AU2013303233C1 (en) 2012-08-15 2018-08-23 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
WO2014035712A1 (en) 2012-08-28 2014-03-06 Pierce Biotechnology, Inc. Benzopyrylium compounds
EP2906106B1 (en) 2012-10-15 2023-06-14 VisEn Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
ES2628529T3 (es) 2012-10-24 2017-08-03 Tintes de cianina-azaindolina sustituidos con hidroxamato, y bioconjugados de los mismos
NL2010040C2 (en) * 2012-12-21 2014-06-24 Internat Inst For Diagnostic And Analitical Affairs B V Cleavable coating material having microbial functionality.
WO2014165216A1 (en) * 2013-03-12 2014-10-09 The Trustees Of The University Of Pennsylvania Diagnosing and treating cancer
KR20160037834A (ko) 2013-03-14 2016-04-06 ๋ฃจ๋ฏธ์…€, ์•„์ด์—”์”จ. ์˜๋ฃŒ ์ด๋ฏธ์ง• ์žฅ์น˜ ๋ฐ ์‚ฌ์šฉ ๋ฐฉ๋ฒ•
JP6192799B2 (ja) * 2013-03-15 2017-09-06 ใƒ‘ใƒผใƒ‡ใƒฅใƒผใƒปใƒชใ‚ตใƒผใƒใƒปใƒ•ใ‚กใ‚ฆใƒณใƒ‡ใƒผใ‚ทใƒงใƒณ๏ผฐ๏ฝ•๏ฝ’๏ฝ„๏ฝ•๏ฝ… ๏ผฒ๏ฝ…๏ฝ“๏ฝ…๏ฝ๏ฝ’๏ฝƒ๏ฝˆ ๏ผฆ๏ฝ๏ฝ•๏ฝŽ๏ฝ„๏ฝ๏ฝ”๏ฝ‰๏ฝ๏ฝŽ ่…ซ็˜ใฎๆจ™็š„็”ปๅƒๅŒ–ใซไฝฟ็”จใ•ใ‚Œใ‚‹ๅŒ–ๅˆ็‰ฉใซใ‚ณใƒณใ‚ธใƒฅใ‚ฒใƒผใƒˆใ—ใฆใ„ใ‚‹ใ‚ขใƒŸใƒŽ้…ธ้€ฃ็ตๅŸบใฎๅˆๆˆใŠใ‚ˆใณ็ต„ๆˆ็‰ฉ
CA2901000C (en) 2013-03-15 2023-03-14 Visen Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
AU2014228504C1 (en) 2013-03-15 2019-10-03 Visen Medical, Inc. Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection
HK1221747A1 (zh) 2013-07-30 2017-06-09 ๅ“ˆไฝ›ๅญฆ้™ข้™ข้•ฟๅŠ่‘ฃไบ‹ ๅŸบๆ–ผdna็š„ๅฎš้‡ๆˆๅƒๅ’Œ่ถ…ๅˆ†่พจๆˆๅƒ
EP3019559A4 (en) 2013-08-22 2017-04-05 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
WO2015038968A1 (en) 2013-09-13 2015-03-19 The General Hospital Corporation Activatable fibrin-binding probes
CN106455979A (zh) 2013-12-31 2017-02-22 ็บชๅฟตๆ–ฏ้š†-ๅ‡ฏ็‰น็ณ็™Œ็—‡ไธญๅฟƒ ็”จไบŽ่งๅ…‰ๆบๅฎžๆ—ถๅคš้€š้“ๆˆๅƒ็š„็ณป็ปŸใ€ๆ–นๆณ•ๅ’Œ่ฎพๅค‡
KR101829159B1 (ko) 2014-01-16 2018-02-13 ์†Œ๋‹ˆ ์ฃผ์‹ํšŒ์‚ฌ ์ˆ˜์šฉ์„ฑ ํ˜•๊ด‘ ๋˜๋Š” ์œ ์ƒ‰ ์—ผ๋ฃŒ
JP6757255B2 (ja) 2014-03-11 2020-09-16 ใƒ—ใƒฌใ‚ธใƒ‡ใƒณใƒˆ ใ‚ขใƒณใƒ‰ ใƒ•ใ‚งใƒญใƒผใ‚บ ใ‚ชใƒ– ใƒใƒผใƒใƒผใƒ‰ ใ‚ซใƒฌใƒƒใ‚ธ ใƒ—ใƒญใ‚ฐใƒฉใƒ ๅฏ่ƒฝใชๆ ธ้…ธใƒ—ใƒญใƒผใƒ–ใ‚’็”จใ„ใŸ้ซ˜ใ‚นใƒซใƒผใƒ—ใƒƒใƒˆๅŠใณ้ซ˜ๅบฆๅคš้‡ๅŒ–ใ‚คใƒกใƒผใ‚ธใƒณใ‚ฐ
EP2944326B1 (en) * 2014-05-16 2018-11-21 Cyanagen Srl Tricarbocyanine-cyclodextrin-conjugates and their use for the diagnosis of kidney diseases
