HU215534B - Biokompatíbilis, perforált membránok, eljárás előállításukra, hámszövet sejtek in vitro növekedésének elősegítésére való alkalmazásuk és az így kapott mesterséges bőr - Google Patents
Biokompatíbilis, perforált membránok, eljárás előállításukra, hámszövet sejtek in vitro növekedésének elősegítésére való alkalmazásuk és az így kapott mesterséges bőr Download PDFInfo
- Publication number
- HU215534B HU215534B HU911834A HU183491A HU215534B HU 215534 B HU215534 B HU 215534B HU 911834 A HU911834 A HU 911834A HU 183491 A HU183491 A HU 183491A HU 215534 B HU215534 B HU 215534B
- Authority
- HU
- Hungary
- Prior art keywords
- biocompatible
- synthetic
- acid
- natural
- membrane
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 56
- 238000000034 method Methods 0.000 title claims abstract description 26
- 210000002919 epithelial cell Anatomy 0.000 title claims abstract description 13
- 230000012010 growth Effects 0.000 title claims description 4
- 238000000338 in vitro Methods 0.000 title description 9
- 238000002360 preparation method Methods 0.000 title description 4
- 230000001737 promoting effect Effects 0.000 title description 2
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- 229920002994 synthetic fiber Polymers 0.000 claims abstract description 4
- 210000003491 skin Anatomy 0.000 claims description 21
- -1 benzyl ester Chemical class 0.000 claims description 18
- 210000002510 keratinocyte Anatomy 0.000 claims description 18
- 210000004027 cell Anatomy 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 16
- 102000008186 Collagen Human genes 0.000 claims description 13
- 108010035532 Collagen Proteins 0.000 claims description 13
- 229920001436 collagen Polymers 0.000 claims description 13
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 8
- 229920001817 Agar Polymers 0.000 claims description 8
- 239000008272 agar Substances 0.000 claims description 8
- 239000002649 leather substitute Substances 0.000 claims description 8
- 229920001661 Chitosan Polymers 0.000 claims description 7
- 229920000615 alginic acid Polymers 0.000 claims description 7
- 235000010443 alginic acid Nutrition 0.000 claims description 7
- 229920002674 hyaluronan Polymers 0.000 claims description 7
- 229960003160 hyaluronic acid Drugs 0.000 claims description 7
- 229920002101 Chitin Polymers 0.000 claims description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- 210000000981 epithelium Anatomy 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 229920000936 Agarose Polymers 0.000 claims description 5
- 229920002230 Pectic acid Polymers 0.000 claims description 5
- 229920001277 pectin Polymers 0.000 claims description 5
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 claims description 4
- 229920002148 Gellan gum Polymers 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 239000000783 alginic acid Substances 0.000 claims description 4
- 229960001126 alginic acid Drugs 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 229920002635 polyurethane Polymers 0.000 claims description 4
- 239000004814 polyurethane Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 244000043261 Hevea brasiliensis Species 0.000 claims description 3
- 229920000954 Polyglycolide Polymers 0.000 claims description 3
- 150000004781 alginic acids Chemical class 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 239000003349 gelling agent Substances 0.000 claims description 3
- 229920003052 natural elastomer Polymers 0.000 claims description 3
- 229920001206 natural gum Polymers 0.000 claims description 3
- 229920005615 natural polymer Polymers 0.000 claims description 3
- 229920001194 natural rubber Polymers 0.000 claims description 3
- 239000001814 pectin Substances 0.000 claims description 3
- 235000010987 pectin Nutrition 0.000 claims description 3
- 229920002492 poly(sulfone) Polymers 0.000 claims description 3
- 229920000447 polyanionic polymer Polymers 0.000 claims description 3
