HU176827B - Process for producing nitrogen-containing polysaccharides of tumor-inhibiting activity with extracting fungi of coriolus species - Google Patents
Process for producing nitrogen-containing polysaccharides of tumor-inhibiting activity with extracting fungi of coriolus species Download PDFInfo
- Publication number
- HU176827B HU176827B HU76KU510A HUKU000510A HU176827B HU 176827 B HU176827 B HU 176827B HU 76KU510 A HU76KU510 A HU 76KU510A HU KU000510 A HUKU000510 A HU KU000510A HU 176827 B HU176827 B HU 176827B
- Authority
- HU
- Hungary
- Prior art keywords
- coriolus
- ferm
- quél
- extraction
- fungi
- Prior art date
Links
- 241000222356 Coriolus Species 0.000 title claims abstract description 20
- 241000233866 Fungi Species 0.000 title claims abstract description 19
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 17
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 17
- -1 nitrogen-containing polysaccharides Chemical class 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims description 25
- 206010028980 Neoplasm Diseases 0.000 title description 6
- 230000002401 inhibitory effect Effects 0.000 title description 2
- 238000000605 extraction Methods 0.000 claims description 35
- 230000000259 anti-tumor effect Effects 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 10
- 238000007670 refining Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 241000222355 Trametes versicolor Species 0.000 abstract description 32
- 239000003125 aqueous solvent Substances 0.000 abstract description 11
- 241000221198 Basidiomycota Species 0.000 abstract description 8
- 238000000502 dialysis Methods 0.000 abstract description 7
- 239000000463 material Substances 0.000 abstract description 7
- 241000222357 Trametes hirsuta Species 0.000 abstract description 3
- 239000012670 alkaline solution Substances 0.000 abstract description 3
- 239000002904 solvent Substances 0.000 abstract description 3
- 150000004676 glycans Chemical class 0.000 abstract description 2
- 241001676647 Trametes pubescens Species 0.000 abstract 1
- 239000006286 aqueous extract Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000004480 active ingredient Substances 0.000 description 11
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 208000006268 Sarcoma 180 Diseases 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- 239000002246 antineoplastic agent Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 description 5
- 239000007858 starting material Substances 0.000 description 5
- 238000011282 treatment Methods 0.000 description 4
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 3
- 241000123247 Inonotus Species 0.000 description 3
- 241001619412 Meruliaceae Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 241000222341 Polyporaceae Species 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 238000007912 intraperitoneal administration Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 241000222384 Corticiaceae Species 0.000 description 2
- 241001480628 Cortinariaceae Species 0.000 description 2
- 241000959662 Hydnaceae Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- MYKOKMFESWKQRX-UHFFFAOYSA-N 10h-anthracen-9-one;sulfuric acid Chemical compound OS(O)(=O)=O.C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 MYKOKMFESWKQRX-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241001600097 Coniophoraceae Species 0.000 description 1
- 241001492317 Crepidotaceae Species 0.000 description 1
- 241001331143 Cystidiophorus castaneus Species 0.000 description 1
- 241000039767 Daedalea dickinsii Species 0.000 description 1
- 241000654305 Daedaleopsis styracina Species 0.000 description 1
- 241000171444 Echinodontium tsugicola Species 0.000 description 1
- 241001378514 Favolus Species 0.000 description 1
- 241000123110 Fuscoporia gilva Species 0.000 description 1
- 241000410085 Gloeostereum incarnatum Species 0.000 description 1
- 241001062293 Gymnopilus aeruginosus Species 0.000 description 1
- 241001101005 Ilex maximowicziana var. kanehirae Species 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 241000123249 Inonotus hispidus Species 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 241000959614 Laxitextum bicolor Species 0.000 description 1
- 241000222635 Lenzites betulinus Species 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- 241000196843 Lopharia mirabilis Species 0.000 description 1
- 241000218554 Lyophyllum Species 0.000 description 1
- 241000318230 Merulius Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000222639 Panellus stipticus Species 0.000 description 1
- 101150003018 Patj gene Proteins 0.000 description 1
- 241000222395 Phlebia Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000778153 Rhodophyllus Species 0.000 description 1
- 241000306752 Salmoneus Species 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 241000231258 Suillus granulatus Species 0.000 description 1
- 241000180926 Tillandsia albida Species 0.000 description 1
- 241000222645 Trametes cinnabarina Species 0.000 description 1
- 241000321980 Trametes gibbosa Species 0.000 description 1
- 241001346358 Trametes orientalis Species 0.000 description 1
- 241000042002 Trametes sanguinea Species 0.000 description 1
- 241000222433 Tricholomataceae Species 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001371 alpha-amino acids Chemical class 0.000 description 1
- 235000008206 alpha-amino acids Nutrition 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000010200 folin Substances 0.000 description 1
- 229940118198 galzin Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- HHIVCXLCMPHUSC-UHFFFAOYSA-N hydron;1h-indol-1-ium;sulfate Chemical compound OS(O)(=O)=O.C1=CC=C2NC=CC2=C1 HHIVCXLCMPHUSC-UHFFFAOYSA-N 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- HFOJRTIFHRRHGA-UHFFFAOYSA-N naphthalen-1-ol;sulfuric acid Chemical compound OS(O)(=O)=O.C1=CC=C2C(O)=CC=CC2=C1 HFOJRTIFHRRHGA-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000009938 salting Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- DJWUNCQRNNEAKC-UHFFFAOYSA-L zinc acetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O DJWUNCQRNNEAKC-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15011475A JPS5290614A (en) | 1975-12-18 | 1975-12-18 | Preparation of anti-tumor substance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU176827B true HU176827B (en) | 1981-05-28 |
Family
ID=15489783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU76KU510A HU176827B (en) | 1975-12-18 | 1976-12-13 | Process for producing nitrogen-containing polysaccharides of tumor-inhibiting activity with extracting fungi of coriolus species |
Country Status (26)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851395A (en) * | 1976-07-07 | 1989-07-25 | Kureha Kagaku Kogyo Kabushiki Kausha | Nitrogen-containing polysaccharide |
| JPS536413A (en) * | 1976-07-07 | 1978-01-20 | Kureha Chem Ind Co Ltd | Preparation of n-containing polysaccharides |
| JPS536412A (en) * | 1976-07-07 | 1978-01-20 | Kureha Chem Ind Co Ltd | Preparation of n-containing polysaccharides |
| JPS5315495A (en) * | 1976-07-22 | 1978-02-13 | Kureha Chem Ind Co Ltd | Preparation of polysaccharides |
| JPS5432610A (en) * | 1977-08-15 | 1979-03-10 | Kisaku Mori | Extracting of pharmaceutically effective substance of mushrooms |
| JPS5446830A (en) * | 1977-09-16 | 1979-04-13 | Kureha Chem Ind Co Ltd | Pesticide for plant viral disease |
| DE3071750D1 (en) * | 1979-07-04 | 1986-10-16 | Kureha Chemical Ind Co Ltd | Nasal preparations, process for making same and their use |
