HU193124B - Process for preparing new crystalline modifications - Google Patents
Process for preparing new crystalline modifications Download PDFInfo
- Publication number
- HU193124B HU193124B HU842978A HU297885A HU193124B HU 193124 B HU193124 B HU 193124B HU 842978 A HU842978 A HU 842978A HU 297885 A HU297885 A HU 297885A HU 193124 B HU193124 B HU 193124B
- Authority
- HU
- Hungary
- Prior art keywords
- amino
- strong
- hydroxypropane
- diphosphonate
- disodium
- Prior art date
Links
- 230000004048 modification Effects 0.000 title description 17
- 238000012986 modification Methods 0.000 title description 17
- 238000004519 manufacturing process Methods 0.000 title description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 99
- CEYUIFJWVHOCPP-UHFFFAOYSA-L disodium;(3-amino-1-hydroxy-1-phosphonatopropyl)phosphonic acid Chemical compound [Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O CEYUIFJWVHOCPP-UHFFFAOYSA-L 0.000 claims description 72
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 57
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 38
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- 241000416162 Astragalus gummifer Species 0.000 description 1
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- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical compound [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- FHKOFTIRTOMUDT-UHFFFAOYSA-L disodium;(6-amino-1-hydroxy-1-phosphonatohexyl)phosphonic acid Chemical compound [Na+].[Na+].NCCCCCC(O)(P(O)(O)=O)P([O-])([O-])=O FHKOFTIRTOMUDT-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH376884 | 1984-08-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT38361A HUT38361A (en) | 1986-05-28 |
| HU193124B true HU193124B (en) | 1987-08-28 |
Family
ID=4263070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU842978A HU193124B (en) | 1984-08-06 | 1985-08-05 | Process for preparing new crystalline modifications |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US4639338A (en:Method) |
| EP (1) | EP0177443B1 (en:Method) |
| JP (1) | JPS6143196A (en:Method) |
| KR (1) | KR940000817B1 (en:Method) |
| AR (4) | AR240832A1 (en:Method) |
| AT (1) | ATE47396T1 (en:Method) |
| AU (1) | AU591066B2 (en:Method) |
| CA (1) | CA1255694A (en:Method) |
| CY (1) | CY1570A (en:Method) |
| DD (1) | DD239597A5 (en:Method) |
| DE (1) | DE3573783D1 (en:Method) |
| DK (1) | DK167282B1 (en:Method) |
| DO (1) | DOP1990004769A (en:Method) |
| ES (2) | ES8701188A1 (en:Method) |
| FI (1) | FI79712C (en:Method) |
| GR (1) | GR851910B (en:Method) |
| HK (1) | HK42591A (en:Method) |
| HU (1) | HU193124B (en:Method) |
| IE (1) | IE58077B1 (en:Method) |
| IL (1) | IL75990A (en:Method) |
| MX (1) | MX9203373A (en:Method) |
| NO (1) | NO165401C (en:Method) |
| PH (1) | PH24854A (en:Method) |
| PT (1) | PT80916B (en:Method) |
| SG (1) | SG91390G (en:Method) |
| ZA (1) | ZA855892B (en:Method) |
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| CH664158A5 (fr) * | 1984-07-18 | 1988-02-15 | Symphar Sa | Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant. |
| EP0243173B1 (en) * | 1986-04-24 | 1991-06-26 | Fujisawa Pharmaceutical Co., Ltd. | New diphosphonic acid compounds, processes for the preparation thereof and pharmaceutical composition comprising the same |
| US4963681A (en) * | 1987-07-06 | 1990-10-16 | Norwich Eaton Pharmaceuticals, Inc. | Process for synthesis of aminomethylene phosphonoalkylphosphinates |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| IT1222734B (it) * | 1987-09-25 | 1990-09-12 | Scalvo S P A | Formulaziopne farmaceutiche e forme di dosaggio per la somminaistarzione rettale di calcitonina |
| PH26923A (en) * | 1989-03-08 | 1992-12-03 | Ciba Geigy | N-substituted amino alkanediphosphonic acids |
| US4922007A (en) * | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| PH27186A (en) * | 1989-09-07 | 1993-04-16 | Ciba Geigy Ag | Double-coated granules of disodium pamidronate |
| US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
| US5270365A (en) * | 1991-12-17 | 1993-12-14 | Merck & Co., Inc. | Prevention and treatment of periodontal disease with alendronate |
| TW237386B (en:Method) | 1992-04-15 | 1995-01-01 | Ciba Geigy | |
| US5358941A (en) * | 1992-12-02 | 1994-10-25 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids with lactose |
| US6406714B1 (en) | 1992-12-02 | 2002-06-18 | Merck & Co., Inc. | Dry mix formulation for bisphosphonic acids |
| JP3266395B2 (ja) * | 1993-11-24 | 2002-03-18 | 富士写真フイルム株式会社 | 有機薬品の晶析方法 |
| TW390813B (en) * | 1994-04-29 | 2000-05-21 | Merck & Co Inc | Wet granulation formulation for bisphosphonic acids |
| US20010007863A1 (en) | 1998-06-18 | 2001-07-12 | Merck & Co., Inc. | Wet granulation formulation for bisphosphonic acids |
| GB9408775D0 (en) * | 1994-05-04 | 1994-06-22 | Ciba Geigy Ag | Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration |
| DE19719680A1 (de) | 1997-05-09 | 1998-11-19 | Boehringer Mannheim Gmbh | Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz |
| DE69827079T2 (de) * | 1997-07-15 | 2005-09-08 | Gador S.A. | Kristalline Form von N,N-dimethyl-3-amino-1-hydroxypropan-1,1-Diphosphonsäure Mononatriumsalz Monohydrat und ein Verfahren zu ihrer Herstellung |
| SK2482001A3 (en) | 1998-08-27 | 2002-01-07 | Teva Pharma | Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
| EP1702924A3 (en) * | 1998-08-27 | 2007-07-18 | Teva Pharmaceutical Industries Ltd | Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
| EP0998933A1 (de) | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation |
| EP0998932A1 (de) | 1998-10-09 | 2000-05-10 | Boehringer Mannheim Gmbh | Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung |
| ATE238315T1 (de) * | 1998-12-10 | 2003-05-15 | Aesgen Inc | Verfahren zur herstellung von dinatriumpamidronat |
| US6160165A (en) * | 1998-12-10 | 2000-12-12 | Aesgen, Inc. | Method for preparation of disodium pamidronate |
| US6794536B1 (en) * | 1998-12-10 | 2004-09-21 | Aesqen, Inc. | Method for preparation of disodium pamidronate |
| US6315566B1 (en) | 1999-05-18 | 2001-11-13 | 3M Innovative Properties Company | Dental materials |
| US6143919A (en) * | 1999-05-18 | 2000-11-07 | 3M Innovative Properties Company | Polymerizable acidic compounds and methods of preparation |
| US6963008B2 (en) * | 1999-07-19 | 2005-11-08 | Teva Pharmaceutical Industries Ltd. | Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
| ES2153794B1 (es) * | 1999-08-06 | 2001-10-16 | Medichem Sa | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
| KR100343232B1 (ko) * | 1999-12-10 | 2002-07-10 | 김재윤 | 결정성 파미드론산 이나트륨염 수화물과 그의 제조방법 |
| CN1441674A (zh) * | 2000-09-18 | 2003-09-10 | 福荷福尔丁和考有限公司 | 二磷酸盐溶液 |
| DE60111574T2 (de) * | 2001-01-23 | 2006-05-11 | Gador S.A. | Bisphosphonate enthaltende Zusammensetzungen zur Vorbeugung und/oder Heilung von metabolischen Knochenkrankheiten, Verfahren zu ihrer Herstellung und Benutzung dieser Zusammensetzungen |
| CA2445584A1 (en) | 2001-05-02 | 2002-11-07 | Sicor Inc. | Injectable pamidronate disodium |
| CA2372450A1 (en) * | 2001-05-10 | 2001-09-19 | Pharmaceutical Partners Of Canada Inc. | Liquid injectable formulation of disodium pamidronate |
| ITMI20012751A1 (it) * | 2001-12-21 | 2003-06-21 | Lyogen Ltd | Sale monosodico dell'acido pamidronico e procedimento per la sua preparazione |
| US20040052843A1 (en) * | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
| NZ552514A (en) * | 2001-12-24 | 2008-08-29 | Teva Pharma | Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it |
| IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
| US20040138180A1 (en) * | 2002-10-03 | 2004-07-15 | Barr Laboratories, Inc. | Bisphosphonate composition and process for the preparation thereof |
| NZ536273A (en) * | 2002-12-20 | 2007-08-31 | Hoffmann La Roche | High dose ibandronate formulation |
| US20050119230A1 (en) * | 2003-09-18 | 2005-06-02 | Alexandra Glausch | Pharmaceutical products comprising bisphosphonated |
| WO2005054260A1 (en) * | 2003-12-04 | 2005-06-16 | Mustafa Nevzat Ilac Sanayii A.S. | Method for producing pure disodium pamidronate |
| BRPI0511530A (pt) | 2004-05-24 | 2008-01-02 | Procter & Gamble | formas de dosagem de bisfosfonatos |
| US7687482B2 (en) * | 2006-03-17 | 2010-03-30 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods |
| EP1802641B8 (en) * | 2004-10-08 | 2012-03-07 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
| US8012949B2 (en) * | 2004-10-08 | 2011-09-06 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS |
| WO2008116133A1 (en) * | 2007-03-21 | 2008-09-25 | Duke University | Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture |
| CA2708281A1 (en) | 2007-12-11 | 2009-08-27 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties |
| PT2473172E (pt) | 2009-09-01 | 2015-06-25 | Univ Duke | Composições de bisfosfonato e métodos para o tratamento de insuficiência cardíaca |
| FR2954320B1 (fr) | 2009-12-17 | 2012-06-15 | Cll Pharma | Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels |
| BR112012026098A2 (pt) | 2010-04-16 | 2016-11-22 | Novartis Ag | métodos e composições para melhorar a osseointegração de implante. |
| CA2856030A1 (en) | 2011-11-16 | 2013-05-23 | Duke University | Bisphosphonate compositions and methods for treating and/or reducing cardiac dysfunction |
| GB201200868D0 (en) | 2012-01-19 | 2012-02-29 | Depuy Int Ltd | Bone filler composition |
| US11654152B2 (en) | 2012-05-14 | 2023-05-23 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating disease |
| EP3323418A1 (en) * | 2012-05-14 | 2018-05-23 | Antecip Bioventures II LLC | Compositions comprising zoledronic acid or related compounds for relieving inflammatory pain and related conditions |
| KR101995432B1 (ko) * | 2016-10-13 | 2019-07-02 | 엘지전자 주식회사 | 공기조화기 및 그 제어방법 |
| EP3553067A1 (en) * | 2018-04-10 | 2019-10-16 | Abiogen Pharma S.p.A. | Polymorph of sodium neridronate and preparation process thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2130794C3 (de) * | 1971-06-22 | 1974-07-11 | Joh. A. Benckiser Gmbh, 6700 Ludwigshafen | Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure |
| DE2405254C2 (de) * | 1974-02-04 | 1982-05-27 | Henkel KGaA, 4000 Düsseldorf | Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper |
| US4134969A (en) * | 1974-02-04 | 1979-01-16 | Henkel Kommanditgesellschaft Auf Aktien (Henkel Kgaa) | Method of treatment of calcium disorders using aminoalkane-diphosphonic acids |
| DE2534391C2 (de) * | 1975-08-01 | 1983-01-13 | Henkel KGaA, 4000 Düsseldorf | 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren |
| DE2553963A1 (de) * | 1975-12-01 | 1977-06-08 | Henkel & Cie Gmbh | Pharmazeutische praeparate zur behandlung von stoerungen des calciumstoffwechsels |
| SE7612534L (sv) * | 1975-12-01 | 1977-06-02 | Henkel & Cie Gmbh | Forfarande for framstellning av farmaceutiska preparat for behandling av storningar i kalciumemnesomsettning |
| JPS5283957A (en) * | 1975-12-01 | 1977-07-13 | Henkel & Cie Gmbh | Medicine for treating metabolic obstruction of calcium |
| SE409706B (sv) * | 1976-05-21 | 1979-09-03 | Astra Pharma Prod | Forfarande for framstellning av n,n-dimetyl-3-(4-bromfenyl)-3-3(3-pyridyl)-allylamin dihydroklorid monohydrat |
| DE2702631A1 (de) * | 1977-01-22 | 1978-07-27 | Henkel Kgaa | Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren |
| DE2943498C2 (de) * | 1979-10-27 | 1983-01-27 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure |
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
| DE3151038A1 (de) * | 1981-12-23 | 1983-07-28 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure |
| US4446052A (en) * | 1982-05-17 | 1984-05-01 | The Procter & Gamble Company | Aqueous gel containing tricalcium di(1-hydroxy-3-aminopropane-1,1-diphosphonate |
| CH664158A5 (fr) * | 1984-07-18 | 1988-02-15 | Symphar Sa | Derives propylidenediphosphonates-1,3 substitues en position 2, leur procede de preparation et compositions pharmaceutiques les contenant. |
-
1985
- 1985-07-29 US US06/759,985 patent/US4639338A/en not_active Expired - Lifetime
- 1985-07-30 EP EP85810352A patent/EP0177443B1/de not_active Expired
- 1985-07-30 DE DE8585810352T patent/DE3573783D1/de not_active Expired
- 1985-07-30 AT AT85810352T patent/ATE47396T1/de not_active IP Right Cessation
- 1985-08-01 PH PH32593A patent/PH24854A/en unknown
- 1985-08-01 IL IL75990A patent/IL75990A/xx not_active IP Right Cessation
- 1985-08-02 IE IE193185A patent/IE58077B1/en not_active IP Right Cessation
- 1985-08-02 FI FI852986A patent/FI79712C/fi not_active IP Right Cessation
- 1985-08-02 CA CA000488039A patent/CA1255694A/en not_active Expired
- 1985-08-05 GR GR851910A patent/GR851910B/el unknown
- 1985-08-05 HU HU842978A patent/HU193124B/hu unknown
- 1985-08-05 DK DK355485A patent/DK167282B1/da not_active IP Right Cessation
- 1985-08-05 JP JP60171301A patent/JPS6143196A/ja active Granted
- 1985-08-05 PT PT80916A patent/PT80916B/pt unknown
- 1985-08-05 KR KR1019850005620A patent/KR940000817B1/ko not_active Expired - Lifetime
- 1985-08-05 ES ES545899A patent/ES8701188A1/es not_active Expired
- 1985-08-05 ZA ZA855892A patent/ZA855892B/xx unknown
- 1985-08-05 AU AU45777/85A patent/AU591066B2/en not_active Expired
- 1985-08-05 NO NO853087A patent/NO165401C/no not_active IP Right Cessation
- 1985-08-05 DD DD85279373A patent/DD239597A5/de not_active IP Right Cessation
- 1985-08-06 AR AR301204A patent/AR240832A1/es active
-
1986
- 1986-06-02 ES ES555602A patent/ES8706707A1/es not_active Expired
- 1986-09-08 US US06/905,097 patent/US4711880A/en not_active Expired - Lifetime
-
1989
- 1989-06-29 AR AR89314298A patent/AR244698A1/es active
- 1989-06-29 AR AR89314300A patent/AR244697A1/es active
- 1989-06-29 AR AR89314299A patent/AR244696A1/es active
-
1990
- 1990-11-13 SG SG913/90A patent/SG91390G/en unknown
- 1990-11-20 DO DO1990004769A patent/DOP1990004769A/es unknown
-
1991
- 1991-05-30 HK HK425/91A patent/HK42591A/xx not_active IP Right Cessation
- 1991-12-20 CY CY1570A patent/CY1570A/xx unknown
-
1992
- 1992-06-25 MX MX9203373A patent/MX9203373A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HPC4 | Succession in title of patentee |
Owner name: HENKEL KG. AUF AKTIEN, DE Owner name: NOVARTIS AG, CH |