- 239000004633 polyglycolic acid Substances 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- 150000004804 polysaccharides Chemical class 0.000 claims description 3
- 230000001376 precipitating effect Effects 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 238000004080 punching Methods 0.000 claims description 2
- 239000000560 biocompatible material Substances 0.000 claims 6
- LCLHHZYHLXDRQG-ZNKJPWOQSA-N pectic acid Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)O[C@H](C(O)=O)[C@@H]1OC1[C@H](O)[C@@H](O)[C@@H](OC2[C@@H]([C@@H](O)[C@@H](O)[C@H](O2)C(O)=O)O)[C@@H](C(O)=O)O1 LCLHHZYHLXDRQG-ZNKJPWOQSA-N 0.000 claims 4
- 239000010318 polygalacturonic acid Substances 0.000 claims 4
- 229920001285 xanthan gum Polymers 0.000 claims 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
- 229940072056 alginate Drugs 0.000 claims 2
- 229920003175 pectinic acid Polymers 0.000 claims 2
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims 2
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 2
- 239000000622 polydioxanone Substances 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229960005188 collagen Drugs 0.000 description 8
- 238000011161 development Methods 0.000 description 8
- 230000018109 developmental process Effects 0.000 description 8
- 238000004113 cell culture Methods 0.000 description 5
- 210000002950 fibroblast Anatomy 0.000 description 5
- 239000007943 implant Substances 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 238000003556 assay Methods 0.000 description 3
- 239000012620 biological material Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 238000011081 inoculation Methods 0.000 description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 231100000518 lethal Toxicity 0.000 description 2
- 230000001665 lethal effect Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 229920000544 Gore-Tex Polymers 0.000 description 1
- 229920001774 Perfluoroether Polymers 0.000 description 1
- 101000972349 Phytolacca americana Lectin-A Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000000975 co-precipitation Methods 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 150000004985 diamines Chemical class 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- CDMADVZSLOHIFP-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane;decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 CDMADVZSLOHIFP-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- AZIQALWHRUQPHV-UHFFFAOYSA-N prop-2-eneperoxoic acid Chemical compound OOC(=O)C=C AZIQALWHRUQPHV-UHFFFAOYSA-N 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/10—Hair or skin implants
- A61F2/105—Skin implants, e.g. artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/80—Hyaluronan
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2539/00—Supports and/or coatings for cell culture characterised by properties
- C12N2539/10—Coating allowing for selective detachment of cells, e.g. thermoreactive coating
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24273—Structurally defined web or sheet [e.g., overall dimension, etc.] including aperture
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT02051390A IT1248934B (it) | 1990-06-01 | 1990-06-01 | Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU911834D0 HU911834D0 (en) | 1991-12-30 |
| HUT60514A HUT60514A (en) | 1992-09-28 |
| HU215534B true HU215534B (hu) | 1999-01-28 |
Family
ID=11168072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU911834A HU215534B (hu) | 1990-06-01 | 1991-05-31 | Biokompatíbilis, perforált membránok, eljárás előállításukra, hámszövet sejtek in vitro növekedésének elősegítésére való alkalmazásuk és az így kapott mesterséges bőr |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US5326356A (en, 2012) |
| EP (1) | EP0462426B1 (en, 2012) |
| JP (1) | JP3202257B2 (en, 2012) |
| KR (1) | KR100195574B1 (en, 2012) |
| AR (1) | AR244354A1 (en, 2012) |
| AT (1) | ATE156689T1 (en, 2012) |
