HRP960294B1 - Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments - Google Patents

Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments

Info

Publication number
HRP960294B1
HRP960294B1 HR960294A HRP960294A HRP960294B1 HR P960294 B1 HRP960294 B1 HR P960294B1 HR 960294 A HR960294 A HR 960294A HR P960294 A HRP960294 A HR P960294A HR P960294 B1 HRP960294 B1 HR P960294B1
Authority
HR
Croatia
Prior art keywords
inhaler
metering device
pharmaceutical powder
powder cartridge
powdered medicaments
Prior art date
Application number
HR960294A
Other languages
English (en)
Inventor
Andre Narodylo
Wolfgang Goettenauer
Joachim Goede
Coenraad Lerk
Anne H De Boer
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19522415A external-priority patent/DE19522415C2/de
Priority claimed from DE1995122416 external-priority patent/DE19522416C2/de
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of HRP960294A2 publication Critical patent/HRP960294A2/xx
Publication of HRP960294B1 publication Critical patent/HRP960294B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0095—Preventing manual activation in absence of inhalation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • External Artificial Organs (AREA)
  • Basic Packing Technique (AREA)
HR960294A 1995-06-21 1996-06-20 Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments HRP960294B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19522415A DE19522415C2 (de) 1995-06-21 1995-06-21 Arzneimittelpulverpatrone mit integrierter Dosiereinrichtung und Pulverinhalator mit Mitteln zum Betätigen der Dosiereinrichtung der Arzneimittelpulverpatrone
DE1995122416 DE19522416C2 (de) 1995-06-21 1995-06-21 Vorrichtung zum Dispergieren von Pulver in einem Luftstrom zur Verwendung mit Pulver-Inhalatoren

Publications (2)

Publication Number Publication Date
HRP960294A2 HRP960294A2 (en) 1998-06-30
HRP960294B1 true HRP960294B1 (en) 2002-06-30

Family

ID=26016125

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960294A HRP960294B1 (en) 1995-06-21 1996-06-20 Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments

Country Status (29)

Country Link
US (2) US5840279A (cs)
EP (1) EP0837710B1 (cs)
JP (1) JP3299971B2 (cs)
KR (1) KR100269060B1 (cs)
CN (2) CN1325129C (cs)
AR (1) AR002534A1 (cs)
AT (1) ATE209518T1 (cs)
AU (1) AU719449B2 (cs)
BR (1) BR9608997A (cs)
CA (2) CA2225396C (cs)
CZ (2) CZ294700B6 (cs)
DE (1) DE69617431T2 (cs)
DK (1) DK0837710T3 (cs)
ES (1) ES2168488T3 (cs)
HR (1) HRP960294B1 (cs)
HU (1) HU220227B (cs)
ID (1) ID17207A (cs)
IL (1) IL122494A (cs)
IN (1) IN189233B (cs)
NO (1) NO314879B1 (cs)
NZ (2) NZ310990A (cs)
PL (2) PL182715B1 (cs)
PT (1) PT837710E (cs)
RU (1) RU2162346C2 (cs)
SI (1) SI9620081B (cs)
SK (1) SK284303B6 (cs)
TR (1) TR199701665T1 (cs)
TW (1) TW325409B (cs)
WO (1) WO1997000703A1 (cs)

Families Citing this family (177)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9608997A (pt) * 1995-06-21 1999-06-29 Asta Medica Ag Cartucho para pó farmacêutico com dispositivo de medição integrado e intalador para medicamentos em pó
SE9700940D0 (sv) * 1997-03-14 1997-03-14 Astra Ab Powder inhaler IV
US6293279B1 (en) 1997-09-26 2001-09-25 Trudell Medical International Aerosol medication delivery apparatus and system
US6345617B1 (en) 1997-09-26 2002-02-12 1263152 Ontario Inc. Aerosol medication delivery apparatus and system
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
DE19961300A1 (de) * 1999-12-18 2001-06-21 Asta Medica Ag Vorratssystem für Arzneimittel in Pulverform und damit ausgestatteter Inhalator
EP1261316B1 (en) * 2000-02-28 2008-04-23 PharmaKodex Limited Device for the delivery of oral drugs
FI20000810A0 (fi) 2000-04-06 2000-04-06 Orion Yhtymae Oyj Jauheinhalaattori
CA2826724C (en) 2000-04-11 2016-02-02 Trudell Medical International Aerosol delivery apparatus with positive expiratory pressure capacity
PE20020163A1 (es) * 2000-06-23 2002-03-04 Norton Healthcare Ltd Sistema presurizado de receptaculo para inhalador de medicamento
US6629524B1 (en) * 2000-07-12 2003-10-07 Ponwell Enterprises Limited Inhaler
US7335205B2 (en) * 2001-03-02 2008-02-26 Woodwelding Ag Implants, device and method for joining tissue parts
US6698422B2 (en) 2001-03-12 2004-03-02 Birdsong Medical Devices, Inc. Canister inhaler having a spacer and easy to operate lever mechanism and a flexible, elastic mouthpiece
US6523536B2 (en) 2001-03-12 2003-02-25 Birdsong Medical Devices, Inc. Dual-canister inhaler having a spacer and easy to operate lever mechanism
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
DE10129703A1 (de) * 2001-06-22 2003-01-02 Sofotec Gmbh & Co Kg Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
US7258118B2 (en) * 2002-01-24 2007-08-21 Sofotec Gmbh & Co, Kg Pharmaceutical powder cartridge, and inhaler equipped with same
DE10202940A1 (de) * 2002-01-24 2003-07-31 Sofotec Gmbh & Co Kg Patrone für einen Pulverinhalator
JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
US20030205226A1 (en) 2002-05-02 2003-11-06 Pre Holding, Inc. Aerosol medication inhalation system
US6904908B2 (en) 2002-05-21 2005-06-14 Trudell Medical International Visual indicator for an aerosol medication delivery apparatus and system
SG134169A1 (en) * 2002-10-11 2007-08-29 Otsuka Pharma Co Ltd Powder inhalator
DE10300032B3 (de) * 2003-01-03 2004-05-27 E. Braun Gmbh Pulverinhalator
GB2398254B (en) * 2003-02-11 2005-12-07 Bespak Plc Dispensing Apparatus
EP1632260A1 (en) * 2003-06-11 2006-03-08 Hitachi, Ltd. Inhalation type medication apparatus
GB0315509D0 (en) * 2003-07-02 2003-08-06 Meridica Ltd Dispensing device
SE0303569L (sv) * 2003-12-03 2005-06-04 Microdrug Ag DPI för avlämning av fuktkänsliga medikament
RU2385156C2 (ru) 2004-05-31 2010-03-27 Лабораториос Альмираль С.А. Комбинации, содержащие антимускариновые средства и кортикостероиды
ES2257152B1 (es) 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
KR101214823B1 (ko) 2004-07-16 2012-12-24 알미랄, 에스.에이. 분말 약제의 투약을 위한 흡입기 및 이 흡입기와 함께사용하기 위한 분말 카트리지 시스템
KR101273120B1 (ko) 2004-08-20 2013-06-13 맨카인드 코포레이션 다이케토피페라진 합성의 촉매 작용
