AR240832A2 - Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico. - Google Patents

Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico.

Info

Publication number
AR240832A2
AR240832A2 AR30120485A AR30120485A AR240832A2 AR 240832 A2 AR240832 A2 AR 240832A2 AR 30120485 A AR30120485 A AR 30120485A AR 30120485 A AR30120485 A AR 30120485A AR 240832 A2 AR240832 A2 AR 240832A2
Authority
AR
Argentina
Prior art keywords
hydroxy
amino
propan
diphosphonate
water
Prior art date
Application number
AR30120485A
Other languages
English (en)
Other versions
AR240832A1 (es
Original Assignee
Ciba Geigy Ag Henkel Kommandit
Ien
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4263070&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR240832(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag Henkel Kommandit, Ien filed Critical Ciba Geigy Ag Henkel Kommandit
Application granted granted Critical
Publication of AR240832A2 publication Critical patent/AR240832A2/es
Publication of AR240832A1 publication Critical patent/AR240832A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 3-AMINO-1-HIDROXI-PROPAN-1,1-DIFOSFONATO DISODICO DE LA FORMULA (I), EN FORMA NO-HOGROSCOPICA, CRISTALINA, CONTENIENDO AGUA DE CRISTALIZACION, MEDIANTE LA DISOLUCION DE 3-AMINO-1-HIDROXI-PROPAN-1,1-DIFOSFANATO DISODICO EN AGUA A 70 C-80 C O POR NEUTRALIZACION DE ACIDO 3-AMINO-1-HIDROXI-PROPAN-1,1-DIFOSFONICO CON LA SOLUCION ACUOSA DE UNA SAL DE SODIO BASICA A 35 C-85 C, SE ELABORA UNA SOLUCION ACUOSA DE 10%- 55% DE 3-AMINO-1-HIDROXI-PROPAN-1,1-DIFOSFONATO DISODICO, SE CONCENTRA A 70 C-80 C EN TAL MEDIDA QUE EL PUNTO DE SATURACION SE UBICA ENTRE LAS TEMPERATURAS DE 50 C A 70 C, SE ENFRIA EL MISMO, LUEGO DE INICIADA LA FORMACION DE CRISTALES, BAJO EVENTUAL AGREGADO DE 20 A 45% POR VOLUMEN (REFERIDO A LA CANTIDAD TOTAL DE AGUA) DE UN ALCANO INFERIOR MISCIBLE CON AGUA A 25 C-0 C, SE ACUMULAN LOS CRISTALES FORMADOS Y LOS MISMOS SE SECAN A 15 C-60 C, HASTA ALCANZAR CONSTANCIA EN EL PESO.
AR301204A 1984-08-06 1985-08-06 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico. AR240832A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH376884 1984-08-06

Publications (2)

Publication Number Publication Date
AR240832A2 true AR240832A2 (es) 1991-02-28
AR240832A1 AR240832A1 (es) 1991-02-28

Family

ID=4263070

Family Applications (4)

Application Number Title Priority Date Filing Date
AR301204A AR240832A1 (es) 1984-08-06 1985-08-06 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-propan-1,1-difosfonato disodico.
AR89314300A AR244697A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico
AR89314299A AR244696A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.
AR89314298A AR244698A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.

Family Applications After (3)

Application Number Title Priority Date Filing Date
AR89314300A AR244697A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico
AR89314299A AR244696A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.
AR89314298A AR244698A1 (es) 1984-08-06 1989-06-29 Procedimiento para obtener una nueva modificacion cristalina del 3-amino-1-hidroxi-1,1-difosfonato disodico.

Country Status (26)

Country Link
US (2) US4639338A (es)
EP (1) EP0177443B1 (es)
JP (1) JPS6143196A (es)
KR (1) KR940000817B1 (es)
AR (4) AR240832A1 (es)
AT (1) ATE47396T1 (es)
AU (1) AU591066B2 (es)
CA (1) CA1255694A (es)
CY (1) CY1570A (es)
DD (1) DD239597A5 (es)
DE (1) DE3573783D1 (es)
DK (1) DK167282B1 (es)
DO (1) DOP1990004769A (es)
ES (2) ES8701188A1 (es)
FI (1) FI79712C (es)
GR (1) GR851910B (es)
HK (1) HK42591A (es)
HU (1) HU193124B (es)
IE (1) IE58077B1 (es)
IL (1) IL75990A (es)
MX (1) MX9203373A (es)
NO (1) NO165401C (es)
PH (1) PH24854A (es)
PT (1) PT80916B (es)
SG (1) SG91390G (es)
ZA (1) ZA855892B (es)

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Also Published As

Publication number Publication date
DK355485D0 (da) 1985-08-05
ZA855892B (en) 1986-03-26
IE851931L (en) 1986-02-06
DK355485A (da) 1986-02-07
ES8706707A1 (es) 1987-07-01
DOP1990004769A (es) 1999-08-19
KR860001821A (ko) 1986-03-22
GR851910B (es) 1985-12-03
HU193124B (en) 1987-08-28
ES545899A0 (es) 1986-11-16
HUT38361A (en) 1986-05-28
FI79712B (fi) 1989-10-31
FI852986A0 (fi) 1985-08-02
ES555602A0 (es) 1987-07-01
CY1570A (en) 1991-12-20
PT80916B (pt) 1987-12-30
AR244698A1 (es) 1993-11-30
HK42591A (en) 1991-06-07
IL75990A (en) 1989-07-31
IE58077B1 (en) 1993-06-30
SG91390G (en) 1991-01-18
US4639338A (en) 1987-01-27
DD239597A5 (de) 1986-10-01
NO165401C (no) 1991-02-06
JPH058717B2 (es) 1993-02-02
CA1255694A (en) 1989-06-13
NO853087L (no) 1986-02-07
NO165401B (no) 1990-10-29
DE3573783D1 (en) 1989-11-23
EP0177443A1 (de) 1986-04-09
DK167282B1 (da) 1993-10-04
FI79712C (fi) 1990-02-12
AR244697A1 (es) 1993-11-30
MX9203373A (es) 1992-09-01
US4711880A (en) 1987-12-08
EP0177443B1 (de) 1989-10-18
ATE47396T1 (de) 1989-11-15
PT80916A (en) 1985-09-01
AR244696A1 (es) 1993-11-30
ES8701188A1 (es) 1986-11-16
AU591066B2 (en) 1989-11-30
PH24854A (en) 1990-12-26
JPS6143196A (ja) 1986-03-01
FI852986L (fi) 1986-02-07
AR240832A1 (es) 1991-02-28
KR940000817B1 (ko) 1994-02-02
AU4577785A (en) 1986-02-13

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