| JPS5626198A (en) * | 1979-08-08 | 1981-03-13 | Takara Shuzo Co Ltd | Preparation of antitumor substance |
| US4512972A (en) * | 1980-06-30 | 1985-04-23 | Kureha Chemical Industry Co., Ltd. | Nasal preparation and processes for their production |
| JPS5932480B2 (ja) * | 1981-02-10 | 1984-08-09 | 呉羽化学工業株式会社 | 新規な糖蛋白複合体 |
| US4614733A (en) * | 1981-12-31 | 1986-09-30 | Kureha Kagaku Kogyo Kabushiki Kaisha | Polysaccharides pharmaceutical compositions and the use thereof |
| DE3448152C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1983-08-11 | 1989-11-02 | Kureha Kagaku Kogyo K.K., Nihonbashi, Tokio/Tokyo, Jp | |
| JPH0825896B2 (ja) * | 1987-06-18 | 1996-03-13 | 呉羽化学工業株式会社 | 抗レトロウィルス剤 |
| JPH01228480A (ja) * | 1988-03-09 | 1989-09-12 | Nippon Hai Potsukusu:Kk | 食用担子菌菌糸体培養抽出物の製造方法 |
| JPH0643336B2 (ja) * | 1988-06-30 | 1994-06-08 | 呉羽化学工業株式会社 | 血管増殖抑制剤 |
| JPH0678367B2 (ja) * | 1990-05-15 | 1994-10-05 | 呉羽化学工業株式会社 | 食物繊維、その製造法及びその食物繊維を含有する生理活性剤 |
| JP2746532B2 (ja) * | 1994-02-23 | 1998-05-06 | 宮 和男 | イザリア型虫草を主成分とする免疫強化食品 |
| US7048932B2 (en) * | 2002-05-22 | 2006-05-23 | The Chinese University Of Hong Kong | Preparation and standardization of immunomodulatory peptide-linked glucans with verifiable oral absorbability from coriolus versicolor |
| RU2323966C2 (ru) * | 2005-11-07 | 2008-05-10 | Общество с ограниченной ответственностью "Микролек" | Штамм гриба trametes pubescens c-23 - продуцент эргостерина и препарат, положительно влияющий на тканевый обмен, стимулирующий иммуногенез и способствующий восстановлению нарушенной оксидаз-смешанной функции печени |
| RU2475529C2 (ru) * | 2011-03-14 | 2013-02-20 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВБ "Вектор") | ИНГИБИТОР РЕПРОДУКЦИИ ВИРУСА ГРИППА А НА ОСНОВЕ ЭКСТРАКТА БАЗИДИАЛЬНОГО ГРИБА Phallus impudicus |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE757248A (fr) * | 1969-10-15 | 1971-04-08 | Kureha Chemical Ind Co Ltd | Substance a propriete anticancereuse et procedes pour sa preparation |
-
1975
- 1975-12-18 JP JP15011475A patent/JPS5290614A/ja active Granted
-
1976
- 1976-05-25 BR BR8526/76A patent/BR7608526A/pt unknown
- 1976-12-08 AU AU20354/76A patent/AU496814B2/en not_active Expired
- 1976-12-09 DE DE2655844A patent/DE2655844C3/de not_active Expired
- 1976-12-13 US US05/749,621 patent/US4202885A/en not_active Expired - Lifetime
- 1976-12-13 HU HU76KU510A patent/HU176827B/hu not_active IP Right Cessation
- 1976-12-13 YU YU3037/76A patent/YU40467B/xx unknown
- 1976-12-13 CH CH1562576A patent/CH622948A5/de not_active IP Right Cessation
- 1976-12-13 CA CA267,695A patent/CA1055487A/en not_active Expired
- 1976-12-14 IN IN2196/CAL/76A patent/IN142077B/en unknown
- 1976-12-14 PH PH19246A patent/PH12234A/en unknown
- 1976-12-15 GB GB52440/76A patent/GB1521168A/en not_active Expired
- 1976-12-16 ES ES76454304A patent/ES454304A1/es not_active Expired
- 1976-12-16 SU SU762428806A patent/SU786855A3/ru active
- 1976-12-16 CS CS768288A patent/CS200503B2/cs unknown
- 1976-12-16 RO RO88758A patent/RO69485A2/ro unknown
- 1976-12-16 BE BE173321A patent/BE849476A/xx not_active IP Right Cessation
- 1976-12-17 DK DK570176A patent/DK147766C/da not_active IP Right Cessation
- 1976-12-17 NL NLAANVRAGE7614016,A patent/NL171224C/xx not_active IP Right Cessation
- 1976-12-17 PL PL1976194482A patent/PL101771B1/pl unknown
- 1976-12-17 AT AT934876A patent/AT347031B/de not_active IP Right Cessation
- 1976-12-17 DD DD7600196446A patent/DD129330A5/xx unknown
- 1976-12-17 FR FR7638134A patent/FR2335235A1/fr active Granted
- 1976-12-17 SE SE7614202A patent/SE435678B/xx not_active IP Right Cessation
- 1976-12-17 MX MX765250U patent/MX4646E/es unknown
- 1976-12-20 IT IT30642/76A patent/IT1123693B/it active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |