CN102617370B - (S)-5-氯-α-(环丙乙炔基)-2-(((4-甲氧基苯基)甲基)氨基)-α-(三氟甲基)苯甲醇的制备方法 - Google Patents
(S)-5-氯-α-(环丙乙炔基)-2-(((4-甲氧基苯基)甲基)氨基)-α-(三氟甲基)苯甲醇的制备方法 Download PDFInfo
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过渡金属 | 反应产物的ee%值 |
a | Fe铁 | 97~99 |
b | Co钴 | 90~96 |
c | Ni镍 | 70~88 |
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CN102617370B true CN102617370B (zh) | 2014-06-04 |
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US5633405A (en) * | 1995-05-25 | 1997-05-27 | Merck & Co., Inc. | Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one |
CN1331601C (zh) * | 2003-05-16 | 2007-08-15 | 中国科学院上海有机化学研究所 | 手性氨基醇配体应用于端炔对含氟烷基芳基酮的不对称加成的方法 |
ZA200806473B (en) * | 2008-01-31 | 2009-04-29 | Aptuit Laurus Pvt Ltd | An efficient process to induce enantioselectivity in procarbonyl compounds |
CN101786959A (zh) * | 2009-01-23 | 2010-07-28 | 上海迪赛诺医药发展有限公司 | 制备手性环丙基乙炔基叔醇类化合物的方法 |
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Denomination of invention: (S) - 5-Chloro- a-( Cyclopropylacetyl) - 2 - ((4-methoxyphenyl) methyl) amino)- a-( Preparation of trifluoromethyl benzyl alcohol Effective date of registration: 20210630 Granted publication date: 20140604 Pledgee: Zhejiang Taizhou Jiaojiang Rural Commercial Bank Co.,Ltd. Zhang'an sub branch Pledgor: ZHEJIANG JIANGBEI PHARMACEUTICAL Co.,Ltd. Registration number: Y2021330000757 |
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Denomination of invention: (S) - 5-Chlorine- a- (cyclopropylethynyl) - 2 - (((4-methoxyphenyl) methyl) amino)- a- Preparation method of (trifluoromethyl) benzyl alcohol Effective date of registration: 20230103 Granted publication date: 20140604 Pledgee: Zhejiang Taizhou Jiaojiang Rural Commercial Bank Co.,Ltd. Zhang'an sub branch Pledgor: ZHEJIANG JIANGBEI PHARMACEUTICAL Co.,Ltd. Registration number: Y2023330000016 |