| AU (1) | AU637235B2 (en, 2012) |
| BR (1) | BR9102225A (en, 2012) |
| CA (1) | CA2043527C (en, 2012) |
| DE (1) | DE69127235T2 (en, 2012) |
| DK (1) | DK0462426T3 (en, 2012) |
| ES (1) | ES2108019T3 (en, 2012) |
| FI (1) | FI108918B (en, 2012) |
| GR (1) | GR3025075T3 (en, 2012) |
| HU (1) | HU215534B (en, 2012) |
| IE (1) | IE911825A1 (en, 2012) |
| IL (1) | IL98255A (en, 2012) |
| IT (1) | IT1248934B (en, 2012) |
| NO (1) | NO303562B1 (en, 2012) |
| PT (1) | PT97832B (en, 2012) |
| SG (1) | SG52545A1 (en, 2012) |
| TW (1) | TW208652B (en, 2012) |
| UY (1) | UY23231A1 (en, 2012) |
| ZA (1) | ZA914098B (en, 2012) |
Families Citing this family (165)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10237531A1 (de) | 2002-08-16 | 2004-02-26 | Tutogen Medical Gmbh | Implantat |
| US6033437A (en) | 1991-09-30 | 2000-03-07 | Orbital Implant Technology | Pegs for orbital implants |
| IT1263144B (it) * | 1993-02-04 | 1996-08-01 | Lanfranco Callegaro | Composizioni farmaceutiche comprendenti materiale spugnoso costituito da derivati esterei dell'acido ialuronico in associazione con altre sostanze farmacologicamente attive |
| IT1263316B (it) * | 1993-02-12 | 1996-08-05 | Fidia Advanced Biopolymers Srl | Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico |
| US6176874B1 (en) * | 1993-10-18 | 2001-01-23 | Masschusetts Institute Of Technology | Vascularized tissue regeneration matrices formed by solid free form fabrication techniques |
| USD362120S (en) | 1994-03-16 | 1995-09-12 | Confab, Inc. | Apertured coverstock for absorbent articles |
| DE4426315C1 (de) * | 1994-07-25 | 1996-03-21 | Gore W L & Ass Gmbh | Membran zur Regeneration von Körpergeweben und Verwendung der Membran als Wundabdeckung und Hautersatz |
| US6294202B1 (en) * | 1994-10-06 | 2001-09-25 | Genzyme Corporation | Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers |
| JP3543869B2 (ja) * | 1995-03-07 | 2004-07-21 | 株式会社メニコン | 培養皮膚およびその製造法 |
| IT1281870B1 (it) * | 1995-04-27 | 1998-03-03 | Fidia Advanced Biopolymers Srl | Pelle artificiale umana costituita da materiali biocompatibili a base di derivati dell'acido ialuronico |
| US20040002772A1 (en) * | 1995-04-28 | 2004-01-01 | Organogenesis, Inc. | Tissue equivalents with perforations for improved integration to host tissues and methods for producing perforated tissue equivalents |
| GB9512529D0 (en) * | 1995-06-20 | 1995-08-23 | Bnfl Fluorchem Ltd | Cell treatment |
| US5693332C1 (en) * | 1995-08-11 | 2001-01-09 | Univ California | Human keratinocytes supported on a hydrophilic membrane and methods of using same to effect wound closure |
| WO1997006837A1 (en) * | 1995-08-16 | 1997-02-27 | Integra Lifesciences Corporation | Perforated artificial skin grafts |
| JPH11511344A (ja) * | 1995-08-29 | 1999-10-05 | フィディア・アドバンスト・バイオポリマーズ・ソシエタ・ア・レスポンサビリタ・リミタータ | ヒアルロン酸誘導体からなる術後癒着予防用生体適合材料 |
| IT1282207B1 (it) * | 1995-11-20 | 1998-03-16 | Fidia Advanced Biopolymers Srl | Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico |
| US5939323A (en) * | 1996-05-28 | 1999-08-17 | Brown University | Hyaluronan based biodegradable scaffolds for tissue repair |
| US5919234A (en) * | 1996-08-19 | 1999-07-06 | Macropore, Inc. | Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
| US6306491B1 (en) | 1996-12-20 | 2001-10-23 | Gore Enterprise Holdings, Inc. | Respiratory aids |
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US20050033132A1 (en) | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
| US7192450B2 (en) | 2003-05-21 | 2007-03-20 | Dexcom, Inc. | Porous membranes for use with implantable devices |
| US6741877B1 (en) | 1997-03-04 | 2004-05-25 | Dexcom, Inc. | Device and method for determining analyte levels |
| TW586934B (en) * | 1997-05-19 | 2004-05-11 | Sumitomo Pharma | Immunopotentiating composition |
| ES2132027B1 (es) * | 1997-07-04 | 2000-04-01 | Comunitario De Transfusion Del | Desarrollo de una piel artificial mediante cultivo de queratinocitos sobre una base de fibrina y fibroblastos humanos y metodo de preparacion de esta piel para trasplante. |
| US6063117A (en) * | 1998-01-22 | 2000-05-16 | Perry; Arthur C. | Porous orbital implant structure |
| CA2318865A1 (en) * | 1998-01-23 | 1999-07-29 | Marcopore, Inc. | Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration |
| AU761058B2 (en) | 1998-04-07 | 2003-05-29 | Macropore, Inc. | Membrane with tissue-guiding surface corrugations |
| US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| ITPD980149A1 (it) | 1998-06-17 | 1999-12-17 | Fidia Advanced Biopolymers Srl | Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la |
| US5976150A (en) * | 1998-08-25 | 1999-11-02 | Alcon Laboratories, Inc. | Intraocular lens injection system |
| US6278079B1 (en) | 1999-02-09 | 2001-08-21 | Edwards Lifesciences Corp. | Laser cutting of fabric grafts |
| FR2792650B1 (fr) | 1999-04-20 | 2003-02-28 | Oreal | Equivalent de peau agee, son procede de preparation et son utilisation |
| WO2000066055A1 (fr) * | 1999-04-30 | 2000-11-09 | Boris Alexeevich Paramonov | Bandage |
| DE19922078A1 (de) * | 1999-05-15 | 2000-11-23 | Weitzel Kage Doris | Gewebekonstrukt für die Transplantationschirurgie |
| IT1306679B1 (it) * | 1999-06-29 | 2001-10-02 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico per la preparazione dicomposizoni farmaceutiche e biomateriali per la prevenzione della |
| US6733530B1 (en) * | 1999-08-02 | 2004-05-11 | Eric Sun-Yin Chan | Material and method for engraftment of a composite biocompatible skin graft on the neodermis of artificial skin |
| ATE423517T1 (de) * | 1999-12-03 | 2009-03-15 | Univ Leeds | Wiederherstellung von beschädigtem gewebe |
| DE19959750C1 (de) * | 1999-12-11 | 2001-05-31 | Axel Thierauf | Verfahren zur Herstellung eines Hautimplantats, insbesondere Eigenhaut-Implantat und nach dem Verfahren hergestelltes Implantat |
| US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US6974697B2 (en) * | 2001-03-02 | 2005-12-13 | Stratech Corporation | Skin substitutes with improved barrier function |
| ES2457092T3 (es) * | 2001-03-02 | 2014-04-24 | Stratatech Corporation | Sustitutos de piel mejorados y usos de los mismos |
| EP1397068A2 (en) | 2001-04-02 | 2004-03-17 | Therasense, Inc. | Blood glucose tracking apparatus and methods |
| DE10135676A1 (de) * | 2001-07-21 | 2003-02-06 | Degussa Bioactives Deutschland | Physiologisch verträglicher, Cellulose enthaltender Film |
| US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
| US6702857B2 (en) | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
| DE10151296A1 (de) | 2001-10-17 | 2003-04-30 | Boehringer Ingelheim Pharma | Keratinozyten verwendbar als biologisch aktive Substanz bei der Behandlung von Wunden |
| KR20030032420A (ko) * | 2001-10-18 | 2003-04-26 | 한국과학기술연구원 | 손상된 안구 조직의 재생을 위한 생분해성 고분자로제조된 다공성 지지체 |
| US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
| US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
| US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US9247901B2 (en) | 2003-08-22 | 2016-02-02 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| EP1549738B1 (en) * | 2002-04-30 | 2010-04-21 | Stratatech Corporation | Keratinocytes expressing exogenous angiogenic growth factors |
| US7226978B2 (en) | 2002-05-22 | 2007-06-05 | Dexcom, Inc. | Techniques to improve polyurethane membranes for implantable glucose sensors |
| US20040059356A1 (en) * | 2002-07-17 | 2004-03-25 | Peter Gingras | Soft tissue implants and methods for making same |
| WO2004028584A1 (en) * | 2002-09-30 | 2004-04-08 | Bioland Ltd. | Dermal substitute consisting of amnion and biodegradable polymer, the preparation method and the use thereof |
| US8685943B2 (en) | 2003-03-12 | 2014-04-01 | Hill's Pet Nutrition, Inc. | Methods for reducing diarrhea in a companion animal |
| US7134999B2 (en) | 2003-04-04 | 2006-11-14 | Dexcom, Inc. | Optimized sensor geometry for an implantable glucose sensor |
