JPS54154712A - Preparation of optically active omega-cyano-alpha-acylamino derivative - Google Patents
Preparation of optically active omega-cyano-alpha-acylamino derivativeInfo
- Publication number
- JPS54154712A JPS54154712A JP6203978A JP6203978A JPS54154712A JP S54154712 A JPS54154712 A JP S54154712A JP 6203978 A JP6203978 A JP 6203978A JP 6203978 A JP6203978 A JP 6203978A JP S54154712 A JPS54154712 A JP S54154712A
- Authority
- JP
- Japan
- Prior art keywords
- cyano
- optically active
- alpha
- preparation
- asymmetric hydrogenation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To obtain the title compound with high optical purity which is an intermediate for pharmaceuticals, pesticides, esp. for lysine, by the asymmetric hydrogenation of a novel α-acylaminoacrylic acid derivative in the presence of a specific asymmetric hydrogenation catalyst.
CONSTITUTION: An optically active ω-cyano-α-acylamino derivative of formula II (× shows an asymmetric center) is obtained by the catalytic asymmetric hydrogenation of a novel α-acylaminoacrylic acid derivative of formula I (R1=H, alkyl, or aralkyl; R2=alkyl, aralkyl, or aryl; n=0W3) in the presence of a Rh complex having optically a tive phosphine ligands. For example, (S)-N-acetyl-δ-cyano- norvaline.ethyl ester is obtained in a 90.6% yield.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6203978A JPS588390B2 (en) | 1978-05-23 | 1978-05-23 | Method for producing optically active ω↓-cyano↓-α↓-acyl amino acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6203978A JPS588390B2 (en) | 1978-05-23 | 1978-05-23 | Method for producing optically active ω↓-cyano↓-α↓-acyl amino acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54154712A true JPS54154712A (en) | 1979-12-06 |
JPS588390B2 JPS588390B2 (en) | 1983-02-15 |
Family
ID=13188618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6203978A Expired JPS588390B2 (en) | 1978-05-23 | 1978-05-23 | Method for producing optically active ω↓-cyano↓-α↓-acyl amino acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS588390B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009073841A (en) * | 2000-01-27 | 2009-04-09 | Warner-Lambert Co Llc | Asymmetric synthesis of pregabalin |
-
1978
- 1978-05-23 JP JP6203978A patent/JPS588390B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009073841A (en) * | 2000-01-27 | 2009-04-09 | Warner-Lambert Co Llc | Asymmetric synthesis of pregabalin |
Also Published As
Publication number | Publication date |
---|---|
JPS588390B2 (en) | 1983-02-15 |
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