HU190774B - Process for preparing ether derivatives with pharmacological activity - Google Patents
Process for preparing ether derivatives with pharmacological activity Download PDFInfo
- Publication number
- HU190774B HU190774B HU801601A HU160180A HU190774B HU 190774 B HU190774 B HU 190774B HU 801601 A HU801601 A HU 801601A HU 160180 A HU160180 A HU 160180A HU 190774 B HU190774 B HU 190774B
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- group
- formyl
- compound
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/30—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing —CHO groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/74—Unsaturated compounds containing —CHO groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7922781 | 1979-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU190774B true HU190774B (en) | 1986-11-28 |
Family
ID=10506199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU801601A HU190774B (en) | 1979-06-29 | 1980-06-27 | Process for preparing ether derivatives with pharmacological activity |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4410537A (enExample) |
| EP (1) | EP0022229B1 (enExample) |
| JP (1) | JPS5649335A (enExample) |
| KR (2) | KR850000073B1 (enExample) |
| AU (1) | AU545274B2 (enExample) |
| DE (1) | DE3061269D1 (enExample) |
| DK (1) | DK159770C (enExample) |
| FI (1) | FI71929C (enExample) |
| GB (1) | GB2053218B (enExample) |
| GR (1) | GR68748B (enExample) |
| HU (1) | HU190774B (enExample) |
| IL (1) | IL60422A (enExample) |
| IT (1) | IT1133025B (enExample) |
| MW (1) | MW2380A1 (enExample) |
| OA (1) | OA06699A (enExample) |
| ZA (1) | ZA803880B (enExample) |
| ZM (1) | ZM5780A1 (enExample) |
| ZW (1) | ZW14480A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL64573A (en) * | 1980-12-18 | 1985-04-30 | Wellcome Found | Derivatives of formylphenoxyalkanoic acids and formylphenoxymethylbenzoic acids,their preparation and pharmaceutical formulations containing them |
| GB8606913D0 (en) * | 1986-03-20 | 1986-04-23 | Hider R C | Treatment of sickle cell disease |
| WO1998030141A2 (en) | 1997-01-09 | 1998-07-16 | Cohesion Technologies, Inc. | Devices for tissue repair and methods for preparation and use thereof |
| US7129274B1 (en) | 1999-11-05 | 2006-10-31 | Emisphere Technologies Inc. | Phenoxy carboxylic acid compounds and compositions for delivering active agents |
| US7279597B1 (en) | 1999-11-05 | 2007-10-09 | Emisphere Technologies, Inc. | Phenyl amine carboxylic acid compounds and compositions for delivering active agents |
| MXPA02004092A (es) * | 1999-11-05 | 2003-02-12 | Emisphere Tech Inc | Compuestos y composiciones de acido fenilaminocarboxilico para administrar agentes activos. |
| RU2300516C2 (ru) * | 1999-11-05 | 2007-06-10 | Эмисфере Текнолоджиз, Инк. | Соединения феноксикарбоновой кислоты и композиции для доставки активных веществ |
| JP2003528068A (ja) | 2000-03-17 | 2003-09-24 | コリクサ コーポレイション | 新規両親媒性アルデヒドならびにアジュバントおよび免疫エフェクターとしてのそれらの使用 |
| US8246969B2 (en) | 2001-11-16 | 2012-08-21 | Skinmedica, Inc. | Compositions containing aromatic aldehydes and their use in treatments |
| WO2012094638A1 (en) | 2011-01-07 | 2012-07-12 | Skinmedica, Inc. | Melanin modification compositions and methods of use |
| PL2797416T3 (pl) | 2011-12-28 | 2017-12-29 | Global Blood Therapeutics, Inc. | Podstawione związki benzaldehydowe i sposoby ich zastosowania do zwiększania natlenienia tkanek |
| US9012450B2 (en) | 2011-12-28 | 2015-04-21 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| JP6426694B2 (ja) * | 2013-03-15 | 2018-11-21 | グローバル ブラッド セラピューティクス インコーポレイテッド | ヘモグロビンの修飾のための化合物及びその使用 |
| BR112015021982B1 (pt) | 2013-03-15 | 2022-12-13 | Global Blood Therapeutics, Inc | Compostos e seus usos para a modulação de hemoglobina |
| US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| EP2968299B1 (en) | 2013-03-15 | 2021-01-20 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| WO2015027067A2 (en) * | 2013-08-23 | 2015-02-26 | Virginia Commonwealth University | Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| AP2016009261A0 (en) | 2014-02-07 | 2016-06-30 | Global Blood Therapeutics Inc | Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
| HK1249052A1 (zh) | 2015-03-06 | 2018-10-26 | BeyondSpring Pharmaceuticals Inc. | 治疗与ras突变相关的癌症的方法 |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| PL3383392T3 (pl) | 2015-12-04 | 2025-11-17 | Global Blood Therapeutics, Inc. | Schematy dawkowania dla 2-hydroksy-6-((2-(1-izopropylo-1H-pirazol-5-ilo)pirydyn3-ylo)metoksy)benzaldehydu |