PL1791542T3 (pl) 2004-08-23 2015-11-30 Mannkind Corp Sole diketopiperazyny do dostarczania leków
PT2377557T (pt) 2004-11-24 2017-02-07 Meda Pharmaceuticals Inc Composições que compreendem azelastina e seus métodos de utilização
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US20070020330A1 (en) * 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
GB0507100D0 (en) * 2005-04-08 2005-05-11 Team Holdings Uk Ltd Improvements in or relating to inhalers
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
KR101488403B1 (ko) 2005-05-18 2015-02-04 엠펙스 파마슈티컬즈, 인코포레이티드 에어로졸화된 플루오로퀴놀론 및 이의 용도
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
MX381952B (es) 2005-09-14 2025-03-13 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
KR20080096809A (ko) 2006-02-22 2008-11-03 맨카인드 코포레이션 디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
CN101437562A (zh) * 2006-03-03 2009-05-20 Stc.Unm公司 具有气动力弹性分散机构的干粉吸入器
PT2063940E (pt) * 2006-12-22 2012-03-27 Almirall Sa Dispositivo de inalação para fármacos em forma de pó
ES2319596B1 (es) 2006-12-22 2010-02-08 Laboratorios Almirall S.A. Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
ES2306595B1 (es) 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
US20090110679A1 (en) * 2007-07-13 2009-04-30 Luk-Chiu Li Methods and compositions for pulmonary administration of a TNFa inhibitor
UY31272A1 (es) 2007-08-10 2009-01-30 Almirall Lab Nuevos derivados de ácido azabifenilaminobenzoico
DE102007056263A1 (de) * 2007-11-22 2009-05-28 Siegfried Generics International Ag Dosiervorrichtung zur Inhalierung einer pulverförmigen Substanz
ES2320961B1 (es) 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2.
EP2534957B1 (en) 2007-12-14 2015-05-27 AeroDesigns, Inc Delivering aerosolizable products
EP2096105A1 (en) 2008-02-28 2009-09-02 Laboratorios Almirall, S.A. Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) * 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
KR101629154B1 (ko) 2008-06-13 2016-06-21 맨카인드 코포레이션 건조 분말 흡입기 및 약물 투여 시스템
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US20190262557A1 (en) * 2010-03-04 2019-08-29 Mannkind Corporation Dry powder drug delivery system
EP2135610A1 (en) 2008-06-20 2009-12-23 Laboratorios Almirall, S.A. Combination comprising DHODH inhibitors and methotrexate
CN103751892B (zh) 2008-06-20 2017-03-01 曼金德公司 用于对吸入工作进行实时描绘的交互式设备和方法
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
KR20110091510A (ko) 2008-10-07 2011-08-11 엠펙스 파마슈티컬즈, 인코포레이티드 약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형
PT2346509T (pt) 2008-10-07 2020-08-05 Horizon Orphan Llc Inalação de levofloxacina para redução da inflamação pulmonar
EP2177521A1 (en) 2008-10-14 2010-04-21 Almirall, S.A. New 2-Amidothiadiazole Derivatives
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
UY32297A (es) 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
EP2202232A1 (en) 2008-12-26 2010-06-30 Laboratorios Almirall, S.A. 1,2,4-oxadiazole derivatives and their therapeutic use
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DE202008017185U1 (de) 2008-12-30 2010-05-12 Siegfried Generics International Ag Dosiervorrichtung
EP2210890A1 (en) 2009-01-19 2010-07-28 Almirall, S.A. Oxadiazole derivatives as S1P1 receptor agonists