| US7875293B2 (en) | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
| JP2007500196A (ja) * | 2003-05-24 | 2007-01-11 | バイヤースドルフ・アクチエンゲゼルシヤフト | 化粧品の成分として使用される組織培養培地 |
| WO2007120442A2 (en) | 2003-07-25 | 2007-10-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US8423113B2 (en) | 2003-07-25 | 2013-04-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US20100168657A1 (en) | 2003-08-01 | 2010-07-01 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| US7774145B2 (en) | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
| US8845536B2 (en) | 2003-08-01 | 2014-09-30 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8060173B2 (en) | 2003-08-01 | 2011-11-15 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US8275437B2 (en) | 2003-08-01 | 2012-09-25 | Dexcom, Inc. | Transcutaneous analyte sensor |
| PT3100611T (pt) | 2003-08-01 | 2018-12-14 | Stratatech Corp | Equivalentes de pele humana que expressam polipéptidos exógenos |
| US20080119703A1 (en) | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
| US8160669B2 (en) | 2003-08-01 | 2012-04-17 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7519408B2 (en) | 2003-11-19 | 2009-04-14 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
| US8999167B2 (en) | 2003-08-07 | 2015-04-07 | Asahi Kasei Medical Co., Ltd. | Composite porous membrane and process for producing the same |
| US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| ATE480761T1 (de) | 2003-12-05 | 2010-09-15 | Dexcom Inc | Kalibrationsmethoden für einen kontinuierlich arbeitenden analytsensor |
| US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| EP2301428B1 (en) | 2003-12-09 | 2016-11-30 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
| US7364592B2 (en) * | 2004-02-12 | 2008-04-29 | Dexcom, Inc. | Biointerface membrane with macro-and micro-architecture |
| WO2009048462A1 (en) | 2007-10-09 | 2009-04-16 | Dexcom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
| US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| WO2005094725A1 (en) * | 2004-03-31 | 2005-10-13 | Merlin Md Pte Ltd | A method for treating aneurysms |
| US8500751B2 (en) * | 2004-03-31 | 2013-08-06 | Merlin Md Pte Ltd | Medical device |
| US8715340B2 (en) | 2004-03-31 | 2014-05-06 | Merlin Md Pte Ltd. | Endovascular device with membrane |
| US8792955B2 (en) | 2004-05-03 | 2014-07-29 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20050245799A1 (en) * | 2004-05-03 | 2005-11-03 | Dexcom, Inc. | Implantable analyte sensor |
| HUP0401054A2 (en) * | 2004-05-26 | 2006-07-28 | Dr Juhasz Zsuzsanna Rethyne | Process for growing of living tissue on living organism |
| JP2008504412A (ja) * | 2004-06-30 | 2008-02-14 | コロプラスト アクティーゼルスカブ | 絆創膏接着製品およびその製造方法 |
| US8886272B2 (en) | 2004-07-13 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
| US8565848B2 (en) | 2004-07-13 | 2013-10-22 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7783333B2 (en) | 2004-07-13 | 2010-08-24 | Dexcom, Inc. | Transcutaneous medical device with variable stiffness |
| US20060016700A1 (en) | 2004-07-13 | 2006-01-26 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7654956B2 (en) | 2004-07-13 | 2010-02-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US8452368B2 (en) | 2004-07-13 | 2013-05-28 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20070045902A1 (en) | 2004-07-13 | 2007-03-01 | Brauker James H | Analyte sensor |
| US20060029633A1 (en) * | 2004-08-03 | 2006-02-09 | Arthrotek, Inc | Biological patch for use in medical procedures |
| WO2006094070A2 (en) | 2005-03-01 | 2006-09-08 | Stratatech Corporation | Human skin equivalents expressing exogenous polypeptides |
| CA2601595C (en) | 2005-03-17 | 2015-02-24 | Stratatech Corporation | Skin substitutes with improved purity |
| JP4716092B2 (ja) * | 2005-03-31 | 2011-07-06 | オリンパステルモバイオマテリアル株式会社 | タンパク質多孔マトリックスの製造方法 |
| JP2007006987A (ja) * | 2005-06-28 | 2007-01-18 | Hokkaido Univ | 皮膚再生用の細胞シートを作製するための構造体およびその利用 |
| GB0513552D0 (en) | 2005-07-01 | 2005-08-10 | Bristol Myers Squibb Co | Bandage |
| US20070038299A1 (en) * | 2005-08-12 | 2007-02-15 | Arthrotek, Inc | Multilayer microperforated implant |
| EP1937183B1 (en) | 2005-09-12 | 2018-11-28 | Proxy Biomedical Limited | Soft tissue implants |
| CN103251449B (zh) | 2005-10-13 | 2016-03-02 | 斯恩蒂斯有限公司 | 载药包装物 |
| JP5039715B2 (ja) * | 2006-01-24 | 2012-10-03 | ブラウン ユニバーシティ | 細胞凝集及び封入デバイス及び方法 |
| US20070185238A1 (en) * | 2006-02-06 | 2007-08-09 | No-Burn Investments, Llc | Paint with mold inhibitor and insecticide |
| WO2007102842A2 (en) | 2006-03-09 | 2007-09-13 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| WO2007143225A2 (en) | 2006-06-07 | 2007-12-13 | Abbott Diabetes Care, Inc. | Analyte monitoring system and method |
| EP2049041A1 (en) * | 2006-08-10 | 2009-04-22 | AO Technology AG | Biomedical polymer material for tissue repair and engineering |
| JP4517125B2 (ja) * | 2007-03-30 | 2010-08-04 | 国立大学法人九州大学 | 細胞の立体構造体の製造方法 |
| US20200037874A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| WO2008154312A1 (en) | 2007-06-08 | 2008-12-18 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| DE102007028423A1 (de) * | 2007-06-20 | 2008-12-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren und Vorrichtung zur Bildung von Aggregaten biologischer Zellen |
| US20090123766A1 (en) * | 2007-11-13 | 2009-05-14 | G3 Enterprises | Modified barrier layers in liners for container closures, capable of providing varible, controlled oxygen ingress |
| PT2215212T (pt) | 2007-11-14 | 2017-12-01 | Stratatech Corp | Armazenamento a frio de equivalentes de pele cultivados de forma organotípica para aplicações clínicas |
| EP2252196A4 (en) | 2008-02-21 | 2013-05-15 | Dexcom Inc | SYSTEMS AND METHOD FOR PROCESSING, TRANSMITTING AND DISPLAYING SENSOR DATA |
| US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8241616B2 (en) * | 2008-04-03 | 2012-08-14 | Rohm And Haas Company | Hair styling composition |
| WO2009155334A1 (en) | 2008-06-20 | 2009-12-23 | Escape Therapeutics, Inc. | Differentiation of mesenchymal stem cells into fibroblasts, compositions comprising mesenchymal stem cell-derived fibroblasts, and methods of using the same |
| CN102076365B (zh) * | 2008-06-20 | 2014-07-30 | 泰国研究基金会 | 生产人造皮肤的方法和系统 |
| TW201010747A (en) * | 2008-09-02 | 2010-03-16 | Univ Nat Taiwan | Porous material duct and method of fabricating the same |
| WO2010052584A2 (en) * | 2008-11-07 | 2010-05-14 | Sofradim Production | Medical device including a bacterial cellulose sheet, perforated or microperforated as a mesh |
| AU2009312480B2 (en) | 2008-11-07 | 2015-03-19 | Sofradim Production | Composite mesh including a 3D mesh and a non porous film of oxidized cellulose from bacterial cellulose origin |
| US9610463B2 (en) | 2009-01-30 | 2017-04-04 | Beiersdorf Ag | Cosmetic or dermatological preparation comprising collagen, chitosan, glycosylaminoglycan and cell growth promoting peptide and/or cellular complex |
| US8501476B2 (en) * | 2009-10-07 | 2013-08-06 | Brown University | Assays and methods for fusing cell aggregates to form proto-tissues |
| IT1398807B1 (it) * | 2009-10-29 | 2013-03-18 | Marzaro | Metodo di preparazione di un tessuto organico a-cellulare di origine umana o animale per la rivitalizzazione |
| CN102858955A (zh) | 2010-02-23 | 2013-01-02 | 国家医疗保健研究所 | 由人多潜能干细胞制备人黑色素细胞的方法 |
| US20140080096A1 (en) * | 2010-09-13 | 2014-03-20 | BioEconeer, Inc. | Guided Tissue Regeneration Membrane |
| US20120065741A1 (en) * | 2010-09-13 | 2012-03-15 | Chao-Fu Chang | Guided tissue regeneration membrane |
| EP2697650B1 (en) | 2011-04-15 | 2020-09-30 | Dexcom, Inc. | Advanced analyte sensor calibration and error detection |
| US9468680B2 (en) | 2011-09-22 | 2016-10-18 | Brown University | Differential effects of drugs on transport in a multi-layer 3D spheroid model |
| US9243278B2 (en) | 2011-09-22 | 2016-01-26 | Brown University | Mechanotransduction by the synergistic action of heterotypic cell interactions |
| TWI590843B (zh) * | 2011-12-28 | 2017-07-11 | 信迪思有限公司 | 膜及其製造方法 |
| US10987208B2 (en) | 2012-04-06 | 2021-04-27 | Merlin Md Pte Ltd. | Devices and methods for treating an aneurysm |
| USD702445S1 (en) * | 2012-05-11 | 2014-04-15 | Columbia Sportswear North America, Inc. | Printed cooling material |
| USD696522S1 (en) * | 2012-05-11 | 2013-12-31 | Columbia Sportswear North America, Inc. | Printed cooling material |
| CN102697600A (zh) * | 2012-05-19 | 2012-10-03 | 江苏百得医疗器械有限公司 | 医用可吸收防粘连薄膜 |
| JP2015518843A (ja) | 2012-05-25 | 2015-07-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 創傷、例えば、糖尿病性創傷の処置における、ｄｐｐ−４阻害剤と組み合わせてもよい生物活性物質としてのケラチン生成細胞の使用 |
| CA2905656C (en) | 2013-03-13 | 2020-04-14 | Stratatech Corporation | Cryopreservation of viable human skin substitutes |
| US20160144067A1 (en) * | 2013-06-21 | 2016-05-26 | DePuy Synthes Products, Inc. | Films and methods of manufacture |
| CN103394122B (zh) * | 2013-08-08 | 2014-10-29 | 中国科学技术大学 | 一种人工皮肤及其制备方法和应用 |
| ITMI20131904A1 (it) * | 2013-11-18 | 2015-05-19 | Antonio Sambusseti | Dispositivo per la ricostruzione di cute |
| EP3148598B1 (en) | 2014-05-30 | 2018-11-07 | Sofradim Production | Implant comprising oxidized cellulose and method for preparing such an implant |
| USD786509S1 (en) * | 2014-08-28 | 2017-05-09 | 3M Innovative Properties Company | Welding helmet having a button |
| EP3592397A4 (en) | 2017-03-06 | 2020-12-30 | Tei Biosciences, Inc. | PERFORATED FABRIC GRAFT |
| US20190120785A1 (en) | 2017-10-24 | 2019-04-25 | Dexcom, Inc. | Pre-connected analyte sensors |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| JP7290302B2 (ja) * | 2018-10-26 | 2023-06-13 | 国立研究開発法人農業・食品産業技術総合研究機構 | ハイドロゲル膜及びその使用 |
| AU2020353695A1 (en) * | 2019-09-27 | 2022-03-31 | Stratatech Corporation | Methods for treating acute wounds and improving outcomes |
| US12059509B1 (en) | 2020-05-05 | 2024-08-13 | Integra Lifesciences Corporation | Method and matrix for tissue regeneration |
| EP4001296A1 (de) | 2020-11-20 | 2022-05-25 | Eberhard Karls Universität Tübingen | Neue zyklische verbindungen, verfahren zu deren herstellung und die verwendung dieser zyklischen verbindungen in kosmetischen zubereitungen |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2671444A (en) * | 1951-12-08 | 1954-03-09 | Jr Benjamin F Pease | Nonmetallic mesh surgical insert for hernia repair |
| NL8001236A (nl) * | 1980-02-29 | 1981-10-01 | Doornes Transmissie Bv | Transmissie, voorzien van een traploos variabele drijfriemoverbrenging. |
| SE444640B (sv) * | 1980-08-28 | 1986-04-28 | Bergentz Sven Erik | I djur eller menniska implanterbar kerlprotes samt sett for dess framstellning |
| US4553272A (en) * | 1981-02-26 | 1985-11-19 | University Of Pittsburgh | Regeneration of living tissues by growth of isolated cells in porous implant and product thereof |
| US4604346A (en) * | 1984-10-09 | 1986-08-05 | Massachusetts Institute Of Technology | Skin-equivalent prepared by the use of punch biopsy |
| EP0183184A1 (en) * | 1984-11-30 | 1986-06-04 | Ppg Industries, Inc. | Method of cultivating cellular biomaterial and glass fibers with cellular biomaterial or biomaterial |
| US4765985A (en) * | 1985-03-05 | 1988-08-23 | Ciba-Geigy Corporation | Devices and methods for treating memory impairment |
| IL75554A (en) * | 1985-06-18 | 1993-01-14 | Yeda Res & Dev | Matrix for cell cultivation in vitro |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| DE3539270A1 (de) * | 1985-11-06 | 1987-05-07 | Rolf Prof Dr Med Hettich | Folien-spannrahmen fuer mischtransplantat |
| US5032508A (en) * | 1988-09-08 | 1991-07-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
| JPS62246371A (ja) * | 1986-04-19 | 1987-10-27 | 株式会社 高研 | 人工皮膚及びその製造方法 |
| ATE86115T1 (de) | 1987-04-28 | 1993-03-15 | Univ California | Vorrichtung und verfahren zur herstellung eines komposithautersatzes. |
| FR2616318A1 (fr) * | 1987-06-15 | 1988-12-16 | Centre Nat Rech Scient | Peau artificielle et son procede de preparation |
| US5015584A (en) * | 1987-10-14 | 1991-05-14 | Board Of Regents, The University Of Texas System | Epidermal graft system |
| US5122470A (en) * | 1988-07-05 | 1992-06-16 | Banes Albert J | Floating cell culture device and method |
| NL8801741A (nl) * | 1988-07-08 | 1990-02-01 | Utermoehlen Nv | Kunsthuid. |
| DE3830481A1 (de) * | 1988-09-08 | 1990-03-22 | Ethicon Gmbh | Schlauchfoermiges implantat, sowie verfahren zu dessen herstellung |
| JPH0662678B2 (ja) * | 1988-11-28 | 1994-08-17 | 電気化学工業株式会社 | ヒアルロン酸固定化蛋白質及びその製造方法 |
| US5202227A (en) * | 1989-06-03 | 1993-04-13 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Control of cell arrangement |
-
1990
- 1990-06-01 IT IT02051390A patent/IT1248934B/it active IP Right Grant
-
1991
- 1991-05-24 IL IL98255A patent/IL98255A/xx not_active IP Right Cessation
- 1991-05-28 DE DE69127235T patent/DE69127235T2/de not_active Expired - Lifetime
- 1991-05-28 AT AT91108654T patent/ATE156689T1/de not_active IP Right Cessation
- 1991-05-28 ES ES91108654T patent/ES2108019T3/es not_active Expired - Lifetime
- 1991-05-28 EP EP91108654A patent/EP0462426B1/en not_active Expired - Lifetime
- 1991-05-28 SG SG1996005810A patent/SG52545A1/en unknown
- 1991-05-28 IE IE182591A patent/IE911825A1/en not_active IP Right Cessation
- 1991-05-28 DK DK91108654.4T patent/DK0462426T3/da active
- 1991-05-29 BR BR919102225A patent/BR9102225A/pt not_active IP Right Cessation
- 1991-05-29 NO NO912058A patent/NO303562B1/no not_active IP Right Cessation
- 1991-05-29 ZA ZA914098A patent/ZA914098B/xx unknown
- 1991-05-30 FI FI912591A patent/FI108918B/fi active
- 1991-05-30 CA CA002043527A patent/CA2043527C/en not_active Expired - Lifetime
- 1991-05-30 AR AR91319818A patent/AR244354A1/es active
- 1991-05-30 AU AU78066/91A patent/AU637235B2/en not_active Expired
- 1991-05-30 TW TW080104245A patent/TW208652B/zh not_active IP Right Cessation
- 1991-05-31 PT PT97832A patent/PT97832B/pt not_active IP Right Cessation
- 1991-05-31 KR KR1019910008999A patent/KR100195574B1/ko not_active Expired - Lifetime
- 1991-05-31 HU HU911834A patent/HU215534B/hu unknown
- 1991-05-31 UY UY23231A patent/UY23231A1/es not_active IP Right Cessation
- 1991-05-31 JP JP12924591A patent/JP3202257B2/ja not_active Expired - Lifetime
-
1993
- 1993-02-16 US US08/019,818 patent/US5326356A/en not_active Expired - Lifetime
-
1994
- 1994-03-14 US US08/209,626 patent/US5650164A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/478,541 patent/US5658331A/en not_active Expired - Lifetime
-
1997
- 1997-10-16 GR GR970402714T patent/GR3025075T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HU215534B (hu) | Biokompatíbilis, perforált membránok, eljárás előállításukra, hámszövet sejtek in vitro növekedésének elősegítésére való alkalmazásuk és az így kapott mesterséges bőr | |
| US4418691A (en) | Method of promoting the regeneration of tissue at a wound | |
| US5665391A (en) | Cultured, full-thickness integument substitutes based on three-dimensional matrix membranes | |
| US5015584A (en) | Epidermal graft system | |
| US8765468B2 (en) | Surgical device for skin therapy or testing | |
| JP2820796B2 (ja) | 生物療法性細胞被覆微小球状体 | |
| EP0091952B1 (en) | Cell-seeding procedures involving fibrous lattices | |
| US6699287B2 (en) | Dermal scaffold using alkaline pre-treated chitosan matrix or alkaline pre-treated chitosan and alkaline pre-treated collagen mixed matrix | |
| WO2000016817A1 (en) | Dermal scaffold using neutralized chitosan sponge or neutralized chitosan/collagen mixed sponge | |
| JP3554412B2 (ja) | 培養皮膚用基材、培養皮膚およびその製造法 | |
| CN101790581A (zh) | 含胶原蛋白的细胞载体 | |
| RU2805473C2 (ru) | Способ создания и применения мицелиальных скаффолдов | |
| KR100427557B1 (ko) | 뼈의 콜라겐 지지체 | |
| CA1202898A (en) | Cell-seeding into fibrous lattices by means of centrifugation |