FI71929C - Foerfarande foer framstaellning av terapeutiskt anvaendbara eterfoereningar samt vid deras framstaellning anvaendbara mellanprodukter. - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara eterfoereningar samt vid deras framstaellning anvaendbara mellanprodukter. Download PDF

Info

Publication number
FI71929C
FI71929C FI802052A FI802052A FI71929C FI 71929 C FI71929 C FI 71929C FI 802052 A FI802052 A FI 802052A FI 802052 A FI802052 A FI 802052A FI 71929 C FI71929 C FI 71929C
Authority
FI
Finland
Prior art keywords
formyl
formula
hydroxyphenoxy
mixture
water
Prior art date
Application number
FI802052A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI802052A7 (fi
FI71929B (fi
Inventor
Geoffrey Kneen
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI802052A7 publication Critical patent/FI802052A7/fi
Publication of FI71929B publication Critical patent/FI71929B/fi
Application granted granted Critical
Publication of FI71929C publication Critical patent/FI71929C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/30—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing —CHO groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/74—Unsaturated compounds containing —CHO groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
FI802052A 1979-06-29 1980-06-27 Foerfarande foer framstaellning av terapeutiskt anvaendbara eterfoereningar samt vid deras framstaellning anvaendbara mellanprodukter. FI71929C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7922781 1979-06-29
GB7922781 1979-06-29

Publications (3)

Publication Number Publication Date
FI802052A7 FI802052A7 (fi) 1980-12-30
FI71929B FI71929B (fi) 1986-11-28
FI71929C true FI71929C (fi) 1987-03-09

Family

ID=10506199

Family Applications (1)

Application Number Title Priority Date Filing Date
FI802052A FI71929C (fi) 1979-06-29 1980-06-27 Foerfarande foer framstaellning av terapeutiskt anvaendbara eterfoereningar samt vid deras framstaellning anvaendbara mellanprodukter.

Country Status (18)

Country Link
US (1) US4410537A (enExample)
EP (1) EP0022229B1 (enExample)
JP (1) JPS5649335A (enExample)
KR (2) KR850000073B1 (enExample)
AU (1) AU545274B2 (enExample)
DE (1) DE3061269D1 (enExample)
DK (1) DK159770C (enExample)
FI (1) FI71929C (enExample)
GB (1) GB2053218B (enExample)
GR (1) GR68748B (enExample)
HU (1) HU190774B (enExample)
IL (1) IL60422A (enExample)
IT (1) IT1133025B (enExample)
MW (1) MW2380A1 (enExample)
OA (1) OA06699A (enExample)
ZA (1) ZA803880B (enExample)
ZM (1) ZM5780A1 (enExample)
ZW (1) ZW14480A1 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL64573A (en) * 1980-12-18 1985-04-30 Wellcome Found Derivatives of formylphenoxyalkanoic acids and formylphenoxymethylbenzoic acids,their preparation and pharmaceutical formulations containing them
GB8606913D0 (en) * 1986-03-20 1986-04-23 Hider R C Treatment of sickle cell disease
WO1998030141A2 (en) 1997-01-09 1998-07-16 Cohesion Technologies, Inc. Devices for tissue repair and methods for preparation and use thereof
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
US7279597B1 (en) 1999-11-05 2007-10-09 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
MXPA02004092A (es) * 1999-11-05 2003-02-12 Emisphere Tech Inc Compuestos y composiciones de acido fenilaminocarboxilico para administrar agentes activos.
RU2300516C2 (ru) * 1999-11-05 2007-06-10 Эмисфере Текнолоджиз, Инк. Соединения феноксикарбоновой кислоты и композиции для доставки активных веществ
JP2003528068A (ja) 2000-03-17 2003-09-24 コリクサ コーポレイション 新規両親媒性アルデヒドならびにアジュバントおよび免疫エフェクターとしてのそれらの使用
US8246969B2 (en) 2001-11-16 2012-08-21 Skinmedica, Inc. Compositions containing aromatic aldehydes and their use in treatments
WO2012094638A1 (en) 2011-01-07 2012-07-12 Skinmedica, Inc. Melanin modification compositions and methods of use
PL2797416T3 (pl) 2011-12-28 2017-12-29 Global Blood Therapeutics, Inc. Podstawione związki benzaldehydowe i sposoby ich zastosowania do zwiększania natlenienia tkanek
US9012450B2 (en) 2011-12-28 2015-04-21 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
JP6426694B2 (ja) * 2013-03-15 2018-11-21 グローバル ブラッド セラピューティクス インコーポレイテッド ヘモグロビンの修飾のための化合物及びその使用
BR112015021982B1 (pt) 2013-03-15 2022-12-13 Global Blood Therapeutics, Inc Compostos e seus usos para a modulação de hemoglobina
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2014145040A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
EP2968299B1 (en) 2013-03-15 2021-01-20 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
WO2015027067A2 (en) * 2013-08-23 2015-02-26 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
AP2016009261A0 (en) 2014-02-07 2016-06-30 Global Blood Therapeutics Inc Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
HK1249052A1 (zh) 2015-03-06 2018-10-26 BeyondSpring Pharmaceuticals Inc. 治疗与ras突变相关的癌症的方法
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
PL3383392T3 (pl) 2015-12-04 2025-11-17 Global Blood Therapeutics, Inc. Schematy dawkowania dla 2-hydroksy-6-((2-(1-izopropylo-1H-pirazol-5-ilo)pirydyn3-ylo)metoksy)benzaldehydu
US10912748B2 (en) * 2016-02-08 2021-02-09 Beyondspring Pharmaceuticals, Inc. Compositions containing tucaresol or its analogs
TWI663160B (zh) 2016-05-12 2019-06-21 全球血液治療公司 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
CN109475524A (zh) 2016-06-06 2019-03-15 万春药业公司 用于减少中性粒细胞减少症的组合物和方法
TW202332423A (zh) 2016-10-12 2023-08-16 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
WO2018129381A1 (en) 2017-01-06 2018-07-12 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
KR20190109479A (ko) 2017-02-01 2019-09-25 비욘드스프링 파마수티컬스, 인코포레이티드. 호중구감소증의 감소 방법
US11401241B2 (en) * 2018-03-22 2022-08-02 Virginia Commonwealth University Aromatic aldehydes with sustained and enhanced in vitro and in vivo pharmacologic activity to treat sickle cell disease
EP3860975B1 (en) 2018-10-01 2023-10-18 Global Blood Therapeutics, Inc. Modulators of hemoglobin for the treatment of sickle cell disease
PT3880654T (pt) 2018-11-19 2022-04-08 Global Blood Therapeutics Inc Compostos de 2-formil-3-hidroxifeniloximetil capazes de modular hemoglobina
US12479816B2 (en) 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors
EP4319751A4 (en) 2021-04-09 2025-02-26 Beyondspring Pharmaceuticals, Inc. THERAPEUTIC COMPOSITIONS AND METHODS FOR THE TREATING OF TUMORS
IL320636A (en) * 2022-11-07 2025-07-01 Univ Virginia Commonwealth Benzaldehyde compounds with destabilizing effects on polymers for the treatment of sickle cell disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL105100C (enExample) * 1958-04-30
CH543472A (fr) * 1969-01-31 1973-10-31 Orchimed Sa Procédé pour la préparation d'acides phénoxyalcoyl-carboxyliques
DE2209128C3 (de) 1971-03-05 1981-10-22 CIBA-GEIGY AG, 4002 Basel Bis-Stilbenverbindungen, Verfahren zu deren Herstellung und deren Verwendung als optische Aufheller
CH550776A (de) 1971-03-05 1974-06-28 Ciba Geigy Ag Herstellung neuer bis-stilbenverbindungen.
GB1511645A (en) 1974-05-31 1978-05-24 Univ Ife Sickle cell anaemia treatment
US4137309A (en) * 1976-10-14 1979-01-30 The Procter & Gamble Company Therapeutic treatment