EP2210615A1 (en) 2009-01-21 2010-07-28 Almirall, S.A. Combinations comprising methotrexate and DHODH inhibitors
EP2221055A1 (en) 2009-02-18 2010-08-25 Almirall, S.A. 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one for the treatment of lung function
EP2221297A1 (en) 2009-02-18 2010-08-25 Almirall, S.A. 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one and its use in the treatment of pulmonary diseases
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
EP2676695A3 (en) 2009-03-11 2017-03-01 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
EP2239256A1 (en) 2009-03-13 2010-10-13 Almirall, S.A. Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
KR20190090092A (ko) 2009-06-12 2019-07-31 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
CN102724983A (zh) 2009-09-04 2012-10-10 Mpex医药有限公司 雾化左氧氟沙星治疗囊性纤维化的用途
EP2305660A1 (en) 2009-09-25 2011-04-06 Almirall, S.A. New thiadiazole derivatives
EP2314577A1 (en) 2009-10-16 2011-04-27 Almirall, S.A. Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
EP2322176A1 (en) 2009-11-11 2011-05-18 Almirall, S.A. New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
EP2343287A1 (en) 2009-12-10 2011-07-13 Almirall, S.A. New 2-aminothiadiazole derivatives
EP2338888A1 (en) 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors
UY33213A (es) 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
EP2360158A1 (en) 2010-02-18 2011-08-24 Almirall, S.A. Pyrazole derivatives as jak inhibitors
EP2366702A1 (en) 2010-03-18 2011-09-21 Almirall, S.A. New oxadiazole derivatives
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2386555A1 (en) 2010-05-13 2011-11-16 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities
EP2390252A1 (en) 2010-05-19 2011-11-30 Almirall, S.A. New pyrazole derivatives
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
EP2397482A1 (en) 2010-06-15 2011-12-21 Almirall, S.A. Heteroaryl imidazolone derivatives as jak inhibitors
KR20130117755A (ko) 2010-06-21 2013-10-28 맨카인드 코포레이션 건조 분말 약물 운반 시스템 및 방법
EP2441755A1 (en) 2010-09-30 2012-04-18 Almirall, S.A. Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors
EP2455081A1 (en) 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of crohn's disease
EP2455080A1 (en) 2010-11-23 2012-05-23 Almirall, S.A. S1P1 receptor agonists for use in the treatment of multiple sclerosis
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
EP2463289A1 (en) 2010-11-26 2012-06-13 Almirall, S.A. Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors
JP6050758B2 (ja) 2010-12-07 2016-12-21 レスピラ セラピューティクス インコーポレイテッドＲｅｓｐｉｒａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 乾燥粉末吸入器及びその作動方法
WO2012106382A1 (en) 2011-01-31 2012-08-09 Genoa Pharmaceuticals, Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
AU2012236150B2 (en) 2011-04-01 2016-03-31 Mannkind Corporation Blister package for pharmaceutical cartridges
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
EP2518070A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Pyrrolotriazinone derivatives as PI3K inhibitors
EP2518071A1 (en) 2011-04-29 2012-10-31 Almirall, S.A. Imidazopyridine derivatives as PI3K inhibitors
EP2527344A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases
EP2526945A1 (en) 2011-05-25 2012-11-28 Almirall, S.A. New CRTH2 Antagonists
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2548863A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists.
EP2548876A1 (en) 2011-07-18 2013-01-23 Almirall, S.A. New CRTh2 antagonists
EP2554544A1 (en) 2011-08-01 2013-02-06 Almirall, S.A. Pyridin-2(1h)-one derivatives as jak inhibitors
WO2013045996A1 (en) 2011-09-26 2013-04-04 Trudell Medical International Dose counter and medication delivery device
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
HK1200318A1 (en) 2011-10-24 2015-08-07 曼金德公司 Methods and compositions for treating pain
GB201118845D0 (en) 2011-11-01 2011-12-14 Euro Celtique Sa Dispenser
EP2592077A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2592078A1 (en) 2011-11-11 2013-05-15 Almirall, S.A. New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities
EP2617450A1 (en) 2012-01-20 2013-07-24 Almirall S.A. Inhaltion device for powdered drugs
EP2617448A1 (en) * 2012-01-20 2013-07-24 Almirall S.A. Inhalation device for powdered drugs
EP2617449A1 (en) 2012-01-20 2013-07-24 Almirall S.A. Inhalation device for powdered drugs
WO2013114374A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy
US10463815B2 (en) 2012-02-21 2019-11-05 Respira Therapeutics, Inc. Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
EP2647627A1 (en) 2012-04-02 2013-10-09 Almirall, S.A. Salts of 5-[(1r)-2-({2-[4-(2,2-difluoro-2-phenylethoxy)phenyl] ethyl}amino)-1-hydroxyethyl]-8-hydroxyquinolin-2(1h)-one.
EP2666465A1 (en) 2012-05-25 2013-11-27 Almirall, S.A. Novel dosage and formulation
EP2668941A1 (en) 2012-05-31 2013-12-04 Almirall, S.A. Novel dosage form and formulation of abediterol
ES2624294T3 (es) 2012-07-12 2017-07-13 Mannkind Corporation Sistemas de suministro de fármacos en polvo seco
WO2014060431A1 (en) 2012-10-16 2014-04-24 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
EP2738172A1 (en) 2012-11-28 2014-06-04 Almirall, S.A. New bicyclic compounds as crac channel modulators
PT2931275T (pt) 2012-12-17 2022-06-30 Almirall Sa Aclidínio para usar no aumento da atividade física na vida diária de um doente que sofre de doença pulmonar obstrutiva crónica
US9518050B2 (en) 2012-12-18 2016-12-13 Almirall, S.A. Cyclohexyl and quinuclidinyl carbamate derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activity
AR094797A1 (es) 2013-02-15 2015-08-26 Almirall Sa Derivados de pirrolotriazina como inhibidores de pi3k
SG10201708090TA (en) 2013-03-15 2017-11-29 Mannkind Corp Microcrystalline diketopiperazine compositions and methods
EP2848615A1 (en) 2013-07-03 2015-03-18 Almirall, S.A. New pyrazole derivatives as CRAC channel modulators
JP6491658B2 (ja) 2013-07-18 2019-03-27 マンカインド コーポレイション 熱安定性乾燥粉末医薬組成物及び方法
AU2014296032A1 (en) 2013-07-31 2016-03-17 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
CN105517607A (zh) 2013-08-05 2016-04-20 曼金德公司 吹入设备和方法
WO2015091285A1 (en) 2013-12-19 2015-06-25 Almirall S.A. Dosage formulation comprising salmeterol and fluticasone propionate
CA2936330C (en) 2014-01-10 2023-01-03 Genoa Pharmaceuticals Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
HRP20180735T1 (hr) * 2014-06-06 2018-06-29 Rijksuniversiteit Groningen Inhalator za suhi prah aktiviran udisanjem
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US20170304459A1 (en) 2014-10-10 2017-10-26 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
CA3206868A1 (en) 2015-01-14 2016-07-21 Respira Therapeutics, Inc. Powder dispersion methods and devices
EP3061501A1 (en) 2015-02-27 2016-08-31 Rottapharm Ltd. Composition for the treatment of acne
EP3286178A1 (en) 2015-04-21 2018-02-28 Almirall S.A. Amino-substituted heterocyclic derivatives as sodium channel inhibitors
WO2016202800A1 (en) 2015-06-16 2016-12-22 Almirall, S.A. Pyrrolotriazinone derivatives as pi3k inhibitors
EP3117825A1 (en) 2015-07-16 2017-01-18 Rottapharm S.p.A. Oral formulation comprising berberine and morus alba extract
WO2017076990A1 (en) 2015-11-05 2017-05-11 Almirall, S.A. Addition salts of n-[4-(4-{[(1s)-1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-5-yl)-1h-indol-6-yl]sulfamide
GB201605102D0 (en) 2016-03-24 2016-05-11 Nicoventures Holdings Ltd Mechanical connector for electronic vapour provision system
US11285274B2 (en) 2016-05-03 2022-03-29 Pneuma Respiratory, Inc. Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device
US11285285B2 (en) 2016-05-03 2022-03-29 Pneuma Respiratory, Inc. Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment
US11285284B2 (en) 2016-05-03 2022-03-29 Pneuma Respiratory, Inc. Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency
EP3452152B1 (en) 2016-05-03 2025-07-02 Pneuma Respiratory, Inc. A droplet delivery device for generating and delivering droplets to the pulmonary system
WO2018213834A1 (en) 2017-05-19 2018-11-22 Pneuma Respiratory, Inc. Dry powder delivery device and methods of use
TW201919682A (zh) 2017-08-08 2019-06-01 西班牙商阿爾米雷爾有限公司 活化Ｎｒｆ２路徑的新穎化合物
JP2020536614A (ja) 2017-10-04 2020-12-17 ニューマ・リスパイラトリー・インコーポレイテッド 呼吸により電気的に作動するインライン液滴送達装置および使用方法
WO2019079461A1 (en) 2017-10-17 2019-04-25 Pneuma Respiratory, Inc. NASAL MEDICATION DELIVERY APPARATUS AND METHODS OF USE
FR3072294B1 (fr) * 2017-10-18 2019-10-11 Aptar France Sas Dispositif de distribution de produit fluide synchronise avec l'inhalation.
EP3706843B1 (en) 2017-11-08 2024-06-26 Pneuma Respiratory, Inc. Electronic breath actuated in-line droplet delivery device with small volume ampoule
CN110201278B (zh) * 2018-02-28 2021-07-30 张江 用于吸入给药的药盒和吸入给药组合结构
WO2019195239A1 (en) * 2018-04-02 2019-10-10 Pneuma Respiratory, Inc. Handheld digital nebulizer device and methods of use
RU189757U1 (ru) * 2019-01-09 2019-06-03 Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации Дисковый распылитель для получения полидисперсных аэрозолей из порошкообразных материалов
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
US11793945B2 (en) 2021-06-22 2023-10-24 Pneuma Respiratory, Inc. Droplet delivery device with push ejection
CN115702961A (zh) * 2021-08-03 2023-02-17 上海臣邦医药科技股份有限公司 一种单剂量可抛弃型粉雾剂装置
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof
WO2023117929A1 (en) * 2021-12-21 2023-06-29 Chiesi Farmaceutici S.P.A. Powder inhaler
KR102795270B1 (ko) * 2022-07-01 2025-04-15 주식회사 케이티앤지 인헤일러
US12161795B2 (en) 2022-07-18 2024-12-10 Pneuma Respiratory, Inc. Small step size and high resolution aerosol generation system and method
CN117771490B (zh) * 2023-12-20 2025-07-18 上海新黄河制药有限公司 一种双储库粉雾剂装置

