HRP960233B1 - Asymmetric synthesis of (-)6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2h-3,1-benzoxazin-2-one - Google Patents

Asymmetric synthesis of (-)6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2h-3,1-benzoxazin-2-one

Info

Publication number
HRP960233B1
HRP960233B1 HR960233A HRP960233A HRP960233B1 HR P960233 B1 HRP960233 B1 HR P960233B1 HR 960233 A HR960233 A HR 960233A HR P960233 A HRP960233 A HR P960233A HR P960233 B1 HRP960233 B1 HR P960233B1
Authority
HR
Croatia
Prior art keywords
benzoxazin
ethynyl
cyclopropyl
dihydro
trifluoromethyl
Prior art date
Application number
HR960233A
Other languages
English (en)
Inventor
Andrew S Thompson
Edward G Corley
Edward J J Grabowski
Nobuyoshi Yasuda
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HRP960233A2 publication Critical patent/HRP960233A2/hr
Publication of HRP960233B1 publication Critical patent/HRP960233B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/70—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HR960233A 1995-05-25 1996-05-23 Asymmetric synthesis of (-)6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2h-3,1-benzoxazin-2-one HRP960233B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/450,330 US5633405A (en) 1995-05-25 1995-05-25 Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one

Publications (2)

Publication Number Publication Date
HRP960233A2 HRP960233A2 (en) 1997-08-31
HRP960233B1 true HRP960233B1 (en) 2001-08-31

Family

ID=23787667

Family Applications (1)

Application Number Title Priority Date Filing Date
HR960233A HRP960233B1 (en) 1995-05-25 1996-05-23 Asymmetric synthesis of (-)6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2h-3,1-benzoxazin-2-one

Country Status (26)

Country Link
US (2) US5633405A (xx)
EP (1) EP0828703B1 (xx)
JP (1) JP2839717B2 (xx)
KR (1) KR100399511B1 (xx)
CN (1) CN1119319C (xx)
AR (1) AR002997A1 (xx)
AT (1) ATE196463T1 (xx)
AU (1) AU709273B2 (xx)
BR (1) BR9608839A (xx)
CA (1) CA2220389C (xx)
CZ (1) CZ292848B6 (xx)
DE (1) DE69610422T2 (xx)
DK (1) DK0828703T3 (xx)
EA (1) EA000107B1 (xx)
ES (1) ES2151666T3 (xx)
GR (1) GR3034897T3 (xx)
HR (1) HRP960233B1 (xx)
HU (1) HU223565B1 (xx)
MX (1) MX199501B (xx)
NZ (1) NZ308824A (xx)
PT (1) PT828703E (xx)
SK (1) SK282412B6 (xx)
TW (1) TW402581B (xx)
UA (1) UA56137C2 (xx)
WO (1) WO1996037457A1 (xx)
YU (1) YU48940B (xx)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004535A1 (en) * 1996-07-26 1998-02-05 Du Pont Pharmaceuticals Company A practical synthesis of benzoxazinones useful as hiv reverse transcriptase inhibitors
US5874430A (en) * 1996-10-02 1999-02-23 Dupont Pharmaceuticals Company 4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same
AU5521498A (en) * 1996-12-16 1998-07-15 Du Pont Pharmaceuticals Company An improved synthesis of cyclopropylacetylene
US5932726A (en) * 1996-12-16 1999-08-03 Dupont Pharmaceuticals Company Asymmetric synthesis of benzoxazinones
JP2000507970A (ja) * 1997-01-10 2000-06-27 メルク エンド カンパニー インコーポレーテッド キラルメディエータの効率的な合成
PL197740B1 (pl) * 1997-02-05 2008-04-30 Merck & Co Inc Postać krystaliczna I (-)-6-chloro-4-cyklopropyloetynylo-4-trifluorometylo-1,4-dihydro-2H-3,1-benzoksazyn-2-onu i sposób krystalizacji postaci I (-)-6-chloro-4-cyklopropylo-etynylo-4-trifluorometylo-1,4-dihydro-2H-3,1-benzoksazyn-2-onu
AU760075B2 (en) * 1997-02-05 2003-05-08 Merck Sharp & Dohme Corp. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
US5965729A (en) 1997-02-05 1999-10-12 Merck & Co., Inc. Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
TW480253B (en) * 1997-02-12 2002-03-21 Merck & Co Inc Efficient synthesis of a 1,4-dihydro-2H-3,1-benzoxazin-2-one
US5922864A (en) * 1997-02-12 1999-07-13 Merck & Co., Inc. Efficient synthesis of a 1,4-dihydro2H-3,1-benzoxazin-2-one
CA2285000A1 (en) * 1997-04-07 1998-10-15 Dupont Pharmaceuticals Company Asymmetric synthesis of benzoxazinones via new intermediates
AR011731A1 (es) * 1997-05-16 2000-08-30 Merck & Co Inc Un proceso de reaccion de adicion enantioselectiva eficiente utilizando un reactivo de organozinc.
WO1999007657A1 (en) * 1997-08-06 1999-02-18 Merck & Co., Inc. Efficient synthesis of cyclopropylacetylene
US6072094A (en) * 1997-08-06 2000-06-06 Merck & Co., Inc. Efficient synthesis of cyclopropylacetylene
WO1999048848A1 (en) * 1998-03-24 1999-09-30 Great Lakes Chemical Corporation Method to reduce the amount of phosphorus oxyhalides and dihalogenated pentenes in 1,1-dihalo-1-cyclopropylethanes
CO5070643A1 (es) * 1998-05-27 2001-08-28 Merck & Co Inc Formulacion en tabletas comprimidas
US20010014352A1 (en) 1998-05-27 2001-08-16 Udit Batra Compressed tablet formulation
EP1332757B1 (en) * 1998-05-27 2012-06-13 Merck Sharp & Dohme Corp. Efavirenz compressed tablet formulation
US6673372B1 (en) 1998-06-11 2004-01-06 Bristol-Myers Squibb Pharma Company Crystalline Efavirenz
HRP990182A2 (en) * 1998-06-11 2000-02-29 Du Pont Pharm Co Crystalline efavirenz
US6235957B1 (en) 1998-06-29 2001-05-22 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
US6288297B1 (en) 1998-10-01 2001-09-11 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
WO2000018706A1 (en) 1998-10-01 2000-04-06 Du Pont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
GB2355988A (en) 1999-10-28 2001-05-09 Merck & Co Inc Synthesis of cyclopropylacetylene in a one-pot process using a diazo-keto-phos phonate
GB2355724A (en) 1999-10-28 2001-05-02 Merck & Co Inc Synthesis of cyclopropylacetylene from propiolic acid (2-propynoic acid)
WO2004087628A1 (fr) * 2003-04-04 2004-10-14 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Ligand amino-alcool et son utilisation dans la preparation d'alcools tertiaires propargyliques et d'amines tertiaires par le biais d'une reaction d'addition eniantioselective
CN1331601C (zh) * 2003-05-16 2007-08-15 中国科学院上海有机化学研究所 手性氨基醇配体应用于端炔对含氟烷基芳基酮的不对称加成的方法
US7271252B2 (en) 2003-04-22 2007-09-18 Roche Diagnostics Operations, Inc. Reagents for detecting efavirenz
US7420043B2 (en) * 2003-12-10 2008-09-02 Roche Diagnostics Operations, Inc. Reagents for detecting efavirenz
ZA200806473B (en) * 2008-01-31 2009-04-29 Aptuit Laurus Pvt Ltd An efficient process to induce enantioselectivity in procarbonyl compounds
US9073817B2 (en) 2008-01-31 2015-07-07 Laurus Labs Private Limited Efficient process to induce enantioselectivity in procarbonyl compounds
US8604189B2 (en) * 2008-05-30 2013-12-10 Emcure Pharmaceuticals Limited Process for the preparation of Efavirenz
WO2010115639A1 (en) 2009-04-09 2010-10-14 Lonza Ltd Process for the synthesis of a propargylic alcohol
EP2417097A2 (en) 2009-04-09 2012-02-15 Lonza Ltd. Autocatalytic process for the synthesis of chiral propargylic alcohols
EP2448917A2 (de) 2009-07-03 2012-05-09 Archimica GmbH Verfahren zur enantioselektiven addition von organometallischen kohlenstoffnukleophilen an trifluormethylketone und verwendung des verfahrens in der synthese von hiv reverse transcriptase inhibitoren
CN101844990B (zh) * 2010-05-27 2013-03-20 浙江沙星医药化工有限公司 中间体4-氯-2-(三氟乙酰基)苯胺盐酸盐水合物的合成方法
EP2447255A1 (en) 2010-10-14 2012-05-02 Lonza Ltd. Process for the synthesis of cyclic carbamates
EP2447247A1 (en) 2010-10-14 2012-05-02 Lonza Ltd. Process for the synthesis of chiral propargylic alcohols
EP2471783A1 (en) 2010-12-23 2012-07-04 Esteve Química, S.A. Novel polymorphic form of efavirenz
CN102617370B (zh) * 2012-03-05 2014-06-04 浙江江北药业有限公司 (S)-5-氯-α-(环丙乙炔基)-2-(((4-甲氧基苯基)甲基)氨基)-α-(三氟甲基)苯甲醇的制备方法
WO2015118515A1 (en) * 2014-02-10 2015-08-13 Discovery Intermediates Private Limited An improved process for the preparation of a non-nucleoside reverse transcriptase inhibitor
CN104016936B (zh) * 2014-06-18 2016-08-17 中国科学院上海有机化学研究所 手性氨基酚配体在依法韦仑不对称合成中的应用
DE202015104551U1 (de) 2015-08-27 2015-12-03 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Reaktoren für die Herstellung von Efavirenz sowie Zwischenprodukte
US9676735B2 (en) 2015-08-27 2017-06-13 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Process for the preparation of efavirenz and devices suitable therefore
CN105801442A (zh) * 2015-10-16 2016-07-27 浙江沙星医药化工有限公司 4-氯-2-(三氟乙酰基)苯胺盐酸盐水合物的制备方法
JP7071036B2 (ja) 2019-02-15 2022-05-18 福建永晶科技股▲ふん▼有限公司 Ｆｒｉｅｄｅｌ－Ｃｒａｆｔｓ反応の新しい新方法及び当該方法に用いられる触媒