Also Published As

Publication number Publication date
ZM5780A1 (en) 1983-11-21
ZW14480A1 (en) 1982-03-17
EP0022229A1 (en) 1981-01-14
KR830002693A (ko) 1983-05-30
FI802052A7 (fi) 1980-12-30
AU545274B2 (en) 1985-07-11
EP0022229B1 (en) 1982-12-08
DK159770C (da) 1991-04-22
IT1133025B (it) 1986-07-09
JPH0154339B2 (enExample) 1989-11-17
MW2380A1 (en) 1982-03-10
ZA803880B (en) 1982-02-24
DK159770B (da) 1990-12-03
KR850000072B1 (ko) 1985-02-18
IT8049108A0 (it) 1980-06-27
OA06699A (fr) 1982-05-31
DE3061269D1 (en) 1983-01-13
DK279780A (da) 1980-12-30
GR68748B (enExample) 1982-02-16
KR840004668A (ko) 1984-10-22
HU190774B (en) 1986-11-28
FI71929B (fi) 1986-11-28
US4410537A (en) 1983-10-18
IL60422A (en) 1984-06-29
AU5969780A (en) 1981-01-08
GB2053218A (en) 1981-02-04
IL60422A0 (en) 1980-09-16
GB2053218B (en) 1984-01-25
KR850000073B1 (ko) 1985-02-18
JPS5649335A (en) 1981-05-02

Similar Documents

Publication Publication Date Title
FI71929B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara etrfoereningar samt vid deras framstaellning anvaendbara me llnprodukter
EP0054924B1 (en) Pharmaceutical compounds, their preparation and use
EP0248594B1 (en) Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same
US7691843B2 (en) N-hydroxyamide derivatives possessing antibacterial activity
HU207289B (en) Process for producing oxime-carbamates and pharmaceutical compositions containing them as active components
JP2848375B2 (ja) ピラゾリル誘導体及びその製造方法
US4532344A (en) Fluoranthene derivatives
US20040087632A1 (en) Anilino liver X-receptor modulators
AU779408B2 (en) Vitamin D3 analogs
JPH10182583A (ja) 新規ヒドロキサム酸誘導体
MXPA04011690A (es) Moduladores de receptor x de higado de sulfona.
JPS63154658A (ja) ３−［ω−（３，５−ジ−ｔ−ブチル−４−ヒドロキシフェニル）アルカノイル］ピロール類、それらのデオキシ類似体およびそれらの治療用途
US3860636A (en) Substituted indenyl phosphonic acids having anti-inflammatory activity
US5541221A (en) Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss
US4946963A (en) Compounds for the control of hyperlipidemia using N-substituted isoxazolidine-3,5-diones
JPH07103105B2 (ja) インドール誘導体及びその製造方法
JP2790335B2 (ja) 共役γ―オキシブテノライド化合物およびこれを有効成分とする抗潰瘍剤
US5371284A (en) Phenyl acetylenic acetals
HU198694B (en) Process for producing azol derivatives and pharmaceutical compositions containing them as active components
US4717729A (en) Triphenylene derivatives
WO1991005757A1 (en) Lipoxygenase inhibitors
EP1474390B1 (en) Indole derivatives substituted with long-chain alcohols and medicaments containing them
KR880001754B1 (ko) 에테르류 화합물의 제조방법
JPS60146860A (ja) 有機化合物およびその薬剤使用
JPH0157114B2 (enExample)

Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: THE WELLCOME FOUNDATION LIMITED