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE483136A (cs) * 1947-09-04 1942-06-30
US2587215A (en) * 1949-04-27 1952-02-26 Frank P Priestly Inhalator
US3972123A (en) * 1973-10-04 1976-08-03 Black Robert B Air-abrasive prophylaxis equipment
US4125969A (en) * 1977-01-25 1978-11-21 A. Long & Company Limited Wet abrasion blasting
US4274403A (en) * 1979-08-29 1981-06-23 Struve Roger L Inhaler
DE3043377A1 (de) * 1980-11-17 1982-07-01 Brugger, Inge, 8130 Starnberg Zerstaeuber
EP0079478A1 (en) * 1981-11-03 1983-05-25 Miles Laboratories, Inc. Medicament inhalation device
US4570630A (en) * 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
DE3335745C1 (de) * 1983-10-01 1985-01-17 Sanitätshaus Ulrich Klimt, 7910 Neu-Ulm Inhalationsgerät
FI69963C (fi) * 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
DK481884D0 (da) * 1984-10-09 1984-10-09 Karl Holm Medicinsk mund- eller svaelgsprayapparat
SE448277B (sv) * 1985-04-12 1987-02-09 Draco Ab Indikeringsanordning vid en doseringsanordning for lekemedel
DE4004904A1 (de) * 1990-02-16 1990-09-13 Gerhard Brendel Trommel-applikator
US5020527A (en) * 1990-02-20 1991-06-04 Texax-Glynn Corporation Inhaler device with counter/timer means
GB9015522D0 (en) * 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
DE4027391A1 (de) * 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
EP0640354B1 (en) * 1990-09-26 2001-12-05 Pharmachemie B.V. Whirl chamber powder inhaler
GB9026025D0 (en) * 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
GB9107806D0 (en) * 1991-04-12 1991-05-29 Rochester N J Ltd Gas extraction
DE69122388T2 (de) 1991-04-15 1997-03-27 Leiras Oy Vorrichtung zum dosieren eines pulverförmigen medikaments für die inhalation
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
CA2093809A1 (en) * 1991-08-15 1993-02-16 Franco Del Bon Inhaler
BR9206429A (pt) * 1991-08-26 1995-10-24 Minnesota Mining & Mfg Aparelho capaz de distribuir reprodutivelmente múltiplas doses individuais de um medicamento em pó seco,processo para distribuir múltiplas doses induviduais de um medicamento em pó seco,aparelho distribuidor,processo de distribuir medicamento em pó sexo a um paciente e cartucho adaptado para ser recebido em um aparelho distribuidor de medicamento em pó seco
US5341801A (en) * 1991-12-03 1994-08-30 Sandoz Ltd. Inhaler
FR2684732B1 (fr) * 1991-12-10 1994-02-18 Somfy Reducteur planetaire pour moteur tubulaire.
DE4211475A1 (de) * 1991-12-14 1993-06-17 Asta Medica Ag Pulverinhalator
GB2262452B (en) * 1991-12-19 1995-12-20 Minnesota Mining & Mfg Inhalation device
KR970004121B1 (ko) * 1991-12-27 1997-03-25 마쯔시다덴기산교 가부시기가이샤 필름콘덴서와 그 제조방법
GB9203761D0 (en) * 1992-02-21 1992-04-08 Innovata Biomed Ltd Inhaler
US5284133A (en) * 1992-07-23 1994-02-08 Armstrong Pharmaceuticals, Inc. Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means
DE4239402A1 (de) * 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
US5829434A (en) * 1992-12-18 1998-11-03 Schering Corporation Inhaler for powdered medications
DE4319514C2 (de) * 1993-06-14 2003-06-18 Sofotec Gmbh & Co Kg Pulverinhalator
DE4340768A1 (de) * 1993-11-30 1995-06-01 Bayer Ag Vorrichtung zum Inhalieren
ZA942721B (en) * 1994-04-20 1995-01-09 Dieter Koehler Process and apparatus for producing an aerosol from a pulverulent substance
FI942196L (fi) * 1994-05-11 1995-11-12 Orion Yhtymae Oy Jauheinhalaattori
BR9608997A (pt) * 1995-06-21 1999-06-29 Asta Medica Ag Cartucho para pó farmacêutico com dispositivo de medição integrado e intalador para medicamentos em pó

Also Published As

Publication number Publication date
HU220227B (hu) 2001-11-28
NZ502870A (en) 2001-06-29
CA2225396C (en) 2003-03-25
HUP9802201A2 (hu) 1999-01-28
CN1325129C (zh) 2007-07-11
TR199701665T1 (xx) 1998-06-22
CN1535737A (zh) 2004-10-13
HK1018011A1 (en) 1999-12-10
SI9620081B (en) 2001-06-30
CA2378713A1 (en) 1997-01-09
PL182715B1 (pl) 2002-02-28
ES2168488T3 (es) 2002-06-16
DE69617431T2 (de) 2002-08-01
SK172597A3 (en) 1998-11-04
US6071498A (en) 2000-06-06
DK0837710T3 (da) 2002-04-02
CA2225396A1 (en) 1997-01-09
CZ413997A3 (cs) 1999-08-11
BR9608997A (pt) 1999-06-29
CN1188420A (zh) 1998-07-22
NO314879B1 (no) 2003-06-10
ID17207A (id) 1997-12-11
PL182198B1 (en) 2001-11-30
US5840279A (en) 1998-11-24
CA2378713C (en) 2003-08-12
HRP960294A2 (en) 1998-06-30
AU6221196A (en) 1997-01-22
CZ189499A3 (cs) 1999-11-17
IN189233B (cs) 2003-01-11
TW325409B (en) 1998-01-21
PT837710E (pt) 2002-05-31
EP0837710B1 (en) 2001-11-28
AU719449B2 (en) 2000-05-11
NZ310990A (en) 2000-03-27
CZ294700B6 (cs) 2005-02-16
CN1181896C (zh) 2004-12-29
IL122494A0 (en) 1998-06-15
NO975945D0 (no) 1997-12-17
KR100269060B1 (ko) 2000-11-01
KR19990028323A (ko) 1999-04-15
JP3299971B2 (ja) 2002-07-08
HUP9802201A3 (en) 1999-03-01
IL122494A (en) 2001-08-08
ATE209518T1 (de) 2001-12-15
WO1997000703A1 (en) 1997-01-09
RU2162346C2 (ru) 2001-01-27
SI9620081A (sl) 1998-08-31
CZ294782B6 (cs) 2005-03-16
JPH10511594A (ja) 1998-11-10
HK1069346A1 (en) 2005-05-20
NO975945L (no) 1998-02-18
AR002534A1 (es) 1998-03-25
EP0837710A1 (en) 1998-04-29
DE69617431D1 (de) 2002-01-10
SK284303B6 (sk) 2005-01-03
PL324504A1 (en) 1998-05-25

Similar Documents

Publication Publication Date Title
HUP9802201A3 (en) Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
GB2306891B (en) Casing and spirometer for metered dose inhaler
HUP0002538A3 (en) Inhaler for powdered medicaments
HUP9900352A3 (en) Inhaler for dosing into airstrom of powdered material
DE69612163D1 (de) Inhalator für Arzneimittel in Pulverform
NZ242061A (en) Inhaler for powdered medicament
PL328485A1 (en) Powdered medicine inhaler
AP9701114A0 (en) Metered dose inhaler for albuterol
IL102316A0 (en) Inhalation device for powdered medicaments
HUP9802278A3 (en) Metered dose inhaler
EP0745401A3 (en) Medication inhaler
NO953388D0 (no) Medikamentbærer for törr-pulver inhalator
IL117706A0 (en) Powdered drug storage and delivery system
AP9701113A0 (en) Metered dose inhaler for salmeterol
PL322781A1 (en) Beclomethasone inhaler with dosis metering feature
ATE240095T1 (de) Pharmazeutische zusammensetzung enthaltend proliposomen pulver zur inhalation
ZA965244B (en) Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
GB9100950D0 (en) Metered dose atomising and delivery device
GB9928545D0 (en) Casing and spirometer for metered dose inhaler
AU6564894A (en) Powder inhaler with metering device
AU7554698A (en) Powder inhaler with metering device
GB0024326D0 (en) Composition containing a herbal medicinal substance and a pharmaceutical drug
HRP920392B1 (en) Inhalation device for powdered medicaments
SI0820323T1 (en) Metered dose inhaler for salmeterol
HK1031682A (en) Stabilized preparations for use in metered dose inhalers

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PPPP Transfer of rights

Owner name: SOFOTEC GMBH & CO. KG, DE

PNAN Change of the applicant name, address/residence

Owner name: SOFOTEC GMBH & CO. KG, DE

PPPP Transfer of rights

Owner name: MEDA PHARMA GMBH & CO. KG, DE

PPPP Transfer of rights

Owner name: LABORATORIOS ALMIRALL, S.A., ES

PNAN Change of the applicant name, address/residence

Owner name: ALMIRALL, S.A., ES

ODRP Renewal fee for the maintenance of a patent

Payment date: 20150507

Year of fee payment: 20

PPPP Transfer of rights

Owner name: ASTRAZENECA AB, SE

PB20 Patent expired after termination of 20 years

Effective date: 20160620