| US10912748B2 (en) * | 2016-02-08 | 2021-02-09 | Beyondspring Pharmaceuticals, Inc. | Compositions containing tucaresol or its analogs |
| TWI663160B (zh) | 2016-05-12 | 2019-06-21 | 全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
| CN109475524A (zh) | 2016-06-06 | 2019-03-15 | 万春药业公司 | 用于减少中性粒细胞减少症的组合物和方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| WO2018129381A1 (en) | 2017-01-06 | 2018-07-12 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
| KR20190109479A (ko) | 2017-02-01 | 2019-09-25 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증의 감소 방법 |
| US11401241B2 (en) * | 2018-03-22 | 2022-08-02 | Virginia Commonwealth University | Aromatic aldehydes with sustained and enhanced in vitro and in vivo pharmacologic activity to treat sickle cell disease |
| EP3860975B1 (en) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
| PT3880654T (pt) | 2018-11-19 | 2022-04-08 | Global Blood Therapeutics Inc | Compostos de 2-formil-3-hidroxifeniloximetil capazes de modular hemoglobina |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
| EP4319751A4 (en) | 2021-04-09 | 2025-02-26 | Beyondspring Pharmaceuticals, Inc. | THERAPEUTIC COMPOSITIONS AND METHODS FOR THE TREATING OF TUMORS |
| IL320636A (en) * | 2022-11-07 | 2025-07-01 | Univ Virginia Commonwealth | Benzaldehyde compounds with destabilizing effects on polymers for the treatment of sickle cell disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL105100C (enExample) * | 1958-04-30 | |||
| CH543472A (fr) * | 1969-01-31 | 1973-10-31 | Orchimed Sa | Procédé pour la préparation d'acides phénoxyalcoyl-carboxyliques |
| DE2209128C3 (de) | 1971-03-05 | 1981-10-22 | CIBA-GEIGY AG, 4002 Basel | Bis-Stilbenverbindungen, Verfahren zu deren Herstellung und deren Verwendung als optische Aufheller |
| CH550776A (de) | 1971-03-05 | 1974-06-28 | Ciba Geigy Ag | Herstellung neuer bis-stilbenverbindungen. |
| GB1511645A (en) | 1974-05-31 | 1978-05-24 | Univ Ife | Sickle cell anaemia treatment |
| US4137309A (en) * | 1976-10-14 | 1979-01-30 | The Procter & Gamble Company | Therapeutic treatment |
-
1980
- 1980-06-27 IT IT49108/80A patent/IT1133025B/it active
- 1980-06-27 AU AU59697/80A patent/AU545274B2/en not_active Ceased
- 1980-06-27 DK DK279780A patent/DK159770C/da not_active IP Right Cessation
- 1980-06-27 MW MW23/80A patent/MW2380A1/xx unknown
- 1980-06-27 ZA ZA00803880A patent/ZA803880B/xx unknown
- 1980-06-27 GR GR62311A patent/GR68748B/el unknown
- 1980-06-27 JP JP8764580A patent/JPS5649335A/ja active Granted
- 1980-06-27 HU HU801601A patent/HU190774B/hu not_active IP Right Cessation
- 1980-06-27 KR KR1019800002541A patent/KR850000073B1/ko not_active Expired
- 1980-06-27 ZW ZW144/80A patent/ZW14480A1/xx unknown
- 1980-06-27 FI FI802052A patent/FI71929C/fi not_active IP Right Cessation
- 1980-06-27 ZM ZM57/80A patent/ZM5780A1/xx unknown
- 1980-06-27 GB GB8021219A patent/GB2053218B/en not_active Expired
- 1980-06-27 IL IL60422A patent/IL60422A/xx not_active IP Right Cessation
- 1980-06-27 DE DE8080103657T patent/DE3061269D1/de not_active Expired
- 1980-06-27 EP EP80103657A patent/EP0022229B1/en not_active Expired
- 1980-08-09 OA OA57193A patent/OA06699A/xx unknown
-
1981
- 1981-06-09 US US06/271,950 patent/US4410537A/en not_active Expired - Lifetime
-
1984
- 1984-03-13 KR KR1019840001263A patent/KR850000072B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZM5780A1 (en) | 1983-11-21 |
| ZW14480A1 (en) | 1982-03-17 |
| EP0022229A1 (en) | 1981-01-14 |
| KR830002693A (ko) | 1983-05-30 |
| FI802052A7 (fi) | 1980-12-30 |
| AU545274B2 (en) | 1985-07-11 |
| EP0022229B1 (en) | 1982-12-08 |
| DK159770C (da) | 1991-04-22 |
| IT1133025B (it) | 1986-07-09 |
| JPH0154339B2 (enExample) | 1989-11-17 |
| MW2380A1 (en) | 1982-03-10 |
| ZA803880B (en) | 1982-02-24 |
| DK159770B (da) | 1990-12-03 |
| KR850000072B1 (ko) | 1985-02-18 |
| IT8049108A0 (it) | 1980-06-27 |
| OA06699A (fr) | 1982-05-31 |
| DE3061269D1 (en) | 1983-01-13 |
| DK279780A (da) | 1980-12-30 |
| GR68748B (enExample) | 1982-02-16 |
| KR840004668A (ko) | 1984-10-22 |
| FI71929B (fi) | 1986-11-28 |
| US4410537A (en) | 1983-10-18 |
| IL60422A (en) | 1984-06-29 |
| AU5969780A (en) | 1981-01-08 |
| GB2053218A (en) | 1981-02-04 |
| FI71929C (fi) | 1987-03-09 |
| IL60422A0 (en) | 1980-09-16 |
| GB2053218B (en) | 1984-01-25 |
| KR850000073B1 (ko) | 1985-02-18 |
| JPS5649335A (en) | 1981-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |