HU193992B - Process for preparing substituted 3,4-diamino-1,2,5-thiadiazole derivatives and pharmaceutical compositions containing such active ingredients - Google Patents
Process for preparing substituted 3,4-diamino-1,2,5-thiadiazole derivatives and pharmaceutical compositions containing such active ingredients Download PDFInfo
- Publication number
- HU193992B HU193992B HU852443A HU244385A HU193992B HU 193992 B HU193992 B HU 193992B HU 852443 A HU852443 A HU 852443A HU 244385 A HU244385 A HU 244385A HU 193992 B HU193992 B HU 193992B
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- compounds
- compound
- reaction
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/623,588 US4644006A (en) | 1984-06-22 | 1984-06-22 | Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT42087A HUT42087A (en) | 1987-06-29 |
| HU193992B true HU193992B (en) | 1987-12-28 |
Family
ID=24498651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU852443A HU193992B (en) | 1984-06-22 | 1985-06-21 | Process for preparing substituted 3,4-diamino-1,2,5-thiadiazole derivatives and pharmaceutical compositions containing such active ingredients |
Country Status (33)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0535227A4 (en) * | 1990-05-29 | 1993-08-18 | Nippon Soda Co., Ltd. | N-substituted heterocyclic amidine derivative |
| US20230349922A1 (en) | 2020-08-11 | 2023-11-02 | Université De Strasbourg | H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3657237A (en) * | 1968-05-22 | 1972-04-18 | Frosst & Co Charles E | Process for making 1 2 5-thiadiazoles in the sinister configuration |
| FI76795C (fi) * | 1979-09-04 | 1988-12-12 | Bristol Myers Co | Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara 3,4-disubstituerade 1,2,5-tiadiazol-1-oxider och -1,1-dioxider samt nya mellanprodukter. |
| DE3175201D1 (en) * | 1980-04-30 | 1986-10-02 | Merck & Co Inc | Aminothiadiazoles as gastric secretion inhibitors |
| US4394508A (en) * | 1980-06-07 | 1983-07-19 | Bristol-Myers Company | Chemical compounds |
| EP0045155B1 (en) * | 1980-07-30 | 1985-01-02 | Imperial Chemical Industries Plc | Guanidine derivatives |
| EP0060730A3 (en) * | 1981-03-18 | 1982-12-08 | Imperial Chemical Industries Plc | Bicyclic derivatives |
| EP0065823A1 (en) * | 1981-05-13 | 1982-12-01 | Imperial Chemical Industries Plc | Heterocyclic guanidines as histamine H-2 antagonists |
| US4528378A (en) * | 1982-03-29 | 1985-07-09 | Bristol-Myers Company | Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity |
| US4588826A (en) * | 1982-03-29 | 1986-05-13 | Bristol-Myers Company | Ethanediimidamide intermediates |
| US4517366A (en) * | 1982-03-29 | 1985-05-14 | Bristol-Myers Company | Intermediates for preparing 3,4-diamino-1,2,5-thiadiazoles |
| US4528377A (en) * | 1982-03-29 | 1985-07-09 | Bristol-Myers Company | Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity |
| ES8404683A1 (es) * | 1982-03-29 | 1984-05-16 | Bristol Myers Co | Un procedimiento para la preparacion de antagonistas de los receptores hidrogeno de la histamina. |
| US4528375A (en) * | 1982-03-29 | 1985-07-09 | Bristol-Myers Company | Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity |
| FI832519L (fi) * | 1982-07-12 | 1984-01-13 | Bristol Myers Co | Farmaceutiska foerfaranden och sammansaettningar |
| US4520025A (en) * | 1982-07-21 | 1985-05-28 | William H. Rorer, Inc. | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
| JPS5978171A (ja) * | 1982-10-26 | 1984-05-04 | Ikeda Mohandou:Kk | 複素環式化合物 |
| US4440933A (en) * | 1983-03-16 | 1984-04-03 | Bristol-Myers Company | Process for preparing 1,2,5-thiadiazoles |
-
1984
- 1984-06-22 US US06/623,588 patent/US4644006A/en not_active Expired - Fee Related
-
1985
- 1985-06-05 SU SU853906050A patent/SU1537136A3/ru active
- 1985-06-07 CA CA000483419A patent/CA1267412A/en not_active Expired - Lifetime
- 1985-06-07 FR FR8508668A patent/FR2566406B1/fr not_active Expired
- 1985-06-12 CS CS854247A patent/CS257276B2/cs unknown
- 1985-06-13 NZ NZ212403A patent/NZ212403A/xx unknown
- 1985-06-17 FI FI852405A patent/FI852405L/fi not_active Application Discontinuation
- 1985-06-19 IL IL75567A patent/IL75567A0/xx not_active IP Right Cessation
- 1985-06-19 AR AR300752A patent/AR240935A1/es active
- 1985-06-19 DD DD85277533A patent/DD240889A5/de not_active IP Right Cessation
- 1985-06-19 NL NL8501766A patent/NL8501766A/nl not_active Application Discontinuation
- 1985-06-20 DE DE19853522101 patent/DE3522101A1/de not_active Withdrawn
- 1985-06-20 SE SE8503110A patent/SE464305B/sv not_active IP Right Cessation
- 1985-06-20 IT IT21217/85A patent/IT1190372B/it active
- 1985-06-20 GR GR851514A patent/GR851514B/el unknown
- 1985-06-20 KR KR1019850004457A patent/KR900004321B1/ko not_active IP Right Cessation
- 1985-06-21 ES ES544409A patent/ES8702902A1/es not_active Expired
- 1985-06-21 CH CH2657/85A patent/CH665210A5/de not_active IP Right Cessation
- 1985-06-21 AT AT0185885A patent/AT390790B/de not_active IP Right Cessation
- 1985-06-21 AU AU43920/85A patent/AU580605B2/en not_active Ceased
- 1985-06-21 ZA ZA854710A patent/ZA854710B/xx unknown
- 1985-06-21 JP JP60135861A patent/JPS6118775A/ja active Pending
- 1985-06-21 PT PT80684A patent/PT80684B/pt not_active IP Right Cessation
- 1985-06-21 ZW ZW103/85A patent/ZW10385A1/xx unknown
- 1985-06-21 IE IE501/89A patent/IE57937B1/en not_active IP Right Cessation
- 1985-06-21 NO NO852519A patent/NO161856C/no unknown
- 1985-06-21 LU LU85969A patent/LU85969A1/fr unknown
- 1985-06-21 IE IE155785A patent/IE58261B1/en not_active IP Right Cessation
- 1985-06-21 BE BE0/215242A patent/BE902724A/fr not_active IP Right Cessation
- 1985-06-21 DK DK282885A patent/DK282885A/da unknown
- 1985-06-21 HU HU852443A patent/HU193992B/hu not_active IP Right Cessation
- 1985-06-21 GB GB08515749A patent/GB2161157B/en not_active Expired
- 1985-06-24 YU YU105185A patent/YU45725B/sh unknown
- 1985-08-18 OA OA58614A patent/OA08039A/xx unknown
- 1985-10-04 JP JP60221721A patent/JPS61186369A/ja active Pending
-
1986
- 1986-01-31 ES ES551506A patent/ES8702881A1/es not_active Expired
-
1987
- 1987-06-03 YU YU102587A patent/YU45822B/sh unknown
- 1987-07-09 GB GB08716149A patent/GB2192884B/en not_active Expired
-
1989
- 1989-02-08 AU AU29775/89A patent/AU614331B2/en not_active Ceased
- 1989-05-12 CA CA000599622A patent/CA1297875C/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI68820C (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara amnotiazoler | |
| SU1400508A3 (ru) | Способ получени производных арилтиазолов | |
| HU194802B (en) | Process for production of substituted derivatives of 1,2-diamin-cyclobuthen-3,4-dion | |
| PL135749B1 (en) | Method of obtaining novel imidazolilophenylamidines | |
| KR840001075B1 (ko) | 티아졸 유도체의 제조방법 | |
| US3818070A (en) | Carbaliphatic-oxy aminophenylamidines | |
| DE2916140A1 (de) | 1,3-diphenyl-2-iminoimidazolidine und 1,3-diphenyl-2-iminohexahydropyrimidine, verfahren zu ihrer herstellung und solche enthaltende arzneimittel | |
| HU180294B (en) | Process for producing amidinesulfonic acid derivatives | |
| HU182645B (en) | Process for preparing n-cyano-n'-2-//4-methyl-5-imidazolyl/-methyl-thio/-ethyl-n''-alkinyl-guanidine | |
| SU1364240A3 (ru) | Способ получени производных 4,5,6,7-тетра-гидротиазоло-(5,4-с)-пиридина или их фармацевтически приемлемых солей | |
| HU193992B (en) | Process for preparing substituted 3,4-diamino-1,2,5-thiadiazole derivatives and pharmaceutical compositions containing such active ingredients | |
| US4692531A (en) | Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity | |
| GB1598628A (en) | Guanidine derivatives | |
| EP0189307A2 (en) | Antihistamine-H2 alkyne thiadiazole derivatives | |
| KR860000103B1 (ko) | 3'-치환-5'-(2-아미노-4-피리딜)-1', 2', 4'-트리아졸류의 제조 방법 | |
| CS228930B2 (cs) | Způsob výroby krystalických, nehygroskopických, ve vodě rozpustných solí N- (2-pyridyl) -2-methyl-4-hydroxy-2H-l,2-benzothiazin-3- -karboxamid-l,l-dioxidu | |
| US4126670A (en) | Method of stimulating histamine H2 -receptors | |
| HU188742B (en) | Process for producing substituted 3,4-diamni-1,2,5-thiadiazoles and pharmaceutical compositions of hystamine-h2-receptor antagonistic aczivity containing them as active agents | |
| US4036972A (en) | 2-(N-thienylmethyl-phenylamino)-imidazolines-(2) and salts thereof | |
| FI66354B (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara n-2,6-disubstituerad-fenyl)-n'-(2-imidazolidinyliden)-uread ervat | |
| WO1992006080A1 (en) | Antiarrhythmic agents | |
| HU191496B (en) | Process for producing derivates 2-guanidino-4thiazolyl-thiazoles | |
| DE3441086A1 (de) | 3,4-diazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel | |
| KR810000632B1 (ko) | 히스타민 h₂수용기 길항제 또는 비독성인 그의 약조제 가능한 산 첨가염의 제조방법 | |
| EP0149140A2 (en) | Novel compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |