JPS55145625A - Preparation of alkynyl alcohol - Google Patents

Preparation of alkynyl alcohol

Info

Publication number
JPS55145625A
JPS55145625A JP5373379A JP5373379A JPS55145625A JP S55145625 A JPS55145625 A JP S55145625A JP 5373379 A JP5373379 A JP 5373379A JP 5373379 A JP5373379 A JP 5373379A JP S55145625 A JPS55145625 A JP S55145625A
Authority
JP
Japan
Prior art keywords
aldehyde
acetylide
alkynyl alcohol
preparation
hight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5373379A
Other languages
Japanese (ja)
Inventor
Mitsuaki Mukoyama
Keisuke Suzuki
Kenzou Sogou
Toshio Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Kasei Corp
Original Assignee
Mitsubishi Kasei Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Kasei Corp filed Critical Mitsubishi Kasei Corp
Priority to JP5373379A priority Critical patent/JPS55145625A/en
Publication of JPS55145625A publication Critical patent/JPS55145625A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the title compound, useful as an intermediate for the synthesis of prostaglandin, vitamin E, pheromone, etc., by the reaction of an acetylide with an aldehyde, in the presence of a specific ligand.
CONSTITUTION: An aldehyde, e.g. benzaldehyde, is reacted with an acetylide of formula R'-C≡C-X (R' is H or silyl; X is alkali metal), e.g. lithium trimethylsilyl acetylide, in the presence of asymmetric 2-hydroxymethyl-1-[(1-methylpyrrolidin-2-yl)methyl]pyrrolidine or its salt in a molar amount of about 2W10 times that of the aldehyde, to give an optically active alkynyl alcohol, e.g. 1-phenyl-2- propyn-1-ol.
EFFECT: Hight optical purity of the product.
COPYRIGHT: (C)1980,JPO&Japio
JP5373379A 1979-05-01 1979-05-01 Preparation of alkynyl alcohol Pending JPS55145625A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5373379A JPS55145625A (en) 1979-05-01 1979-05-01 Preparation of alkynyl alcohol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5373379A JPS55145625A (en) 1979-05-01 1979-05-01 Preparation of alkynyl alcohol

Publications (1)

Publication Number Publication Date
JPS55145625A true JPS55145625A (en) 1980-11-13

Family

ID=12951023

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5373379A Pending JPS55145625A (en) 1979-05-01 1979-05-01 Preparation of alkynyl alcohol

Country Status (1)

Country Link
JP (1) JPS55145625A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037457A1 (en) * 1995-05-25 1996-11-28 Merck & Co., Inc. Asymmetric synthesis of (-) 6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2h-3,1-benzoxazin-2-one

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMISTRY LETTERS=1978 *
CHEMISTRY=1978 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037457A1 (en) * 1995-05-25 1996-11-28 Merck & Co., Inc. Asymmetric synthesis of (-) 6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2h-3,1-benzoxazin-2-one

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