HU210919B - Process for producing benzene or pyridine conpensed oxazine and thiazine derivatives and pharmaceutical compositions containing them as active ingredients - Google Patents

Process for producing benzene or pyridine conpensed oxazine and thiazine derivatives and pharmaceutical compositions containing them as active ingredients Download PDF

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Publication number
HU210919B
HU210919B HU912003A HU200391A HU210919B HU 210919 B HU210919 B HU 210919B HU 912003 A HU912003 A HU 912003A HU 200391 A HU200391 A HU 200391A HU 210919 B HU210919 B HU 210919B
Authority
HU
Hungary
Prior art keywords
formula
group
dihydro
methyl
oxo
Prior art date
Application number
HU912003A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT61298A (en
HU912003D0 (en
Inventor
Graham Charles Crawley
Pierre Andre Raymond Bruneau
Original Assignee
Zeneca Ltd
Zeneca Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd, Zeneca Pharma Sa filed Critical Zeneca Ltd
Publication of HU912003D0 publication Critical patent/HU912003D0/hu
Publication of HUT61298A publication Critical patent/HUT61298A/hu
Publication of HU210919B publication Critical patent/HU210919B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HU912003A 1990-06-21 1991-06-17 Process for producing benzene or pyridine conpensed oxazine and thiazine derivatives and pharmaceutical compositions containing them as active ingredients HU210919B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90401757 1990-06-21
EP91400076 1991-01-15

Publications (3)

Publication Number Publication Date
HU912003D0 HU912003D0 (en) 1991-12-30
HUT61298A HUT61298A (en) 1992-12-28
HU210919B true HU210919B (en) 1995-09-28

Family

ID=26127306

Family Applications (2)

Application Number Title Priority Date Filing Date
HU912003A HU210919B (en) 1990-06-21 1991-06-17 Process for producing benzene or pyridine conpensed oxazine and thiazine derivatives and pharmaceutical compositions containing them as active ingredients
HU95P/P00301P HU211133A9 (en) 1990-06-21 1995-06-21 Et bicyclic heterocyclic compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU95P/P00301P HU211133A9 (en) 1990-06-21 1995-06-21 Et bicyclic heterocyclic compounds

Country Status (26)

Country Link
US (3) US5217969A (OSRAM)
EP (1) EP0462813B1 (OSRAM)
JP (1) JP3112981B2 (OSRAM)
KR (1) KR920000738A (OSRAM)
AR (1) AR247886A1 (OSRAM)
AT (1) ATE129497T1 (OSRAM)
AU (1) AU637500B2 (OSRAM)
CA (1) CA2044219A1 (OSRAM)
CS (1) CS187491A3 (OSRAM)
DE (1) DE69114052T2 (OSRAM)
DK (1) DK0462813T3 (OSRAM)
ES (1) ES2079576T3 (OSRAM)
FI (1) FI913048L (OSRAM)
GB (1) GB9113132D0 (OSRAM)
GR (1) GR3017888T3 (OSRAM)
HU (2) HU210919B (OSRAM)
IE (1) IE911919A1 (OSRAM)
IL (1) IL98396A (OSRAM)
MY (1) MY106366A (OSRAM)
NO (1) NO912411L (OSRAM)
NZ (1) NZ238470A (OSRAM)
PL (1) PL168310B1 (OSRAM)
PT (1) PT98041A (OSRAM)
RU (1) RU2059627C1 (OSRAM)
TW (1) TW217412B (OSRAM)
ZW (1) ZW7091A1 (OSRAM)

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* Cited by examiner, † Cited by third party
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US5254581A (en) * 1990-06-21 1993-10-19 Imperial Chemical Industries Plc Pyran derivatives and their use as inhibitors of 5-lipoxygenase
IE911853A1 (en) * 1990-06-21 1992-01-01 Ici Plc Heterocyclene derivatives
IE913655A1 (en) * 1990-11-06 1992-05-22 Zeneca Ltd Synergistic agents
IE914005A1 (en) * 1990-12-14 1992-06-17 Zeneca Ltd Novel intermediates
DE69206725T2 (de) * 1991-09-10 1996-05-02 Zeneca Ltd Benzolsulfonamidderivate als 5-Lipoxygenasehemmer
CA2094465A1 (en) * 1992-04-23 1993-10-24 Pierre Andre Raymond Bruneau Cycloalkane derivatives
CA2095005A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Hydroxylamine derivatives
CA2095006A1 (en) * 1992-05-12 1993-11-13 Philip Neil Edwards Oxime derivatives
AU4444393A (en) * 1992-09-01 1994-03-10 Zeneca Limited Pyrrolidine derivatives
US5354865A (en) * 1992-09-10 1994-10-11 Abbott Laboratories Phenylmethyl derivatives having lipoxygenase inhibitory activity
IL109254A (en) * 1993-04-29 1999-03-12 Zeneca Ltd Tetrahydropyran and tetrahydrofuran ether derivatives their preparation and pharmaceutical compositions comprising them
US5424320A (en) * 1993-06-23 1995-06-13 Merck Frosst Canada, Inc. Heteroaryl coumarins as inhibitors of leukotriene biosynthesis
US5360815A (en) * 1993-06-23 1994-11-01 Merck Frosst Canada, Inc. Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthesis
US5459271A (en) * 1993-07-20 1995-10-17 Merck Frosst Canada, Inc. Arylbicyclooctanes as inhibitors of leukotriene biosynthesis
ZA945250B (en) * 1993-07-27 1995-01-27 Zeneca Ltd Thiazole derivatives
IL110280A0 (en) * 1993-07-27 1994-10-21 Zeneca Ltd Thiazole derivatives
EP0636624A1 (en) * 1993-07-27 1995-02-01 Zeneca Limited Thiazole derivatives as lipoxygenase inhibitors
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
CA2186513C (en) * 1994-03-28 1999-03-16 James F. Eggler Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis
WO1995030668A1 (en) * 1994-05-06 1995-11-16 Zeneca Limited Cyclic ether derivatives and pharmaceutical composition containing them
US5643933A (en) * 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
US5891460A (en) * 1995-06-07 1999-04-06 University Of Southern California University Park Campus Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof
US6677364B2 (en) * 1998-04-20 2004-01-13 G.D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
EP1385835A1 (en) 2001-04-23 2004-02-04 Astrazeneca AB Benzoxazinone derivatives for use in the treatment of angiogenesis
BR0308518A (pt) * 2002-03-19 2005-02-22 Ono Pharmaceutical Co Compostos ácidos carboxìlicos e drogas contendo os compostos como o ingrediente ativo
PL1666473T3 (pl) * 2003-09-17 2013-05-31 Ono Pharmaceutical Co Związki oparte na kwasie karboksylowym i kompozycje medyczne zawierające je jako składnik aktywny
US7378415B2 (en) 2004-09-30 2008-05-27 Roche Palo Alto Llc Benzoxazine and quinoxaline derivatives and uses thereof
CA2636043A1 (en) * 2006-01-23 2007-08-02 Amira Pharmaceuticals, Inc. Tricyclic inhibitors of 5-lipoxygenase
US8048977B2 (en) * 2006-04-28 2011-11-01 E. I. Du Pont De Nemours And Company Organosilicon polymers
KR20210103586A (ko) * 2007-06-04 2021-08-23 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same