ES2743458T5 (es) 2014-08-08 2023-06-08 Us Health Eliminaciรณn fotocontrolada de dianas in vitro e in vivo
KR20170094268A (ko) 2014-12-15 2017-08-17 ๋ฉ”๋ชจ๋ฆฌ์–ผ ์Šฌ๋กœ์•ˆ-์ผ€ํ„ฐ๋ง ์บ”์„œ ์„ผํ„ฐ ํ–ฅ์ƒ๋œ ์‹ ๊ฒฝ-๊ฒฐํ•ฉ ์„ ํƒ์„ฑ์„ ๊ฐ–๋Š” ๊ณ ๋ฆฌํ˜• ํŽฉํ‹ฐ๋“œ, ์ƒ๊ธฐ ๊ณ ๋ฆฌํ˜• ํŽฉํ‹ฐ๋“œ์™€ ๊ฒฐํ•ฉ๋œ ๋‚˜๋…ธ์ž…์ž, ๋ฐ ์‹ค์‹œ๊ฐ„ ์ƒ์ฒด๋‚ด ์‹ ๊ฒฝ ์กฐ์ง ์˜์ƒํ™”๋ฅผ ์œ„ํ•œ ์ด๋“ค์˜ ์šฉ๋„
US10124111B2 (en) 2015-02-24 2018-11-13 The Board Of Trustees Of The Leland Stanford Junior University Small molecule dye for molecular imaging and photothermal therapy
KR102676814B1 (ko) 2015-02-26 2024-06-21 ์†Œ๋‹ˆ๊ทธ๋ฃน์ฃผ์‹ํšŒ์‚ฌ ์ ‘ํ•ฉ ๊ทธ๋ฃน์„ ํฌํ•จํ•˜๋Š” ์ˆ˜์šฉ์„ฑ ํ˜•๊ด‘ ๋˜๋Š” ์ฐฉ์ƒ‰ ์—ผ๋ฃŒ
WO2016138457A1 (en) 2015-02-26 2016-09-01 Sony Corporation Phenylethynylnaphthalene dyes and methods for their use
JP6849599B2 (ja) 2015-05-11 2021-03-24 ใ‚ฝใƒ‹ใƒผๆ ชๅผไผš็คพ ่ถ…ๆ˜Ž่‰ฒใƒ€ใ‚คใƒžใƒผใพใŸใฏใƒใƒชใƒžใƒผๆŸ“ๆ–™
KR102557419B1 (ko) 2015-08-07 2023-07-19 ํ”„๋ ˆ์ง€๋˜ํŠธ ์•ค๋“œ ํŽ ๋กœ์šฐ์ฆˆ ์˜ค๋ธŒ ํ•˜๋ฐ”๋“œ ์นผ๋ฆฌ์ง€ ๋‹จ๋ฐฑ์งˆ-๋‹จ๋ฐฑ์งˆ ์ƒํ˜ธ์ž‘์šฉ์˜ ์ดˆํ•ด์ƒ๋„ ์˜์ƒํ™”
EP3331909A1 (en) 2015-08-07 2018-06-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Near infrared photoimmunotherapy (nir-pit) of suppressor cells to treat cancer
CN114699525A (zh) 2015-08-18 2022-07-05 ไนๅคฉๅŒป่ฏ็”ŸๆŠ€่‚กไปฝๆœ‰้™ๅ…ฌๅธ ้…ž่ๆŸ“ๆ–™ๅถ่”็‰ฉ็š„ๅˆถ้€ ๆ–นๆณ•ๅŠ็จณๅฎšๅถ่”็‰ฉ
EP3827846B1 (en) 2015-08-18 2024-10-02 Rakuten Medical, Inc. Compositions, combinations and related methods for photoimmunotherapy
CN105199430B (zh) * 2015-11-05 2017-03-22 ๆตŽๅฎๅš่”็”Ÿ็‰ฉ็ง‘ๆŠ€ๆœ‰้™ๅ…ฌๅธ ไธ€็งไธŠ็šฎ็ป„็ป‡ๆŸ“่‰ฒๅ‰‚ๅŠๅ…ถๅˆถๅค‡ๆ–นๆณ•
KR20180093961A (ko) 2015-12-15 2018-08-22 ๋ฉ”๋ชจ๋ฆฌ์–ผ ์Šฌ๋กœ์•ˆ-์ผ€ํ„ฐ๋ง ์บ”์„œ ์„ผํ„ฐ ์กฐ์ง ๊ตฌ๋ณ„, ์˜ˆ๋ฅผ ๋“ค์–ด, ์ˆ˜์ˆ  ์ค‘ ์‹œ๊ฐํ™”๋ฅผ ์œ„ํ•œ ์˜์ƒํ™” ์‹œ์Šคํ…œ ๋ฐ ๋ฐฉ๋ฒ•
US11434377B2 (en) 2016-04-01 2022-09-06 Sony Corporation Ultra bright dimeric or polymeric dyes with rigid spacing groups
KR102530707B1 (ko) 2016-04-01 2023-05-11 ์†Œ๋‹ˆ๊ทธ๋ฃน์ฃผ์‹ํšŒ์‚ฌ ์ดˆํœ˜๋„ ์ด๋Ÿ‰์ฒด์„ฑ ๋˜๋Š” ์ค‘ํ•ฉ์ฒด์„ฑ ์—ผ๋ฃŒ
KR20180133890A (ko) 2016-04-06 2018-12-17 ์†Œ๋‹ˆ ์ฃผ์‹ํšŒ์‚ฌ ์ŠคํŽ˜์ด์‹ฑ ๋ง์ปค ๊ทธ๋ฃน์„ ํฌํ•จํ•˜๋Š” ์ดˆ๊ณ ๋ช…๋„ ์ด๋Ÿ‰์ฒด์„ฑ ๋˜๋Š” ์ค‘ํ•ฉ์ฒด์„ฑ ์—ผ๋ฃŒ
WO2017196954A1 (en) 2016-05-10 2017-11-16 Sony Corporation Ultra bright polymeric dyes with peptide backbones
WO2017197014A2 (en) 2016-05-10 2017-11-16 Sony Corporation Compositions comprising a polymeric dye and a cyclodextrin and uses thereof
EP3455300A1 (en) 2016-05-11 2019-03-20 Sony Corporation Ultra bright dimeric or polymeric dyes
JP7068191B2 (ja) 2016-06-06 2022-05-16 ใ‚ฝใƒ‹ใƒผใ‚ฐใƒซใƒผใƒ—ๆ ชๅผไผš็คพ ่›ๅ…‰ใพใŸใฏๆœ‰่‰ฒใƒฌใƒใƒผใ‚ฟใƒผๅŸบใ‚’ๅซใ‚€ใ‚คใ‚ชใƒณๆ€งใƒใƒชใƒžใƒผ
US12018159B2 (en) 2016-07-29 2024-06-25 Sony Group Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
WO2018102372A1 (en) 2016-11-30 2018-06-07 Memorial Sloan Kettering Cancer Center Inhibitor-functionalized ultrasmall nanoparticles and methods thereof
AU2017370751B2 (en) 2016-12-09 2023-11-09 Ultivue, Inc. Improved methods for multiplex imaging using labeled nucleic acid imaging agents
EP3568689B1 (en) 2017-01-10 2025-09-03 Sun Chemical Corporation In-line coating weight and radiant energy exposure measurement
JP7551056B2 (ja) 2017-10-05 2024-09-17 ใ‚ฝใƒ‹ใƒผใ‚ฐใƒซใƒผใƒ—ๆ ชๅผไผš็คพ ใƒ—ใƒญใ‚ฐใƒฉใƒžใƒ–ใƒซใชใƒใƒชใƒžใƒผ่–ฌ็‰ฉ
EP3691689A1 (en) 2017-10-05 2020-08-12 Sony Corporation Programmable dendritic drugs
CN111836645A (zh) 2017-11-16 2020-10-27 ็ดขๅฐผๅ…ฌๅธ ๅฏ็ผ–็จ‹็š„่šๅˆ่ฏ็‰ฉ
WO2019140301A1 (en) 2018-01-12 2019-07-18 Sony Corporation Polymers with rigid spacing groups comprising biologically active compounds
EP4616912A3 (en) 2018-01-12 2025-11-19 Sony Group Corporation Phosphoalkyl ribose polymers comprising biologically active compounds
KR102742386B1 (ko) 2018-03-19 2024-12-16 ์†Œ๋‹ˆ๊ทธ๋ฃน์ฃผ์‹ํšŒ์‚ฌ ํ˜•๊ด‘ ์‹ ํ˜ธ ํ–ฅ์ƒ์„ ์œ„ํ•œ 2๊ฐ€ ๊ธˆ์†์˜ ์‚ฌ์šฉ
WO2019182766A1 (en) 2018-03-21 2019-09-26 Sony Corporation Polymeric tandem dyes with linker groups
EP3773153A4 (en) 2018-03-30 2021-11-17 Perkinelmer Health Sciences Inc. SYSTEMS AND PROCEDURES FOR THE 3D RECONSTRUCTION OF ANATOMICAL ORGANS AND INCLUSIONS USING SHORT WAVE INFRARED (SWIR) PROJECTION STOMOGRAPHY
KR102854332B1 (ko) 2018-06-27 2025-09-03 ์†Œ๋‹ˆ๊ทธ๋ฃน์ฃผ์‹ํšŒ์‚ฌ ๋””์˜ฅ์‹œ๋ฆฌ๋ณด์˜ค์Šค๋ฅผ ํฌํ•จํ•˜๋Š” ๋ง์ปค ๊ตฐ์„ ๊ฐ–๋Š” ์ค‘ํ•ฉ์ฒด์„ฑ ์—ผ๋ฃŒ
KR102132885B1 (ko) * 2018-09-03 2020-07-10 (์ฃผ)์”จ๋ฐ”์ด์˜ค๋ฉ•์Šค ์ƒ์ฒด๋ฌผ์งˆ๊ณผ ์—ฐ๊ฒฐ๋  ์ˆ˜ ์žˆ๋Š” ์–‘์ชฝ์„ฑ ํ˜•๊ด‘๋ฌผ์งˆ
KR102486779B1 (ko) 2019-09-26 2023-01-12 ์†Œ๋‹ˆ๊ทธ๋ฃน์ฃผ์‹ํšŒ์‚ฌ ๋ง์ปค ๊ทธ๋ฃน์„ ๊ฐ–๋Š” ์ค‘ํ•ฉ์ฒด์„ฑ ํƒ ๋ค ์—ผ๋ฃŒ