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55145625A (en) * 1979-05-01 1980-11-13 Mitsubishi Chem Ind Ltd Preparation of alkynyl alcohol
JPH0436252A (ja) * 1990-05-30 1992-02-06 Nippon Alkyl Alum Kk 光学活性アルキニルアルコールの製造方法
US5663169A (en) * 1992-08-07 1997-09-02 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
IL106507A (en) * 1992-08-07 1997-11-20 Merck & Co Inc Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type

Also Published As

Publication number Publication date
DE69610422T2 (de) 2001-04-19
ATE196463T1 (de) 2000-10-15
CA2220389A1 (en) 1996-11-28
US5698741A (en) 1997-12-16
KR19990021899A (ko) 1999-03-25
SK156997A3 (en) 1998-09-09
EA199700426A1 (ru) 1998-06-25
TW402581B (en) 2000-08-21
UA56137C2 (uk) 2003-05-15
YU48940B (sh) 2002-12-10
CN1119319C (zh) 2003-08-27
CN1185146A (zh) 1998-06-17
PT828703E (pt) 2001-01-31
JP2839717B2 (ja) 1998-12-16
BR9608839A (pt) 1999-06-08
EP0828703B1 (en) 2000-09-20
HUP9802566A3 (en) 2001-01-29
GR3034897T3 (en) 2001-02-28
YU31496A (sh) 1998-11-05
HUP9802566A2 (hu) 1999-06-28
NZ308824A (en) 1998-11-25
US5633405A (en) 1997-05-27
ES2151666T3 (es) 2001-01-01
CZ292848B6 (cs) 2003-12-17
DE69610422D1 (de) 2000-10-26
AU5866796A (en) 1996-12-11
MX199501B (es) 2000-11-10
DK0828703T3 (da) 2000-11-20
MX9709064A (es) 1998-03-31
KR100399511B1 (ko) 2003-12-31
HRP960233A2 (en) 1997-08-31
AU709273B2 (en) 1999-08-26
EA000107B1 (ru) 1998-08-27
EP0828703A1 (en) 1998-03-18
JPH10506642A (ja) 1998-06-30
WO1996037457A1 (en) 1996-11-28
SK282412B6 (sk) 2002-01-07
HU223565B1 (hu) 2004-09-28
CZ370997A3 (cs) 1998-04-15
CA2220389C (en) 2005-12-06
AR002997A1 (es) 1998-05-27

Similar Documents

Publication Publication Date Title
HRP960233B1 (en) Asymmetric synthesis of (-)6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2h-3,1-benzoxazin-2-one
HUP0004388A3 (en) Process for the preparation of oxazolidinones, intermediates and preparation thereof
ZA9610687B (en) Novel synthesis.
FI973086A (fi) Parannettu syklopropyyliasetyleenisynteesi
ZA982956B (en) Asymmetric synthesis of benzoxazinones.
HUP0001313A3 (en) Process for the crystallization of (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2h-3,1-benzoxazin-2-one
HUP0000168A3 (en) Process for asymmetric synthesis of benzoxazinones
ZA965853B (en) Asymmetric synthesis of r and s warfarin and its analogs.
HK1009747A1 (en) New cryptophycins from synthesis.
IL123171A0 (en) One pot synthesis of 2-oxazolidinone
HUP9601699A2 (en) Bis-phosphins, preparation and use thereof as catalysts for asymmetrical reactions
EP0815653A4 (en) ANNULAR COMPENSATION FREQUENCY CHANGER
AU2196897A (en) Novel asymmetric synthesis of r-alpha-propyl-piperonyl amine and its analogs
AU5521498A (en) An improved synthesis of cyclopropylacetylene
HUP9600708A2 (en) Novel methods for the preparation of taxanes using oxazolidine intermediate
HK1016965A1 (en) Process for the preparation of cyclopropylacetylene derivatives
ZA986885B (en) A process for the preparation of cyclopropylacetylene.
AU5115598A (en) Novel pentaerythritol derivatives, preparation and use thereof and intermediates for the synthesis thereof
HUP9602774A2 (en) Benzoxazepine derivatives, pharmaceutical compositions containing them and intermediates
AU6152598A (en) Efficient synthesis of a 1,4-dihydro-2h-3,1-benzoxazin-2-one
EP0781750A3 (en) Asymmetric synthesis of alpha-cycloalkylalkyl substituted methanamines
GB9706082D0 (en) Efficient synthesis of A 1,4-dihydro-2H-3,1-benzoxazin-2-one
ZA9711256B (en) Asymmetric synthesis of benzoxazinones
ZA963753B (en) Synthesis of benzoquinolinones.
PL336261A1 (en) Dissymmetrical synthesis of benzoxazinones through novel intermediate compounds

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: MERCK SHARP & DOHME CORP., US

PNAN Change of the applicant name, address/residence

Owner name: MERCK SHARP & DOHME CORP., US

Owner name: SCHERING CORPORATION, US

ODRP Renewal fee for the maintenance of a patent

Payment date: 20150519

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20160523