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US3743737A (en) * 1970-05-21 1973-07-03 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperindinylcarbinol compositions
US3661917A (en) * 1970-05-21 1972-05-09 Smith Kline French Lab 3-sulfonamido-4-hydroxyphenyl-2-piperidylcarbinols
US4567184A (en) * 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
US4794188A (en) * 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
US4625034A (en) * 1985-02-04 1986-11-25 Usv Pharmaceutical Corp. 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4725619A (en) * 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4728668A (en) * 1985-04-16 1988-03-01 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4876346A (en) * 1985-05-02 1989-10-24 American Home Products Corporation Quinoline compounds
EP0271287A3 (en) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Quinoline dioic acids and amides
US4920130A (en) * 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920133A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4918081A (en) * 1988-06-20 1990-04-17 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene d4
EP0349062A1 (en) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Quinoline ether alkanoic acid
GB8926981D0 (en) * 1988-12-23 1990-01-17 Ici Plc Heterocyclic derivatives
US5003087A (en) * 1989-02-03 1991-03-26 Tanabe Seiyaku Co., Ltd. Process for preparing a naphthalene derivative and a synthetic intermediate thereof
IE70521B1 (en) * 1989-02-28 1996-12-11 Zeneca Pharma Sa Heterocycles with inhibitory activity of 5-lipoxygenase
IL93344A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cyclic ethers
IL93343A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cycloalkanes
JP2996475B2 (ja) * 1989-12-22 1999-12-27 サントリー株式会社 ベンズオキサジノン誘導体及びそれを有効成分として含有する除草剤

Also Published As

Publication number Publication date
AU7816191A (en) 1992-01-02
AR247886A1 (es) 1995-04-28
CA2044219A1 (en) 1991-12-22
NZ238470A (en) 1993-07-27
EP0462813A3 (en) 1992-01-22
IL98396A (en) 1995-11-27
HU211133A9 (en) 1995-10-30
JP3112981B2 (ja) 2000-11-27
RU2059627C1 (ru) 1996-05-10
PT98041A (pt) 1992-04-30
CS187491A3 (en) 1992-02-19
GR3017888T3 (en) 1996-01-31
TW217412B (OSRAM) 1993-12-11
GB9113132D0 (en) 1991-08-07
KR920000738A (ko) 1992-01-29
HUT61298A (en) 1992-12-28
FI913048A0 (fi) 1991-06-20
DE69114052D1 (de) 1995-11-30
EP0462813B1 (en) 1995-10-25
IL98396A0 (en) 1992-07-15
FI913048A7 (fi) 1991-12-22
US5217969A (en) 1993-06-08
PL168310B1 (pl) 1996-02-29
MY106366A (en) 1995-05-30
US5321025A (en) 1994-06-14
EP0462813A2 (en) 1991-12-27
AU637500B2 (en) 1993-05-27
FI913048L (fi) 1991-12-22
DE69114052T2 (de) 1996-10-17
HU912003D0 (en) 1991-12-30
NO912411L (no) 1991-12-23
PL290757A1 (en) 1992-08-24
ES2079576T3 (es) 1996-01-16
JPH04230283A (ja) 1992-08-19
NO912411D0 (no) 1991-06-20
US5373007A (en) 1994-12-13
ZW7091A1 (en) 1992-03-25
DK0462813T3 (da) 1996-02-05
ATE129497T1 (de) 1995-11-15
IE911919A1 (en) 1992-01-01

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Legal Events

Date Code Title Description
DGB9 Succession in title of applicant

Owner name: ZENECA LTD., GB

HMM4 Cancellation of final prot. due to non-payment of fee