KR102336507B1 (ko) * 2020-02-21 2021-12-06 ํ•œ๋ฆผ๋Œ€ํ•™๊ต ์‚ฐํ•™ํ˜‘๋ ฅ๋‹จ ๊ตญ์†Œ๋‡Œ์‚ฐ์†Œํฌํ™”๋„๋ฅผ ์ด์šฉํ•œ ์ง€์—ฐ์„ฑ ๋‡Œํ—ˆํ˜ˆ ์ง„๋‹จ ๋ฐฉ๋ฒ•
KR102369155B1 (ko) * 2020-07-07 2022-02-28 ํ•œ๋ฆผ๋Œ€ํ•™๊ต ์‚ฐํ•™ํ˜‘๋ ฅ๋‹จ ๊ทผ์ ์™ธ์„  ๋ถ„๊ด‘๋ถ„์„๋ฒ•์„ ์ด์šฉํ•œ ์ง€์—ฐ์„ฑ ๋‡Œํ—ˆํ˜ˆ ์ง„๋‹จ ๋ฐฉ๋ฒ•
CN112062797B (zh) * 2020-08-19 2021-09-21 ๅŽๅ—็†ๅทฅๅคงๅญฆ ไธ€็งไบŒ่šไฝ“ๅ‰่ฏๅŠๅ…ถๅˆถๅค‡ๆ–นๆณ•ๅ’Œๅบ”็”จ
EP4256078A1 (en) 2020-12-07 2023-10-11 Sony Group Corporation Spacing linker group design for brightness enhancement in dimeric or polymeric dyes
EP4015004A1 (en) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglycan specific branched peptides
CN114748640B (zh) * 2022-05-06 2024-02-09 ๅ—ๆ–นๅŒป็ง‘ๅคงๅญฆ็ ๆฑŸๅŒป้™ข ไธ€็งpHๅ“ๅบ”ๆ€ง็š„siRNA้€’้€็ณป็ปŸ
EP4573360A1 (en) 2023-01-26 2025-06-25 Sun Chemical Corporation Fluorescent ink and imaging system for defect detection on printed photosensitive objects
WO2025107185A1 (zh) * 2023-11-22 2025-05-30 ไธญๅ›ฝ็ง‘ๅญฆ้™ขๆทฑๅœณๅ…ˆ่ฟ›ๆŠ€ๆœฏ็ ”็ฉถ้™ข ไธ€็ง่ฝฝไฝ“ใ€้ถๅ‘็บณ็ฑณ้ข—็ฒ’ๅŠๅ…ถๅˆถๅค‡ๆ–นๆณ•ๅ’Œๅบ”็”จ

Family Cites Families (15)

* Cited by examiner, โ€  Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986001720A1 (en) * 1984-09-13 1986-03-27 Cytogen Corporation Antibody therapeutic agent conjugates
US5569587A (en) 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US5066490A (en) * 1988-06-01 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Protein crosslinking reagents cleavable within acidified intracellular vesicles
CA2048089A1 (en) * 1990-09-17 1992-03-18 Wolfgang A. Wrasidlo Chemical conjugation of morpholino anthracyclines to antibodies
JPH07145148A (ja) 1992-06-02 1995-06-06 Bio Sensor Kenkyusho:Kk ใƒใƒชใƒกใƒใƒณ็ณปๅŒ–ๅˆ็‰ฉใŠใ‚ˆใณใใ‚Œใ‚’็”จใ„ใ‚‹ๆธฌๅฎšๆ–นๆณ•
GB9310978D0 (en) * 1993-05-27 1993-07-14 Zeneca Ltd Compounds
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5968479A (en) * 1995-01-30 1999-10-19 Daiichi Pure Chemicals Co., Ltd. Diagnostic marker
US5741657A (en) * 1995-03-20 1998-04-21 The Regents Of The University Of California Fluorogenic substrates for ฮฒ-lactamase and methods of use
IT1276833B1 (it) 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
DE19539409C2 (de) * 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel fรผr die Nahinfrarot-Diagnostik
