HRP960581B1 - Method for the synthesis of a benzimidazole compound - Google Patents

Method for the synthesis of a benzimidazole compound

Info

Publication number
HRP960581B1
HRP960581B1 HR960581A HRP960581A HRP960581B1 HR P960581 B1 HRP960581 B1 HR P960581B1 HR 960581 A HR960581 A HR 960581A HR P960581 A HRP960581 A HR P960581A HR P960581 B1 HRP960581 B1 HR P960581B1
Authority
HR
Croatia
Prior art keywords
synthesis
benzimidazole compound
benzimidazole
compound
Prior art date
Application number
HR960581A
Other languages
English (en)
Inventor
Anders Gustavsson
Ake Kaellstroem
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HRP960581A2 publication Critical patent/HRP960581A2/hr
Publication of HRP960581B1 publication Critical patent/HRP960581B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR960581A 1995-12-15 1996-12-09 Method for the synthesis of a benzimidazole compound HRP960581B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9504503A SE521100C2 (sv) 1995-12-15 1995-12-15 Förfarande för framställning av en bensimidazolförening

Publications (2)

Publication Number Publication Date
HRP960581A2 HRP960581A2 (en) 1998-02-28
HRP960581B1 true HRP960581B1 (en) 2001-12-31

Family

ID=20400614

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960581A HRP960581B1 (en) 1995-12-15 1996-12-09 Method for the synthesis of a benzimidazole compound

Country Status (40)

Country Link
US (1) US5958955A (de)
EP (1) EP0868423B1 (de)
JP (1) JP3523267B2 (de)
KR (1) KR100433436B1 (de)
CN (1) CN1113879C (de)
AR (1) AR004834A1 (de)
AT (1) ATE205201T1 (de)
AU (1) AU704422B2 (de)
CA (1) CA2238864C (de)
CO (1) CO4750654A1 (de)
CZ (1) CZ288661B6 (de)
DE (2) DE868423T1 (de)
DK (1) DK0868423T3 (de)
DZ (1) DZ2137A1 (de)
EE (1) EE03768B1 (de)
EG (1) EG23859A (de)
ES (1) ES2125210T3 (de)
HK (1) HK1010539A1 (de)
HR (1) HRP960581B1 (de)
HU (1) HUP9900110A3 (de)
IL (1) IL124856A (de)
IS (1) IS1891B (de)
MA (1) MA24026A1 (de)
MX (1) MX9804603A (de)
MY (1) MY115661A (de)
NO (1) NO314306B1 (de)
NZ (1) NZ324482A (de)
PL (1) PL186132B1 (de)
PT (1) PT868423E (de)
RU (1) RU2166502C2 (de)
SE (1) SE521100C2 (de)
SI (1) SI0868423T1 (de)
SK (1) SK282347B6 (de)
TN (1) TNSN96148A1 (de)
TR (1) TR199801070T2 (de)
TW (1) TW460474B (de)
UA (1) UA62921C2 (de)
WO (1) WO1997022603A1 (de)
YU (1) YU49420B (de)
ZA (1) ZA9610067B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6645988B2 (en) 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SK283805B6 (sk) 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
US6303787B1 (en) * 1998-05-27 2001-10-16 Natco Pharma Limited Intermediates and an improved process for the preparation of Omeprazole employing the said intermediates
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
IL142703A (en) 1998-11-10 2006-04-10 Astrazeneca Ab Crystalline form of omeprazole
UA72748C2 (en) * 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
DE19951960C2 (de) 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
EP1469839A2 (de) * 2002-01-25 2004-10-27 Santarus, Inc. Transmukosale verabreichung von protonenpumpeninhibitoren
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
ZA200706613B (en) * 2004-12-16 2009-03-25 Cipla Ltd Process
CN100393712C (zh) * 2006-01-23 2008-06-11 中国科学院成都有机化学有限公司 苯并咪唑型质子泵抑止剂及其前体的改进制备和分离纯化方法
WO2007122686A1 (ja) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. ベンズイミダゾール化合物
NZ579136A (en) * 2007-02-21 2012-05-25 Cipla Ltd Process for the preparation of esomeprazole magnesium dihydrate
CN101492459B (zh) * 2008-01-25 2011-04-27 山东轩竹医药科技有限公司 含烷氧乙酰基二氢异噁唑并吡啶化合物
CN101497603B (zh) * 2008-01-30 2012-11-07 山东轩竹医药科技有限公司 含有被烷氧烷胺氧基取代的吡啶的苯并咪唑衍生物
CN103664885A (zh) * 2013-12-12 2014-03-26 武汉工程大学 苯并咪唑型质子泵抑制剂中间体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US461997A (en) * 1891-10-27 Sand-pump or other pipes
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
US4619997A (en) * 1984-09-06 1986-10-28 The Upjohn Company Substituted 2-pyridylmethylthio and sulfinyl-benzimidazoles as gastric antisecretory agents
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening

Also Published As

Publication number Publication date
KR100433436B1 (ko) 2004-07-16
DE69615052D1 (de) 2001-10-11
CN1204332A (zh) 1999-01-06
NZ324482A (en) 2000-04-28
HUP9900110A3 (en) 2002-10-28
WO1997022603A1 (en) 1997-06-26
EE9800183A (et) 1998-12-15
AU1155097A (en) 1997-07-14
SE521100C2 (sv) 2003-09-30
IS1891B (is) 2003-09-19
SK76898A3 (en) 1998-12-02
TR199801070T2 (xx) 1998-08-21
DK0868423T3 (da) 2001-12-03
NO982624L (no) 1998-06-08
IS4750A (is) 1998-05-22
ES2125210T3 (es) 2002-02-01
EP0868423B1 (de) 2001-09-05
EE03768B1 (et) 2002-06-17
CZ288661B6 (cs) 2001-08-15
JP2000502101A (ja) 2000-02-22
EG23859A (en) 2007-11-18
ZA9610067B (en) 1997-06-17
IL124856A (en) 2002-12-01
AR004834A1 (es) 1999-03-10
MY115661A (en) 2003-08-30
ATE205201T1 (de) 2001-09-15
PL327334A1 (en) 1998-12-07
EP0868423A1 (de) 1998-10-07
CA2238864C (en) 2006-01-24
JP3523267B2 (ja) 2004-04-26
YU64296A (sh) 1999-07-28
NO982624D0 (no) 1998-06-08
ES2125210T1 (es) 1999-03-01
SI0868423T1 (en) 2002-04-30
TW460474B (en) 2001-10-21
DE69615052T2 (de) 2002-06-27
CA2238864A1 (en) 1997-06-26
CN1113879C (zh) 2003-07-09
IL124856A0 (en) 1999-01-26
YU49420B (sh) 2006-01-16
HK1010539A1 (en) 1999-06-25
PT868423E (pt) 2002-02-28
PL186132B1 (pl) 2003-10-31
MX9804603A (es) 1998-10-31
NO314306B1 (no) 2003-03-03
MA24026A1 (fr) 1997-07-01
AU704422B2 (en) 1999-04-22
HUP9900110A2 (hu) 2000-03-28
CO4750654A1 (es) 1999-03-31
SE9504503D0 (sv) 1995-12-15
DZ2137A1 (fr) 2002-10-23
UA62921C2 (en) 2004-01-15
RU2166502C2 (ru) 2001-05-10
US5958955A (en) 1999-09-28
KR20000064399A (ko) 2000-11-06
DE868423T1 (de) 1999-06-02
HRP960581A2 (en) 1998-02-28
TNSN96148A1 (fr) 2005-03-15
SE9504503L (sv) 1997-06-16
CZ168598A3 (cs) 1998-09-16
SK282347B6 (sk) 2002-01-07

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: ASTRAZENECA AB, SE

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20081121

Year of fee payment: 13

PBON Lapse due to non-payment of renewal fee

Effective date: 20091210