WO1997040104A1 (en) * 1996-04-19 1997-10-30 Amersham Pharmacia Biotech Uk Limited Squarate dyes and their use in fluorescent sequencing method
DE19649971A1 (de) * 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Sรคurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
KR20050103308A (ko) 2003-02-28 2005-10-28 ์…€ ์ธํ„ฐ๋‚˜์ตธ๋‚˜์•„๋ ˆ ๋ ˆ์‚ฌ์•„์น˜ ๋งˆ์•„์ธ ์ƒคํ”ผ ๋น„์ด๋ถ€์ด ๋ฐฉ๋ฒ•

Also Published As

Publication number Publication date
PT988060E (pt) 2007-08-17
JP2010116413A (ja) 2010-05-27
JP2001521530A (ja) 2001-11-06
JP5118790B2 (ja) 2013-01-16
WO1998047538A2 (de) 1998-10-29
NO995181L (no) 1999-10-22
HUP0003132A2 (hu) 2001-01-29
KR100613306B1 (ko) 2006-08-17
EP0988060A2 (de) 2000-03-29
NO327495B1 (no) 2009-07-20
US6534041B1 (en) 2003-03-18
AU733757B2 (en) 2001-05-24
CA2287262A1 (en) 1998-10-29
CA2287262C (en) 2007-02-06
DK0988060T3 (da) 2007-10-15
CN1253507A (zh) 2000-05-17
WO1998047538A3 (de) 1999-01-21
EP0988060B1 (de) 2007-06-13
CY1106860T1 (el) 2012-05-23
AU7905798A (en) 1998-11-13
ATE364404T1 (de) 2007-07-15
ES2289786T3 (es) 2008-02-01
NO995181D0 (no) 1999-10-22
HUP0003132A3 (en) 2003-03-28
DE59814030D1 (de) 2007-07-26
KR20010020183A (ko) 2001-03-15
DE19717904A1 (de) 1998-10-29

Similar Documents

Publication Publication Date Title
HU226812B1 (en) Enzymatically divisible dye compounds for diagnosis with near infrared light
EP2035505B1 (en) Optical fluorescent imaging using cyanine dyes
EP2630196B1 (en) Cyanine dyes and their conjugates
EP1181940B1 (de) Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US5672333A (en) Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging
US20040171827A1 (en) Phthalocyanine dyes
US6423547B1 (en) Non-covalent bioconjugates useful for diagnosis and therapy
JP2012524153A (ja) ็ฝฎๆ›ใ‚ทใ‚ขใƒ‹ใƒณๆŸ“ๆ–™ใ‚’็”จใ„ใŸ่›ๅ…‰ใ‚คใƒกใƒผใ‚ธใƒณใ‚ฐ
CA2272320A1 (en) Optical diagnostic agents for diagnosis of neurodegenerative diseases by means of near infra-red radiation (nir radiation)
KR20100017102A (ko) ๊ด‘ํ•™ ์กฐ์˜์ œ
NZ517944A (en) Antibody dye conjugates for binding to target structures of angiogenesis in order to intraoperatively depict tumor peripheries
HK1027035A (en) Acid-labile and enzymatically divisible dye compounds for diagnosis with near infrared light and for therapy

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees